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P25750 (CH60_BUCAI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
60 kDa chaperonin
Alternative name(s):
GroEL protein
Protein Cpn60
Symbionin
Gene names
Name:groL
Synonyms:groEL, mopA, symL
Ordered Locus Names:BU019
OrganismBuchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium) [Reference proteome] [HAMAP]
Taxonomic identifier107806 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length548 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions By similarity. HAMAP-Rule MF_00600

Subunit structure

Oligomer of 14 subunits composed of two stacked rings of 7 subunits By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00600.

Sequence similarities

Belongs to the chaperonin (HSP60) family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionChaperone
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein refolding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 54854860 kDa chaperonin HAMAP-Rule MF_00600
PRO_0000063305

Sequences

Sequence LengthMass (Da)Tools
P25750 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: 9B33AE1E629E7592

FASTA54857,911
        10         20         30         40         50         60 
MAAKDVKFGN EARIKMLRGV NVLADAVKVT LGPKGRNVVL DKSFGAPSIT KDGVSVAREI 

        70         80         90        100        110        120 
ELEDKFENMG AQMVKEVASK ANDAAGDGTT TATLLAQSIV NEGLKAVAAG MNPMDLKRGI 

       130        140        150        160        170        180 
DKAVISAVEE LKHLSVPCSD SKAITQVGTI SANADEKVGS LIAEAMEKVG NDGVITVEEG 

       190        200        210        220        230        240 
TGLQDELEVV KGMQFDRGYL SPYFINKPET GIVELENPYI LMADKKISNV REMLPILESV 

       250        260        270        280        290        300 
AKSGKPLLII SEDLEGEALA TLVVNSMRGI VKVAAVKAPG FGDRRKAMLQ DISILTGGSV 

       310        320        330        340        350        360 
ISEELAMELE KSTLEDLGQA KRVVISKDTT TIIGGVGEKH SIQSRISQIR QEIQEATSDY 

       370        380        390        400        410        420 
DKEKLNERLA KLSGGVAVLK VGAATEVEMK EKKARVEDAL HATRAAVEEG VVAGGGVALV 

       430        440        450        460        470        480 
RVAGKIADLR GQNEDQNVGI RVALRAMEAP LRQIVSNSGE EPSVVTNNVK DGKGNYGYNA 

       490        500        510        520        530        540 
ATDEYGDMID FGILDPTKVT RSALQYAASV AGLMITTECM VTDLPKEDKS SDSSSSPAGG 


MGGMGGMM 

« Hide

References

« Hide 'large scale' references
[1]"Structures of chaperonins from an intracellular symbiont and their functional expression in Escherichia coli groE mutants."
Ohtaka C., Nakamura H., Ishikawa H.
J. Bacteriol. 174:1869-1874(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS."
Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.
Nature 407:81-86(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: APS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X61150 Genomic DNA. Translation: CAA43460.1.
BA000003 Genomic DNA. Translation: BAB12746.1.
RefSeqNP_239860.1. NC_002528.1.

3D structure databases

ProteinModelPortalP25750.
SMRP25750. Positions 2-526.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING107806.BU019.

Proteomic databases

PRIDEP25750.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB12746; BAB12746; BAB12746.
GeneID1109527.
KEGGbuc:BU019.
PATRIC21243542. VBIBucAph127364_0031.

Phylogenomic databases

eggNOGCOG0459.
HOGENOMHOG000076290.
KOK04077.
OMANMKELLP.
OrthoDBEOG6JDWBZ.
ProtClustDBPRK00013.

Enzyme and pathway databases

BioCycBAPH107806:GBZJ-19-MONOMER.

Family and domain databases

Gene3D1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPMF_00600. CH60.
InterProIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PANTHERPTHR11353. PTHR11353. 1 hit.
PfamPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSPR00298. CHAPERONIN60.
SUPFAMSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
TIGRFAMsTIGR02348. GroEL. 1 hit.
PROSITEPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCH60_BUCAI
AccessionPrimary (citable) accession number: P25750
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: February 19, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Buchnera aphidicola (subsp. Acyrthosiphon pisum)

Buchnera aphidicola (subsp. Acyrthosiphon pisum): entries and gene names