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Protein

Rhombotin-1

Gene

LMO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors.1 Publication

GO - Molecular functioni

  1. zinc ion binding Source: InterPro

GO - Biological processi

  1. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  2. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Rhombotin-1
Alternative name(s):
Cysteine-rich protein TTG-1
LIM domain only protein 1
Short name:
LMO-1
T-cell translocation protein 1
Gene namesi
Name:LMO1
Synonyms:RBTN1, RHOM1, TTG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:6641. LMO1.

Subcellular locationi

  1. Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving LMO1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p15;q11) with TCRD.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

MIMi186921. gene+phenotype.
PharmGKBiPA30407.

Polymorphism and mutation databases

BioMutaiLMO1.
DMDMi132532.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 156156Rhombotin-1PRO_0000075894Add
BLAST

Proteomic databases

MaxQBiP25800.
PaxDbiP25800.
PRIDEiP25800.

PTM databases

PhosphoSiteiP25800.

Miscellaneous databases

PMAP-CutDBP25800.

Expressioni

Tissue specificityi

Expressed mainly in the central nervous. Low level of expression in other tissues including thymus.1 Publication

Gene expression databases

BgeeiP25800.
CleanExiHS_LMO1.
ExpressionAtlasiP25800. baseline and differential.
GenevestigatoriP25800.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAMTSL4Q6UY14-33EBI-8639312,EBI-10173507
AESQ081173EBI-8639312,EBI-717810
BCL11AQ9H165-23EBI-8639312,EBI-10183342
BLZF1Q9H2G93EBI-8639312,EBI-2548012
C9orf138A8K8803EBI-8639312,EBI-10174528
CARD9Q9H2573EBI-8639312,EBI-751319
CDCA7LQ96GN53EBI-8639312,EBI-5278764
CDX4O146273EBI-8639312,EBI-10181162
CEP170P1Q96L143EBI-8639312,EBI-743488
CEP44Q9C0F13EBI-8639312,EBI-744115
FAM208BQ5VWN6-23EBI-8639312,EBI-10172380
GABPB1Q065474EBI-8639312,EBI-618165
GOLGA2Q083793EBI-8639312,EBI-618309
IKZF3Q9UKT93EBI-8639312,EBI-747204
KANK2Q63ZY33EBI-8639312,EBI-2556193
KRT40Q6A1623EBI-8639312,EBI-10171697
LDB1Q86U705EBI-8639312,EBI-677177
LPXNO607113EBI-8639312,EBI-744222
LZTS2Q9BRK43EBI-8639312,EBI-741037
NUTM1Q86Y263EBI-8639312,EBI-10178410
PHC2Q8IXK03EBI-8639312,EBI-713786
PTPN3P260453EBI-8639312,EBI-1047946
RBBP8Q99708-23EBI-8639312,EBI-10203615
RELQ048643EBI-8639312,EBI-307352
SOX5P357113EBI-8639312,EBI-3505701
SPERTQ8NA613EBI-8639312,EBI-741724
TCF4P158843EBI-8639312,EBI-533224
TFIP11Q9UBB93EBI-8639312,EBI-1105213
TRIM27P143733EBI-8639312,EBI-719493
ZBTB43O432983EBI-8639312,EBI-740718
ZNF219Q9P2Y43EBI-8639312,EBI-3937106

Protein-protein interaction databases

BioGridi110190. 37 interactions.
IntActiP25800. 31 interactions.
STRINGi9606.ENSP00000338207.

Structurei

3D structure databases

ProteinModelPortaliP25800.
SMRiP25800. Positions 24-149.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 8360LIM zinc-binding 1PROSITE-ProRule annotationAdd
BLAST
Domaini88 – 14760LIM zinc-binding 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiNOG288849.
GeneTreeiENSGT00720000108603.
HOGENOMiHOG000232175.
HOVERGENiHBG054231.
InParanoidiP25800.
OMAiCPRTGRP.
OrthoDBiEOG75J0PF.
PhylomeDBiP25800.
TreeFamiTF351071.

Family and domain databases

Gene3Di2.10.110.10. 2 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00132. LIM. 2 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P25800-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMVLDKEDGV PMLSVQPKGK QKGCAGCNRK IKDRYLLKAL DKYWHEDCLK
60 70 80 90 100
CACCDCRLGE VGSTLYTKAN LILCRRDYLR LFGTTGNCAA CSKLIPAFEM
110 120 130 140 150
VMRARDNVYH LDCFACQLCN QRFCVGDKFF LKNNMILCQM DYEEGQLNGT

FESQVQ
Length:156
Mass (Da):17,828
Last modified:May 1, 1992 - v1
Checksum:i6BAFBE1F870CCAAC
GO
Isoform 2 (identifier: P25800-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MMVLDKEDG → MVLDQEDG

Note: No experimental confirmation available.

Show »
Length:155
Mass (Da):17,697
Checksum:iD18E9D3F21705F4A
GO

Sequence cautioni

The sequence AAH39512.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 99MMVLDKEDG → MVLDQEDG in isoform 2. 1 PublicationVSP_046664

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26682 mRNA. Translation: AAA36819.1.
AJ277662 Genomic DNA. Translation: CAC14587.1.
AC091013 Genomic DNA. No translation available.
BC039512 mRNA. Translation: AAH39512.1. Different initiation.
BC069673 mRNA. Translation: AAH69673.1.
BC069752 mRNA. Translation: AAH69752.1.
BC069793 mRNA. Translation: AAH69793.1.
BC096056 mRNA. Translation: AAH96056.1.
BC096057 mRNA. Translation: AAH96057.1.
CCDSiCCDS44534.1. [P25800-1]
CCDS58118.1. [P25800-2]
PIRiA32795.
RefSeqiNP_001257357.1. NM_001270428.1. [P25800-2]
NP_002306.1. NM_002315.2. [P25800-1]
UniGeneiHs.654426.

Genome annotation databases

EnsembliENST00000335790; ENSP00000338207; ENSG00000166407. [P25800-1]
ENST00000428101; ENSP00000404538; ENSG00000166407. [P25800-2]
GeneIDi4004.
KEGGihsa:4004.
UCSCiuc001mgg.2. human. [P25800-1]

Polymorphism and mutation databases

BioMutaiLMO1.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26682 mRNA. Translation: AAA36819.1.
AJ277662 Genomic DNA. Translation: CAC14587.1.
AC091013 Genomic DNA. No translation available.
BC039512 mRNA. Translation: AAH39512.1. Different initiation.
BC069673 mRNA. Translation: AAH69673.1.
BC069752 mRNA. Translation: AAH69752.1.
BC069793 mRNA. Translation: AAH69793.1.
BC096056 mRNA. Translation: AAH96056.1.
BC096057 mRNA. Translation: AAH96057.1.
CCDSiCCDS44534.1. [P25800-1]
CCDS58118.1. [P25800-2]
PIRiA32795.
RefSeqiNP_001257357.1. NM_001270428.1. [P25800-2]
NP_002306.1. NM_002315.2. [P25800-1]
UniGeneiHs.654426.

3D structure databases

ProteinModelPortaliP25800.
SMRiP25800. Positions 24-149.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110190. 37 interactions.
IntActiP25800. 31 interactions.
STRINGi9606.ENSP00000338207.

PTM databases

PhosphoSiteiP25800.

Polymorphism and mutation databases

BioMutaiLMO1.
DMDMi132532.

Proteomic databases

MaxQBiP25800.
PaxDbiP25800.
PRIDEiP25800.

Protocols and materials databases

DNASUi4004.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335790; ENSP00000338207; ENSG00000166407. [P25800-1]
ENST00000428101; ENSP00000404538; ENSG00000166407. [P25800-2]
GeneIDi4004.
KEGGihsa:4004.
UCSCiuc001mgg.2. human. [P25800-1]

Organism-specific databases

CTDi4004.
GeneCardsiGC11M008245.
HGNCiHGNC:6641. LMO1.
MIMi186921. gene+phenotype.
neXtProtiNX_P25800.
PharmGKBiPA30407.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG288849.
GeneTreeiENSGT00720000108603.
HOGENOMiHOG000232175.
HOVERGENiHBG054231.
InParanoidiP25800.
OMAiCPRTGRP.
OrthoDBiEOG75J0PF.
PhylomeDBiP25800.
TreeFamiTF351071.

Miscellaneous databases

ChiTaRSiLMO1. human.
GeneWikiiLMO1.
GenomeRNAii4004.
NextBioi15708.
PMAP-CutDBP25800.
PROiP25800.
SOURCEiSearch...

Gene expression databases

BgeeiP25800.
CleanExiHS_LMO1.
ExpressionAtlasiP25800. baseline and differential.
GenevestigatoriP25800.

Family and domain databases

Gene3Di2.10.110.10. 2 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00132. LIM. 2 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein."
    McGuire E.A., Hockett R.D., Pollock K.M., Bartholdi M.F., O'Brien S.J., Korsmeyer S.J.
    Mol. Cell. Biol. 9:2124-2132(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "An unusual structure of a putative T cell oncogene which allows production of similar proteins from distinct mRNAs."
    Boehm T., Greenberg J.M., Buluwela L., Lavenir I., Forster A., Rabbitts T.H.
    EMBO J. 9:857-868(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells."
    McGuire E.A., Davis A.R., Korsmeyer S.J.
    Blood 77:599-606(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
  4. "Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1)."
    Cichutek A., Brueckmann T., Seipel B., Hauser H., Schlaubitz S., Prawitt D., Hankeln T., Schmidt E.R., Winterpacht A., Zabel B.U.
    Cytogenet. Cell Genet. 93:277-283(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Blood.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Eye.
  7. "Developmentally regulated and tissue specific expression of mRNAs encoding the two alternative forms of the LIM domain oncogene rhombotin: evidence for thymus expression."
    Boehm T., Spillantini M.G., Sofroniew M.V., Surani M.A., Rabbitts T.H.
    Oncogene 6:695-703(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiRBTN1_HUMAN
AccessioniPrimary (citable) accession number: P25800
Secondary accession number(s): E9PSF5, Q4VBC5, Q8IXR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: April 29, 2015
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.