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Protein

HTH-type transcriptional regulator GalS

Gene

galS

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Repressor of the mgl operon. Binds galactose and D-fucose as inducers. GalS binds to an operator DNA sequence within its own coding sequence (corresponding to residues 15 to 20).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi4 – 23H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • DNA binding Source: EcoCyc

GO - Biological processi

  • regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:PD00261

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator GalS
Alternative name(s):
Mgl repressor and galactose ultrainduction factor
Gene namesi
Name:galS
Ordered Locus Names:b2151, JW2138
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10365 galS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001079561 – 346HTH-type transcriptional regulator GalSAdd BLAST346

Proteomic databases

PaxDbiP25748
PRIDEiP25748

Interactioni

Subunit structurei

Homodimer.

Binary interactionsi

WithEntry#Exp.IntActNotes
galRP030245EBI-1117006,EBI-556902

Protein-protein interaction databases

DIPiDIP-9734N
IntActiP25748, 7 interactors
STRINGi316385.ECDH10B_2308

Structurei

3D structure databases

ProteinModelPortaliP25748
SMRiP25748
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 56HTH lacI-typePROSITE-ProRule annotationAdd BLAST56

Phylogenomic databases

eggNOGiENOG41060NJ Bacteria
COG1609 LUCA
HOGENOMiHOG000220179
InParanoidiP25748
KOiK02529
OMAiMRVILCN
PhylomeDBiP25748

Family and domain databases

CDDicd01392 HTH_LacI, 1 hit
InterProiView protein in InterPro
IPR000843 HTH_LacI
IPR010982 Lambda_DNA-bd_dom_sf
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF00356 LacI, 1 hit
PRINTSiPR00036 HTHLACI
SMARTiView protein in SMART
SM00354 HTH_LACI, 1 hit
SUPFAMiSSF47413 SSF47413, 1 hit
SSF53822 SSF53822, 1 hit
PROSITEiView protein in PROSITE
PS00356 HTH_LACI_1, 1 hit
PS50932 HTH_LACI_2, 1 hit

Sequencei

Sequence statusi: Complete.

P25748-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITIRDVARQ AGVSVATVSR VLNNSTLVSA DTREAVMKAV SELDYRPNAN
60 70 80 90 100
AQALATQVSD TIGVVVMDVS DAFFGALVKA VDLVAQQHQK YVLIGNSYHE
110 120 130 140 150
AEKERHAIEV LIRQRCNALI VHSKALSDDE LAQFMDNIPG MVLINRVVPG
160 170 180 190 200
YAHRCVCLDN LSGARMATRM LLNNGHQRIG YLSSSHGIED DAMRKAGWMS
210 220 230 240 250
ALKEQDIIPP ESWIGAGTPD MPGGEAAMVE LLGRNLQLTA VFAYNDNMAA
260 270 280 290 300
GALTALKDNG IAIPLHLSII GFDDIPIARY TDPQLTTVRY PIASMAKLAT
310 320 330 340
ELALQGAAGN IDPRASHCFM PTLVRRHSVA TRQNAAAITN STNQAM
Length:346
Mass (Da):37,357
Last modified:November 1, 1997 - v2
Checksum:iF13D9DF41A29ADDA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104 – 105ER → DG in CAA44390 (PubMed:1619663).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62529 Genomic DNA Translation: CAA44390.1
U00007 Genomic DNA Translation: AAA60528.1
U00096 Genomic DNA Translation: AAC75212.1
AP009048 Genomic DNA Translation: BAE76628.1
PIRiF64983
RefSeqiNP_416656.1, NC_000913.3
WP_000628648.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75212; AAC75212; b2151
BAE76628; BAE76628; BAE76628
GeneIDi949043
KEGGiecj:JW2138
eco:b2151
PATRICifig|1411691.4.peg.90

Similar proteinsi

Entry informationi

Entry nameiGALS_ECOLI
AccessioniPrimary (citable) accession number: P25748
Secondary accession number(s): Q2MAS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

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