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P25800

- RBTN1_HUMAN

UniProt

P25800 - RBTN1_HUMAN

Protein

Rhombotin-1

Gene

LMO1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors.1 Publication

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    GO - Biological processi

    1. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    2. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rhombotin-1
    Alternative name(s):
    Cysteine-rich protein TTG-1
    LIM domain only protein 1
    Short name:
    LMO-1
    T-cell translocation protein 1
    Gene namesi
    Name:LMO1
    Synonyms:RBTN1, RHOM1, TTG1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:6641. LMO1.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    A chromosomal aberration involving LMO1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p15;q11) with TCRD.

    Keywords - Diseasei

    Proto-oncogene

    Organism-specific databases

    MIMi186921. gene+phenotype.
    PharmGKBiPA30407.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 156156Rhombotin-1PRO_0000075894Add
    BLAST

    Proteomic databases

    MaxQBiP25800.
    PaxDbiP25800.
    PRIDEiP25800.

    PTM databases

    PhosphoSiteiP25800.

    Miscellaneous databases

    PMAP-CutDBP25800.

    Expressioni

    Tissue specificityi

    Expressed mainly in the central nervous. Low level of expression in other tissues including thymus.1 Publication

    Gene expression databases

    ArrayExpressiP25800.
    BgeeiP25800.
    CleanExiHS_LMO1.
    GenevestigatoriP25800.

    Interactioni

    Protein-protein interaction databases

    BioGridi110190. 6 interactions.
    IntActiP25800. 1 interaction.
    STRINGi9606.ENSP00000338207.

    Structurei

    3D structure databases

    ProteinModelPortaliP25800.
    SMRiP25800. Positions 24-149.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 8360LIM zinc-binding 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini88 – 14760LIM zinc-binding 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

    Keywords - Domaini

    LIM domain, Repeat

    Phylogenomic databases

    eggNOGiNOG288849.
    HOGENOMiHOG000232175.
    HOVERGENiHBG054231.
    InParanoidiP25800.
    OMAiGSFETQV.
    OrthoDBiEOG75J0PF.
    PhylomeDBiP25800.
    TreeFamiTF351071.

    Family and domain databases

    Gene3Di2.10.110.10. 2 hits.
    InterProiIPR001781. Znf_LIM.
    [Graphical view]
    PfamiPF00412. LIM. 2 hits.
    [Graphical view]
    SMARTiSM00132. LIM. 2 hits.
    [Graphical view]
    PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
    PS50023. LIM_DOMAIN_2. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P25800-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMVLDKEDGV PMLSVQPKGK QKGCAGCNRK IKDRYLLKAL DKYWHEDCLK    50
    CACCDCRLGE VGSTLYTKAN LILCRRDYLR LFGTTGNCAA CSKLIPAFEM 100
    VMRARDNVYH LDCFACQLCN QRFCVGDKFF LKNNMILCQM DYEEGQLNGT 150
    FESQVQ 156
    Length:156
    Mass (Da):17,828
    Last modified:May 1, 1992 - v1
    Checksum:i6BAFBE1F870CCAAC
    GO
    Isoform 2 (identifier: P25800-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-9: MMVLDKEDG → MVLDQEDG

    Note: No experimental confirmation available.

    Show »
    Length:155
    Mass (Da):17,697
    Checksum:iD18E9D3F21705F4A
    GO

    Sequence cautioni

    The sequence AAH39512.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 99MMVLDKEDG → MVLDQEDG in isoform 2. 1 PublicationVSP_046664

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M26682 mRNA. Translation: AAA36819.1.
    AJ277662 Genomic DNA. Translation: CAC14587.1.
    AC091013 Genomic DNA. No translation available.
    BC039512 mRNA. Translation: AAH39512.1. Different initiation.
    BC069673 mRNA. Translation: AAH69673.1.
    BC069752 mRNA. Translation: AAH69752.1.
    BC069793 mRNA. Translation: AAH69793.1.
    BC096056 mRNA. Translation: AAH96056.1.
    BC096057 mRNA. Translation: AAH96057.1.
    CCDSiCCDS44534.1. [P25800-1]
    CCDS58118.1. [P25800-2]
    PIRiA32795.
    RefSeqiNP_001257357.1. NM_001270428.1. [P25800-2]
    NP_002306.1. NM_002315.2. [P25800-1]
    UniGeneiHs.654426.

    Genome annotation databases

    EnsembliENST00000335790; ENSP00000338207; ENSG00000166407. [P25800-1]
    ENST00000428101; ENSP00000404538; ENSG00000166407. [P25800-2]
    GeneIDi4004.
    KEGGihsa:4004.
    UCSCiuc001mgg.2. human. [P25800-1]

    Polymorphism databases

    DMDMi132532.

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M26682 mRNA. Translation: AAA36819.1 .
    AJ277662 Genomic DNA. Translation: CAC14587.1 .
    AC091013 Genomic DNA. No translation available.
    BC039512 mRNA. Translation: AAH39512.1 . Different initiation.
    BC069673 mRNA. Translation: AAH69673.1 .
    BC069752 mRNA. Translation: AAH69752.1 .
    BC069793 mRNA. Translation: AAH69793.1 .
    BC096056 mRNA. Translation: AAH96056.1 .
    BC096057 mRNA. Translation: AAH96057.1 .
    CCDSi CCDS44534.1. [P25800-1 ]
    CCDS58118.1. [P25800-2 ]
    PIRi A32795.
    RefSeqi NP_001257357.1. NM_001270428.1. [P25800-2 ]
    NP_002306.1. NM_002315.2. [P25800-1 ]
    UniGenei Hs.654426.

    3D structure databases

    ProteinModelPortali P25800.
    SMRi P25800. Positions 24-149.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110190. 6 interactions.
    IntActi P25800. 1 interaction.
    STRINGi 9606.ENSP00000338207.

    PTM databases

    PhosphoSitei P25800.

    Polymorphism databases

    DMDMi 132532.

    Proteomic databases

    MaxQBi P25800.
    PaxDbi P25800.
    PRIDEi P25800.

    Protocols and materials databases

    DNASUi 4004.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000335790 ; ENSP00000338207 ; ENSG00000166407 . [P25800-1 ]
    ENST00000428101 ; ENSP00000404538 ; ENSG00000166407 . [P25800-2 ]
    GeneIDi 4004.
    KEGGi hsa:4004.
    UCSCi uc001mgg.2. human. [P25800-1 ]

    Organism-specific databases

    CTDi 4004.
    GeneCardsi GC11M008202.
    HGNCi HGNC:6641. LMO1.
    MIMi 186921. gene+phenotype.
    neXtProti NX_P25800.
    PharmGKBi PA30407.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG288849.
    HOGENOMi HOG000232175.
    HOVERGENi HBG054231.
    InParanoidi P25800.
    OMAi GSFETQV.
    OrthoDBi EOG75J0PF.
    PhylomeDBi P25800.
    TreeFami TF351071.

    Miscellaneous databases

    ChiTaRSi LMO1. human.
    GeneWikii LMO1.
    GenomeRNAii 4004.
    NextBioi 15708.
    PMAP-CutDB P25800.
    PROi P25800.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P25800.
    Bgeei P25800.
    CleanExi HS_LMO1.
    Genevestigatori P25800.

    Family and domain databases

    Gene3Di 2.10.110.10. 2 hits.
    InterProi IPR001781. Znf_LIM.
    [Graphical view ]
    Pfami PF00412. LIM. 2 hits.
    [Graphical view ]
    SMARTi SM00132. LIM. 2 hits.
    [Graphical view ]
    PROSITEi PS00478. LIM_DOMAIN_1. 2 hits.
    PS50023. LIM_DOMAIN_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein."
      McGuire E.A., Hockett R.D., Pollock K.M., Bartholdi M.F., O'Brien S.J., Korsmeyer S.J.
      Mol. Cell. Biol. 9:2124-2132(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "An unusual structure of a putative T cell oncogene which allows production of similar proteins from distinct mRNAs."
      Boehm T., Greenberg J.M., Buluwela L., Lavenir I., Forster A., Rabbitts T.H.
      EMBO J. 9:857-868(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells."
      McGuire E.A., Davis A.R., Korsmeyer S.J.
      Blood 77:599-606(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    4. "Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1)."
      Cichutek A., Brueckmann T., Seipel B., Hauser H., Schlaubitz S., Prawitt D., Hankeln T., Schmidt E.R., Winterpacht A., Zabel B.U.
      Cytogenet. Cell Genet. 93:277-283(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Blood.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Eye.
    7. "Developmentally regulated and tissue specific expression of mRNAs encoding the two alternative forms of the LIM domain oncogene rhombotin: evidence for thymus expression."
      Boehm T., Spillantini M.G., Sofroniew M.V., Surani M.A., Rabbitts T.H.
      Oncogene 6:695-703(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiRBTN1_HUMAN
    AccessioniPrimary (citable) accession number: P25800
    Secondary accession number(s): E9PSF5, Q4VBC5, Q8IXR0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 133 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3