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Protein

Maternal protein tudor

Gene

tud

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation.

GO - Biological processi

  • germ cell development Source: FlyBase
  • intracellular mRNA localization Source: FlyBase
  • mitochondrial rRNA export from mitochondrion Source: FlyBase
  • P granule organization Source: FlyBase
  • pole cell development Source: FlyBase
  • pole plasm assembly Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Oogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Maternal protein tudor
Gene namesi
Name:tud
ORF Names:CG9450
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0003891. tud.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: FlyBase
  • mitochondrion Source: FlyBase
  • nucleus Source: FlyBase
  • P granule Source: FlyBase
  • pole plasm Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001831601 – 2515Maternal protein tudorAdd BLAST2515

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei226Phosphoserine1 Publication1
Modified residuei235Phosphoserine1 Publication1
Modified residuei239Phosphoserine1 Publication1
Modified residuei800Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP25823.
PRIDEiP25823.

PTM databases

iPTMnetiP25823.

Expressioni

Developmental stagei

Expressed throughout the life cycle.

Gene expression databases

BgeeiFBgn0003891.
ExpressionAtlasiP25823. baseline.
GenevisibleiP25823. DM.

Interactioni

Subunit structurei

Interacts with vls.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
AGO3Q7PLK05EBI-498741,EBI-3431981
aubO769227EBI-498741,EBI-98862

Protein-protein interaction databases

BioGridi63051. 5 interactors.
IntActiP25823. 4 interactors.
MINTiMINT-1334222.
STRINGi7227.FBpp0071508.

Structurei

Secondary structure

12515
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1982 – 1990Combined sources9
Beta strandi1993 – 1998Combined sources6
Helixi1999 – 2001Combined sources3
Helixi2002 – 2014Combined sources13
Beta strandi2029 – 2033Combined sources5
Turni2035 – 2037Combined sources3
Beta strandi2040 – 2048Combined sources9
Beta strandi2054 – 2058Combined sources5
Turni2059 – 2061Combined sources3
Beta strandi2064 – 2068Combined sources5
Helixi2075 – 2077Combined sources3
Beta strandi2085 – 2089Combined sources5
Helixi2093 – 2097Combined sources5
Helixi2099 – 2111Combined sources13
Turni2112 – 2115Combined sources4
Beta strandi2116 – 2123Combined sources8
Beta strandi2126 – 2128Combined sources3
Beta strandi2130 – 2137Combined sources8
Helixi2143 – 2159Combined sources17
Beta strandi2164 – 2174Combined sources11
Beta strandi2177 – 2182Combined sources6
Helixi2183 – 2185Combined sources3
Helixi2186 – 2194Combined sources9
Beta strandi2217 – 2220Combined sources4
Turni2221 – 2224Combined sources4
Beta strandi2225 – 2228Combined sources4
Beta strandi2231 – 2234Combined sources4
Beta strandi2241 – 2244Combined sources4
Turni2246 – 2248Combined sources3
Beta strandi2251 – 2255Combined sources5
Turni2262 – 2266Combined sources5
Beta strandi2272 – 2277Combined sources6
Helixi2285 – 2297Combined sources13
Beta strandi2304 – 2309Combined sources6
Beta strandi2318 – 2324Combined sources7
Helixi2329 – 2337Combined sources9
Helixi2344 – 2347Combined sources4
Beta strandi2349 – 2358Combined sources10
Beta strandi2361 – 2366Combined sources6
Helixi2367 – 2369Combined sources3
Helixi2370 – 2383Combined sources14
Helixi2384 – 2386Combined sources3
Beta strandi2398 – 2402Combined sources5
Turni2404 – 2406Combined sources3
Beta strandi2409 – 2417Combined sources9
Beta strandi2419 – 2421Combined sources3
Beta strandi2423 – 2426Combined sources4
Turni2428 – 2430Combined sources3
Beta strandi2433 – 2437Combined sources5
Helixi2444 – 2447Combined sources4
Beta strandi2452 – 2458Combined sources7
Helixi2460 – 2462Combined sources3
Helixi2465 – 2476Combined sources12
Turni2477 – 2480Combined sources4
Beta strandi2481 – 2490Combined sources10
Beta strandi2492 – 2494Combined sources3
Beta strandi2496 – 2502Combined sources7
Helixi2507 – 2510Combined sources4
Turni2512 – 2514Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3NTHX-ray2.80A2344-2515[»]
3NTIX-ray2.80A2344-2515[»]
3NTKX-ray1.80A/B2346-2514[»]
4Q5WX-ray1.80A/B1978-2160[»]
4Q5YX-ray3.00A2164-2515[»]
ProteinModelPortaliP25823.
SMRiP25823.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP25823.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini455 – 513Tudor 1PROSITE-ProRule annotationAdd BLAST59
Domaini641 – 696Tudor 2PROSITE-ProRule annotationAdd BLAST56
Domaini1062 – 1122Tudor 3PROSITE-ProRule annotationAdd BLAST61
Domaini1355 – 1414Tudor 4PROSITE-ProRule annotationAdd BLAST60
Domaini1662 – 1718Tudor 5PROSITE-ProRule annotationAdd BLAST57
Domaini1839 – 1898Tudor 6PROSITE-ProRule annotationAdd BLAST60
Domaini2023 – 2082Tudor 7PROSITE-ProRule annotationAdd BLAST60
Domaini2211 – 2269Tudor 8PROSITE-ProRule annotationAdd BLAST59
Domaini2392 – 2451Tudor 9PROSITE-ProRule annotationAdd BLAST60

Sequence similaritiesi

Contains 9 Tudor domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IPR2. Eukaryota.
ENOG410ZHUW. LUCA.
GeneTreeiENSGT00730000110295.
InParanoidiP25823.
KOiK18405.
OMAiREMRQFY.
OrthoDBiEOG091G01J3.
PhylomeDBiP25823.

Family and domain databases

InterProiIPR002999. Tudor.
[Graphical view]
PfamiPF00567. TUDOR. 9 hits.
[Graphical view]
SMARTiSM00333. TUDOR. 10 hits.
[Graphical view]
PROSITEiPS50304. TUDOR. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25823-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGQARIALP SKVDLYITHV DHVGPYLKVY GHVNRDAASL ISERIRNLLP
60 70 80 90 100
TCFAIEPSWS VERQQALLIP GTFCIFKNIN GPAPGDVEYR RIRVVSADLE
110 120 130 140 150
GQSMRAEIDF VDFGYKRTVD SHDLMFPKQP KLLQNIPLHC FQYIVLGICS
160 170 180 190 200
EWDQTDLAEV RRLVVNQIVK ITVEPTQICD QKFASLRWKD FELNEFLVQQ
210 220 230 240 250
KQIGVSVDKQ LMMDHCKKLW KDNPQSPVTE YNNNSIHNSK TPMEIAREQL
260 270 280 290 300
AVRQSLAARL DAQRSVQVTP SRPLNADAPD YTPKHLPLVN VTNVQVQMPG
310 320 330 340 350
LNNTQKPVFV STNPYNRANY QPAVPAAQPY VPKANPRSQY TYYNVRMNKP
360 370 380 390 400
INAMPPPAGP HVPIQHFNQQ ANNVSLSYVP ARFTPPPTPS IAQHQIPIPA
410 420 430 440 450
FRTTSLTVGL TYDVVISYVE NGPYLFWVHL KSSDHDLSTM MGQIERTKLK
460 470 480 490 500
ALAQAPELGT ACVARFSEDG HLYRAMVCAV YAQRYRVVYV DYGNSELLSA
510 520 530 540 550
SDLFQIPPEL LEIKPFAFRF ALAGTKEIEP IDDSMKRIFK KSAIYRNFEL
560 570 580 590 600
TVQAPESVGS MQTCHLNQNG TNMLELLRQL KNSRQSYKKA EQLENDDAVE
610 620 630 640 650
IRFIDSPSNF YVQKVANIGK FEQLMDEMFS YYNANQRVPD QLILGAPCIV
660 670 680 690 700
KCDQEWYRAE ILRVDDSVIV RHVDFGYEQN VKRHLIGHIA EKHLEMPRQA
710 720 730 740 750
IKCCLKGFEN SELSEDKITD QFEMLAEESN IRRRTFSVRI FRIEPDGLNV
760 770 780 790 800
VNLLAKNLNV MKKLYKLSMP FEQYLSLEKG QFNANNTRAE SVISSELNKS
810 820 830 840 850
HILNSTSIGE TENRLQEQEK EQQQKKVDVR QQQLAVEIPQ AVKSVSGSKN
860 870 880 890 900
STDWDKRSST SAGSKDSKRQ QQQQIQRIDR HLDFSCETQS TGSYSSGMSS
910 920 930 940 950
PRKGNRQQNG RTPIQSPRHN EKQEAKKNAR FSNSESPRRS RDGQQGNQRS
960 970 980 990 1000
QNAPQGYAQK PQRQKSTLDG NISSKRSSGV GSDIASSSSE SVAAAKPEKY
1010 1020 1030 1040 1050
VSLDKPYALQ EMKTPSKEAA SLSWWLSPFQ FYIVPKSVSA KYDNIMRDMR
1060 1070 1080 1090 1100
EFYRQKQHQP LQLKVGSTVV VRQRKDNAIL RATVTACNHM MRKYRVFCVD
1110 1120 1130 1140 1150
TGSLITVTSE DIWQLEQRFA DPPCMAHRCS FHSVVTNYDP LYIVDRMETF
1160 1170 1180 1190 1200
VPVNAKVDCE FVSKEKSNQG SNTSSTCSYT VNIFVNGASL RDMLVKAEFL
1210 1220 1230 1240 1250
TEVAPEIRVN LLAGQQIRGK FTSIRDMTSF KVQFDYGNNV NFLCTYDDAK
1260 1270 1280 1290 1300
FVKSNPNLAR RFKEFYEGKS FALNVKNVCE NNIVHLRPVM PLFMEDRRSF
1310 1320 1330 1340 1350
ICPYPVVLSS FQALVVYTAK PYRVYVQPQA IVPSMQTLLD NMYEHYKAKG
1360 1370 1380 1390 1400
DSLKKFDVGQ ICAVRSSDGN WYRARISGKD SNAACFEVFY IDYGNTEEIK
1410 1420 1430 1440 1450
RDDIKALDAK FYEHASGFAV EINLPIGRPS NDTKLKARIS EILEEKVVTI
1460 1470 1480 1490 1500
KSIEVRRSHL IADVILENNQ SVIDLLKAEK LVPGKDLDYM RKQMEKGKSR
1510 1520 1530 1540 1550
TYEYIETVDL TLDEEEDKGR KETVSKSGSA NASPKKKQHN DKDREPKKSK
1560 1570 1580 1590 1600
PAEPARTVAP QPVALKTPSP VPAEPAPVPK PATPVPEVVE VPEINPTVRE
1610 1620 1630 1640 1650
AAAESKQAPA QEDPYKDLDC VVLSHCDNPA QFYVHPIDQL SKLNQLHENL
1660 1670 1680 1690 1700
QIVSPSLPQL MNVVNGADCV SMYSVDKCWY RAKIIDAELM VLLFIDYGNT
1710 1720 1730 1740 1750
DCVSDATDIK ESMWSHIEPF CLPCALPIRP KGTADWVDAA NGIFNESYSK
1760 1770 1780 1790 1800
VPRLEYLTQG DHYTTSYVNM YIDGEDVAKK LIADGFARPL EYLASGCSCY
1810 1820 1830 1840 1850
ISHVNGICDF FIQLERDSKA LELIELYLRK KDTLKPLEGF EKGLIVAALF
1860 1870 1880 1890 1900
EDDELWYRAQ LQKELPDSRY EVLFIDYGNT STTSKCLMLS EEIASLPSLS
1910 1920 1930 1940 1950
KKCSLQLPDA YISWSPEAEA KFAELTGEGE LVFTTQLLKP GQDHVTIDLL
1960 1970 1980 1990 2000
LDGENIIDRL LPLCQRKEPK EASKESLAVT TKAIITHVEN TSRIYLQFSE
2010 2020 2030 2040 2050
KDSLMDIICE KLNGSKLQPK TEKAAVDDMC VVQFADDLEF YRSRILEVLE
2060 2070 2080 2090 2100
DDQYKVILID YGNTTVVDKL YELPQEFTLI KPVAEICSME PSAIFEKNKA
2110 2120 2130 2140 2150
LTLTTFDALL DSCKGVVAVE FVNKSASPPV VRLTTKDKRS LKIYEHLQKL
2160 2170 2180 2190 2200
VQAELKLIQK RNENSECIIS YGNSPKSFYV QMKHNSADLD LIVKTLQSLK
2210 2220 2230 2240 2250
KEKLKKLIDP TTNSNGVCYS QEDACYYRCS IKSVLDPSQG FEVFLLDYGN
2260 2270 2280 2290 2300
TLVVPEVWQL PQEIEPIPSL ALHCQLSKIP MDVSDEKLEE AFAALLEQHF
2310 2320 2330 2340 2350
GELYEITTQP NEDETKPLIA ELRINYKDFV QELVSTVTGV QKPLEAELHN
2360 2370 2380 2390 2400
CVVVQFDGPM SFYVQMESDV PALEQMTDKL LDAEQDLPAF SDLKEGALCV
2410 2420 2430 2440 2450
AQFPEDEVFY RAQIRKVLDD GKCEVHFIDF GNNAVTQQFR QLPEELAKPA
2460 2470 2480 2490 2500
RYSRHCELDA STISKCDAAL LQSFIDTRFS ETFQVEILAT KGTGTHVVRL
2510
FYQSKNISEK LQECQ
Length:2,515
Mass (Da):285,267
Last modified:August 30, 2005 - v2
Checksum:i1218700174D66701
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti116K → N in CAA44286 (PubMed:1936993).Curated1
Sequence conflicti635 – 638NQRV → TREF in CAA44286 (PubMed:1936993).Curated4
Sequence conflicti1763Y → I in CAA44286 (PubMed:1936993).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62420 mRNA. Translation: CAA44286.1.
AE013599 Genomic DNA. Translation: AAF46693.1.
PIRiA41519.
RefSeqiNP_476773.1. NM_057425.3.

Genome annotation databases

EnsemblMetazoaiFBtr0071582; FBpp0071508; FBgn0003891.
GeneIDi37417.
KEGGidme:Dmel_CG9450.
UCSCiCG9450-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62420 mRNA. Translation: CAA44286.1.
AE013599 Genomic DNA. Translation: AAF46693.1.
PIRiA41519.
RefSeqiNP_476773.1. NM_057425.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3NTHX-ray2.80A2344-2515[»]
3NTIX-ray2.80A2344-2515[»]
3NTKX-ray1.80A/B2346-2514[»]
4Q5WX-ray1.80A/B1978-2160[»]
4Q5YX-ray3.00A2164-2515[»]
ProteinModelPortaliP25823.
SMRiP25823.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi63051. 5 interactors.
IntActiP25823. 4 interactors.
MINTiMINT-1334222.
STRINGi7227.FBpp0071508.

PTM databases

iPTMnetiP25823.

Proteomic databases

PaxDbiP25823.
PRIDEiP25823.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0071582; FBpp0071508; FBgn0003891.
GeneIDi37417.
KEGGidme:Dmel_CG9450.
UCSCiCG9450-RA. d. melanogaster.

Organism-specific databases

CTDi37417.
FlyBaseiFBgn0003891. tud.

Phylogenomic databases

eggNOGiENOG410IPR2. Eukaryota.
ENOG410ZHUW. LUCA.
GeneTreeiENSGT00730000110295.
InParanoidiP25823.
KOiK18405.
OMAiREMRQFY.
OrthoDBiEOG091G01J3.
PhylomeDBiP25823.

Miscellaneous databases

ChiTaRSitud. fly.
EvolutionaryTraceiP25823.
GenomeRNAii37417.
PROiP25823.

Gene expression databases

BgeeiFBgn0003891.
ExpressionAtlasiP25823. baseline.
GenevisibleiP25823. DM.

Family and domain databases

InterProiIPR002999. Tudor.
[Graphical view]
PfamiPF00567. TUDOR. 9 hits.
[Graphical view]
SMARTiSM00333. TUDOR. 10 hits.
[Graphical view]
PROSITEiPS50304. TUDOR. 9 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTUD_DROME
AccessioniPrimary (citable) accession number: P25823
Secondary accession number(s): Q9W2J8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: August 30, 2005
Last modified: November 30, 2016
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Miscellaneous

The TUD mRNA accumulates within the posterior region of the developing oocyte during the early to middle stages of oogenesis.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.