P25800 (RBTN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Rhombotin-1

Alternative name(s):
Cysteine-rich protein TTG-1
LIM domain only protein 1
Short name=LMO-1
T-cell translocation protein 1

Gene names

Name:	LMO1
Synonyms:	RBTN1, RHOM1, TTG1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	156 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors. Ref.3
Subcellular location	Nucleus By similarity.
Tissue specificity	Expressed mainly in the central nervous. Low level of expression in other tissues including thymus. Ref.7
Involvement in disease	A chromosomal aberration involving LMO1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p15;q11) with TCRD.
Sequence similarities	Contains 2 LIM zinc-binding domains.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Chromosomal rearrangement
Disease	Proto-oncogene
Domain	LIM domain Repeat
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from mutant phenotype PubMed 20855495. Source: BHF-UCL
Cellular_component	nucleus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 156	156	Rhombotin-1		PRO_0000075894
Regions
	Domain	24 – 83	60	LIM zinc-binding 1
	Domain	88 – 147	60	LIM zinc-binding 2

Sequences

	Sequence		Length	Mass (Da)
	P25800 [UniParc]. Last modified May 1, 1992. Version 1. Checksum: 6BAFBE1F870CCAAC	FASTA	156	17,828
	10 20 30 40 50 60 MMVLDKEDGV PMLSVQPKGK QKGCAGCNRK IKDRYLLKAL DKYWHEDCLK CACCDCRLGE 70 80 90 100 110 120 VGSTLYTKAN LILCRRDYLR LFGTTGNCAA CSKLIPAFEM VMRARDNVYH LDCFACQLCN 130 140 150 QRFCVGDKFF LKNNMILCQM DYEEGQLNGT FESQVQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein." McGuire E.A., Hockett R.D., Pollock K.M., Bartholdi M.F., O'Brien S.J., Korsmeyer S.J. Mol. Cell. Biol. 9:2124-2132(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"An unusual structure of a putative T cell oncogene which allows production of similar proteins from distinct mRNAs." Boehm T., Greenberg J.M., Buluwela L., Lavenir I., Forster A., Rabbitts T.H. EMBO J. 9:857-868(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells." McGuire E.A., Davis A.R., Korsmeyer S.J. Blood 77:599-606(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
[4]	"Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1)." Cichutek A., Brueckmann T., Seipel B., Hauser H., Schlaubitz S., Prawitt D., Hankeln T., Schmidt E.R., Winterpacht A., Zabel B.U. Cytogenet. Cell Genet. 93:277-283(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Blood.
[5]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]	"Developmentally regulated and tissue specific expression of mRNAs encoding the two alternative forms of the LIM domain oncogene rhombotin: evidence for thymus expression." Boehm T., Spillantini M.G., Sofroniew M.V., Surani M.A., Rabbitts T.H. Oncogene 6:695-703(1991) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M26682 mRNA. Translation: AAA36819.1. AJ277662 Genomic DNA. Translation: CAC14587.1. AC091013 Genomic DNA. No translation available. BC069673 mRNA. Translation: AAH69673.1. BC069752 mRNA. Translation: AAH69752.1. BC069793 mRNA. Translation: AAH69793.1. BC096056 mRNA. Translation: AAH96056.1. BC096057 mRNA. Translation: AAH96057.1.
IPI	IPI00396316.
PIR	A32795.
RefSeq	NP_002306.1. NM_002315.2.
UniGene	Hs.654426.
3D structure databases
ProteinModelPortal	P25800.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000338207.
PTM databases
PhosphoSite	P25800.
Polymorphism databases
DMDM	132532.
Proteomic databases
PaxDb	P25800.
PRIDE	P25800.
Protocols and materials databases
DNASU	4004.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000335790; ENSP00000338207; ENSG00000166407.
GeneID	4004.
KEGG	hsa:4004.
UCSC	uc001mgg.1. human.
Organism-specific databases
CTD	4004.
GeneCards	GC11M008202.
HGNC	HGNC:6641. LMO1.
MIM	186921. gene+phenotype.
neXtProt	NX_P25800.
PharmGKB	PA30407.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG288849.
HOGENOM	HOG000232175.
HOVERGEN	HBG054231.
InParanoid	P25800.
OMA	GSFETQV.
OrthoDB	EOG405S2K.
Gene expression databases
ArrayExpress	P25800.
Bgee	P25800.
CleanEx	HS_LMO1.
Genevestigator	P25800.
GermOnline	ENSG00000166407. Homo sapiens.
Family and domain databases
Gene3D	2.10.110.10. 2 hits.
InterPro	IPR001781. Znf_LIM. [Graphical view]
Pfam	PF00412. LIM. 2 hits. [Graphical view]
SMART	SM00132. LIM. 2 hits. [Graphical view]
PROSITE	PS00478. LIM_DOMAIN_1. 2 hits. PS50023. LIM_DOMAIN_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	LMO1. human.
GenomeRNAi	4004.
NextBio	15708.
PMAP-CutDB	P25800.
SOURCE	Search...

Entry information

Entry name

RBTN1_HUMAN

Accession

Primary (citable) accession number: P25800
Secondary accession number(s): Q4VBC5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
Last sequence update:	May 1, 1992
Last modified:	May 1, 2013
This is version 120 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.