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Protein

Peptidase 1

Gene

EURM1

Organism
Euroglyphus maynei (Mayne's house dust mite)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable thiol protease.

Catalytic activityi

Broad endopeptidase specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei133 – 1331By similarity
Active sitei269 – 2691By similarity
Active sitei289 – 2891By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiC01.073.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidase 1 (EC:3.4.22.65)
Alternative name(s):
Allergen Eur m I
Mite group 1 allergen Eur m 1
Allergen: Eur m 1
Gene namesi
Name:EURM1
OrganismiEuroglyphus maynei (Mayne's house dust mite)
Taxonomic identifieri6958 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataPsoroptidiaAnalgoideaPyroglyphidaePyroglyphinaeEuroglyphus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei1359. Eur m 1.0101.
1360. Eur m 1.0102.
338. Eur m 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Propeptidei19 – 9880PRO_0000026378Add
BLAST
Chaini99 – 321223Peptidase 1PRO_0000026379Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi34 – 341N-linked (GlcNAc...)Sequence analysis
Disulfide bondi130 ↔ 170By similarity
Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Structurei

3D structure databases

ProteinModelPortaliP25780.
SMRiP25780. Positions 22-321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25780-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIILAIASL LVLSAVYARP ASIKTFEEFK KAFNKTYATP EKEEVARKNF
60 70 80 90 100
LESLKYVESN KGAINHLSDL SLDEFKNQFL MNANAFEQLK TQFDLNAETY
110 120 130 140 150
ACSINSVSLP SELDLRSLRT VTPIRMQGGC GSCWAFSGVA STESAYLAYR
160 170 180 190 200
NMSLDLAEQE LVDCASQNGC HGDTIPRGIE YIQQNGVVQE HYYPYVAREQ
210 220 230 240 250
SCHRPNAQRY GLKNYCQISP PDSNKIRQAL TQTHTAVAVI IGIKDLNAFR
260 270 280 290 300
HYDGRTIMQH DNGYQPNYHA VNIVGYGNTQ GVDYWIVRNS WDTTWGDNGY
310 320
GYFAANINLM MIEQYPYVVM L
Length:321
Mass (Da):36,290
Last modified:June 20, 2001 - v2
Checksum:i6CFD44FEC725999E
GO

Sequence cautioni

The sequence AAC82352 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti36 – 361T → S in Eur m 1.0102.
Natural varianti126 – 1261M → N in Eur m 1.0102.
Natural varianti320 – 3201M → I in Eur m 1.0102.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047610 mRNA. Translation: AAC82351.1.
AF047611 mRNA. Translation: AAC82352.1. Different initiation.
AF047612 mRNA. Translation: AAC82353.1.
X60073 Genomic DNA. Translation: CAA42677.1.
PIRiS21864.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047610 mRNA. Translation: AAC82351.1.
AF047611 mRNA. Translation: AAC82352.1. Different initiation.
AF047612 mRNA. Translation: AAC82353.1.
X60073 Genomic DNA. Translation: CAA42677.1.
PIRiS21864.

3D structure databases

ProteinModelPortaliP25780.
SMRiP25780. Positions 22-321.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei1359. Eur m 1.0101.
1360. Eur m 1.0102.
338. Eur m 1.
MEROPSiC01.073.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPEPT1_EURMA
AccessioniPrimary (citable) accession number: P25780
Secondary accession number(s): Q9TZZ3, Q9TZZ4, Q9UBA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: June 20, 2001
Last modified: October 14, 2015
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.