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P25703

- BMP2A_XENLA

UniProt

P25703 - BMP2A_XENLA

Protein

Bone morphogenetic protein 2-A

Gene

bmp2-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
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    Functioni

    Induces cartilage and bone formation.

    GO - Biological processi

    1. cartilage development Source: UniProtKB-KW
    2. cell differentiation Source: UniProtKB-KW
    3. growth Source: InterPro
    4. ossification Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cytokine, Developmental protein, Growth factor

    Keywords - Biological processi

    Chondrogenesis, Differentiation, Osteogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bone morphogenetic protein 2-A
    Alternative name(s):
    BMP-2-I
    Gene namesi
    Name:bmp2-a
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-481833. bmp2.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Propeptidei24 – 284261Sequence AnalysisPRO_0000033832Add
    BLAST
    Chaini285 – 398114Bone morphogenetic protein 2-APRO_0000033833Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi298 ↔ 363By similarity
    Disulfide bondi327 ↔ 395By similarity
    Disulfide bondi331 ↔ 397By similarity
    Glycosylationi340 – 3401N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi362 – 362InterchainBy similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.

    Structurei

    3D structure databases

    ProteinModelPortaliP25703.
    SMRiP25703. Positions 293-398.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG004860.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR002405. Inhibin_asu.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view]
    PRINTSiPR00669. INHIBINA.
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P25703-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVAGIHSLLL LLFYQVLLSG CTGLIPEEGK RKYTESGRSS PQQSQRVLNQ    50
    FELRLLSMFG LKRRPTPGKN VVIPPYMLDL YHLHLAQLAA DEGTSAMDFQ 100
    MERAASRANT VRSFHHEESM EEIPESREKT IQRFFFNLSS IPNEELVTSA 150
    ELRIFREQVQ EPFESDSSKL HRINIYDIVK PAAAASRGPV VRLLDTRLVH 200
    HNESKWESFD VTPAIARWIA HKQPNHGFVV EVNHLDNDKN VPKKHVRISR 250
    SLTPDKDNWP QIRPLLVTFS HDGKGHALHK RQKRQARHKQ RKRLKSSCRR 300
    HPLYVDFSDV GWNDWIVAPP GYHAFYCHGE CPFPLADHLN STNHAIVQTL 350
    VNSVNTNIPK ACCVPTELSA ISMLYLDENE KVVLKNYQDM VVEGCGCR 398
    Length:398
    Mass (Da):45,575
    Last modified:May 1, 1992 - v1
    Checksum:i150AC64A47D2E15F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti7 – 71S → P in CAA45018. (PubMed:1510675)Curated
    Sequence conflicti16 – 161V → L in CAA45018. (PubMed:1510675)Curated
    Sequence conflicti233 – 2331N → T in CAA45018. (PubMed:1510675)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55031 mRNA. Translation: CAA38850.1.
    X63424 mRNA. Translation: CAA45018.1.
    PIRiJH0687.
    UniGeneiXl.1138.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55031 mRNA. Translation: CAA38850.1 .
    X63424 mRNA. Translation: CAA45018.1 .
    PIRi JH0687.
    UniGenei Xl.1138.

    3D structure databases

    ProteinModelPortali P25703.
    SMRi P25703. Positions 293-398.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    Xenbasei XB-GENE-481833. bmp2.

    Phylogenomic databases

    HOVERGENi HBG004860.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR002405. Inhibin_asu.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view ]
    PRINTSi PR00669. INHIBINA.
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA sequence of Xenopus laevis bone morphogenetic protein 2 (BMP-2)."
      Plessow S., Koester M., Knoechel W.
      Biochim. Biophys. Acta 1089:280-282(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Genes for bone morphogenetic proteins are differentially transcribed in early amphibian embryos."
      Nishimatsu S., Suzuki A., Shoda A., Murakami K., Ueno N.
      Biochem. Biophys. Res. Commun. 186:1487-1495(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiBMP2A_XENLA
    AccessioniPrimary (citable) accession number: P25703
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3