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P25710

- NUJM_NEUCR

UniProt

P25710 - NUJM_NEUCR

Protein

NADH-ubiquinone oxidoreductase 21.3 kDa subunit

Gene

B13D24.010

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5- Protein predictedi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
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    Functioni

    Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
    NADH + acceptor = NAD+ + reduced acceptor.

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD, Ubiquinone

    Protein family/group databases

    TCDBi3.D.1.6.2. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-ubiquinone oxidoreductase 21.3 kDa subunit (EC:1.6.5.3, EC:1.6.99.3)
    Gene namesi
    ORF Names:B13D24.010, NCU02280
    OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
    Taxonomic identifieri367110 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
    ProteomesiUP000001805: Chromosome 7, Linkage Group VII

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 200200NADH-ubiquinone oxidoreductase 21.3 kDa subunitPRO_0000118738Add
    BLAST

    Interactioni

    Subunit structurei

    Complex I is composed of about 40 different subunits.

    Protein-protein interaction databases

    STRINGi5141.NCU02280.1.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei16 – 3621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei48 – 6821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei105 – 12521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGieuNOG09048.
    HOGENOMiHOG000216595.
    OMAiYHPKDAI.
    OrthoDBiEOG7BZW52.

    Family and domain databases

    InterProiIPR003397. Tim17/Tim22/Tim23/PMP24.
    [Graphical view]
    PfamiPF02466. Tim17. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P25710-1 [UniParc]FASTAAdd to Basket

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    MAPQGDDTVF QPKDAIKSGV SGALFSGGAG LLMASLRTSM KKNNVGSMHV    50
    FTHGGGTIIS FTLAGGIYRF AQQASANLRE KEDGWNHAIG AFLGGSVMGL 100
    RSLRFPVILG FGAMAGSVVG AFAFSGGLTG WGRDPNVDEF ERKEAMRLNR 150
    RRPVEETLAE VGEGRGIYPP GYQERRRQRL LEKYGVEVKP VSADPNVASA 200
    Length:200
    Mass (Da):21,349
    Last modified:May 1, 1992 - v1
    Checksum:iB74C1F11CDFAA3DF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56612 Genomic DNA. Translation: CAA39949.1.
    BX908789 Genomic DNA. Translation: CAF05866.1.
    CM002242 Genomic DNA. Translation: EAA30688.1.
    PIRiS14277.
    RefSeqiXP_959924.1. XM_954831.1.

    Genome annotation databases

    EnsemblFungiiEFNCRT00000003209; EFNCRP00000003209; EFNCRG00000003206.
    GeneIDi3876046.
    KEGGincr:NCU02280.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56612 Genomic DNA. Translation: CAA39949.1 .
    BX908789 Genomic DNA. Translation: CAF05866.1 .
    CM002242 Genomic DNA. Translation: EAA30688.1 .
    PIRi S14277.
    RefSeqi XP_959924.1. XM_954831.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5141.NCU02280.1.

    Protein family/group databases

    TCDBi 3.D.1.6.2. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EFNCRT00000003209 ; EFNCRP00000003209 ; EFNCRG00000003206 .
    GeneIDi 3876046.
    KEGGi ncr:NCU02280.

    Phylogenomic databases

    eggNOGi euNOG09048.
    HOGENOMi HOG000216595.
    OMAi YHPKDAI.
    OrthoDBi EOG7BZW52.

    Family and domain databases

    InterProi IPR003397. Tim17/Tim22/Tim23/PMP24.
    [Graphical view ]
    Pfami PF02466. Tim17. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA and genomic DNA sequence of the 21.3 kDa subunit of NADH:ubiquinone reductase (complex I) from Neurospora crassa."
      Nehls U., Hemmer S., Roehlen D.-A., van der Pas J.C., Preis D., Sackmann U., Weiss H.
      Biochim. Biophys. Acta 1088:325-326(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 74-ORS-6a / FGSC 4200.
    2. "What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
      Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
      Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
    3. "The genome sequence of the filamentous fungus Neurospora crassa."
      Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
      , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
      Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

    Entry informationi

    Entry nameiNUJM_NEUCR
    AccessioniPrimary (citable) accession number: P25710
    Secondary accession number(s): Q7S588
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3