Reviewed, UniProtKB/Swiss-Prot P25791 (RBTN2_HUMAN)

Names and origin

Protein names

Recommended name:
    Rhombotin-2
Alternative name(s):
    LIM domain only protein 2
    Cysteine-rich protein TTG-2
    T-cell translocation protein 2

Gene names

Name:	LMO2
Synonyms:	RBTN2, RBTNL1, RHOM2, TTG2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	158 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.
Subunit structure	Interacts via its LIM domains with ELF2 and LBD1. Also interacts with basic helix-loop-helix protein TAL1/SCL and can assemble in a complex with LMO2 and TAL1/SCL By similarity. Interacts with BEX2 and JARID1A.
Subcellular location	NucleusPotential.
Domain	The second LIM zinc-binding domain interacts with JARID1A.
Involvement in disease	A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p13;q11) with TCRD.
Sequence similarities	Contains 2 LIM zinc-binding domains.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Chromosomal rearrangement
Disease	Proto-oncogene
Domain	LIM domain Repeat
Ligand	Metal-binding Zinc
Gene Ontology (GO)
Biological process	multicellular organismal development Ref.1 Traceable author statement. Source: ProtInc
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein binding Inferred from sequence or structural similarity. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P25791-1)

Also known as: LMO2a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P25791-2)

Also known as: LMO2b;

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MSSAIERKSLDPSE → MLGLLSR

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 158	158	Rhombotin-2		PRO_0000075896
Regions
	Domain	30 – 89	60	LIM zinc-binding 1
	Domain	94 – 153	60	LIM zinc-binding 2
Natural variations
	Alternative sequence	1 – 14	14	MSSAI…LDPSE → MLGLLSR in isoform 2.		VSP_003119

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (LMO2a) [UniParc]. Last modified May 1, 1992. Version 1. Checksum: 1B4FF02505528C93	FASTA	158	18,358
	10 20 30 40 50 60 MSSAIERKSL DPSEEPVDEV LQIPPSLLTC GGCQQNIGDR YFLKAIDQYW HEDCLSCDLC 70 80 90 100 110 120 GCRLGEVGRR LYYKLGRKLC RRDYLRLFGQ DGLCASCDKR IRAYEMTMRV KDKVYHLECF 130 140 150 KCAACQKHFC VGDRYLLINS DIVCEQDIYE WTKINGMI
	Isoform 2 (LMO2b) [UniParc]. Checksum: 38132BFC24AC218F		151	17,598
	10 20 30 40 50 60 MLGLLSREPV DEVLQIPPSL LTCGGCQQNI GDRYFLKAID QYWHEDCLSC DLCGCRLGEV 70 80 90 100 110 120 GRRLYYKLGR KLCRRDYLRL FGQDGLCASC DKRIRAYEMT MRVKDKVYHL ECFKCAACQK 130 140 150 HFCVGDRYLL INSDIVCEQD IYEWTKINGM I

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11)." Royer-Pokora B., Loos L., Ludwig W.D. Oncogene 6:1887-1893(1991) [PubMed: 1923511] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INVOLVEMENT IN T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA. Tissue: Kidney.
[2]	"New 5'-end of LMO2 (TTG-2/RBTN2)." Zhu T. Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Kidney.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain and Colon.
[4]	"T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding protein 2." Mao S., Neale G.A.M., Goorha R.M. Oncogene 14:1531-1539(1997) [PubMed: 9129143] [Abstract] Cited for: INTERACTION WITH JARID1A.
[5]	"Human Bex2 interacts with LMO2 and regulates the transcriptional activity of a novel DNA-binding complex." Han C., Liu H., Liu J., Yin K., Xie Y., Shen X., Wang Y., Yuan J., Qiang B., Liu Y.-J., Peng X. Nucleic Acids Res. 33:6555-6565(2005) [PubMed: 16314316] [Abstract] Cited for: INTERACTION WITH BEX2.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBLGenBankDDBJ	X61118 mRNA. Translation: CAA43430.1. AF257211 mRNA. Translation: AAF98804.1. BC034041 mRNA. Translation: AAH34041.1. BC035607 mRNA. Translation: AAH35607.1. BC042426 mRNA. Translation: AAH42426.1. BC073973 mRNA. Translation: AAH73973.1.
PIR	S29477.
RefSeq	NP_005565.1.
UniGene	Hs.34560
3D structure databases
HSSP	HSSP built from PDB template 1J2O based on UniProtKB P25801.
SMR	P25791. Positions 26-87.
ModBase	Search...
Protein-protein interaction databases
IntAct	P25791.
PTM databases
PhosphoSite	P25791.
Genome annotation databases
Ensembl	ENSG00000135363. Homo sapiens. [Contig view]
GeneID	4005.
KEGG	hsa:4005.
Organism-specific databases
H-InvDB	HIX0009544.
HGNC	HGNC:6642. LMO2.
HPA	CAB016258.
MIM	180385. gene.
PharmGKB	PA27755.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	P25791.
HOVERGEN	P25791.
Gene expression databases
ArrayExpress	P25791.
CleanEx	HS_LMO2.
GermOnline	ENSG00000135363. Homo sapiens.
Family and domain databases
InterPro	IPR001781. Znf_LIM. [Graphical view]
Gene3D	G3DSA:2.10.110.10. Znf_LIM. 1 hit.
Pfam	PF00412. LIM. 2 hits. [Graphical view]
ProDom	PD000094. LIM. 2 hits. [Graphical view] [Entries sharing at least one domain]
SMART	SM00132. LIM. 2 hits. [Graphical view]
PROSITE	PS00478. LIM_DOMAIN_1. 2 hits. PS50023. LIM_DOMAIN_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	15712.
SOURCE	Search...

Entry information

Entry name

RBTN2_HUMAN

Accession

Primary (citable) accession number: P25791
Secondary accession number(s): Q9HD58

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
Last sequence update:	May 1, 1992
Last modified:	November 25, 2008
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)