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Reviewed, UniProtKB/Swiss-Prot P25713 (MT3_HUMAN)

Last modified December 15, 2009. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Metallothionein-3
      Short name=MT-3
Alternative name(s):
    Metallothionein-III
      Short name=MT-III
    Growth inhibitory factor
    GIFB
      Short name=GIF
Gene names
Name: MT3
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length68 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro.

Tissue specificity

Abundant in a subset of astrocytes in the normal human brain, but greatly reduced in the Alzheimer disease (AD) brain.

Sequence similarities

Belongs to the metallothionein superfamily. Type 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6868Metallothionein-3
PRO_0000197250

Regions

Region1 – 3030Beta
Region31 – 6838Alpha

Sites

Metal binding61Cluster B By similarity
Metal binding81Cluster B By similarity
Metal binding141Cluster B By similarity
Metal binding161Cluster B By similarity
Metal binding201Cluster B By similarity
Metal binding221Cluster B By similarity
Metal binding251Cluster B By similarity
Metal binding271Cluster B By similarity
Metal binding301Cluster B By similarity
Metal binding341Cluster A By similarity
Metal binding351Cluster A By similarity
Metal binding371Cluster A By similarity
Metal binding381Cluster A By similarity
Metal binding421Cluster A By similarity
Metal binding451Cluster A By similarity
Metal binding491Cluster A By similarity
Metal binding511Cluster A By similarity
Metal binding641Cluster A By similarity
Metal binding661Cluster A By similarity
Metal binding671Cluster A By similarity

Amino acid modifications

Modified residue11N-acetylmethionine

Secondary structure

..... 68
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P25713-1 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: 59801ECF5BC8A406

FASTA686,927
        10         20         30         40         50         60 
MDPETCPCPS GGSCTCADSC KCEGCKCTSC KKSCCSCCPA ECEKCAKDCV CKGGEAAEAE 


AEKCSCCQ 

« Hide

References

« Hide 'large scale' references
[1]"The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein."
Uchida Y., Takio K., Titani K., Ihara Y., Tomonaga M.
Neuron 7:337-347(1991) [PubMed: 1873033] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Brain.
[2]"MT-III, a brain-specific member of the metallothionein gene family."
Palmiter R.D., Findley S.D., Whitmore T.E., Durnam D.M.
Proc. Natl. Acad. Sci. U.S.A. 89:6333-6337(1992) [PubMed: 1631128] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Brain.
[3]"Molecular cloning of human growth inhibitory factor cDNA and its down-regulation in Alzheimer's disease."
Tsuji S., Kobayashi H., Uchida Y., Ihara Y., Miyatake T.
EMBO J. 11:4843-4850(1992) [PubMed: 1464312] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Structures of the human and mouse growth inhibitory factor-encoding genes."
Naruse S., Igarashi S., Furuya T., Kobayashi H., Miyatake T., Tsuji S.
Gene 144:283-287(1994) [PubMed: 8039715] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"Modulation of metallothionein-III mRNA content and growth rate of rat C6-glial cells by transfection with human 5-HT1D receptor genes."
Amoureux M.C., Wurch T., Pauwels P.J.
Biochem. Biophys. Res. Commun. 214:639-645(1995) [PubMed: 7677777] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[6]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]NIEHS SNPs program
Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

M93311 Genomic DNA. Translation: AAA36214.1.
D13365 mRNA. No translation available.
S72043 Genomic DNA. Translation: AAB31396.1.
X89604 mRNA. Translation: CAA61763.1.
BT007030 mRNA. Translation: AAP35677.1.
DQ297144 Genomic DNA. Translation: ABB84467.1.
BC013081 mRNA. Translation: AAH13081.1.
IPIIPI00016666.
PIRB46034.
RefSeqNP_005945.1.
UniGeneHs.73133

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
2F5HNMR-A32-68[»]
2FJ4NMR-A32-68[»]
2FJ5NMR-A32-68[»]
ModBaseSearch...

Protein-protein interaction databases

STRINGP25713.

Proteomic databases

PRIDEP25713.

Genome annotation databases

EnsemblENST00000200691; ENSP00000200691; ENSG00000087250; Homo sapiens. [Genome view]
GeneID4504.
KEGGhsa:4504.
UCSCuc002ejf.1. human.

Organism-specific databases

CTD4504.
GeneCardsGC16P055180.
H-InvDBHIX0013054.
HGNCHGNC:7408. MT3.
HPACAB017779.
HPA004011.
MIM139255. gene.
PharmGKBPA31216.
GenAtlasSearch...

Phylogenomic databases

HOVERGENP25713.
InParanoidP25713.
OMAETCPCPT.
OrthoDBEOG9TXFCK.

Gene expression databases

ArrayExpressP25713.
BgeeP25713.
CleanExHS_MT3.
GenevestigatorP25713.
GermOnlineENSG00000087250. Homo sapiens.

Family and domain databases

InterProIPR017854. Metallothionein_sfam.
IPR003019. Metallothionein_sfam_euk.
IPR000006. Metallothionein_vert.
IPR018064. Metallothionein_vert_metal_BS.
[Graphical view]
Gene3DG3DSA:4.10.10.10. Metallothionein_vert. 1 hit.
PANTHERPTHR23299. Metallothionein_vert. 1 hit.
PfamPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSPR00860. MTVERTEBRATE.
PROSITEPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio17412.
SOURCESearch...

Entry information

Entry nameMT3_HUMAN
AccessionPrimary (citable) accession number: P25713
Secondary accession number(s): Q2V574
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: December 15, 2009
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM

Metallothioneins

Classification of metallothioneins and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents