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Protein

NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

Gene

NDUFV3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.By similarity

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6799198. Complex I biogenesis.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
Alternative name(s):
Complex I-9kD
Short name:
CI-9kD
NADH-ubiquinone oxidoreductase 9 kDa subunit
Gene namesi
Name:NDUFV3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 34Mitochondrion1 PublicationAdd BLAST34
ChainiPRO_000002002435 – 109NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrialAdd BLAST75

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei106PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP25712.
PRIDEiP25712.

Expressioni

Gene expression databases

BgeeiENSBTAG00000021491.
ExpressionAtlasiP25712. baseline.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.1 Publication

Protein-protein interaction databases

CORUMiP25712.
DIPiDIP-38824N.
IntActiP25712. 2 interactors.
STRINGi9913.ENSBTAP00000041265.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LNKelectron microscopy3.90a35-109[»]
SMRiP25712.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFV3 subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IXG2. Eukaryota.
ENOG410YVZC. LUCA.
GeneTreeiENSGT00390000012196.
HOGENOMiHOG000013001.
HOVERGENiHBG082013.
InParanoidiP25712.
KOiK03944.

Family and domain databases

InterProiView protein in InterPro
IPR026193. NDUFV3.
PANTHERiPTHR17117. PTHR17117. 1 hit.
PfamiView protein in Pfam
PF15880. NDUFV3. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25712-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASLLLRQG RAGALKTVLL EAGVFRGVAP AVSLSAESGK NEKGLPPNPK
60 70 80 90 100
KQSPPKKPVS AAPTEPFDNT TYKNLQHHDY STYTFLDLNL DLSKFRMPQP

SSGRESPRH
Length:109
Mass (Da):11,857
Last modified:May 1, 1992 - v1
Checksum:iA49719C74AC1AC70
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48N → D in AAI03275 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59048 mRNA. Translation: CAA41775.1.
BC103274 mRNA. Translation: AAI03275.1.
PIRiS15107.
RefSeqiNP_787024.1. NM_175830.1.
UniGeneiBt.43863.

Genome annotation databases

EnsembliENSBTAT00000028645; ENSBTAP00000028645; ENSBTAG00000021491.
GeneIDi327717.
KEGGibta:327717.

Entry informationi

Entry nameiNDUV3_BOVIN
AccessioniPrimary (citable) accession number: P25712
Secondary accession number(s): Q3SZ08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: September 27, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families