Reviewed,
UniProtKB/Swiss-Prot P25800 (RBTN1_HUMAN)
Last modified
June 16, 2009.
Version 79.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Rhombotin-1 Alternative name(s): LIM domain only protein 1 Cysteine-rich protein TTG-1 T-cell translocation protein 1 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 156 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors. Ref.3 |
| Subcellular location | Nucleus By similarity. |
| Tissue specificity | Expressed mainly in the central nervous. Low level of expression in other tissues including thymus. Ref.7 |
| Involvement in disease | A chromosomal aberration involving LMO1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p15;q11) with TCRD. |
| Sequence similarities | Contains 2 LIM zinc-binding domains. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Nucleus |
| Coding sequence diversity | Chromosomal rearrangement |
| Disease | Proto-oncogene |
| Domain | LIM domain Repeat |
| Ligand | Metal-binding Zinc |
| Gene Ontology (GO) | |
| Biological process | cell proliferation Traceable author statement. Source: ProtInc multicellular organismal developmentTraceable author statement. Source: ProtInc |
| Cellular component | nucleus Inferred from sequence or structural similarity. Source: UniProtKB |
| Molecular function | transcription factor activity Traceable author statement. Source: ProtInc zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein." McGuire E.A., Hockett R.D., Pollock K.M., Bartholdi M.F., O'Brien S.J., Korsmeyer S.J. Mol. Cell. Biol. 9:2124-2132(1989) [PubMed: 2501659] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "An unusual structure of a putative T cell oncogene which allows production of similar proteins from distinct mRNAs." Boehm T., Greenberg J.M., Buluwela L., Lavenir I., Forster A., Rabbitts T.H. EMBO J. 9:857-868(1990) [PubMed: 2311586] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells." McGuire E.A., Davis A.R., Korsmeyer S.J. Blood 77:599-606(1991) [PubMed: 1703797] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION. |
| [4] | "Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1)." Cichutek A., Brueckmann T., Seipel B., Hauser H., Schlaubitz S., Prawitt D., Hankeln T., Schmidt E.R., Winterpacht A., Zabel B.U. Cytogenet. Cell Genet. 93:277-283(2001) [PubMed: 11528126] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Blood. |
| [5] | "Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. Sakaki Y.Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [7] | "Developmentally regulated and tissue specific expression of mRNAs encoding the two alternative forms of the LIM domain oncogene rhombotin: evidence for thymus expression." Boehm T., Spillantini M.G., Sofroniew M.V., Surani M.A., Rabbitts T.H. Oncogene 6:695-703(1991) [PubMed: 2052354] [Abstract] Cited for: TISSUE SPECIFICITY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| M26682 mRNA. Translation: AAA36819.1. AJ277662 Genomic DNA. Translation: CAC14587.1. AC091013 Genomic DNA. No translation available. BC069673 mRNA. Translation: AAH69673.1. BC069752 mRNA. Translation: AAH69752.1. BC069793 mRNA. Translation: AAH69793.1. BC096056 mRNA. Translation: AAH96056.1. BC096057 mRNA. Translation: AAH96057.1. | |
| IPI | IPI00396316. |
| PIR | A32795. |
| RefSeq | NP_002306.1. |
| UniGene | Hs.654426 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1J2O based on UniProtKB P25801. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSG00000166407. Homo sapiens. [Contig view] |
| GeneID | 4004. |
| KEGG | hsa:4004. |
Organism-specific databases | |
| GeneCards | GC11M008202. |
| H-InvDB | HIX0035980. |
| HGNC | HGNC:6641. LMO1. |
| MIM | 186921. gene+phenotype. |
| Orphanet | 513. Leukemia, lymphoblastic, acute. |
| PharmGKB | PA27754. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | P25800. |
Gene expression databases | |
| ArrayExpress | P25800. |
| Bgee | P25800. |
| CleanEx | HS_LMO1. |
| GermOnline | ENSG00000166407. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001781. Znf_LIM. [Graphical view] |
| Gene3D | G3DSA:2.10.110.10. Znf_LIM. 1 hit. |
| Pfam | PF00412. LIM. 2 hits. [Graphical view] |
| ProDom | PD000094. LIM. 2 hits. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00132. LIM. 2 hits. [Graphical view] |
| PROSITE | PS00478. LIM_DOMAIN_1. 2 hits. PS50023. LIM_DOMAIN_2. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 15708. |
| PMAP-CutDB | P25800. |
| SOURCE | Search... |
Entry information
| Entry name | RBTN1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P25800 Secondary accession number(s): Q4VBC5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 11 Human chromosome 11: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


