Reviewed, UniProtKB/Swiss-Prot P25706 (NU1C_MAIZE)

Names and origin

Protein names

Recommended name:
    NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic
    EC=1.6.5.-
Alternative name(s):
    NAD(P)H dehydrogenase subunit 1
      Short name=NDH subunit 1
    NADH-plastoquinone oxidoreductase subunit 1

Gene names

Name:	ndhA
Synonyms:	ndh1

Encoded on

Plastid; Chloroplast

Organism

Zea mays (Maize)

Taxonomic identifier

4577 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › PACCAD clade › Panicoideae › Andropogoneae › Zea

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient By similarity.
Catalytic activity	NAD(P)H + plastoquinone = NAD(P)+ + plastoquinol. HAMAP MF_01350
Subunit structure	NDH is composed of at least 16 different subunits, 5 of which are encoded in the nucleus By similarity.
Subcellular location	Plastid › chloroplast thylakoid membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the complex I subunit 1 family.
RNA editing	Edited at positions 17, 158, 188 and 357. Ref.1 Ref.4

Ontologies

Keywords
Cellular component	Chloroplast Membrane Plastid Thylakoid
Coding sequence diversity	RNA editing
Domain	Transmembrane
Ligand	NAD NADP Plastoquinone
Molecular function	Oxidoreductase
PTM	Quinone
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: HAMAP
Cellular component	chloroplast thylakoid membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic HAMAP MF_01350		PRO_0000117509
Regions
	Transmembrane	26 – 48	23	Potential
	Transmembrane	97 – 119	23	Potential
	Transmembrane	126 – 148	23	Potential
	Transmembrane	163 – 185	23	Potential
	Transmembrane	254 – 276	23	Potential
	Transmembrane	296 – 318	23	Potential
	Transmembrane	338 – 360	23	Potential

Sequences

	Sequence		Length	Mass (Da)
	P25706-1 [UniParc]. Last modified June 27, 2006. Version 3. Checksum: BB38174AA9DBA176	FASTA	362	40,511
	10 20 30 40 50 60 MIIDRVEVET INSFSKLELF KEIYGLIWIL PIFALLLGIT IEVLVIVWLE REISASIQQR 70 80 90 100 110 120 IGPEYAGPLG LLQAIADGTK LLLKEDILPS RGDIPLFSIG PSIAVISILL SFLVIPLGYR 130 140 150 160 170 180 FVLADLSIGV FLWIAISSIA PIGLLMAGYS SNNKYSFLGG LRAAAQSISY EIPLTFCVLA 190 200 210 220 230 240 ISLLSNSLST VDIVEAQSKY GFFGWNLWRQ PIGFLVFLIS SLAECERLPF DLPEAEEELV 250 260 270 280 290 300 AGYQTEYSGI KYGLFYLVSY LNLLVSSLFV TVLYLGGWNF SIPYISFFGF FQMNKIIGIL 310 320 330 340 350 360 EMVIGIFITL TKAYLFLFIS ITIRWTLPRM RMDQLLNLGW KFLLPISLGN LLLTTSFQLV SL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Internal editing of the maize chloroplast ndhA transcript restores codons for conserved amino acids." Maier R.M., Hoch B., Zeltz P., Koessel H. Plant Cell 4:609-616(1992) [PubMed: 1498612] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], RNA EDITING OF POSITIONS 17; 158; 188 AND 357.
[2]	"Complete sequence of the maize chloroplast genome: gene content, hotspots of divergence and fine tuning of genetic information by transcript editing." Maier R.M., Neckermann K., Igloi G.L., Koessel H. J. Mol. Biol. 251:614-628(1995) [PubMed: 7666415] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The ndhH genes of gramminean plastomes are linked with the junctions between small single copy and inverted repeat regions." Maier R.M., Doery I., Igloi G., Koessel H. Curr. Genet. 18:245-250(1990) [PubMed: 2249254] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-16.
[4]	"Studies of the Ndh complex and photosystem II from mesophyll and bundle sheath chloroplasts of the C(4)-type plant Zea mays." Darie C.C., De Pascalis L., Mutschler B., Haehnel W. J. Plant Physiol. 163:800-808(2006) [PubMed: 16436305] [Abstract] Cited for: RNA EDITING OF POSITIONS 17; 158 AND 188.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X62370 Genomic DNA. Translation: CAA44228.1. X86563 Genomic DNA. Translation: CAA60353.1. X56521 Genomic DNA. Translation: CAA39869.1.
PIR	JQ1671.
RefSeq	NP_043092.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	845179.
Organism-specific databases
Gramene	P25706.
MaizeGDB	69243.
Family and domain databases
HAMAP	MF_01350. [Tree]
InterPro	IPR001694. NADH_UbQ_OxRdtase_su1. IPR018086. NADH_UbQ_OxRdtase_su1_CS. [Graphical view]
PANTHER	PTHR11432. Resp_NADH_DH_1. 1 hit.
Pfam	PF00146. NADHdh. 1 hit. [Graphical view]
PROSITE	PS00667. COMPLEX1_ND1_1. 1 hit. PS00668. COMPLEX1_ND1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NU1C_MAIZE

Accession

Primary (citable) accession number: P25706

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
Last sequence update:	June 27, 2006
Last modified:	June 16, 2009
This is version 56 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)