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Protein

Flagellar M-ring protein

Gene

fliF

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The M ring may be actively involved in energy transduction.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BioCyciEcoCyc:FLIF-FLAGELLAR-MS-RING

Names & Taxonomyi

Protein namesi
Recommended name:
Flagellar M-ring protein
Gene namesi
Name:fliF
Synonyms:fla AII.1, fla BI
Ordered Locus Names:b1938, JW1922
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11347 fliF

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 43HelicalSequence analysisAdd BLAST21
Transmembranei447 – 467HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Bacterial flagellum, Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001808821 – 552Flagellar M-ring proteinAdd BLAST552

Proteomic databases

PaxDbiP25798
PRIDEiP25798

Interactioni

Subunit structurei

The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The M ring is integral to the inner membrane of the cell and may be connected to the flagellar rod via the S ring. The S (supramembrane ring) lies just distal to the M ring. The L and P rings lie in the outer membrane and the periplasmic space, respectively.

Binary interactionsi

WithEntry#Exp.IntActNotes
fliGP0ABZ14EBI-1126492,EBI-1126524

Protein-protein interaction databases

BioGridi4260383, 20 interactors
DIPiDIP-401N
IntActiP25798, 4 interactors
STRINGi316385.ECDH10B_2080

Structurei

3D structure databases

ProteinModelPortaliP25798
SMRiP25798
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FliF family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C1F Bacteria
COG1766 LUCA
HOGENOMiHOG000265848
InParanoidiP25798
KOiK02409
OMAiNYEVNRI
PhylomeDBiP25798

Family and domain databases

InterProiView protein in InterPro
IPR013556 Flag_M-ring_C
IPR000067 FlgMring_FliF
IPR006182 YscJ_FliF
PANTHERiPTHR30046:SF0 PTHR30046:SF0, 1 hit
PfamiView protein in Pfam
PF01514 YscJ_FliF, 1 hit
PF08345 YscJ_FliF_C, 1 hit
PIRSFiPIRSF004862 FliF, 1 hit
PRINTSiPR01009 FLGMRINGFLIF
TIGRFAMsiTIGR00206 fliF, 1 hit

Sequencei

Sequence statusi: Complete.

P25798-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNATAAQTKS LEWLNRLRAN PKIPLIVAGS AAVAVMVALI LWAKAPDYRT
60 70 80 90 100
LFSNLSDQDG GAIVSQLTQM NIPYRFSEAS GAIEVPADKV HELRLRLAQQ
110 120 130 140 150
GLPKGGAVGF ELLDQEKFGI SQFSEQVNYQ RALEGELSRT IETIGPVKGA
160 170 180 190 200
RVHLAMPKPS LFVREQKSPS ASVTVNLLPG RALDEGQISA IVHLVSSAVA
210 220 230 240 250
GLPPGNVTLV DQGGHLLTQS NTSGRDLNDA QLKYASDVEG RIQRRIEAIL
260 270 280 290 300
SPIVGNGNIH AQVTAQLDFA SKEQTEEQYR PNGDESHAAL RSRQLNESEQ
310 320 330 340 350
SGSGYPGGVP GALSNQPAPA NNAPISTPPA NQNNRQQQAS TTSNSGPRST
360 370 380 390 400
QRNETSNYEV DRTIRHTKMN VGDVQRLSVA VVVNYKTLPD GKPLPLSNEQ
410 420 430 440 450
MKQIEDLTRE AMGFSEKRGD SLNVVNSPFN SSDESGGELP FWQQQAFIDQ
460 470 480 490 500
LLAAGRWLLV LLVAWLLWRK AVRPQLTRRA EAMKAVQQQA QAREEVEDAV
510 520 530 540 550
EVRLSKDEQL QQRRANQRLG AEVMSQRIRE MSDNDPRVVA LVIRQWINND

HE
Length:552
Mass (Da):60,589
Last modified:November 1, 1997 - v3
Checksum:iB2038FDBEA914DA5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti260H → R in BAA14029 (Ref. 1) Curated1
Sequence conflicti266Q → H in BAA14029 (Ref. 1) Curated1
Sequence conflicti541L → V (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89826 Genomic DNA Translation: BAA14029.1
U00096 Genomic DNA Translation: AAC75005.1
AP009048 Genomic DNA Translation: BAA15763.1
M84992 Genomic DNA No translation available.
L13243 Genomic DNA No translation available.
PIRiG64957
RefSeqiNP_416448.1, NC_000913.3
WP_000994427.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75005; AAC75005; b1938
BAA15763; BAA15763; BAA15763
GeneIDi946448
KEGGiecj:JW1922
eco:b1938
PATRICifig|1411691.4.peg.313

Similar proteinsi

Entry informationi

Entry nameiFLIF_ECOLI
AccessioniPrimary (citable) accession number: P25798
Secondary accession number(s): P76324, P76914
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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