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P25703 (BMP2A_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bone morphogenetic protein 2-A
Alternative name(s):
BMP-2-I
Gene names
Name:bmp2-a
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length398 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Induces cartilage and bone formation.

Subunit structure

Homodimer; disulfide-linked.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the TGF-beta family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Propeptide24 – 284261 Potential
PRO_0000033832
Chain285 – 398114Bone morphogenetic protein 2-A
PRO_0000033833

Amino acid modifications

Glycosylation1371N-linked (GlcNAc...) Potential
Glycosylation2021N-linked (GlcNAc...) Potential
Glycosylation3401N-linked (GlcNAc...) Potential
Disulfide bond298 ↔ 363 By similarity
Disulfide bond327 ↔ 395 By similarity
Disulfide bond331 ↔ 397 By similarity
Disulfide bond362Interchain By similarity

Experimental info

Sequence conflict71S → P in CAA45018. Ref.2
Sequence conflict161V → L in CAA45018. Ref.2
Sequence conflict2331N → T in CAA45018. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P25703 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: 150AC64A47D2E15F

FASTA39845,575
        10         20         30         40         50         60 
MVAGIHSLLL LLFYQVLLSG CTGLIPEEGK RKYTESGRSS PQQSQRVLNQ FELRLLSMFG 

        70         80         90        100        110        120 
LKRRPTPGKN VVIPPYMLDL YHLHLAQLAA DEGTSAMDFQ MERAASRANT VRSFHHEESM 

       130        140        150        160        170        180 
EEIPESREKT IQRFFFNLSS IPNEELVTSA ELRIFREQVQ EPFESDSSKL HRINIYDIVK 

       190        200        210        220        230        240 
PAAAASRGPV VRLLDTRLVH HNESKWESFD VTPAIARWIA HKQPNHGFVV EVNHLDNDKN 

       250        260        270        280        290        300 
VPKKHVRISR SLTPDKDNWP QIRPLLVTFS HDGKGHALHK RQKRQARHKQ RKRLKSSCRR 

       310        320        330        340        350        360 
HPLYVDFSDV GWNDWIVAPP GYHAFYCHGE CPFPLADHLN STNHAIVQTL VNSVNTNIPK 

       370        380        390 
ACCVPTELSA ISMLYLDENE KVVLKNYQDM VVEGCGCR 

« Hide

References

[1]"cDNA sequence of Xenopus laevis bone morphogenetic protein 2 (BMP-2)."
Plessow S., Koester M., Knoechel W.
Biochim. Biophys. Acta 1089:280-282(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Genes for bone morphogenetic proteins are differentially transcribed in early amphibian embryos."
Nishimatsu S., Suzuki A., Shoda A., Murakami K., Ueno N.
Biochem. Biophys. Res. Commun. 186:1487-1495(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X55031 mRNA. Translation: CAA38850.1.
X63424 mRNA. Translation: CAA45018.1.
PIRJH0687.
UniGeneXl.1138.

3D structure databases

ProteinModelPortalP25703.
SMRP25703. Positions 293-398.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

XenbaseXB-GENE-481833. bmp2.

Phylogenomic databases

HOVERGENHBG004860.

Family and domain databases

Gene3D2.10.90.10. 1 hit.
InterProIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERPTHR11848. PTHR11848. 1 hit.
PfamPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSPR00669. INHIBINA.
SMARTSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMSSF57501. SSF57501. 1 hit.
PROSITEPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBMP2A_XENLA
AccessionPrimary (citable) accession number: P25703
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: June 11, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families