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Protein

NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

Gene

NDUFV3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6799198. Complex I biogenesis.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
Alternative name(s):
Complex I-9kD
Short name:
CI-9kD
NADH-ubiquinone oxidoreductase 9 kDa subunit
Gene namesi
Name:NDUFV3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

  • mitochondrial respiratory chain complex I Source: UniProtKB

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 34Mitochondrion1 PublicationAdd BLAST34
ChainiPRO_000002002435 – 109NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrialAdd BLAST75

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei106PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP25712.
PRIDEiP25712.

Expressioni

Gene expression databases

BgeeiENSBTAG00000021491.
ExpressionAtlasiP25712. baseline.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.1 Publication

Protein-protein interaction databases

DIPiDIP-38824N.
IntActiP25712. 2 interactors.
STRINGi9913.ENSBTAP00000041265.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LNKelectron microscopy3.90a35-109[»]
SMRiP25712.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFV3 subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IXG2. Eukaryota.
ENOG410YVZC. LUCA.
GeneTreeiENSGT00390000012196.
HOGENOMiHOG000013001.
HOVERGENiHBG082013.
InParanoidiP25712.
KOiK03944.

Family and domain databases

InterProiView protein in InterPro
IPR026193. NDUFV3.
PANTHERiPTHR17117. PTHR17117. 1 hit.
PfamiView protein in Pfam
PF15880. NDUFV3. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25712-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASLLLRQG RAGALKTVLL EAGVFRGVAP AVSLSAESGK NEKGLPPNPK
60 70 80 90 100
KQSPPKKPVS AAPTEPFDNT TYKNLQHHDY STYTFLDLNL DLSKFRMPQP

SSGRESPRH
Length:109
Mass (Da):11,857
Last modified:May 1, 1992 - v1
Checksum:iA49719C74AC1AC70
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48N → D in AAI03275 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59048 mRNA. Translation: CAA41775.1.
BC103274 mRNA. Translation: AAI03275.1.
PIRiS15107.
RefSeqiNP_787024.1. NM_175830.1.
UniGeneiBt.43863.

Genome annotation databases

EnsembliENSBTAT00000028645; ENSBTAP00000028645; ENSBTAG00000021491.
GeneIDi327717.
KEGGibta:327717.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59048 mRNA. Translation: CAA41775.1.
BC103274 mRNA. Translation: AAI03275.1.
PIRiS15107.
RefSeqiNP_787024.1. NM_175830.1.
UniGeneiBt.43863.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LNKelectron microscopy3.90a35-109[»]
SMRiP25712.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-38824N.
IntActiP25712. 2 interactors.
STRINGi9913.ENSBTAP00000041265.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Proteomic databases

PaxDbiP25712.
PRIDEiP25712.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000028645; ENSBTAP00000028645; ENSBTAG00000021491.
GeneIDi327717.
KEGGibta:327717.

Organism-specific databases

CTDi4731.

Phylogenomic databases

eggNOGiENOG410IXG2. Eukaryota.
ENOG410YVZC. LUCA.
GeneTreeiENSGT00390000012196.
HOGENOMiHOG000013001.
HOVERGENiHBG082013.
InParanoidiP25712.
KOiK03944.

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6799198. Complex I biogenesis.

Gene expression databases

BgeeiENSBTAG00000021491.
ExpressionAtlasiP25712. baseline.

Family and domain databases

InterProiView protein in InterPro
IPR026193. NDUFV3.
PANTHERiPTHR17117. PTHR17117. 1 hit.
PfamiView protein in Pfam
PF15880. NDUFV3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNDUV3_BOVIN
AccessioniPrimary (citable) accession number: P25712
Secondary accession number(s): Q3SZ08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: March 15, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.