ID RBTN1_HUMAN Reviewed; 156 AA. AC P25800; E9PSF5; Q4VBC5; Q8IXR0; DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1992, sequence version 1. DT 27-MAR-2024, entry version 194. DE RecName: Full=Rhombotin-1; DE AltName: Full=Cysteine-rich protein TTG-1; DE AltName: Full=LIM domain only protein 1; DE Short=LMO-1; DE AltName: Full=T-cell translocation protein 1; GN Name=LMO1; Synonyms=RBTN1, RHOM1, TTG1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RX PubMed=2501659; DOI=10.1128/mcb.9.5.2124-2132.1989; RA McGuire E.A., Hockett R.D., Pollock K.M., Bartholdi M.F., O'Brien S.J., RA Korsmeyer S.J.; RT "The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line RT activates multiple transcripts, including Ttg-1, a gene encoding a RT potential zinc finger protein."; RL Mol. Cell. Biol. 9:2124-2132(1989). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RX PubMed=2311586; DOI=10.1002/j.1460-2075.1990.tb08183.x; RA Boehm T., Greenberg J.M., Buluwela L., Lavenir I., Forster A., RA Rabbitts T.H.; RT "An unusual structure of a putative T cell oncogene which allows production RT of similar proteins from distinct mRNAs."; RL EMBO J. 9:857-868(1990). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION. RX PubMed=1703797; RA McGuire E.A., Davis A.R., Korsmeyer S.J.; RT "T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally RT expressed in neural lineage cells."; RL Blood 77:599-606(1991). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC TISSUE=Blood; RX PubMed=11528126; DOI=10.1159/000056998; RA Cichutek A., Brueckmann T., Seipel B., Hauser H., Schlaubitz S., RA Prawitt D., Hankeln T., Schmidt E.R., Winterpacht A., Zabel B.U.; RT "Comparative architectural aspects of regions of conserved synteny on human RT chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and RT LMO1)."; RL Cytogenet. Cell Genet. 93:277-283(2001). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16554811; DOI=10.1038/nature04632; RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., RA Hattori M., Rogers J., Lander E.S., Sakaki Y.; RT "Human chromosome 11 DNA sequence and analysis including novel gene RT identification."; RL Nature 440:497-500(2006). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). RC TISSUE=Eye; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [7] RP TISSUE SPECIFICITY. RX PubMed=2052354; RA Boehm T., Spillantini M.G., Sofroniew M.V., Surani M.A., Rabbitts T.H.; RT "Developmentally regulated and tissue specific expression of mRNAs encoding RT the two alternative forms of the LIM domain oncogene rhombotin: evidence RT for thymus expression."; RL Oncogene 6:695-703(1991). CC -!- FUNCTION: May be involved in gene regulation within neural lineage CC cells potentially by direct DNA binding or by binding to other CC transcription factors. {ECO:0000269|PubMed:1703797}. CC -!- INTERACTION: CC P25800; Q8IZP0-5: ABI1; NbExp=3; IntAct=EBI-8639312, EBI-11743294; CC P25800; Q9NYB9-2: ABI2; NbExp=8; IntAct=EBI-8639312, EBI-11096309; CC P25800; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-8639312, EBI-10173507; CC P25800; Q6PJH3: AKAP9; NbExp=3; IntAct=EBI-8639312, EBI-11745576; CC P25800; Q7Z591: AKNA; NbExp=3; IntAct=EBI-8639312, EBI-2799297; CC P25800; Q8WXK1: ASB15; NbExp=3; IntAct=EBI-8639312, EBI-12809012; CC P25800; Q8N9N5-2: BANP; NbExp=3; IntAct=EBI-8639312, EBI-11524452; CC P25800; O75934: BCAS2; NbExp=3; IntAct=EBI-8639312, EBI-1050106; CC P25800; Q9H165-2: BCL11A; NbExp=3; IntAct=EBI-8639312, EBI-10183342; CC P25800; Q86UB2: BIVM; NbExp=3; IntAct=EBI-8639312, EBI-12191873; CC P25800; Q9H2G9: BLZF1; NbExp=7; IntAct=EBI-8639312, EBI-2548012; CC P25800; Q6ZN30: BNC2; NbExp=3; IntAct=EBI-8639312, EBI-6115618; CC P25800; Q13895: BYSL; NbExp=3; IntAct=EBI-8639312, EBI-358049; CC P25800; Q9H257: CARD9; NbExp=3; IntAct=EBI-8639312, EBI-751319; CC P25800; Q8NA61: CBY2; NbExp=3; IntAct=EBI-8639312, EBI-741724; CC P25800; A6NC98: CCDC88B; NbExp=3; IntAct=EBI-8639312, EBI-347573; CC P25800; Q96GN5: CDCA7L; NbExp=3; IntAct=EBI-8639312, EBI-5278764; CC P25800; O14627: CDX4; NbExp=3; IntAct=EBI-8639312, EBI-10181162; CC P25800; Q96L14: CEP170P1; NbExp=3; IntAct=EBI-8639312, EBI-743488; CC P25800; Q9C0F1: CEP44; NbExp=3; IntAct=EBI-8639312, EBI-744115; CC P25800; Q8IYX8: CEP57L1; NbExp=3; IntAct=EBI-8639312, EBI-1104570; CC P25800; Q9NX63: CHCHD3; NbExp=3; IntAct=EBI-8639312, EBI-743375; CC P25800; Q96D03: DDIT4L; NbExp=3; IntAct=EBI-8639312, EBI-742054; CC P25800; O60447: EVI5; NbExp=3; IntAct=EBI-8639312, EBI-852291; CC P25800; Q8IX29: FBXO16; NbExp=3; IntAct=EBI-8639312, EBI-12063229; CC P25800; Q06547: GABPB1; NbExp=4; IntAct=EBI-8639312, EBI-618165; CC P25800; O95995: GAS8; NbExp=3; IntAct=EBI-8639312, EBI-1052570; CC P25800; Q08379: GOLGA2; NbExp=6; IntAct=EBI-8639312, EBI-618309; CC P25800; Q9NWQ4-1: GPATCH2L; NbExp=3; IntAct=EBI-8639312, EBI-11959863; CC P25800; Q6PI77: GPRASP3; NbExp=3; IntAct=EBI-8639312, EBI-11519926; CC P25800; Q7Z353: HDX; NbExp=3; IntAct=EBI-8639312, EBI-1052734; CC P25800; O14964: HGS; NbExp=3; IntAct=EBI-8639312, EBI-740220; CC P25800; Q6NT76: HMBOX1; NbExp=3; IntAct=EBI-8639312, EBI-2549423; CC P25800; Q9NP66: HMG20A; NbExp=3; IntAct=EBI-8639312, EBI-740641; CC P25800; P31943: HNRNPH1; NbExp=3; IntAct=EBI-8639312, EBI-351590; CC P25800; P52272: HNRNPM; NbExp=3; IntAct=EBI-8639312, EBI-486809; CC P25800; Q16082: HSPB2; NbExp=3; IntAct=EBI-8639312, EBI-739395; CC P25800; Q13422-7: IKZF1; NbExp=3; IntAct=EBI-8639312, EBI-11522367; CC P25800; Q9UKT9: IKZF3; NbExp=4; IntAct=EBI-8639312, EBI-747204; CC P25800; Q9ULR0: ISY1; NbExp=3; IntAct=EBI-8639312, EBI-2557660; CC P25800; Q63ZY3: KANK2; NbExp=9; IntAct=EBI-8639312, EBI-2556193; CC P25800; Q719H9: KCTD1; NbExp=3; IntAct=EBI-8639312, EBI-9027502; CC P25800; Q86T90: KIAA1328; NbExp=3; IntAct=EBI-8639312, EBI-3437878; CC P25800; Q5JUW0-3: KRBOX4; NbExp=5; IntAct=EBI-8639312, EBI-12893625; CC P25800; P08779: KRT16; NbExp=3; IntAct=EBI-8639312, EBI-356410; CC P25800; Q6A162: KRT40; NbExp=3; IntAct=EBI-8639312, EBI-10171697; CC P25800; O95678: KRT75; NbExp=3; IntAct=EBI-8639312, EBI-2949715; CC P25800; Q86U70: LDB1; NbExp=5; IntAct=EBI-8639312, EBI-677177; CC P25800; Q86U70-2: LDB1; NbExp=6; IntAct=EBI-8639312, EBI-11979761; CC P25800; O43679: LDB2; NbExp=3; IntAct=EBI-8639312, EBI-2865580; CC P25800; O60711: LPXN; NbExp=7; IntAct=EBI-8639312, EBI-744222; CC P25800; Q9Y250: LZTS1; NbExp=3; IntAct=EBI-8639312, EBI-1216080; CC P25800; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-8639312, EBI-741037; CC P25800; Q9Y6D9: MAD1L1; NbExp=3; IntAct=EBI-8639312, EBI-742610; CC P25800; Q8WWY6: MBD3L1; NbExp=3; IntAct=EBI-8639312, EBI-12516603; CC P25800; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-8639312, EBI-16439278; CC P25800; Q8IVT2: MISP; NbExp=8; IntAct=EBI-8639312, EBI-2555085; CC P25800; Q4VC12: MSS51; NbExp=3; IntAct=EBI-8639312, EBI-11599933; CC P25800; Q9UJ70-2: NAGK; NbExp=5; IntAct=EBI-8639312, EBI-11526455; CC P25800; O95182: NDUFA7; NbExp=3; IntAct=EBI-8639312, EBI-721471; CC P25800; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-8639312, EBI-741158; CC P25800; Q86Y26: NUTM1; NbExp=3; IntAct=EBI-8639312, EBI-10178410; CC P25800; Q8IXK0: PHC2; NbExp=3; IntAct=EBI-8639312, EBI-713786; CC P25800; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-8639312, EBI-79165; CC P25800; Q9BT43: POLR3GL; NbExp=3; IntAct=EBI-8639312, EBI-2855862; CC P25800; Q96KQ4: PPP1R13B; NbExp=3; IntAct=EBI-8639312, EBI-1105153; CC P25800; Q9NQX0: PRDM6; NbExp=3; IntAct=EBI-8639312, EBI-11320284; CC P25800; P20618: PSMB1; NbExp=3; IntAct=EBI-8639312, EBI-372273; CC P25800; P26045: PTPN3; NbExp=6; IntAct=EBI-8639312, EBI-1047946; CC P25800; P49023-2: PXN; NbExp=5; IntAct=EBI-8639312, EBI-11954250; CC P25800; Q99708-2: RBBP8; NbExp=3; IntAct=EBI-8639312, EBI-10203615; CC P25800; Q15293: RCN1; NbExp=3; IntAct=EBI-8639312, EBI-948278; CC P25800; Q04864: REL; NbExp=3; IntAct=EBI-8639312, EBI-307352; CC P25800; Q8IYX7: SAXO1; NbExp=3; IntAct=EBI-8639312, EBI-3957636; CC P25800; P35711: SOX5; NbExp=3; IntAct=EBI-8639312, EBI-3505701; CC P25800; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-8639312, EBI-742688; CC P25800; Q96C24: SYTL4; NbExp=3; IntAct=EBI-8639312, EBI-747142; CC P25800; O75478: TADA2A; NbExp=3; IntAct=EBI-8639312, EBI-742268; CC P25800; Q5VWN6-2: TASOR2; NbExp=3; IntAct=EBI-8639312, EBI-10172380; CC P25800; P15884: TCF4; NbExp=3; IntAct=EBI-8639312, EBI-533224; CC P25800; Q8TDR4: TCP10L; NbExp=3; IntAct=EBI-8639312, EBI-3923210; CC P25800; Q9UBB9: TFIP11; NbExp=7; IntAct=EBI-8639312, EBI-1105213; CC P25800; Q08117: TLE5; NbExp=3; IntAct=EBI-8639312, EBI-717810; CC P25800; P14373: TRIM27; NbExp=3; IntAct=EBI-8639312, EBI-719493; CC P25800; Q9UPQ4-2: TRIM35; NbExp=3; IntAct=EBI-8639312, EBI-17716262; CC P25800; Q9BYV2: TRIM54; NbExp=3; IntAct=EBI-8639312, EBI-2130429; CC P25800; Q9Y3Q8: TSC22D4; NbExp=3; IntAct=EBI-8639312, EBI-739485; CC P25800; Q9NUQ7: UFSP2; NbExp=3; IntAct=EBI-8639312, EBI-11153325; CC P25800; Q8TAS1-2: UHMK1; NbExp=3; IntAct=EBI-8639312, EBI-12157345; CC P25800; Q9H9P5-5: UNKL; NbExp=4; IntAct=EBI-8639312, EBI-12817837; CC P25800; Q9BVJ6: UTP14A; NbExp=3; IntAct=EBI-8639312, EBI-473284; CC P25800; P61758: VBP1; NbExp=3; IntAct=EBI-8639312, EBI-357430; CC P25800; O43298: ZBTB43; NbExp=7; IntAct=EBI-8639312, EBI-740718; CC P25800; Q8NAP8: ZBTB8B; NbExp=3; IntAct=EBI-8639312, EBI-17494306; CC P25800; Q6PEW1: ZCCHC12; NbExp=3; IntAct=EBI-8639312, EBI-748373; CC P25800; Q8TF47: ZFP90; NbExp=3; IntAct=EBI-8639312, EBI-11419867; CC P25800; P52747: ZNF143; NbExp=3; IntAct=EBI-8639312, EBI-2849334; CC P25800; Q13360-2: ZNF177; NbExp=3; IntAct=EBI-8639312, EBI-12272076; CC P25800; P17023: ZNF19; NbExp=3; IntAct=EBI-8639312, EBI-12884200; CC P25800; Q9P2Y4: ZNF219; NbExp=3; IntAct=EBI-8639312, EBI-3937106; CC P25800; P17028: ZNF24; NbExp=5; IntAct=EBI-8639312, EBI-707773; CC P25800; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-8639312, EBI-740727; CC P25800; Q14592: ZNF460; NbExp=3; IntAct=EBI-8639312, EBI-2555738; CC P25800; Q8NB15: ZNF511; NbExp=6; IntAct=EBI-8639312, EBI-10269136; CC P25800; Q8TF50: ZNF526; NbExp=3; IntAct=EBI-8639312, EBI-11035148; CC P25800; Q6ZNG0: ZNF620; NbExp=3; IntAct=EBI-8639312, EBI-4395669; CC P25800; Q96N77-2: ZNF641; NbExp=3; IntAct=EBI-8639312, EBI-12939666; CC P25800; P0C7X2: ZNF688; NbExp=3; IntAct=EBI-8639312, EBI-4395732; CC P25800; P36508: ZNF76; NbExp=3; IntAct=EBI-8639312, EBI-7254550; CC P25800; P51523: ZNF84; NbExp=3; IntAct=EBI-8639312, EBI-2849074; CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=P25800-1; Sequence=Displayed; CC Name=2; CC IsoId=P25800-2; Sequence=VSP_046664; CC -!- TISSUE SPECIFICITY: Expressed mainly in the central nervous. Low level CC of expression in other tissues including thymus. CC {ECO:0000269|PubMed:2052354}. CC -!- DISEASE: Note=A chromosomal aberration involving LMO1 may be a cause of CC a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation CC t(11,14)(p15;q11) with TCRD. CC -!- SEQUENCE CAUTION: CC Sequence=AAH39512.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and CC Haematology; CC URL="https://atlasgeneticsoncology.org/gene/33/LMO1"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M26682; AAA36819.1; -; mRNA. DR EMBL; AJ277662; CAC14587.1; -; Genomic_DNA. DR EMBL; AC091013; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC039512; AAH39512.1; ALT_INIT; mRNA. DR EMBL; BC069673; AAH69673.1; -; mRNA. DR EMBL; BC069752; AAH69752.1; -; mRNA. DR EMBL; BC069793; AAH69793.1; -; mRNA. DR EMBL; BC096056; AAH96056.1; -; mRNA. DR EMBL; BC096057; AAH96057.1; -; mRNA. DR CCDS; CCDS44534.1; -. [P25800-1] DR CCDS; CCDS58118.1; -. [P25800-2] DR PIR; A32795; A32795. DR RefSeq; NP_001257357.1; NM_001270428.1. [P25800-2] DR RefSeq; NP_002306.1; NM_002315.2. [P25800-1] DR AlphaFoldDB; P25800; -. DR SMR; P25800; -. DR BioGRID; 110190; 152. DR IntAct; P25800; 111. DR MINT; P25800; -. DR STRING; 9606.ENSP00000338207; -. DR iPTMnet; P25800; -. DR PhosphoSitePlus; P25800; -. DR BioMuta; LMO1; -. DR DMDM; 132532; -. DR MassIVE; P25800; -. DR MaxQB; P25800; -. DR PaxDb; 9606-ENSP00000338207; -. DR PeptideAtlas; P25800; -. DR ProteomicsDB; 23606; -. DR ProteomicsDB; 54297; -. [P25800-1] DR Antibodypedia; 5875; 181 antibodies from 25 providers. DR DNASU; 4004; -. DR Ensembl; ENST00000335790.8; ENSP00000338207.3; ENSG00000166407.14. [P25800-1] DR Ensembl; ENST00000428101.6; ENSP00000404538.2; ENSG00000166407.14. [P25800-2] DR GeneID; 4004; -. DR KEGG; hsa:4004; -. DR MANE-Select; ENST00000335790.8; ENSP00000338207.3; NM_002315.3; NP_002306.1. DR UCSC; uc001mgg.3; human. [P25800-1] DR AGR; HGNC:6641; -. DR CTD; 4004; -. DR DisGeNET; 4004; -. DR GeneCards; LMO1; -. DR HGNC; HGNC:6641; LMO1. DR HPA; ENSG00000166407; Tissue enhanced (skeletal muscle, tongue). DR MalaCards; LMO1; -. DR MIM; 186921; gene+phenotype. DR neXtProt; NX_P25800; -. DR OpenTargets; ENSG00000166407; -. DR Orphanet; 635; Neuroblastoma. DR PharmGKB; PA30407; -. DR VEuPathDB; HostDB:ENSG00000166407; -. DR eggNOG; KOG0490; Eukaryota. DR GeneTree; ENSGT00940000153908; -. DR InParanoid; P25800; -. DR OMA; KEDGMPM; -. DR OrthoDB; 2875464at2759; -. DR PhylomeDB; P25800; -. DR TreeFam; TF351071; -. DR PathwayCommons; P25800; -. DR Reactome; R-HSA-8939236; RUNX1 regulates transcription of genes involved in differentiation of HSCs. DR SignaLink; P25800; -. DR SIGNOR; P25800; -. DR BioGRID-ORCS; 4004; 19 hits in 1158 CRISPR screens. DR ChiTaRS; LMO1; human. DR GeneWiki; LMO1; -. DR GenomeRNAi; 4004; -. DR Pharos; P25800; Tbio. DR PRO; PR:P25800; -. DR Proteomes; UP000005640; Chromosome 11. DR RNAct; P25800; Protein. DR Bgee; ENSG00000166407; Expressed in primordial germ cell in gonad and 108 other cell types or tissues. DR ExpressionAtlas; P25800; baseline and differential. DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome. DR GO; GO:0005634; C:nucleus; ISS:UniProtKB. DR GO; GO:0140297; F:DNA-binding transcription factor binding; IBA:GO_Central. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central. DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:BHF-UCL. DR GO; GO:0046013; P:regulation of T cell homeostatic proliferation; IEA:Ensembl. DR CDD; cd09388; LIM1_LMO1_LMO3; 1. DR CDD; cd09389; LIM2_LMO1_LMO3; 1. DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 2. DR InterPro; IPR001781; Znf_LIM. DR PANTHER; PTHR45787; LD11652P; 1. DR PANTHER; PTHR45787:SF2; RHOMBOTIN-1; 1. DR Pfam; PF00412; LIM; 2. DR SMART; SM00132; LIM; 2. DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 3. DR PROSITE; PS00478; LIM_DOMAIN_1; 2. DR PROSITE; PS50023; LIM_DOMAIN_2; 2. DR Genevisible; P25800; HS. PE 1: Evidence at protein level; KW Alternative splicing; Chromosomal rearrangement; LIM domain; Metal-binding; KW Nucleus; Proto-oncogene; Reference proteome; Repeat; Zinc. FT CHAIN 1..156 FT /note="Rhombotin-1" FT /id="PRO_0000075894" FT DOMAIN 24..83 FT /note="LIM zinc-binding 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125" FT DOMAIN 88..147 FT /note="LIM zinc-binding 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125" FT VAR_SEQ 1..9 FT /note="MMVLDKEDG -> MVLDQEDG (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_046664" SQ SEQUENCE 156 AA; 17828 MW; 6BAFBE1F870CCAAC CRC64; MMVLDKEDGV PMLSVQPKGK QKGCAGCNRK IKDRYLLKAL DKYWHEDCLK CACCDCRLGE VGSTLYTKAN LILCRRDYLR LFGTTGNCAA CSKLIPAFEM VMRARDNVYH LDCFACQLCN QRFCVGDKFF LKNNMILCQM DYEEGQLNGT FESQVQ //