Reviewed, UniProtKB/Swiss-Prot P25703 (BMP2A_XENLA)

Names and origin

Protein names

Recommended name:
    Bone morphogenetic protein 2-A
Alternative name(s):
    BMP-2-I

Gene names

Name:

bmp2-A

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	398 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Induces cartilage and bone formation.
Subunit structure	Homodimer; disulfide-linked.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the TGF-beta family.

Ontologies

Keywords
Biological process	Chondrogenesis Differentiation Osteogenesis
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine Developmental protein Growth factor
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	cartilage development Inferred from electronic annotation. Source: UniProtKB-KW cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW growth Inferred from electronic annotation. Source: InterPro ossification Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cytokine activity Inferred from electronic annotation. Source: UniProtKB-KW growth factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Propeptide	24 – 284	261	Potential		PRO_0000033832
	Chain	285 – 398	114	Bone morphogenetic protein 2-A		PRO_0000033833
Amino acid modifications
	Glycosylation	137	1	N-linked (GlcNAc...) Potential
	Glycosylation	202	1	N-linked (GlcNAc...) Potential
	Glycosylation	340	1	N-linked (GlcNAc...) Potential
	Disulfide bond	298 ↔ 363		By similarity
	Disulfide bond	327 ↔ 395		By similarity
	Disulfide bond	331 ↔ 397		By similarity
	Disulfide bond	362		Interchain By similarity
Experimental info
	Sequence conflict	7	1	S → P in CAA45018. Ref.2
	Sequence conflict	16	1	V → L in CAA45018. Ref.2
	Sequence conflict	233	1	N → T in CAA45018. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P25703-1 [UniParc]. Last modified May 1, 1992. Version 1. Checksum: 150AC64A47D2E15F	FASTA	398	45,575
	10 20 30 40 50 60 MVAGIHSLLL LLFYQVLLSG CTGLIPEEGK RKYTESGRSS PQQSQRVLNQ FELRLLSMFG 70 80 90 100 110 120 LKRRPTPGKN VVIPPYMLDL YHLHLAQLAA DEGTSAMDFQ MERAASRANT VRSFHHEESM 130 140 150 160 170 180 EEIPESREKT IQRFFFNLSS IPNEELVTSA ELRIFREQVQ EPFESDSSKL HRINIYDIVK 190 200 210 220 230 240 PAAAASRGPV VRLLDTRLVH HNESKWESFD VTPAIARWIA HKQPNHGFVV EVNHLDNDKN 250 260 270 280 290 300 VPKKHVRISR SLTPDKDNWP QIRPLLVTFS HDGKGHALHK RQKRQARHKQ RKRLKSSCRR 310 320 330 340 350 360 HPLYVDFSDV GWNDWIVAPP GYHAFYCHGE CPFPLADHLN STNHAIVQTL VNSVNTNIPK 370 380 390 ACCVPTELSA ISMLYLDENE KVVLKNYQDM VVEGCGCR

References

[1]	"cDNA sequence of Xenopus laevis bone morphogenetic protein 2 (BMP-2)." Plessow S., Koester M., Knoechel W. Biochim. Biophys. Acta 1089:280-282(1991) [PubMed: 2054389] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Genes for bone morphogenetic proteins are differentially transcribed in early amphibian embryos." Nishimatsu S., Suzuki A., Shoda A., Murakami K., Ueno N. Biochem. Biophys. Res. Commun. 186:1487-1495(1992) [PubMed: 1510675] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	X55031 mRNA. Translation: CAA38850.1. X63424 mRNA. Translation: CAA45018.1.
PIR	JH0687.
UniGene	Xl.1138
3D structure databases
SMR	P25703. Positions 293-398.
ModBase	Search...
Organism-specific databases
Xenbase	XB-FEAT-481828. bmp2.
Phylogenomic databases
HOVERGEN	P25703.
Family and domain databases
InterPro	IPR002405. Inhibin_asu. IPR001839. TGFb. IPR017948. TGFb_CS. IPR001111. TGFb_N. IPR015615. TGFbeta. [Graphical view]
PANTHER	PTHR11848. TGFbeta. 1 hit.
Pfam	PF00019. TGF_beta. 1 hit. PF00688. TGFb_propeptide. 1 hit. [Graphical view]
PRINTS	PR00669. INHIBINA.
SMART	SM00204. TGFB. 1 hit. [Graphical view]
PROSITE	PS00250. TGF_BETA_1. 1 hit. PS51362. TGF_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BMP2A_XENLA

Accession

Primary (citable) accession number: P25703

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
Last sequence update:	May 1, 1992
Last modified:	November 24, 2009
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project