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P25710 (NUJM_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
NADH-ubiquinone oxidoreductase 21.3 kDa subunit

EC=1.6.5.3
EC=1.6.99.3
Gene names
ORF Names:B13D24.010, NCU02280
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length200 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Function

Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

NADH + acceptor = NAD+ + reduced acceptor.

Subunit structure

Complex I is composed of about 40 different subunits.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein Potential.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 200200NADH-ubiquinone oxidoreductase 21.3 kDa subunit
PRO_0000118738

Regions

Transmembrane16 – 3621Helical; Potential
Transmembrane48 – 6821Helical; Potential
Transmembrane105 – 12521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P25710 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: B74C1F11CDFAA3DF

FASTA20021,349
        10         20         30         40         50         60 
MAPQGDDTVF QPKDAIKSGV SGALFSGGAG LLMASLRTSM KKNNVGSMHV FTHGGGTIIS 

        70         80         90        100        110        120 
FTLAGGIYRF AQQASANLRE KEDGWNHAIG AFLGGSVMGL RSLRFPVILG FGAMAGSVVG 

       130        140        150        160        170        180 
AFAFSGGLTG WGRDPNVDEF ERKEAMRLNR RRPVEETLAE VGEGRGIYPP GYQERRRQRL 

       190        200 
LEKYGVEVKP VSADPNVASA 

« Hide

References

« Hide 'large scale' references
[1]"cDNA and genomic DNA sequence of the 21.3 kDa subunit of NADH:ubiquinone reductase (complex I) from Neurospora crassa."
Nehls U., Hemmer S., Roehlen D.-A., van der Pas J.C., Preis D., Sackmann U., Weiss H.
Biochim. Biophys. Acta 1088:325-326(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 74-ORS-6a / FGSC 4200.
[2]"What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[3]"The genome sequence of the filamentous fungus Neurospora crassa."
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. expand/collapse author list , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X56612 Genomic DNA. Translation: CAA39949.1.
BX908789 Genomic DNA. Translation: CAF05866.1.
CM002242 Genomic DNA. Translation: EAA30688.1.
PIRS14277.
RefSeqXP_959924.1. XM_954831.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5141.NCU02280.1.

Protein family/group databases

TCDB3.D.1.6.2. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000003209; EFNCRP00000003209; EFNCRG00000003206.
GeneID3876046.
KEGGncr:NCU02280.

Phylogenomic databases

eggNOGeuNOG09048.
HOGENOMHOG000216595.
OMAPPGYEER.
OrthoDBEOG7BZW52.

Family and domain databases

InterProIPR005678. Tim17.
IPR003397. Tim17/Tim22/Tim23/PMP24.
[Graphical view]
PANTHERPTHR10485:SF0. PTHR10485:SF0. 1 hit.
PfamPF02466. Tim17. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNUJM_NEUCR
AccessionPrimary (citable) accession number: P25710
Secondary accession number(s): Q7S588
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: April 16, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program