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P25703

- BMP2A_XENLA

UniProt

P25703 - BMP2A_XENLA

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Protein
Bone morphogenetic protein 2-A
Gene
bmp2-a
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Induces cartilage and bone formation.

GO - Biological processi

  1. cartilage development Source: UniProtKB-KW
  2. cell differentiation Source: UniProtKB-KW
  3. growth Source: InterPro
  4. ossification Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 2-A
Alternative name(s):
BMP-2-I
Gene namesi
Name:bmp2-a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-481833. bmp2.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Propeptidei24 – 284261 Reviewed prediction
PRO_0000033832Add
BLAST
Chaini285 – 398114Bone morphogenetic protein 2-A
PRO_0000033833Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi137 – 1371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi202 – 2021N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi298 ↔ 363 By similarity
Disulfide bondi327 ↔ 395 By similarity
Disulfide bondi331 ↔ 397 By similarity
Glycosylationi340 – 3401N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi362 – 362Interchain By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

Structurei

3D structure databases

ProteinModelPortaliP25703.
SMRiP25703. Positions 293-398.

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG004860.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25703-1 [UniParc]FASTAAdd to Basket

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MVAGIHSLLL LLFYQVLLSG CTGLIPEEGK RKYTESGRSS PQQSQRVLNQ    50
FELRLLSMFG LKRRPTPGKN VVIPPYMLDL YHLHLAQLAA DEGTSAMDFQ 100
MERAASRANT VRSFHHEESM EEIPESREKT IQRFFFNLSS IPNEELVTSA 150
ELRIFREQVQ EPFESDSSKL HRINIYDIVK PAAAASRGPV VRLLDTRLVH 200
HNESKWESFD VTPAIARWIA HKQPNHGFVV EVNHLDNDKN VPKKHVRISR 250
SLTPDKDNWP QIRPLLVTFS HDGKGHALHK RQKRQARHKQ RKRLKSSCRR 300
HPLYVDFSDV GWNDWIVAPP GYHAFYCHGE CPFPLADHLN STNHAIVQTL 350
VNSVNTNIPK ACCVPTELSA ISMLYLDENE KVVLKNYQDM VVEGCGCR 398
Length:398
Mass (Da):45,575
Last modified:May 1, 1992 - v1
Checksum:i150AC64A47D2E15F
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71S → P in CAA45018. 1 Publication
Sequence conflicti16 – 161V → L in CAA45018. 1 Publication
Sequence conflicti233 – 2331N → T in CAA45018. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55031 mRNA. Translation: CAA38850.1.
X63424 mRNA. Translation: CAA45018.1.
PIRiJH0687.
UniGeneiXl.1138.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55031 mRNA. Translation: CAA38850.1 .
X63424 mRNA. Translation: CAA45018.1 .
PIRi JH0687.
UniGenei Xl.1138.

3D structure databases

ProteinModelPortali P25703.
SMRi P25703. Positions 293-398.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Xenbasei XB-GENE-481833. bmp2.

Phylogenomic databases

HOVERGENi HBG004860.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view ]
PANTHERi PTHR11848. PTHR11848. 1 hit.
Pfami PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view ]
PRINTSi PR00669. INHIBINA.
SMARTi SM00204. TGFB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA sequence of Xenopus laevis bone morphogenetic protein 2 (BMP-2)."
    Plessow S., Koester M., Knoechel W.
    Biochim. Biophys. Acta 1089:280-282(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genes for bone morphogenetic proteins are differentially transcribed in early amphibian embryos."
    Nishimatsu S., Suzuki A., Shoda A., Murakami K., Ueno N.
    Biochem. Biophys. Res. Commun. 186:1487-1495(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiBMP2A_XENLA
AccessioniPrimary (citable) accession number: P25703
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: June 11, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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