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Protein

Gut-specific cysteine proteinase

Gene

cpr-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Thiol protease. Has a role as a digestive enzyme.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei113By similarity1
Active sitei275By similarity1
Active sitei295By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

ReactomeiR-CEL-1442490 Collagen degradation
R-CEL-2132295 MHC class II antigen presentation
R-CEL-6798695 Neutrophil degranulation

Protein family/group databases

MEROPSiC01.A32

Names & Taxonomyi

Protein namesi
Recommended name:
Gut-specific cysteine proteinase (EC:3.4.22.-)
Gene namesi
Name:cpr-1
Synonyms:gcp-1
ORF Names:C52E4.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiC52E4.1 ; CE31896 ; WBGene00000781 ; cpr-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
PropeptideiPRO_000002619016 – 84Activation peptideSequence analysisAdd BLAST69
ChainiPRO_000002619185 – 329Gut-specific cysteine proteinaseAdd BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi98 ↔ 127By similarity
Disulfide bondi110 ↔ 155By similarity
Disulfide bondi146 ↔ 204By similarity
Disulfide bondi147 ↔ 151By similarity
Disulfide bondi183 ↔ 208By similarity
Disulfide bondi191 ↔ 196By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

EPDiP25807
PaxDbiP25807
PeptideAtlasiP25807
PRIDEiP25807

Expressioni

Tissue specificityi

Larvae exhibit strong expression in gut cells and weak expression in hypodermal cells. Adults exhibit the reverse: strong expression in hypodermal cells and weaker expression in gut cells.2 Publications

Developmental stagei

Larvae and adults, but not in embryos.2 Publications

Inductioni

Activated by a GATA-like transcription factor.

Gene expression databases

BgeeiWBGene00000781

Interactioni

Protein-protein interaction databases

BioGridi44661, 2 interactors
DIPiDIP-25619N
STRINGi6239.C52E4.1

Structurei

3D structure databases

ProteinModelPortaliP25807
SMRiP25807
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1543 Eukaryota
COG4870 LUCA
GeneTreeiENSGT00900000140859
HOGENOMiHOG000241341
InParanoidiP25807
KOiK01363
OMAiCSLSCQS
OrthoDBiEOG091G094Z
PhylomeDBiP25807

Family and domain databases

InterProiView protein in InterPro
IPR025661 Pept_asp_AS
IPR000169 Pept_cys_AS
IPR025660 Pept_his_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
PANTHERiPTHR12411 PTHR12411, 1 hit
PfamiView protein in Pfam
PF00112 Peptidase_C1, 1 hit
PRINTSiPR00705 PAPAIN
SMARTiView protein in SMART
SM00645 Pept_C1, 1 hit
PROSITEiView protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
PS00639 THIOL_PROTEASE_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25807-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFLILTALC AVTLAFVPIN HQSAVETLTG QALVDYVNSA QSLFKTEHVE
60 70 80 90 100
ITEEEMKFKL MDGKYAAAHS DEIRATEQEV VLASVPATFD SRTQWSECKS
110 120 130 140 150
IKLIRDQATC GSCWAFGAAE MISDRTCIET KGAQQPIISP DDLLSCCGSS
160 170 180 190 200
CGNGCEGGYP IQALRWWDSK GVVTGGDYHG AGCKPYPIAP CTSGNCPESK
210 220 230 240 250
TPSCSMSCQS GYSTAYAKDK HFGVSAYAVP KNAASIQAEI YANGPVEAAF
260 270 280 290 300
SVYEDFYKYK SGVYKHTAGK YLGGHAIKII GWGTESGSPY WLVANSWGVN
310 320
WGESGFFKIY RGDDQCGIES AVVAGKAKV
Length:329
Mass (Da):35,397
Last modified:June 20, 2003 - v2
Checksum:i4FFD6F1B717B537D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74797 Genomic DNA Translation: AAB88058.1
Z78012 Genomic DNA Translation: CAB01410.2
PIRiT20148
RefSeqiNP_506002.2, NM_073601.9
UniGeneiCel.4328

Genome annotation databases

EnsemblMetazoaiC52E4.1; C52E4.1; WBGene00000781
GeneIDi179637
KEGGicel:CELE_C52E4.1
UCSCiC52E4.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiCPR1_CAEEL
AccessioniPrimary (citable) accession number: P25807
Secondary accession number(s): Q18783
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: June 20, 2003
Last modified: May 23, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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