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Protein

Catalase-2

Gene

CAT2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.

Catalytic activityi

2 H2O2 = O2 + 2 H2O.PROSITE-ProRule annotation

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65PROSITE-ProRule annotation1
Active sitei138PROSITE-ProRule annotation1
Metal bindingi348Iron (heme axial ligand)By similarity1

GO - Molecular functioni

  • catalase activity Source: TAIR
  • cobalt ion binding Source: TAIR
  • heme binding Source: GO_Central

GO - Biological processi

  • cell death Source: TAIR
  • cell redox homeostasis Source: TAIR
  • cellular response to nitrogen starvation Source: TAIR
  • cellular response to phosphate starvation Source: TAIR
  • cellular response to sulfate starvation Source: TAIR
  • hydrogen peroxide catabolic process Source: GO_Central
  • photoperiodism Source: TAIR
  • response to cold Source: TAIR
  • response to hydrogen peroxide Source: GO_Central
  • response to light stimulus Source: TAIR
  • response to oxidative stress Source: TAIR

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:AT4G35090-MONOMER
ReactomeiR-ATH-3299685 Detoxification of Reactive Oxygen Species
R-ATH-6798695 Neutrophil degranulation

Protein family/group databases

PeroxiBasei5141 AtKat02

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-2 (EC:1.11.1.6)
Gene namesi
Name:CAT2
Synonyms:CAT
Ordered Locus Names:At4g35090
ORF Names:M4E13.140
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G35090
TAIRilocus:2131591 AT4G35090

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Glyoxysome, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000849311 – 492Catalase-2Add BLAST492

Proteomic databases

PaxDbiP25819
PRIDEiP25819

PTM databases

iPTMnetiP25819
SwissPalmiP25819

Expressioni

Gene expression databases

ExpressionAtlasiP25819 baseline and differential
GenevisibleiP25819 AT

Interactioni

Subunit structurei

Homotetramer and heterotetramer (PubMed:25700484). At least six or seven isozymes are produced from a mixture of 3 gene products. Interacts with NCA1 (PubMed:25700484). Interacts with LSD1 (PubMed:23958864).2 Publications

Protein-protein interaction databases

BioGridi14943, 7 interactors
IntActiP25819, 3 interactors
STRINGi3702.AT4G35090.1

Structurei

3D structure databases

ProteinModelPortaliP25819
SMRiP25819
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the catalase family.Curated

Phylogenomic databases

eggNOGiKOG0047 Eukaryota
COG0753 LUCA
HOGENOMiHOG000087852
KOiK03781
OMAiKLAQFNR
OrthoDBiEOG093606DL
PhylomeDBiP25819

Family and domain databases

Gene3Di2.40.180.10, 1 hit
InterProiView protein in InterPro
IPR018028 Catalase
IPR024708 Catalase_AS
IPR024711 Catalase_clade1/3
IPR011614 Catalase_core
IPR037060 Catalase_core_sf
IPR002226 Catalase_haem_BS
IPR010582 Catalase_immune_responsive
IPR020835 Catalase_sf
PANTHERiPTHR11465 PTHR11465, 1 hit
PfamiView protein in Pfam
PF00199 Catalase, 1 hit
PF06628 Catalase-rel, 1 hit
PIRSFiPIRSF038928 Catalase_clade1-3, 1 hit
PRINTSiPR00067 CATALASE
SMARTiView protein in SMART
SM01060 Catalase, 1 hit
SUPFAMiSSF56634 SSF56634, 1 hit
PROSITEiView protein in PROSITE
PS00437 CATALASE_1, 1 hit
PS00438 CATALASE_2, 1 hit
PS51402 CATALASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: P25819-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPYKYRPAS SYNSPFFTTN SGAPVWNNNS SMTVGPRGPI LLEDYHLVEK
60 70 80 90 100
LANFDRERIP ERVVHARGAS AKGFFEVTHD ISNLTCADFL RAPGVQTPVI
110 120 130 140 150
VRFSTVIHER GSPETLRDPR GFAVKFYTRE GNFDLVGNNF PVFFIRDGMK
160 170 180 190 200
FPDMVHALKP NPKSHIQENW RILDFFSHHP ESLNMFTFLF DDIGIPQDYR
210 220 230 240 250
HMDGSGVNTY MLINKAGKAH YVKFHWKPTC GVKSLLEEDA IRVGGTNHSH
260 270 280 290 300
ATQDLYDSIA AGNYPEWKLF IQIIDPADED KFDFDPLDVT KTWPEDILPL
310 320 330 340 350
QPVGRMVLNK NIDNFFAENE QLAFCPAIIV PGIHYSDDKL LQTRVFSYAD
360 370 380 390 400
TQRHRLGPNY LQLPVNAPKC AHHNNHHEGF MNFMHRDEEV NYFPSRYDQV
410 420 430 440 450
RHAEKYPTPP AVCSGKRERC IIEKENNFKE PGERYRTFTP ERQERFIQRW
460 470 480 490
IDALSDPRIT HEIRSIWISY WSQADKSLGQ KLASRLNVRP SI
Length:492
Mass (Da):56,931
Last modified:December 13, 2001 - v3
Checksum:iAB622230561FD79B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39P → L in CAA45564 (PubMed:16669103).Curated1
Sequence conflicti109E → A in CAA45564 (PubMed:16669103).Curated1
Sequence conflicti154M → I in CAA45564 (PubMed:16669103).Curated1
Sequence conflicti243V → L in CAA45564 (PubMed:16669103).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti421I → V in strain: cv. Landsberg erecta. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64271 mRNA Translation: CAA45564.1
X94447 Genomic DNA Translation: CAA64220.1
AL022023 Genomic DNA Translation: CAA17773.1
AL161586 Genomic DNA Translation: CAB80226.1
CP002687 Genomic DNA Translation: AEE86462.1
AY074301 mRNA Translation: AAL66998.1
AY113854 mRNA Translation: AAM44902.1
PIRiT05779
RefSeqiNP_195235.1, NM_119675.4 [P25819-1]
UniGeneiAt.24350
At.64718

Genome annotation databases

EnsemblPlantsiAT4G35090.1; AT4G35090.1; AT4G35090 [P25819-1]
GeneIDi829661
GrameneiAT4G35090.1; AT4G35090.1; AT4G35090 [P25819-1]
KEGGiath:AT4G35090

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCATA2_ARATH
AccessioniPrimary (citable) accession number: P25819
Secondary accession number(s): O49615
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: December 13, 2001
Last modified: April 25, 2018
This is version 167 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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