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Protein

Multidrug resistance protein MdtG

Gene

mdtG

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Confers resistance to fosfomycin and deoxycholate.1 Publication

GO - Molecular functioni

GO - Biological processi

  • drug transmembrane transport Source: EcoCyc
  • response to antibiotic Source: UniProtKB-KW

Keywordsi

Biological processAntibiotic resistance, Transport

Enzyme and pathway databases

BioCyciEcoCyc:YCEE-MONOMER

Protein family/group databases

TCDBi2.A.1.2.20 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein MdtG
Gene namesi
Name:mdtG
Synonyms:yceE
Ordered Locus Names:b1053, JW1040
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11343 mdtG

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21
Transmembranei319 – 339HelicalSequence analysisAdd BLAST21
Transmembranei378 – 398HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001733341 – 408Multidrug resistance protein MdtGAdd BLAST408

Proteomic databases

PaxDbiP25744
PRIDEiP25744

Interactioni

Protein-protein interaction databases

BioGridi4261506, 14 interactors
STRINGi316385.ECDH10B_1124

Structurei

3D structure databases

ProteinModelPortaliP25744
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C6X Bacteria
ENOG410ZVCH LUCA
HOGENOMiHOG000066093
InParanoidiP25744
KOiK08161
OMAiVIRHNVP
PhylomeDBiP25744

Family and domain databases

CDDicd06174 MFS, 1 hit
HAMAPiMF_01528 MFS_MdtG, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR023692 Mutidrug-R_MdtG
IPR001958 Tet-R_TetA/multi-R_MdtG
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
PRINTSiPR01035 TCRTETA
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

P25744-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPCENDTPI NWKRNLIVAW LGCFLTGAAF SLVMPFLPLY VEQLGVTGHS
60 70 80 90 100
ALNMWSGIVF SITFLFSAIA SPFWGGLADR KGRKLMLLRS ALGMGIVMVL
110 120 130 140 150
MGLAQNIWQF LILRALLGLL GGFVPNANAL IATQVPRNKS GWALGTLSTG
160 170 180 190 200
GVSGALLGPM AGGLLADSYG LRPVFFITAS VLILCFFVTL FCIREKFQPV
210 220 230 240 250
SKKEMLHMRE VVTSLKNPKL VLSLFVTTLI IQVATGSIAP ILTLYVRELA
260 270 280 290 300
GNVSNVAFIS GMIASVPGVA ALLSAPRLGK LGDRIGPEKI LITALIFSVL
310 320 330 340 350
LLIPMSYVQT PLQLGILRFL LGAADGALLP AVQTLLVYNS SNQIAGRIFS
360 370 380 390 400
YNQSFRDIGN VTGPLMGAAI SANYGFRAVF LVTAGVVLFN AVYSWNSLRR

RRIPQVSN
Length:408
Mass (Da):43,867
Last modified:May 1, 1992 - v1
Checksum:iC07B719D54A28D27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59939 Genomic DNA Translation: CAA42562.1
U00096 Genomic DNA Translation: AAC74137.1
AP009048 Genomic DNA Translation: BAA35851.1
PIRiB42290
RefSeqiNP_415571.1, NC_000913.3
WP_000074172.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74137; AAC74137; b1053
BAA35851; BAA35851; BAA35851
GeneIDi945627
KEGGiecj:JW1040
eco:b1053
PATRICifig|1411691.4.peg.1216

Similar proteinsi

Entry informationi

Entry nameiMDTG_ECOLI
AccessioniPrimary (citable) accession number: P25744
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: March 28, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health