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Protein

Protein S100-P

Gene

S100P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE).3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi19 – 32141; low affinityAdd
BLAST
Calcium bindingi62 – 73122; high affinityAdd
BLAST

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • calcium-dependent protein binding Source: HGNC
  • calcium ion binding Source: ProtInc
  • magnesium ion binding Source: HGNC

GO - Biological processi

  • endothelial cell migration Source: UniProtKB
  • response to organic substance Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-P
Alternative name(s):
Migration-inducing gene 9 protein
Short name:
MIG9
Protein S100-E
S100 calcium-binding protein P
Gene namesi
Name:S100P
Synonyms:S100E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:10504. S100P.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • cytoplasm Source: BHF-UCL
  • extracellular exosome Source: UniProtKB
  • microvillus membrane Source: UniProtKB-SubCell
  • nucleus Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi21 – 233Missing in S100Ppa; permanently active, interacts with EZR and PPP5C in absence of calcium; when associated with C-64, K-68 and S-73. 2 Publications
Mutagenesisi64 – 641N → C in S100Ppa; permanently active, interacts with EZR and PPP5C in absence of calcium; when associated with 21-S--G-23, K-68 and S-73. 2 Publications
Mutagenesisi68 – 681Q → K in S100Ppa; permanently active, interacts with EZR and PPP5C in absence of calcium; when associated with 21-S--G-23, C-64 and S-73. 2 Publications
Mutagenesisi73 – 731E → S in S100Ppa; permanently active, interacts with EZR and PPP5C in absence of calcium; when associated with 21-S--G-23, C-64 and K-68. 2 Publications

Organism-specific databases

PharmGKBiPA34913.

Chemistry

DrugBankiDB01003. Cromoglicic acid.

Polymorphism and mutation databases

BioMutaiS100P.
DMDMi134142.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9595Protein S100-PPRO_0000144032Add
BLAST

Proteomic databases

EPDiP25815.
MaxQBiP25815.
PaxDbiP25815.
PeptideAtlasiP25815.
PRIDEiP25815.
TopDownProteomicsiP25815.

PTM databases

iPTMnetiP25815.
PhosphoSiteiP25815.

Expressioni

Tissue specificityi

Detected in all of the tissues except brain, testis and small intestine, expression level is higher in placenta, heart, lung, skeletal muscle, spleen and leukocyte. Up-regulated in various pancreatic ductal adenocarcinomas and pancreatic intraepithelial neoplasias.2 Publications

Gene expression databases

BgeeiENSG00000163993.
CleanExiHS_S100P.
GenevisibleiP25815. HS.

Organism-specific databases

HPAiCAB012900.
HPA019502.

Interactioni

Subunit structurei

Homodimer and heterodimer with S100A1. Interacts with S100PBP and S100Z. Interacts with CACYBP in a calcium-dependent manner. Dimeric form binds to and activates EZR/Ezrin by unmasking its F-actin binding sites. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AGERQ151092EBI-743700,EBI-1646426
CacybpQ9CXW32EBI-743700,EBI-767146From a different organism.
S100A1P232978EBI-743700,EBI-743686
S100A1Q5T7Y64EBI-743700,EBI-11746600
S100BP042714EBI-743700,EBI-458391
TERF2IPQ9NYB02EBI-743700,EBI-750109
TFIP11Q9UBB93EBI-743700,EBI-1105213

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • calcium-dependent protein binding Source: HGNC

Protein-protein interaction databases

BioGridi112194. 21 interactions.
IntActiP25815. 9 interactions.
MINTiMINT-239013.
STRINGi9606.ENSP00000296370.

Structurei

Secondary structure

1
95
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 1816Combined sources
Beta strandi21 – 233Combined sources
Beta strandi25 – 284Combined sources
Helixi30 – 4011Combined sources
Helixi44 – 463Combined sources
Helixi53 – 619Combined sources
Beta strandi63 – 708Combined sources
Helixi71 – 9222Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1J55X-ray2.00A1-95[»]
1OZONMR-A/B1-95[»]
2MJWNMR-B/D1-94[»]
ProteinModelPortaliP25815.
SMRiP25815. Positions 1-94.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP25815.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 4736EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini49 – 8436EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J11V. Eukaryota.
ENOG410YX5D. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP25815.
OMAiLTSACHK.
OrthoDBiEOG091G10QT.
PhylomeDBiP25815.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028494. S100P.
[Graphical view]
PANTHERiPTHR11639:SF69. PTHR11639:SF69. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25815-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTELETAMGM IIDVFSRYSG SEGSTQTLTK GELKVLMEKE LPGFLQSGKD
60 70 80 90
KDAVDKLLKD LDANGDAQVD FSEFIVFVAA ITSACHKYFE KAGLK
Length:95
Mass (Da):10,400
Last modified:December 1, 1992 - v2
Checksum:i786E6E3F3EACC6C1
GO

Sequence cautioni

The sequence AAS00487 differs from that shown.Sequencing error in Met-1 codon.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121I → M in AAS00487 (Ref. 4) Curated
Sequence conflicti32 – 321E → T AA sequence (PubMed:1540168).Curated
Sequence conflicti44 – 441F → E AA sequence (PubMed:1540168).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65614 mRNA. Translation: CAA46566.1.
AF539739 mRNA. Translation: AAO41114.1.
BT007289 mRNA. Translation: AAP35953.1.
AY423724 mRNA. Translation: AAS00487.1. Sequence problems.
BC006819 mRNA. Translation: AAH06819.1.
CCDSiCCDS3391.1.
PIRiS24146.
RefSeqiNP_005971.1. NM_005980.2.
UniGeneiHs.2962.

Genome annotation databases

EnsembliENST00000296370; ENSP00000296370; ENSG00000163993.
GeneIDi6286.
KEGGihsa:6286.
UCSCiuc003gjl.4. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65614 mRNA. Translation: CAA46566.1.
AF539739 mRNA. Translation: AAO41114.1.
BT007289 mRNA. Translation: AAP35953.1.
AY423724 mRNA. Translation: AAS00487.1. Sequence problems.
BC006819 mRNA. Translation: AAH06819.1.
CCDSiCCDS3391.1.
PIRiS24146.
RefSeqiNP_005971.1. NM_005980.2.
UniGeneiHs.2962.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1J55X-ray2.00A1-95[»]
1OZONMR-A/B1-95[»]
2MJWNMR-B/D1-94[»]
ProteinModelPortaliP25815.
SMRiP25815. Positions 1-94.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112194. 21 interactions.
IntActiP25815. 9 interactions.
MINTiMINT-239013.
STRINGi9606.ENSP00000296370.

Chemistry

DrugBankiDB01003. Cromoglicic acid.

PTM databases

iPTMnetiP25815.
PhosphoSiteiP25815.

Polymorphism and mutation databases

BioMutaiS100P.
DMDMi134142.

Proteomic databases

EPDiP25815.
MaxQBiP25815.
PaxDbiP25815.
PeptideAtlasiP25815.
PRIDEiP25815.
TopDownProteomicsiP25815.

Protocols and materials databases

DNASUi6286.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296370; ENSP00000296370; ENSG00000163993.
GeneIDi6286.
KEGGihsa:6286.
UCSCiuc003gjl.4. human.

Organism-specific databases

CTDi6286.
GeneCardsiS100P.
HGNCiHGNC:10504. S100P.
HPAiCAB012900.
HPA019502.
MIMi600614. gene.
neXtProtiNX_P25815.
PharmGKBiPA34913.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J11V. Eukaryota.
ENOG410YX5D. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP25815.
OMAiLTSACHK.
OrthoDBiEOG091G10QT.
PhylomeDBiP25815.
TreeFamiTF332727.

Miscellaneous databases

EvolutionaryTraceiP25815.
GeneWikiiS100P.
GenomeRNAii6286.
PROiP25815.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163993.
CleanExiHS_S100P.
GenevisibleiP25815. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028494. S100P.
[Graphical view]
PANTHERiPTHR11639:SF69. PTHR11639:SF69. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS100P_HUMAN
AccessioniPrimary (citable) accession number: P25815
Secondary accession number(s): Q5J7W2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: December 1, 1992
Last modified: September 7, 2016
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This protein binds two calcium ions.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.