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Protein

Rhombotin-2

Gene

Lmo2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular response to thyroid hormone stimulus Source: MGI
  • embryonic hemopoiesis Source: MGI
  • mRNA transcription from RNA polymerase II promoter Source: MGI
  • negative regulation of erythrocyte differentiation Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Rhombotin-2
Alternative name(s):
Cysteine-rich protein TTG-2
LIM domain only protein 2
Short name:
LMO-2
T-cell translocation protein 2
Gene namesi
Name:Lmo2
Synonyms:Rbtn-2, Rbtn2, Rhom-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:102811. Lmo2.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
  • protein complex Source: UniProtKB
  • transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 158158Rhombotin-2PRO_0000075897Add
BLAST

Proteomic databases

PaxDbiP25801.
PRIDEiP25801.

PTM databases

PhosphoSiteiP25801.

Expressioni

Tissue specificityi

Expressed in early mouse development in central nervous system, lung, kidney, liver and spleen but only very low levels occur in thymus.1 Publication

Gene expression databases

BgeeiENSMUSG00000032698.
CleanExiMM_LMO2.
ExpressionAtlasiP25801. baseline and differential.
GenevisibleiP25801. MM.

Interactioni

Subunit structurei

Interacts with BEX2 and KDM5A (By similarity). Interacts via its LIM domains with ELF2 and LDB1. Also interacts with basic helix-loop-helix protein TAL1/SCL and can assemble in a complex with LMO2 and TAL1/SCL.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Gata1P176795EBI-3903256,EBI-3903251
GATA2P237693EBI-3903256,EBI-2806671From a different organism.
TAL1P175425EBI-3903256,EBI-1753878From a different organism.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201179. 59 interactions.
DIPiDIP-24247N.
IntActiP25801. 5 interactions.
MINTiMINT-2567948.
STRINGi10090.ENSMUSP00000106770.

Structurei

Secondary structure

1
158
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi30 – 334Combined sources
Beta strandi39 – 446Combined sources
Beta strandi46 – 505Combined sources
Turni52 – 543Combined sources
Beta strandi58 – 603Combined sources
Beta strandi67 – 693Combined sources
Helixi81 – 877Combined sources
Beta strandi95 – 984Combined sources
Turni117 – 1193Combined sources
Beta strandi122 – 1254Combined sources
Beta strandi133 – 1375Combined sources
Beta strandi139 – 1435Combined sources
Beta strandi145 – 1473Combined sources
Helixi148 – 1558Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1J2ONMR-A26-87[»]
2L6YNMR-B84-156[»]
2L6ZNMR-C84-156[»]
2LXDNMR-A84-156[»]
ProteinModelPortaliP25801.
SMRiP25801. Positions 9-156.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP25801.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 8960LIM zinc-binding 1PROSITE-ProRule annotationAdd
BLAST
Domaini94 – 15360LIM zinc-binding 2PROSITE-ProRule annotationAdd
BLAST

Domaini

The second LIM zinc-binding domain interacts with KDM5A.By similarity

Sequence similaritiesi

Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
HOGENOMiHOG000232175.
HOVERGENiHBG054231.
InParanoidiP25801.
KOiK15612.

Family and domain databases

Gene3Di2.10.110.10. 2 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00132. LIM. 2 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25801-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSAIERKSL DPSEEPVDEV LQIPPSLLTC GGCQQNIGDR YFLKAIDQYW
60 70 80 90 100
HEDCLSCDLC GCRLGEVGRR LYYKLGRKLC RRDYLRLFGQ DGLCASCDKR
110 120 130 140 150
IRAYEMTMRV KDKVYHLECF KCAACQKHFC VGDRYLLINS DIVCEQDIYE

WTKINGII
Length:158
Mass (Da):18,340
Last modified:May 1, 1992 - v1
Checksum:i1B49302505528C93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64360 mRNA. Translation: AAA40054.1.
BC057880 mRNA. Translation: AAH57880.1.
CCDSiCCDS50652.1.
PIRiA39370.
RefSeqiNP_001135808.1. NM_001142336.1.
NP_001135809.1. NM_001142337.1.
XP_006498883.1. XM_006498820.2.
UniGeneiMm.29266.

Genome annotation databases

EnsembliENSMUST00000123437; ENSMUSP00000117703; ENSMUSG00000032698.
ENSMUST00000170926; ENSMUSP00000128317; ENSMUSG00000032698.
GeneIDi16909.
KEGGimmu:16909.
UCSCiuc012caj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64360 mRNA. Translation: AAA40054.1.
BC057880 mRNA. Translation: AAH57880.1.
CCDSiCCDS50652.1.
PIRiA39370.
RefSeqiNP_001135808.1. NM_001142336.1.
NP_001135809.1. NM_001142337.1.
XP_006498883.1. XM_006498820.2.
UniGeneiMm.29266.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1J2ONMR-A26-87[»]
2L6YNMR-B84-156[»]
2L6ZNMR-C84-156[»]
2LXDNMR-A84-156[»]
ProteinModelPortaliP25801.
SMRiP25801. Positions 9-156.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201179. 59 interactions.
DIPiDIP-24247N.
IntActiP25801. 5 interactions.
MINTiMINT-2567948.
STRINGi10090.ENSMUSP00000106770.

PTM databases

PhosphoSiteiP25801.

Proteomic databases

PaxDbiP25801.
PRIDEiP25801.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000123437; ENSMUSP00000117703; ENSMUSG00000032698.
ENSMUST00000170926; ENSMUSP00000128317; ENSMUSG00000032698.
GeneIDi16909.
KEGGimmu:16909.
UCSCiuc012caj.1. mouse.

Organism-specific databases

CTDi4005.
MGIiMGI:102811. Lmo2.

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
HOGENOMiHOG000232175.
HOVERGENiHBG054231.
InParanoidiP25801.
KOiK15612.

Miscellaneous databases

ChiTaRSiLmo2. mouse.
EvolutionaryTraceiP25801.
PROiP25801.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032698.
CleanExiMM_LMO2.
ExpressionAtlasiP25801. baseline and differential.
GenevisibleiP25801. MM.

Family and domain databases

Gene3Di2.10.110.10. 2 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00132. LIM. 2 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRBTN2_MOUSE
AccessioniPrimary (citable) accession number: P25801
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: September 7, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.