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Protein

Multidrug resistance protein MdtG

Gene

mdtG

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Confers resistance to fosfomycin and deoxycholate.1 Publication

GO - Molecular functioni

GO - Biological processi

  • drug transmembrane transport Source: EcoCyc
  • response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Antibiotic resistance, Transport

Enzyme and pathway databases

BioCyciEcoCyc:YCEE-MONOMER.
ECOL316407:JW1040-MONOMER.

Protein family/group databases

TCDBi2.A.1.2.20. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein MdtG
Gene namesi
Name:mdtG
Synonyms:yceE
Ordered Locus Names:b1053, JW1040
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11343. mdtG.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21
Transmembranei319 – 339HelicalSequence analysisAdd BLAST21
Transmembranei378 – 398HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001733341 – 408Multidrug resistance protein MdtGAdd BLAST408

Proteomic databases

PaxDbiP25744.
PRIDEiP25744.

Interactioni

Protein-protein interaction databases

BioGridi4261506. 14 interactors.
STRINGi511145.b1053.

Structurei

3D structure databases

ProteinModelPortaliP25744.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C6X. Bacteria.
ENOG410ZVCH. LUCA.
HOGENOMiHOG000066093.
InParanoidiP25744.
KOiK08161.
OMAiSYGFRTV.
PhylomeDBiP25744.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_01528. MFS_MdtG. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR023692. Mutidrug-R_MdtG.
IPR001958. Tet-R_TetA/multi-R_MdtG.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PRINTSiPR01035. TCRTETA.
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25744-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPCENDTPI NWKRNLIVAW LGCFLTGAAF SLVMPFLPLY VEQLGVTGHS
60 70 80 90 100
ALNMWSGIVF SITFLFSAIA SPFWGGLADR KGRKLMLLRS ALGMGIVMVL
110 120 130 140 150
MGLAQNIWQF LILRALLGLL GGFVPNANAL IATQVPRNKS GWALGTLSTG
160 170 180 190 200
GVSGALLGPM AGGLLADSYG LRPVFFITAS VLILCFFVTL FCIREKFQPV
210 220 230 240 250
SKKEMLHMRE VVTSLKNPKL VLSLFVTTLI IQVATGSIAP ILTLYVRELA
260 270 280 290 300
GNVSNVAFIS GMIASVPGVA ALLSAPRLGK LGDRIGPEKI LITALIFSVL
310 320 330 340 350
LLIPMSYVQT PLQLGILRFL LGAADGALLP AVQTLLVYNS SNQIAGRIFS
360 370 380 390 400
YNQSFRDIGN VTGPLMGAAI SANYGFRAVF LVTAGVVLFN AVYSWNSLRR

RRIPQVSN
Length:408
Mass (Da):43,867
Last modified:May 1, 1992 - v1
Checksum:iC07B719D54A28D27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59939 Genomic DNA. Translation: CAA42562.1.
U00096 Genomic DNA. Translation: AAC74137.1.
AP009048 Genomic DNA. Translation: BAA35851.1.
PIRiB42290.
RefSeqiNP_415571.1. NC_000913.3.
WP_000074172.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74137; AAC74137; b1053.
BAA35851; BAA35851; BAA35851.
GeneIDi945627.
KEGGiecj:JW1040.
eco:b1053.
PATRICi32117343. VBIEscCol129921_1094.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59939 Genomic DNA. Translation: CAA42562.1.
U00096 Genomic DNA. Translation: AAC74137.1.
AP009048 Genomic DNA. Translation: BAA35851.1.
PIRiB42290.
RefSeqiNP_415571.1. NC_000913.3.
WP_000074172.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP25744.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261506. 14 interactors.
STRINGi511145.b1053.

Protein family/group databases

TCDBi2.A.1.2.20. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiP25744.
PRIDEiP25744.

Protocols and materials databases

DNASUi945627.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74137; AAC74137; b1053.
BAA35851; BAA35851; BAA35851.
GeneIDi945627.
KEGGiecj:JW1040.
eco:b1053.
PATRICi32117343. VBIEscCol129921_1094.

Organism-specific databases

EchoBASEiEB1319.
EcoGeneiEG11343. mdtG.

Phylogenomic databases

eggNOGiENOG4105C6X. Bacteria.
ENOG410ZVCH. LUCA.
HOGENOMiHOG000066093.
InParanoidiP25744.
KOiK08161.
OMAiSYGFRTV.
PhylomeDBiP25744.

Enzyme and pathway databases

BioCyciEcoCyc:YCEE-MONOMER.
ECOL316407:JW1040-MONOMER.

Miscellaneous databases

PROiP25744.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_01528. MFS_MdtG. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR023692. Mutidrug-R_MdtG.
IPR001958. Tet-R_TetA/multi-R_MdtG.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PRINTSiPR01035. TCRTETA.
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMDTG_ECOLI
AccessioniPrimary (citable) accession number: P25744
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 2, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.