CPR3

Functionⁱ

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. This isozyme is required for growth on lactate at high temperature.3 Publications

Miscellaneous

Present with 1960 molecules/cell in log phase SD medium.1 Publication

Catalytic activityⁱ

Peptidylproline (omega=180) = peptidylproline (omega=0).1 Publication

Enzyme regulationⁱ

Inhibited by the immunosuppressant drug cyclosporin A and by SDZ NIM811, a PPIase inhibitor.

GO - Molecular functionⁱ

peptidyl-prolyl cis-trans isomerase activity
Source: SGD
Inferred from direct assayⁱ
- 7603990

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic process
Source: SGD
Inferred from mutant phenotypeⁱ
- 17881727
protein folding
Source: SGD
Inferred from direct assayⁱ
- 7603990

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Isomerase, Rotamase

Molecular function

Isomerase, Rotamase

Enzyme and pathway databases

BioCycⁱ	YEAST:YML078W-MONOMER
Reactomeⁱ	R-SCE-6781823 Formation of TC-NER Pre-Incision Complex R-SCE-6782135 Dual incision in TC-NER R-SCE-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER R-SCE-6798695 Neutrophil degranulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Peptidyl-prolyl cis-trans isomerase C, mitochondrial (EC:5.2.1.8) Short name: PPIase C Alternative name(s): Cyclophilin C PPI-III Rotamase C
Gene namesⁱ	Name:CPR3 Synonyms:CYP3 Ordered Locus Names:YML078W
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome XIII

Organism-specific databases

EuPathDBⁱ	FungiDB:YML078W
Saccharomyces Genome Database More...SGDⁱ	S000004543 CPR3

Keywords - Cellular componentⁱ

Mitochondrion

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	73	R → A: Strongly reduces in vitro PPIase activity and in vivo protein folding activity. Reduces binding to cyclosporin A 2-fold. 1 Publication		1
Mutagenesisⁱ	144	H → Q: Strongly reduces in vitro PPIase activity and in vivo protein folding activity. Reduces binding to cyclosporin A 2-fold. 1 Publication		1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 20	Mitochondrion1 PublicationAdd BLAST		20
ChainⁱPRO_0000025487	21 – 182	Peptidyl-prolyl cis-trans isomerase C, mitochondrialAdd BLAST		162

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P25719
PaxDbⁱ	P25719
PRIDEⁱ	P25719

PTM databases

iPTMnetⁱ	P25719

iPTMnetⁱ

P25719

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	35063, 70 interactors
Database of interacting proteins More...DIPⁱ	DIP-6534N
IntActⁱ	P25719, 2 interactors
Molecular INTeraction database More...MINTⁱ	P25719
STRINGⁱ	4932.YML078W

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P25719
SMRⁱ	P25719
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	25 – 181	PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST		157

Sequence similaritiesⁱ

Belongs to the cyclophilin-type PPIase family.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119119
HOGENOMⁱ	HOG000065981
InParanoidⁱ	P25719
KEGG Orthology (KO) More...KOⁱ	K01802
OMAⁱ	ELKHTGS
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C5DG5

Family and domain databases

Gene3Dⁱ	2.40.100.10, 1 hit
InterProⁱ	View protein in InterPro IPR029000 Cyclophilin-like_dom_sf IPR024936 Cyclophilin-type_PPIase IPR020892 Cyclophilin-type_PPIase_CS IPR002130 Cyclophilin-type_PPIase_dom
PANTHERⁱ	PTHR11071 PTHR11071, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00160 Pro_isomerase, 1 hit
PIRSFⁱ	PIRSF001467 Peptidylpro_ismrse, 1 hit
PRINTSⁱ	PR00153 CSAPPISMRASE
SUPFAMⁱ	SSF50891 SSF50891, 1 hit
PROSITEⁱ	View protein in PROSITE PS00170 CSA_PPIASE_1, 1 hit PS50072 CSA_PPIASE_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P25719-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MFKRSIIQQS RLFSNSASRL GKKVFFDPAV NGTKIGRIEF ELYDNVVPKT 
        60         70         80         90        100
AENFRALCTG EKGWGYKGVP FHRIIPDFMI QGGDTDLTNG FGGKSIYGSK 
       110        120        130        140        150
FADENFVKKH DKAGLLSMAN AGPNTNGSQF FITTVPCPWL DGKHVVFGEV 
       160        170        180 
TKGMDIVKAI ESYGTASGKP RAEIVIEEAG EL

Length:182

Mass (Da):19,919

Last modified:May 1, 1992 - v1

Checksum:ⁱ96C9A5B75250EF55

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M84758 Genomic DNA Translation: AAA34548.1 X56962 Genomic DNA Translation: CAA40282.1 Z46373 Genomic DNA Translation: CAA86500.1 AY557761 Genomic DNA Translation: AAS56087.1 BK006946 Genomic DNA Translation: DAA09819.1
PIRⁱ	S30507
NCBI Reference Sequences More...RefSeqⁱ	NP_013633.1, NM_001182437.1

Genome annotation databases

EnsemblFungiⁱ	YML078W; YML078W; YML078W
GeneIDⁱ	854897
KEGGⁱ	sce:YML078W

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P25719	Peptidyl-prolyl cis-trans isomerase		YEASB		182
Peptidyl-prolyl cis-trans isomerase		YEAS1		182
Peptidyl-prolyl cis-trans isomerase		YEASK		182
Peptidyl-prolyl cis-trans isomerase		YEAS8		182
Peptidyl-prolyl cis-trans isomerase		YEASA		182
+9

Protein	Similar proteins		Species	Score	Length
P25719	Peptidyl-prolyl cis-trans isomerase		YEASB		182
Peptidyl-prolyl cis-trans isomerase		YEAS1		182
Peptidyl-prolyl cis-trans isomerase		YEASK		182
Peptidyl-prolyl cis-trans isomerase		YEAS8		182
Peptidyl-prolyl cis-trans isomerase		YEASA		182
+13

Protein	Similar proteins		Species	Score	Length
P25719	Peptidyl-prolyl cis-trans isomerase A		MOUSE		164
Peptidyl-prolyl cis-trans isomerase		HUMAN		164
Peptidyl-prolyl cis-trans isomerase		Daphnia magna		164
UPI000A317CF4		MUSCR		120
UPI00045D67F9		CHLSB		205
+362

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M84758 Genomic DNA Translation: AAA34548.1 X56962 Genomic DNA Translation: CAA40282.1 Z46373 Genomic DNA Translation: CAA86500.1 AY557761 Genomic DNA Translation: AAS56087.1 BK006946 Genomic DNA Translation: DAA09819.1
PIRⁱ	S30507
NCBI Reference Sequences More...RefSeqⁱ	NP_013633.1, NM_001182437.1

3D structure databases

ProteinModelPortalⁱ	P25719
SMRⁱ	P25719
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	35063, 70 interactors
Database of interacting proteins More...DIPⁱ	DIP-6534N
IntActⁱ	P25719, 2 interactors
Molecular INTeraction database More...MINTⁱ	P25719
STRINGⁱ	4932.YML078W

PTM databases

iPTMnetⁱ	P25719

iPTMnetⁱ

P25719

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P25719
PaxDbⁱ	P25719
PRIDEⁱ	P25719

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	YML078W; YML078W; YML078W
GeneIDⁱ	854897
KEGGⁱ	sce:YML078W

Organism-specific databases

EuPathDBⁱ	FungiDB:YML078W
Saccharomyces Genome Database More...SGDⁱ	S000004543 CPR3

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119119
HOGENOMⁱ	HOG000065981
InParanoidⁱ	P25719
KEGG Orthology (KO) More...KOⁱ	K01802
OMAⁱ	ELKHTGS
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C5DG5

Enzyme and pathway databases

BioCycⁱ	YEAST:YML078W-MONOMER
Reactomeⁱ	R-SCE-6781823 Formation of TC-NER Pre-Incision Complex R-SCE-6782135 Dual incision in TC-NER R-SCE-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER R-SCE-6798695 Neutrophil degranulation

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P25719

PROⁱ

PR:P25719

Family and domain databases

Gene3Dⁱ	2.40.100.10, 1 hit
InterProⁱ	View protein in InterPro IPR029000 Cyclophilin-like_dom_sf IPR024936 Cyclophilin-type_PPIase IPR020892 Cyclophilin-type_PPIase_CS IPR002130 Cyclophilin-type_PPIase_dom
PANTHERⁱ	PTHR11071 PTHR11071, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00160 Pro_isomerase, 1 hit
PIRSFⁱ	PIRSF001467 Peptidylpro_ismrse, 1 hit
PRINTSⁱ	PR00153 CSAPPISMRASE
SUPFAMⁱ	SSF50891 SSF50891, 1 hit
PROSITEⁱ	View protein in PROSITE PS00170 CSA_PPIASE_1, 1 hit PS50072 CSA_PPIASE_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CYPC_YEAST
Accessionⁱ	P25719Primary (citable) accession number: P25719 Secondary accession number(s): D6W0K5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
	Last sequence update:	May 1, 1992
	Last modified:	May 23, 2018
	This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
Yeast chromosome XIII
Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P25719 (CYPC_YEAST)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Peptidyl-prolyl cis-trans isomerase C, mitochondrial

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>This subsection of the ‘Function’ section describes an enzyme regulatory mechanism and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/enzyme_regulation' target='_top'>More...</a></p>Enzyme regulationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

Enzyme regulationⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ