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Protein

Peptidyl-prolyl cis-trans isomerase C, mitochondrial

Gene

CPR3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. This isozyme is required for growth on lactate at high temperature.3 Publications

Miscellaneous

Present with 1960 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).1 Publication

Enzyme regulationi

Inhibited by the immunosuppressant drug cyclosporin A and by SDZ NIM811, a PPIase inhibitor.

GO - Molecular functioni

  • peptidyl-prolyl cis-trans isomerase activity Source: SGD

GO - Biological processi

  • apoptotic process Source: SGD
  • protein folding Source: SGD

Keywordsi

Molecular functionIsomerase, Rotamase

Enzyme and pathway databases

BioCyciYEAST:YML078W-MONOMER
ReactomeiR-SCE-6781823 Formation of TC-NER Pre-Incision Complex
R-SCE-6782135 Dual incision in TC-NER
R-SCE-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-SCE-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase C, mitochondrial (EC:5.2.1.8)
Short name:
PPIase C
Alternative name(s):
Cyclophilin C
PPI-III
Rotamase C
Gene namesi
Name:CPR3
Synonyms:CYP3
Ordered Locus Names:YML078W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YML078W
SGDiS000004543 CPR3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi73R → A: Strongly reduces in vitro PPIase activity and in vivo protein folding activity. Reduces binding to cyclosporin A 2-fold. 1 Publication1
Mutagenesisi144H → Q: Strongly reduces in vitro PPIase activity and in vivo protein folding activity. Reduces binding to cyclosporin A 2-fold. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 20Mitochondrion1 PublicationAdd BLAST20
ChainiPRO_000002548721 – 182Peptidyl-prolyl cis-trans isomerase C, mitochondrialAdd BLAST162

Proteomic databases

MaxQBiP25719
PaxDbiP25719
PRIDEiP25719

PTM databases

iPTMnetiP25719

Interactioni

Protein-protein interaction databases

BioGridi35063, 70 interactors
DIPiDIP-6534N
IntActiP25719, 2 interactors
MINTiP25719
STRINGi4932.YML078W

Structurei

3D structure databases

ProteinModelPortaliP25719
SMRiP25719
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 181PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST157

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00760000119119
HOGENOMiHOG000065981
InParanoidiP25719
KOiK01802
OMAiELKHTGS
OrthoDBiEOG092C5DG5

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PIRSFiPIRSF001467 Peptidylpro_ismrse, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25719-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKRSIIQQS RLFSNSASRL GKKVFFDPAV NGTKIGRIEF ELYDNVVPKT
60 70 80 90 100
AENFRALCTG EKGWGYKGVP FHRIIPDFMI QGGDTDLTNG FGGKSIYGSK
110 120 130 140 150
FADENFVKKH DKAGLLSMAN AGPNTNGSQF FITTVPCPWL DGKHVVFGEV
160 170 180
TKGMDIVKAI ESYGTASGKP RAEIVIEEAG EL
Length:182
Mass (Da):19,919
Last modified:May 1, 1992 - v1
Checksum:i96C9A5B75250EF55
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84758 Genomic DNA Translation: AAA34548.1
X56962 Genomic DNA Translation: CAA40282.1
Z46373 Genomic DNA Translation: CAA86500.1
AY557761 Genomic DNA Translation: AAS56087.1
BK006946 Genomic DNA Translation: DAA09819.1
PIRiS30507
RefSeqiNP_013633.1, NM_001182437.1

Genome annotation databases

EnsemblFungiiYML078W; YML078W; YML078W
GeneIDi854897
KEGGisce:YML078W

Similar proteinsi

Entry informationi

Entry nameiCYPC_YEAST
AccessioniPrimary (citable) accession number: P25719
Secondary accession number(s): D6W0K5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: May 23, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

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