Reviewed, UniProtKB/Swiss-Prot P25773 (CATL1_FELCA)

Names and origin

Protein names

Recommended name:
    Cathepsin L1
    EC=3.4.22.15
Alternative name(s):
    Progesterone-dependent protein
      Short name=PDP

Gene names

Name:	CTSL1
Synonyms:	CTSL

Organism

Felis silvestris catus (Cat)

Taxonomic identifier

9685 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis

Protein attributes

Sequence length	139 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Important for the overall degradation of proteins in lysosomes. May be responsible for preparing the endometrium for blastocyst implantation.
Catalytic activity	Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.
Subunit structure	Dimer of a heavy and a light chain linked by disulfide bonds.
Subcellular location	Lysosome.
Induction	By progesterone.
Sequence similarities	Belongs to the peptidase C1 family.

Ontologies

Keywords
Cellular component	Lysosome
Molecular function	Hydrolase Protease Thiol protease
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cysteine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›139	›139	Cathepsin L1		PRO_0000050536
Sites
	Active site	97	1	By similarity
	Active site	121	1	By similarity
Amino acid modifications
	Glycosylation	42	1	N-linked (GlcNAc...) Potential
	Disulfide bond	‹1 ↔ 32		By similarity
	Disulfide bond	90 ↔ ›139		By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	139	1

Sequences

	Sequence		Length	Mass (Da)
	P25773-1 [UniParc]. Last modified May 1, 1992. Version 1. Checksum: B2B7EAF2B93EDE54	FASTA	139	15,490
	10 20 30 40 50 60 GGLIDDAFQY VKDNGGLDSE ESYPYHAQGD SCKYRPENSV ANVTDYWDIP SKENELMITL 70 80 90 100 110 120 AAVGPISAAI DASLDTFRFY KEGIYYDPSC SSEDVDHGVL VVGYGADGTE TENKKYWIIK 130 NSWGTDWGMD GYIKMAKDR

References

[1]

"Molecular cloning and characterization of a progesterone-dependent cat endometrial secretory protein complementary deoxyribonucleic acid." Jaffe R.C., Donnelly K.M., Mavrogianis P.A., Verhage H.G. Mol. Endocrinol. 3:1807-1814(1989) [PubMed: 2575214] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	M31652 mRNA. Translation: AAA30816.1.
PIR	A41404.
3D structure databases
HSSP	HSSP built from PDB template 1ICF based on UniProtKB P07711.
ModBase	Search...
Protein family/group databases
MEROPS	C01.032.
Phylogenomic databases
HOVERGEN	P25773.
Enzyme and pathway databases
BRENDA	3.4.22.15. 273949.
Family and domain databases
InterPro	IPR000169. Pept_cys_AS. IPR013128. Peptidase_C1A. IPR000668. Peptidase_C1A_C. [Graphical view]
PANTHER	PTHR12411. Peptidase_C1A. 1 hit.
Pfam	PF00112. Peptidase_C1. 1 hit. [Graphical view]
SMART	SM00645. Pept_C1. 1 hit. [Graphical view]
PROSITE	PS00640. THIOL_PROTEASE_ASN. 1 hit. PS00139. THIOL_PROTEASE_CYS. Partial match. PS00639. THIOL_PROTEASE_HIS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CATL1_FELCA

Accession

Primary (citable) accession number: P25773

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
Last sequence update:	May 1, 1992
Last modified:	June 16, 2009
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)