P25815 (S100P_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein S100-P

Alternative name(s):
Protein S100-E
S100 calcium-binding protein P

Gene names

Name:	S100P
Synonyms:	S100E

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	95 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Homodimer. Interacts with S100PBP and S100Z. Ref.6
Subcellular location	Nucleus. Cytoplasm. Note: Colocalizes with S100PBP in the nucleus. Ref.6
Tissue specificity	Up-regulated in various pancreatic ductal adenocarcinomas and pancreatic intraepithelial neoplasias. Ref.6
Miscellaneous	This protein binds two calcium ions.
Sequence similarities	Belongs to the S-100 family. Contains 2 EF-hand domains.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Domain	Repeat
Ligand	Calcium
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	endothelial cell migration Inferred from mutant phenotype. Source: UniProtKB
Cellular component	cytoplasm Traceable author statement Ref.6. Source: HGNC nucleus Inferred from direct assay Ref.6. Source: HGNC
Molecular function	calcium ion binding Traceable author statement. Source: ProtInc calcium-dependent protein binding Inferred from physical interaction Ref.6. Source: HGNC magnesium ion binding Traceable author statement Ref.6. Source: HGNC
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
AGER	Q15109	2	EBI-743700,EBI-1646426
S100A1	P23297	7	EBI-743700,EBI-743686

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 95

95

Protein S100-P

PRO_0000144032

Regions

Domain

12 – 47

36

EF-hand 1

Domain

49 – 84

36

EF-hand 2

Calcium binding

19 – 32

14

1; low affinity

Calcium binding

62 – 73

12

2; high affinity

Experimental info

Sequence conflict

32

1

E → T AA sequence Ref.5

Sequence conflict

44

1

F → E AA sequence Ref.5

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

95

Helix Strand Turn

Details...

Helix

3 – 18

16

Beta strand

21 – 23

3

Helix

30 – 40

11

Helix

53 – 61

9

Beta strand

63 – 70

8

Helix

71 – 92

22

Sequences

	Sequence		Length	Mass (Da)
	P25815 [UniParc]. Last modified December 1, 1992. Version 2. Checksum: 786E6E3F3EACC6C1	FASTA	95	10,400
	10 20 30 40 50 60 MTELETAMGM IIDVFSRYSG SEGSTQTLTK GELKVLMEKE LPGFLQSGKD KDAVDKLLKD 70 80 90 LDANGDAQVD FSEFIVFVAA ITSACHKYFE KAGLK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"S100P, a novel Ca(2+)-binding protein from human placenta. cDNA cloning, recombinant protein expression and Ca2+ binding properties." Becker T., Gerke V., Kube E., Weber K. Eur. J. Biochem. 207:541-547(1992) [PubMed: 1633809] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[2]	"Cloning, expression and characterization of a novel human calcium-binding S100 gene." Jin G., Wang S., Chen J. Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[5]	"Purification and characterization of a new member of the S-100 protein family from human placenta." Emoto Y., Kobayashi R., Akatsuka H., Hidaka H. Biochem. Biophys. Res. Commun. 182:1246-1253(1992) [PubMed: 1540168] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-91. Tissue: Placenta.
[6]	"Expression of S100P and its novel binding partner S100PBPR in early pancreatic cancer." Dowen S.E., Crnogorac-Jurcevic T., Gangeswaran R., Hansen M., Eloranta J.J., Bhakta V., Brentnall T.A., Luettges J., Kloeppel G., Lemoine N.R. Am. J. Pathol. 166:81-92(2005) [PubMed: 15632002] [Abstract] Cited for: INTERACTION WITH S100PBP, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[7]	"The crystal structure at 2A resolution of the Ca2+ -binding protein S100P." Zhang H., Wang G., Ding Y., Wang Z., Barraclough R., Rudland P.S., Fernig D.G., Rao Z. J. Mol. Biol. 325:785-794(2003) [PubMed: 12507480] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X65614 mRNA. Translation: CAA46566.1.
AF539739 mRNA. Translation: AAO41114.1.
BT007289 mRNA. Translation: AAP35953.1.
BC006819 mRNA. Translation: AAH06819.1.

IPI

IPI00017526.

PIR

S24146.

RefSeq

NP_005971.1. NM_005980.2.

UniGene

Hs.2962.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1J55	X-ray	2.00	A	1-95	[»]
1OZO	NMR	-	A/B	1-95	[»]

ProteinModelPortal

P25815.

SMR

P25815. Positions 1-95.

ModBase

Search...

Protein-protein interaction databases

IntAct

P25815. 6 interactions.

MINT

MINT-239013.

STRING

P25815.

Polymorphism databases

DMDM

134142.

Proteomic databases

PeptideAtlas

P25815.

PRIDE

P25815.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000296370; ENSP00000296370; ENSG00000163993.

GeneID

6286.

KEGG

hsa:6286.

UCSC

uc003gjl.1. human.

Organism-specific databases

CTD

6286.

GeneCards

GC04P006696.

H-InvDB

HIX0004067.

HGNC

HGNC:10504. S100P.

HPA

CAB012900.
HPA019502.

MIM

600614. gene.

neXtProt

NX_P25815.

PharmGKB

PA34913.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG21364.

HOGENOM

HBG716817.

HOVERGEN

HBG001479.

InParanoid

P25815.

OMA

KQSLTKG.

OrthoDB

EOG4GQQ6N.

PhylomeDB

P25815.

Gene expression databases

ArrayExpress

P25815.

Bgee

P25815.

CleanEx

HS_S100P.

Genevestigator

P25815.

GermOnline

ENSG00000163993. Homo sapiens.

Family and domain databases

InterPro

IPR011992. EF-hand-like_dom.
IPR018249. EF_HAND_2.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]

Gene3D

G3DSA:1.10.238.10. EF-Hand_type. 1 hit.

Pfam

PF01023. S_100. 1 hit.
[Graphical view]

PROSITE

PS00018. EF_HAND_1. False negative.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

DrugBank

DB01003. Cromoglicate.

NextBio

24409.

SOURCE

Search...

Entry information

Entry name

S100P_HUMAN

Accession

Primary (citable) accession number: P25815

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
Last sequence update:	December 1, 1992
Last modified:	January 25, 2012
This is version 109 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.