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P25800 (RBTN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 132. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Rhombotin-1
Alternative name(s):
Cysteine-rich protein TTG-1
LIM domain only protein 1
Short name=LMO-1
T-cell translocation protein 1
Gene names
Name:LMO1
Synonyms:RBTN1, RHOM1, TTG1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length156 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors. Ref.3

Subcellular location

Nucleus By similarity.

Tissue specificity

Expressed mainly in the central nervous. Low level of expression in other tissues including thymus. Ref.7

Involvement in disease

A chromosomal aberration involving LMO1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p15;q11) with TCRD.

Sequence similarities

Contains 2 LIM zinc-binding domains.

Sequence caution

The sequence AAH39512.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P25800-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P25800-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MMVLDKEDG → MVLDQEDG
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 156156Rhombotin-1
PRO_0000075894

Regions

Domain24 – 8360LIM zinc-binding 1
Domain88 – 14760LIM zinc-binding 2

Natural variations

Alternative sequence1 – 99MMVLDKEDG → MVLDQEDG in isoform 2.
VSP_046664

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: 6BAFBE1F870CCAAC

FASTA15617,828
        10         20         30         40         50         60 
MMVLDKEDGV PMLSVQPKGK QKGCAGCNRK IKDRYLLKAL DKYWHEDCLK CACCDCRLGE 

        70         80         90        100        110        120 
VGSTLYTKAN LILCRRDYLR LFGTTGNCAA CSKLIPAFEM VMRARDNVYH LDCFACQLCN 

       130        140        150 
QRFCVGDKFF LKNNMILCQM DYEEGQLNGT FESQVQ 

« Hide

Isoform 2 [UniParc].

Checksum: D18E9D3F21705F4A
Show »

FASTA15517,697

References

« Hide 'large scale' references
[1]"The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein."
McGuire E.A., Hockett R.D., Pollock K.M., Bartholdi M.F., O'Brien S.J., Korsmeyer S.J.
Mol. Cell. Biol. 9:2124-2132(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"An unusual structure of a putative T cell oncogene which allows production of similar proteins from distinct mRNAs."
Boehm T., Greenberg J.M., Buluwela L., Lavenir I., Forster A., Rabbitts T.H.
EMBO J. 9:857-868(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells."
McGuire E.A., Davis A.R., Korsmeyer S.J.
Blood 77:599-606(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
[4]"Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1)."
Cichutek A., Brueckmann T., Seipel B., Hauser H., Schlaubitz S., Prawitt D., Hankeln T., Schmidt E.R., Winterpacht A., Zabel B.U.
Cytogenet. Cell Genet. 93:277-283(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Blood.
[5]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Eye.
[7]"Developmentally regulated and tissue specific expression of mRNAs encoding the two alternative forms of the LIM domain oncogene rhombotin: evidence for thymus expression."
Boehm T., Spillantini M.G., Sofroniew M.V., Surani M.A., Rabbitts T.H.
Oncogene 6:695-703(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M26682 mRNA. Translation: AAA36819.1.
AJ277662 Genomic DNA. Translation: CAC14587.1.
AC091013 Genomic DNA. No translation available.
BC039512 mRNA. Translation: AAH39512.1. Different initiation.
BC069673 mRNA. Translation: AAH69673.1.
BC069752 mRNA. Translation: AAH69752.1.
BC069793 mRNA. Translation: AAH69793.1.
BC096056 mRNA. Translation: AAH96056.1.
BC096057 mRNA. Translation: AAH96057.1.
CCDSCCDS44534.1. [P25800-1]
CCDS58118.1. [P25800-2]
PIRA32795.
RefSeqNP_001257357.1. NM_001270428.1. [P25800-2]
NP_002306.1. NM_002315.2. [P25800-1]
UniGeneHs.654426.

3D structure databases

ProteinModelPortalP25800.
SMRP25800. Positions 24-149.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110190. 6 interactions.
IntActP25800. 1 interaction.
STRING9606.ENSP00000338207.

PTM databases

PhosphoSiteP25800.

Polymorphism databases

DMDM132532.

Proteomic databases

MaxQBP25800.
PaxDbP25800.
PRIDEP25800.

Protocols and materials databases

DNASU4004.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000335790; ENSP00000338207; ENSG00000166407. [P25800-1]
ENST00000428101; ENSP00000404538; ENSG00000166407. [P25800-2]
GeneID4004.
KEGGhsa:4004.
UCSCuc001mgg.2. human. [P25800-1]

Organism-specific databases

CTD4004.
GeneCardsGC11M008202.
HGNCHGNC:6641. LMO1.
MIM186921. gene+phenotype.
neXtProtNX_P25800.
PharmGKBPA30407.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG288849.
HOGENOMHOG000232175.
HOVERGENHBG054231.
InParanoidP25800.
OMAGSFETQV.
OrthoDBEOG75J0PF.
PhylomeDBP25800.
TreeFamTF351071.

Gene expression databases

ArrayExpressP25800.
BgeeP25800.
CleanExHS_LMO1.
GenevestigatorP25800.

Family and domain databases

Gene3D2.10.110.10. 2 hits.
InterProIPR001781. Znf_LIM.
[Graphical view]
PfamPF00412. LIM. 2 hits.
[Graphical view]
SMARTSM00132. LIM. 2 hits.
[Graphical view]
PROSITEPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSLMO1. human.
GeneWikiLMO1.
GenomeRNAi4004.
NextBio15708.
PMAP-CutDBP25800.
PROP25800.
SOURCESearch...

Entry information

Entry nameRBTN1_HUMAN
AccessionPrimary (citable) accession number: P25800
Secondary accession number(s): E9PSF5, Q4VBC5, Q8IXR0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: July 9, 2014
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM