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Protein

Lipopolysaccharide core heptose(I) kinase RfaP

Gene

rfaP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core.By similarity

Cofactori

Mg2+By similarity

Pathwayi: LPS core biosynthesis

This protein is involved in the pathway LPS core biosynthesis, which is part of Bacterial outer membrane biogenesis.
View all proteins of this organism that are known to be involved in the pathway LPS core biosynthesis and in Bacterial outer membrane biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei162Sequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processLipopolysaccharide biosynthesis
LigandATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG11340-MONOMER
MetaCyc:EG11340-MONOMER
UniPathwayiUPA00958

Names & Taxonomyi

Protein namesi
Recommended name:
Lipopolysaccharide core heptose(I) kinase RfaP (EC:2.7.1.-)
Gene namesi
Name:rfaP
Synonyms:waaP
Ordered Locus Names:b3630, JW3605
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11340 rfaP

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000972851 – 265Lipopolysaccharide core heptose(I) kinase RfaPAdd BLAST265

Proteomic databases

PaxDbiP25741
PRIDEiP25741

Interactioni

Protein-protein interaction databases

BioGridi4260804, 378 interactors
IntActiP25741, 7 interactors
STRINGi316385.ECDH10B_3812

Structurei

3D structure databases

ProteinModelPortaliP25741
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107543 Bacteria
ENOG410XQAT LUCA
HOGENOMiHOG000126215
InParanoidiP25741
KOiK02848
OMAiLGAGQEW

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR010440 LipoPS_kinase
IPR017172 Lsacc_core_hep_kinase_RfaP
PfamiView protein in Pfam
PF06293 Kdo, 1 hit
PIRSFiPIRSF037318 RfaP, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit

Sequencei

Sequence statusi: Complete.

P25741-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVELKEPLAT LWRGKDAFAE VKKLNGEVFR ELETRRTLRF ELSGKSYFLK
60 70 80 90 100
WHKGTTLKEI IKNLLSLRMP VLGADREWHA IHRLSDVGVD TMKGIGFGEK
110 120 130 140 150
GLNPLTRASF IITEDLTPTI SLEDYCADWA VNPPDIRVKR MLIARVATMV
160 170 180 190 200
RKMHTAGINH RDCYICHFLL HLPFTGREDE LKISVIDLHR AQIRAKVPRR
210 220 230 240 250
WRDKDLIGLY FSSMNIGLTQ RDIWRFMKVY FGMPLRKILS LEQNLLNMAS
260
VKAERIKERT QRKGL
Length:265
Mass (Da):30,872
Last modified:May 1, 1992 - v1
Checksum:iE77F1E9956ABDBED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80599 Genomic DNA Translation: AAA24083.1
U00039 Genomic DNA Translation: AAB18607.1
U00096 Genomic DNA Translation: AAC76654.1
AP009048 Genomic DNA Translation: BAE77662.1
PIRiC42595
RefSeqiNP_418087.1, NC_000913.3
WP_000229840.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76654; AAC76654; b3630
BAE77662; BAE77662; BAE77662
GeneIDi948150
KEGGiecj:JW3605
eco:b3630
PATRICifig|1411691.4.peg.3076

Entry informationi

Entry nameiRFAP_ECOLI
AccessioniPrimary (citable) accession number: P25741
Secondary accession number(s): Q2M7U4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: March 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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