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Protein

Rhombotin-1

Gene

LMO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiP25800.

Names & Taxonomyi

Protein namesi
Recommended name:
Rhombotin-1
Alternative name(s):
Cysteine-rich protein TTG-1
LIM domain only protein 1
Short name:
LMO-1
T-cell translocation protein 1
Gene namesi
Name:LMO1
Synonyms:RBTN1, RHOM1, TTG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:6641. LMO1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving LMO1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p15;q11) with TCRD.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi4004.
MalaCardsiLMO1.
MIMi186921. gene+phenotype.
OpenTargetsiENSG00000166407.
PharmGKBiPA30407.

Polymorphism and mutation databases

BioMutaiLMO1.
DMDMi132532.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000758941 – 156Rhombotin-1Add BLAST156

Proteomic databases

MaxQBiP25800.
PaxDbiP25800.
PeptideAtlasiP25800.
PRIDEiP25800.

PTM databases

iPTMnetiP25800.
PhosphoSitePlusiP25800.

Miscellaneous databases

PMAP-CutDBiP25800.

Expressioni

Tissue specificityi

Expressed mainly in the central nervous. Low level of expression in other tissues including thymus.1 Publication

Gene expression databases

BgeeiENSG00000166407.
CleanExiHS_LMO1.
ExpressionAtlasiP25800. baseline and differential.
GenevisibleiP25800. HS.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi110190. 60 interactors.
IntActiP25800. 88 interactors.
STRINGi9606.ENSP00000338207.

Structurei

3D structure databases

ProteinModelPortaliP25800.
SMRiP25800.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 83LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST60
Domaini88 – 147LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST60

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00720000108603.
HOGENOMiHOG000232175.
HOVERGENiHBG054231.
InParanoidiP25800.
OMAiCPRTGRP.
OrthoDBiEOG091G0LKW.
PhylomeDBiP25800.
TreeFamiTF351071.

Family and domain databases

InterProiView protein in InterPro
IPR001781. Znf_LIM.
PfamiView protein in Pfam
PF00412. LIM. 2 hits.
SMARTiView protein in SMART
SM00132. LIM. 2 hits.
PROSITEiView protein in PROSITE
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P25800-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMVLDKEDGV PMLSVQPKGK QKGCAGCNRK IKDRYLLKAL DKYWHEDCLK
60 70 80 90 100
CACCDCRLGE VGSTLYTKAN LILCRRDYLR LFGTTGNCAA CSKLIPAFEM
110 120 130 140 150
VMRARDNVYH LDCFACQLCN QRFCVGDKFF LKNNMILCQM DYEEGQLNGT

FESQVQ
Length:156
Mass (Da):17,828
Last modified:May 1, 1992 - v1
Checksum:i6BAFBE1F870CCAAC
GO
Isoform 2 (identifier: P25800-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MMVLDKEDG → MVLDQEDG

Note: No experimental confirmation available.
Show »
Length:155
Mass (Da):17,697
Checksum:iD18E9D3F21705F4A
GO

Sequence cautioni

The sequence AAH39512 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0466641 – 9MMVLDKEDG → MVLDQEDG in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26682 mRNA. Translation: AAA36819.1.
AJ277662 Genomic DNA. Translation: CAC14587.1.
AC091013 Genomic DNA. No translation available.
BC039512 mRNA. Translation: AAH39512.1. Different initiation.
BC069673 mRNA. Translation: AAH69673.1.
BC069752 mRNA. Translation: AAH69752.1.
BC069793 mRNA. Translation: AAH69793.1.
BC096056 mRNA. Translation: AAH96056.1.
BC096057 mRNA. Translation: AAH96057.1.
CCDSiCCDS44534.1. [P25800-1]
CCDS58118.1. [P25800-2]
PIRiA32795.
RefSeqiNP_001257357.1. NM_001270428.1. [P25800-2]
NP_002306.1. NM_002315.2. [P25800-1]
UniGeneiHs.654426.

Genome annotation databases

EnsembliENST00000335790; ENSP00000338207; ENSG00000166407. [P25800-1]
ENST00000428101; ENSP00000404538; ENSG00000166407. [P25800-2]
GeneIDi4004.
KEGGihsa:4004.
UCSCiuc001mgg.3. human. [P25800-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Similar proteinsi

Entry informationi

Entry nameiRBTN1_HUMAN
AccessioniPrimary (citable) accession number: P25800
Secondary accession number(s): E9PSF5, Q4VBC5, Q8IXR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: August 30, 2017
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot