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Protein

Bone morphogenetic protein 2-A

Gene

bmp2-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Induces cartilage and bone formation.

GO - Biological processi

  1. cartilage development Source: UniProtKB-KW
  2. cell differentiation Source: UniProtKB-KW
  3. growth Source: InterPro
  4. ossification Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 2-A
Alternative name(s):
BMP-2-I
Gene namesi
Name:bmp2-a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-481833. bmp2.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Propeptidei24 – 284261Sequence AnalysisPRO_0000033832Add
BLAST
Chaini285 – 398114Bone morphogenetic protein 2-APRO_0000033833Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi298 ↔ 363By similarity
Disulfide bondi327 ↔ 395By similarity
Disulfide bondi331 ↔ 397By similarity
Glycosylationi340 – 3401N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi362 – 362InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

Structurei

3D structure databases

ProteinModelPortaliP25703.
SMRiP25703. Positions 293-398.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG004860.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25703-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAGIHSLLL LLFYQVLLSG CTGLIPEEGK RKYTESGRSS PQQSQRVLNQ
60 70 80 90 100
FELRLLSMFG LKRRPTPGKN VVIPPYMLDL YHLHLAQLAA DEGTSAMDFQ
110 120 130 140 150
MERAASRANT VRSFHHEESM EEIPESREKT IQRFFFNLSS IPNEELVTSA
160 170 180 190 200
ELRIFREQVQ EPFESDSSKL HRINIYDIVK PAAAASRGPV VRLLDTRLVH
210 220 230 240 250
HNESKWESFD VTPAIARWIA HKQPNHGFVV EVNHLDNDKN VPKKHVRISR
260 270 280 290 300
SLTPDKDNWP QIRPLLVTFS HDGKGHALHK RQKRQARHKQ RKRLKSSCRR
310 320 330 340 350
HPLYVDFSDV GWNDWIVAPP GYHAFYCHGE CPFPLADHLN STNHAIVQTL
360 370 380 390
VNSVNTNIPK ACCVPTELSA ISMLYLDENE KVVLKNYQDM VVEGCGCR
Length:398
Mass (Da):45,575
Last modified:April 30, 1992 - v1
Checksum:i150AC64A47D2E15F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71S → P in CAA45018 (PubMed:1510675).Curated
Sequence conflicti16 – 161V → L in CAA45018 (PubMed:1510675).Curated
Sequence conflicti233 – 2331N → T in CAA45018 (PubMed:1510675).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55031 mRNA. Translation: CAA38850.1.
X63424 mRNA. Translation: CAA45018.1.
PIRiJH0687.
UniGeneiXl.1138.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55031 mRNA. Translation: CAA38850.1.
X63424 mRNA. Translation: CAA45018.1.
PIRiJH0687.
UniGeneiXl.1138.

3D structure databases

ProteinModelPortaliP25703.
SMRiP25703. Positions 293-398.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

XenbaseiXB-GENE-481833. bmp2.

Phylogenomic databases

HOVERGENiHBG004860.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "cDNA sequence of Xenopus laevis bone morphogenetic protein 2 (BMP-2)."
    Plessow S., Koester M., Knoechel W.
    Biochim. Biophys. Acta 1089:280-282(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genes for bone morphogenetic proteins are differentially transcribed in early amphibian embryos."
    Nishimatsu S., Suzuki A., Shoda A., Murakami K., Ueno N.
    Biochem. Biophys. Res. Commun. 186:1487-1495(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiBMP2A_XENLA
AccessioniPrimary (citable) accession number: P25703
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 1992
Last sequence update: April 30, 1992
Last modified: September 30, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.