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Protein

Gurmarin

Gene
N/A
Organism
Gymnema sylvestre (Gurmar) (Periploca sylvestris)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Suppresses strongly the sweet taste responses in the rat with high specificity to sucrose, glucose, glycine, and saccharin. This effect is reversible, but complete recovery of the suppressed responses required at least 3h. Gurmarin showed no effect or only a very weak effect on the sweet taste sensation in humans.

Keywordsi

Molecular functionTaste-modifying protein

Names & Taxonomyi

Protein namesi
Recommended name:
Gurmarin
Alternative name(s):
Sweet taste-suppressing peptide
OrganismiGymnema sylvestre (Gurmar) (Periploca sylvestris)
Taxonomic identifieri4068 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsGentianalesApocynaceaeAsclepiadoideaeMarsdenieaeGymnema

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000447761 – 35GurmarinAdd BLAST35

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1Pyrrolidone carboxylic acid1 Publication1
Disulfide bondi3 ↔ 18
Disulfide bondi10 ↔ 23
Disulfide bondi17 ↔ 33

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Miscellaneous databases

PMAP-CutDBiP25810.

Structurei

Secondary structure

135
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni12 – 14Combined sources3
Beta strandi18 – 20Combined sources3
Beta strandi23 – 29Combined sources7
Beta strandi31 – 33Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1C4ENMR-A1-35[»]
1GURNMR-A2-35[»]
ProteinModelPortaliP25810.
SMRiP25810.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP25810.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

Keywords - Domaini

Knottin

Family and domain databases

InterProiView protein in InterPro
IPR009101. Gurmarin/antifun_pep.
SUPFAMiSSF57048. SSF57048. 1 hit.

Sequencei

Sequence statusi: Complete.

P25810-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
QQCVKKDELC IPYYLDCCEP LECKKVNWWD HKCIG
Length:35
Mass (Da):4,232
Last modified:February 1, 1994 - v2
Checksum:i661BD6FBAF504CB6
GO

Sequence databases

PIRiJX0200.

Entry informationi

Entry nameiGUR_GYMSY
AccessioniPrimary (citable) accession number: P25810
Secondary accession number(s): Q9S8D1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: February 1, 1994
Last modified: May 10, 2017
This is version 83 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references