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P25714

- YIDC_ECOLI

UniProt

P25714 - YIDC_ECOLI

Protein

Membrane protein insertase YidC

Gene

yidC

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Inner membrane protein required for the insertion and/or proper folding and/or complex formation of integral inner membrane proteins. Involved in integration of membrane proteins that insert dependently and independently of the Sec translocase complex, as well as at least 2 lipoproteins. Its own insertion requires SRP and is Sec translocase-dependent. Essential for the integration of Sec-dependent subunit a of the F0ATP synthase, FtsQ and SecE proteins and for Sec-independent subunit c of the F0ATP synthase, M13 phage procoat and the N-terminus of leader peptidase Lep. Probably interacts directly with Sec-independent substrates. Sec-dependent protein FtsQ interacts first with SecY then subsequently with YidC. Sec-dependent LacY and MalF require YidC to acquire tertiary structure and stability, a chaperone-like function, but not for membrane insertion. Stable maltose transport copmplex formation (MalFGK2) also requires YidC. Partially complements a Streptococcus mutans yidC2 disruption mutant.8 Publications

    GO - Molecular functioni

    1. membrane insertase activity Source: EcoCyc
    2. protein binding Source: IntAct

    GO - Biological processi

    1. protein complex assembly Source: UniProtKB
    2. protein folding Source: UniProtKB
    3. protein homooligomerization Source: EcoCyc
    4. protein insertion into membrane Source: EcoCyc

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Protein transport, Transport

    Enzyme and pathway databases

    BioCyciEcoCyc:YIDC.
    ECOL316407:JW3683-MONOMER.

    Protein family/group databases

    TCDBi2.A.9.3.1. the cytochrome oxidase biogenesis (oxa1) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Membrane protein insertase YidC
    Alternative name(s):
    Foldase YidC
    Inner membrane protein YidC
    Membrane integrase YidC
    Oxa1Ec
    Gene namesi
    Name:yidC
    Ordered Locus Names:b3705, JW3683
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG11197. yidC.

    Subcellular locationi

    Cell inner membrane 2 Publications; Multi-pass membrane protein 2 Publications
    Note: Predominantly localized at cell poles at all stages of cell growth.

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. integral component of plasma membrane Source: EcoCyc
    3. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Lethality. Upon depletion experiments insertion of Sec translocase-independent integral membrane proteins ceases. Translocation of Sec-dependent protein decreases to a lesser extent. Also leads to decreased targeting and/or translocation of Lpp and BRP lipoproteins. Both spoIIIJ and yqjG of B.subtilis functionally complement yidC depletion, whereas Streptococcus mutans yidC1 and yidC2 only partially complement depletion.4 Publications

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi24 – 274EQDK → IEGR: Cold-sensitive at 30 degrees Celsius; when associated with 334-W--G-338. Protein accumulates stably.
    Mutagenesisi334 – 3385WFISQ → LEVLFQG: Cold-sensitive at 30 degrees Celsius; when associated with 24-I--R-27. Protein accumulates stably.
    Mutagenesisi361 – 3611I → S: Loss of function. 1 Publication
    Mutagenesisi436 – 4361L → S: Loss of function. 1 Publication
    Mutagenesisi483 – 4875PTTVT → LVPRGS: Temperature-sensitive at 42 degrees Celsius; when associated with 512-ENLYFQG. Protein is not stable.
    Mutagenesisi512 – 5121G → ENLYFQG: Temperature-sensitive at 42 degrees Celsius; when associated with 483-L--S-487. Protein is not stable. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 548548Membrane protein insertase YidCPRO_0000124712Add
    BLAST

    Proteomic databases

    PaxDbiP25714.
    PRIDEiP25714.

    Expressioni

    Inductioni

    At mid-exponential phase in strain MC4100 there are about 2500 copies per cell (at protein level).

    Gene expression databases

    GenevestigatoriP25714.

    Interactioni

    Subunit structurei

    Interacts with SecD and SecF. Component of the SecDFyajC complex, a heterotetrameric translocase complex. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration. Found in 3 different complexes in inner membrane preparations (PubMed:16079137). Can be cross-linked to FtsH, in the larger FtsH/HflKC complex.5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    VIIIP036235EBI-6400779,EBI-8482910From a different organism.

    Protein-protein interaction databases

    DIPiDIP-12442N.
    IntActiP25714. 31 interactions.
    MINTiMINT-6477960.
    STRINGi511145.b3705.

    Structurei

    Secondary structure

    1
    548
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi60 – 645
    Beta strandi69 – 735
    Beta strandi78 – 9013
    Beta strandi95 – 1039
    Beta strandi106 – 11611
    Helixi123 – 1253
    Beta strandi136 – 1394
    Beta strandi145 – 15410
    Beta strandi160 – 1689
    Beta strandi173 – 1819
    Beta strandi184 – 1863
    Beta strandi188 – 20114
    Beta strandi220 – 2245
    Turni226 – 2283
    Beta strandi231 – 2333
    Helixi235 – 2395
    Beta strandi245 – 2506
    Beta strandi252 – 2576
    Beta strandi260 – 28021
    Beta strandi283 – 2897
    Beta strandi293 – 2953
    Beta strandi300 – 31112
    Helixi314 – 3207
    Helixi324 – 3274

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3BLCX-ray2.50A/B26-340[»]
    3BS6X-ray1.80A/B56-329[»]
    ProteinModelPortaliP25714.
    SMRiP25714. Positions 59-329.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP25714.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 55CytoplasmicCurated
    Topological domaini24 – 342319PeriplasmicAdd
    BLAST
    Topological domaini371 – 41646CytoplasmicAdd
    BLAST
    Topological domaini447 – 46317PeriplasmicAdd
    BLAST
    Topological domaini482 – 49312CytoplasmicAdd
    BLAST
    Topological domaini510 – 5123Periplasmic
    Topological domaini536 – 54813CytoplasmicAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei6 – 2318HelicalCuratedAdd
    BLAST
    Transmembranei343 – 37028HelicalCuratedAdd
    BLAST
    Transmembranei417 – 44630HelicalCuratedAdd
    BLAST
    Transmembranei464 – 48118HelicalCuratedAdd
    BLAST
    Transmembranei494 – 50916HelicalCuratedAdd
    BLAST
    Transmembranei513 – 53523HelicalCuratedAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni24 – 264241Can be removed without causing lethality, dispensible for M13 procoat processingAdd
    BLAST
    Regioni215 – 26551Interacts with SecF; not required for insertion of a number of Sec-dependent or Sec-independent substratesAdd
    BLAST
    Regioni265 – 34682Required for Sec-dependent and Sec-independent protein insertionAdd
    BLAST
    Regioni527 – 54822Can be removed without causing lethality, dispensible for M13 procoat processingAdd
    BLAST

    Domaini

    Most of the large periplasmic domain (residues 24-264) is not required for either Sec-dependent or Sec-independent protein insertion. However, residues 265-346, the C-terminal part of the large periplasmic domain, are required for both Sec-dependent and Sec-independent protein insertion.

    Sequence similaritiesi

    Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0706.
    HOGENOMiHOG000101822.
    KOiK03217.
    OMAiELTINTR.
    OrthoDBiEOG6X6RF2.
    PhylomeDBiP25714.

    Family and domain databases

    HAMAPiMF_01810. YidC_type1.
    InterProiIPR019998. Membr_insert_YidC.
    IPR028055. Membr_insert_YidC/Oxa1_C.
    IPR028053. Membr_insert_YidC_N.
    IPR001708. Membrane_insert_OXA1/ALB3/YidC.
    [Graphical view]
    PANTHERiPTHR12428. PTHR12428. 1 hit.
    PfamiPF02096. 60KD_IMP. 1 hit.
    PF14849. YidC_periplas. 1 hit.
    [Graphical view]
    PRINTSiPR00701. 60KDINNERMP.
    PR01900. YIDCPROTEIN.
    TIGRFAMsiTIGR03593. yidC_nterm. 1 hit.
    TIGR03592. yidC_oxa1_cterm. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P25714-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSQRNLLVI ALLFVSFMIW QAWEQDKNPQ PQAQQTTQTT TTAAGSAADQ    50
    GVPASGQGKL ISVKTDVLDL TINTRGGDVE QALLPAYPKE LNSTQPFQLL 100
    ETSPQFIYQA QSGLTGRDGP DNPANGPRPL YNVEKDAYVL AEGQNELQVP 150
    MTYTDAAGNT FTKTFVLKRG DYAVNVNYNV QNAGEKPLEI SSFGQLKQSI 200
    TLPPHLDTGS SNFALHTFRG AAYSTPDEKY EKYKFDTIAD NENLNISSKG 250
    GWVAMLQQYF ATAWIPHNDG TNNFYTANLG NGIAAIGYKS QPVLVQPGQT 300
    GAMNSTLWVG PEIQDKMAAV APHLDLTVDY GWLWFISQPL FKLLKWIHSF 350
    VGNWGFSIII ITFIVRGIMY PLTKAQYTSM AKMRMLQPKI QAMRERLGDD 400
    KQRISQEMMA LYKAEKVNPL GGCFPLLIQM PIFLALYYML MGSVELRQAP 450
    FALWIHDLSA QDPYYILPIL MGVTMFFIQK MSPTTVTDPM QQKIMTFMPV 500
    IFTVFFLWFP SGLVLYYIVS NLVTIIQQQL IYRGLEKRGL HSREKKKS 548
    Length:548
    Mass (Da):61,526
    Last modified:July 1, 1993 - v2
    Checksum:i95EBC5DAB4F2FCFB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L10328 Genomic DNA. Translation: AAA62056.1.
    U00096 Genomic DNA. Translation: AAC76728.1.
    AP009048 Genomic DNA. Translation: BAE77588.1.
    M11056 Genomic DNA. No translation available.
    PIRiB65173.
    RefSeqiNP_418161.1. NC_000913.3.
    YP_491729.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC76728; AAC76728; b3705.
    BAE77588; BAE77588; BAE77588.
    GeneIDi12932517.
    948214.
    KEGGiecj:Y75_p3467.
    eco:b3705.
    PATRICi32122907. VBIEscCol129921_3829.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L10328 Genomic DNA. Translation: AAA62056.1 .
    U00096 Genomic DNA. Translation: AAC76728.1 .
    AP009048 Genomic DNA. Translation: BAE77588.1 .
    M11056 Genomic DNA. No translation available.
    PIRi B65173.
    RefSeqi NP_418161.1. NC_000913.3.
    YP_491729.1. NC_007779.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3BLC X-ray 2.50 A/B 26-340 [» ]
    3BS6 X-ray 1.80 A/B 56-329 [» ]
    ProteinModelPortali P25714.
    SMRi P25714. Positions 59-329.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-12442N.
    IntActi P25714. 31 interactions.
    MINTi MINT-6477960.
    STRINGi 511145.b3705.

    Protein family/group databases

    TCDBi 2.A.9.3.1. the cytochrome oxidase biogenesis (oxa1) family.

    Proteomic databases

    PaxDbi P25714.
    PRIDEi P25714.

    Protocols and materials databases

    DNASUi 948214.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC76728 ; AAC76728 ; b3705 .
    BAE77588 ; BAE77588 ; BAE77588 .
    GeneIDi 12932517.
    948214.
    KEGGi ecj:Y75_p3467.
    eco:b3705.
    PATRICi 32122907. VBIEscCol129921_3829.

    Organism-specific databases

    EchoBASEi EB1183.
    EcoGenei EG11197. yidC.

    Phylogenomic databases

    eggNOGi COG0706.
    HOGENOMi HOG000101822.
    KOi K03217.
    OMAi ELTINTR.
    OrthoDBi EOG6X6RF2.
    PhylomeDBi P25714.

    Enzyme and pathway databases

    BioCyci EcoCyc:YIDC.
    ECOL316407:JW3683-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P25714.
    PROi P25714.

    Gene expression databases

    Genevestigatori P25714.

    Family and domain databases

    HAMAPi MF_01810. YidC_type1.
    InterProi IPR019998. Membr_insert_YidC.
    IPR028055. Membr_insert_YidC/Oxa1_C.
    IPR028053. Membr_insert_YidC_N.
    IPR001708. Membrane_insert_OXA1/ALB3/YidC.
    [Graphical view ]
    PANTHERi PTHR12428. PTHR12428. 1 hit.
    Pfami PF02096. 60KD_IMP. 1 hit.
    PF14849. YidC_periplas. 1 hit.
    [Graphical view ]
    PRINTSi PR00701. 60KDINNERMP.
    PR01900. YIDCPROTEIN.
    TIGRFAMsi TIGR03593. yidC_nterm. 1 hit.
    TIGR03592. yidC_oxa1_cterm. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication."
      Burland V.D., Plunkett G. III, Daniels D.L., Blattner F.R.
      Genomics 16:551-561(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    4. "Physical mapping and nucleotide sequence of the rnpA gene that encodes the protein component of ribonuclease P in Escherichia coli."
      Hansen F.G., Hansen E.B., Atlung T.
      Gene 38:85-93(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-3.
      Strain: K12.
    5. "Membrane topology of the 60-kDa Oxa1p homologue from Escherichia coli."
      Saaf A., Monne M., de Gier J.W., von Heijne G.
      J. Biol. Chem. 273:30415-30418(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY.
      Strain: K12/ MC1061 / TOP10F'.
    6. "YidC, the Escherichia coli homologue of mitochondrial Oxa1p, is a component of the Sec translocase."
      Scotti P.A., Urbanus M.L., Brunner J., de Gier J.-W., von Heijne G., van der Does C., Driessen A.J.M., Oudega B., Luirink J.
      EMBO J. 19:542-549(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN SEC-DEPENDENT PATHWAY, INTERACTION WITH TRANSMEMBRANE SEGMENTS.
    7. Cited for: FUNCTION IN SEC-INDEPENDENT PATHWAY, SUBSTRATES, DISRUPTION PHENOTYPE.
    8. "Sec-dependent membrane protein insertion: sequential interaction of nascent FtsQ with SecY and YidC."
      Urbanus M.L., Scotti P.A., Froderberg L., Saaf A., de Gier J.W., Brunner J., Samuelson J.C., Dalbey R.E., Oudega B., Luirink J.
      EMBO Rep. 2:524-529(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FTSQ AFTER SECY, DISRUPTION PHENOTYPE.
    9. Cited for: SRP- AND SEC-DEPENDENT INSERTION INTO MEMBRANES, SUBCELLULAR LOCATION, TOPOLOGY.
      Strain: K12 / MC4100 / ATCC 35695 / DSM 6574.
    10. "SecDFyajC forms a heterotetrameric complex with YidC."
      Nouwen N., Driessen A.J.M.
      Mol. Microbiol. 44:1397-1405(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SECD AND SECF.
    11. Cited for: FUNCTION.
    12. "Conditional lethal mutations separate the M13 procoat and Pf3 coat functions of YidC: different YidC structural requirements for membrane protein insertion."
      Chen M., Xie K., Nouwen N., Driessen A.J., Dalbey R.E.
      J. Biol. Chem. 278:23295-23300(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF 23-TRP--LYS-27; 334-TRP--GLN-338; 483-PRO--THR-487 AND GLY-512.
    13. "Defining the regions of Escherichia coli YidC that contribute to activity."
      Jiang F., Chen M., Yi L., de Gier J.-W.L., Kuhn A., Dalbey R.E.
      J. Biol. Chem. 278:48965-48972(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF ILE-361 AND LEU-436.
    14. "YidC is strictly required for membrane insertion of subunits a and c of the F(1)F(0)ATP synthase and SecE of the SecYEG translocase."
      Yi L., Jiang F., Chen M., Cain B., Bolhuis A., Dalbey R.E.
      Biochemistry 42:10537-10544(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, ATP SYNTHASE SUBUNIT AND SECE AS SUBSTRATES.
    15. "Targeting and translocation of two lipoproteins in Escherichia coli via the SRP/Sec/YidC pathway."
      Froderberg L., Houben E.N., Baars L., Luirink J., de Gier J.W.
      J. Biol. Chem. 279:31026-31032(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN TARGETING AND/OR TRANSLOCATION OF LIPOPROTEINS.
    16. "Role of YidC in folding of polytopic membrane proteins."
      Nagamori S., Smirnova I.N., Kaback H.R.
      J. Cell Biol. 165:53-62(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN FOLDING BUT NOT INSERTION OF LACY, DISRUPTION PHENOTYPE.
    17. Cited for: SUBUNIT, SUBCELLULAR LOCATION.
      Strain: BL21-DE3.
    18. "Different regions of the nonconserved large periplasmic domain of Escherichia coli YidC are involved in the SecF interaction and membrane insertase activity."
      Xie K., Kiefer D., Nagler G., Dalbey R.E., Kuhn A.
      Biochemistry 45:13401-13408(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION OF PERIPLASMIC DOMAIN.
    19. "Detection of cross-links between FtsH, YidC, HflK/C suggests a linked role for these proteins in quality control upon insertion of bacterial inner membrane proteins."
      van Bloois E., Dekker H.L., Froderberg L., Houben E.N., Urbanus M.L., de Koster C.G., de Gier J.W., Luirink J.
      FEBS Lett. 582:1419-1424(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FTSH.
    20. "Functional overlap but lack of complete cross-complementation of Streptococcus mutans and Escherichia coli YidC orthologs."
      Dong Y., Palmer S.R., Hasona A., Nagamori S., Kaback H.R., Dalbey R.E., Brady L.J.
      J. Bacteriol. 190:2458-2469(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: COMPLEMENTATION BY AND IN STREPTOCOCCUS MUTANS.
    21. "Biogenesis of MalF and the MalFGK(2) maltose transport complex in Escherichia coli requires YidC."
      Wagner S., Pop O.I., Haan G.J., Baars L., Koningstein G., Klepsch M.M., Genevaux P., Luirink J., de Gier J.W.
      J. Biol. Chem. 283:17881-17890(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN FOLDING BUT NOT INSERTION OF MALF OR OF MALFGK(2) COMPLEX.
    22. "Bacillus subtilis SpoIIIJ and YqjG function in membrane protein biogenesis."
      Saller M.J., Fusetti F., Driessen A.J.
      J. Bacteriol. 191:6749-6757(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: COMPLEMENTATION BY SPOIIIJ AND YQJG OF B.SUBTILIS.
    23. "Membrane localization of small proteins in Escherichia coli."
      Fontaine F., Fuchs R.T., Storz G.
      J. Biol. Chem. 286:32464-32474(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
      Strain: K12 / MG1655 / ATCC 47076.
    24. "Crystal structure of the major periplasmic domain of the bacterial membrane protein assembly facilitator YidC."
      Oliver D.C., Paetzel M.
      J. Biol. Chem. 283:5208-5216(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 26-340.
      Strain: K12.
    25. "The crystal structure of the periplasmic domain of the Escherichia coli membrane protein insertase YidC contains a substrate binding cleft."
      Ravaud S., Stjepanovic G., Wild K., Sinning I.
      J. Biol. Chem. 283:9350-9358(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 56-329.
    26. "Assembly of bacterial inner membrane proteins."
      Dalbey R.E., Wang P., Kuhn A.
      Annu. Rev. Biochem. 80:161-187(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiYIDC_ECOLI
    AccessioniPrimary (citable) accession number: P25714
    Secondary accession number(s): Q2M818
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3