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P25699 (FRI_PHAVU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferritin, chloroplastic
EC=1.16.3.1
Gene names
Name:PFE
OrganismPhaseolus vulgaris (Kidney bean) (French bean)
Taxonomic identifier3885 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › fabids › Fabales › Fabaceae › Papilionoideae › Phaseoleae › Phaseolus

Protein attributes

Sequence length254 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation By similarity.

Catalytic activity

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Subunit structure

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited By similarity.

Subcellular location

Plastid › chloroplast. Plastid.

Sequence similarities

Belongs to the ferritin family.

Contains 1 ferritin-like diiron domain.

Ontologies

Keywords
   Biological processIron storage
   Cellular componentChloroplast
Plastid
   DomainTransit peptide
   LigandIron
Metal-binding
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processcellular iron ion homeostasis

Inferred from electronic annotation. Source: UniProtKB-KW

iron ion transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentchloroplast

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionferric iron binding

Inferred from electronic annotation. Source: InterPro

ferroxidase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 4848Chloroplast
Chain49 – 254206Ferritin, chloroplastic
PRO_0000008863

Regions

Domain82 – 235154Ferritin-like diiron
Region49 – 8133Extension peptide (EP)

Sites

Metal binding991Iron 1 By similarity
Metal binding1341Iron 1 By similarity
Metal binding1341Iron 2 By similarity
Metal binding1371Iron 1 By similarity
Metal binding1831Iron 2 By similarity
Metal binding2171Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
P25699 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: 60B0E974D3F4435F

FASTA25428,304
        10         20         30         40         50         60 
MALAPSKVSP FSGFSLSDGV GAVRNPTCSV SLSFLNKKVG SRNLGVSAST VPLTGVIFEP 

        70         80         90        100        110        120 
FEEVKKEELA VPTAGQVSLA RQYYADECES AINEQINVEY NASYVYHSLF AYFDRDNVAL 

       130        140        150        160        170        180 
KGFARFFKES SEEEREHAEK LMKYQNTRGG RVVLHPIKNV PSEFEHVEKG DALYAMELAL 

       190        200        210        220        230        240 
SLEKLVNEKL RSVHSVADRN KDPQLADFIE SEFLSEQVEA IKKISEYVAQ LRMVGKGHGV 

       250 
WHFDQSLLHD GHAA

« Hide

References

[1]"The structure of a Phaseolus vulgaris cDNA encoding the iron storage protein ferritin."
Spence M.J., Henzl M.T., Lammers P.J.
Plant Mol. Biol. 17:499-504(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Tendergreen.
Tissue: Seed.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X58274 mRNA. Translation: CAA41213.1. Sequence problems.
PIRFRFBH. S17426.

3D structure databases

ProteinModelPortalP25699.
ModBaseSearch...

Proteomic databases

ProMEXP25699.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.20.1260.10. 1 hit.
InterProIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERPTHR11431. PTHR11431. 1 hit.
PfamPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMSSF47240. Ferritin/RR_like. 1 hit.
PROSITEPS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFRI_PHAVU
AccessionPrimary (citable) accession number: P25699
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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