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Protein

Cell division control protein 50

Gene

CDC50

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for polarized cell growth.

GO - Biological processi

  • actin cortical patch localization Source: SGD
  • endocytosis Source: SGD
  • intracellular protein transport Source: SGD
  • phospholipid translocation Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-29388-MONOMER.

Protein family/group databases

TCDBi8.A.27.1.2. the cdc50 p-type atpase lipid flippase subunit (cdc50) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 50
Gene namesi
Name:CDC50
Ordered Locus Names:YCR094W
ORF Names:YCR94W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCR094W.
SGDiS000000690. CDC50.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4444CytoplasmicSequence analysisAdd
BLAST
Transmembranei45 – 6521HelicalSequence analysisAdd
BLAST
Topological domaini66 – 331266LumenalSequence analysisAdd
BLAST
Transmembranei332 – 35221HelicalSequence analysisAdd
BLAST
Topological domaini353 – 39139CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • Cdc50p-Drs2p complex Source: SGD
  • integral component of membrane Source: UniProtKB-KW
  • late endosome membrane Source: SGD
  • trans-Golgi network Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 391391Cell division control protein 50PRO_0000207670Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence analysis
Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence analysis
Glycosylationi237 – 2371N-linked (GlcNAc...)Sequence analysis
Glycosylationi288 – 2881N-linked (GlcNAc...)Sequence analysis
Glycosylationi329 – 3291N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP25656.

Interactioni

Subunit structurei

Interacts with DRS2. Might function as an essential subunit for this protein.1 Publication

Protein-protein interaction databases

BioGridi31066. 116 interactions.
DIPiDIP-5138N.
IntActiP25656. 4 interactions.
MINTiMINT-492575.

Structurei

3D structure databases

ProteinModelPortaliP25656.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CDC50/LEM3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000004660.
HOGENOMiHOG000209056.
InParanoidiP25656.
OMAiGWRKPAN.
OrthoDBiEOG092C2TU8.

Family and domain databases

InterProiIPR005045. CDC50/LEM3_fam.
[Graphical view]
PANTHERiPTHR10926. PTHR10926. 1 hit.
PfamiPF03381. CDC50. 1 hit.
[Graphical view]
PIRSFiPIRSF015840. DUF284_TM_euk. 1 hit.

Sequencei

Sequence statusi: Complete.

P25656-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSLFKRGKA PPLTKEGPTS KKPPNTAFRQ QRLKAWQPIL SPQSVLPLLI
60 70 80 90 100
FVACIFTPIG IGLIVSATKV QDLTIDYSHC DTKASTTAFE DIPKKYIKYH
110 120 130 140 150
FKSKVENKPQ WRLTENENGE QSCELQFEIP NDIKKSIFIY YKITNFYQNH
160 170 180 190 200
RRYVQSFDTK QILGEPIKKD DLDTSCSPIR SREDKIIYPC GLIANSMFND
210 220 230 240 250
TFSQVLSGID DTEDYNLTNK HISWSIDRHR FKTTKYNASD IVPPPNWMKK
260 270 280 290 300
YPDGYTDENL PDIHTWEEFQ VWMRTAAFPK FYKLTLKNES ASLPKGKYQM
310 320 330 340 350
NIELNYPISL FGGTKSFVLT TNGAIGGRNM SLGVLYLIVA GLCALFGIIF
360 370 380 390
LVKLIFQPRA MGDHTYLNFD DEENEDYEDV HAENTTLREI L
Length:391
Mass (Da):44,982
Last modified:May 1, 1992 - v1
Checksum:i565575CA402C0C91
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42249.1.
BK006937 Genomic DNA. Translation: DAA07563.1.
PIRiS19510.
RefSeqiNP_010018.1. NM_001178800.1.

Genome annotation databases

EnsemblFungiiCAA42249; CAA42249; CAA42249.
YCR094W; YCR094W; YCR094W.
GeneIDi850456.
KEGGisce:YCR094W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42249.1.
BK006937 Genomic DNA. Translation: DAA07563.1.
PIRiS19510.
RefSeqiNP_010018.1. NM_001178800.1.

3D structure databases

ProteinModelPortaliP25656.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31066. 116 interactions.
DIPiDIP-5138N.
IntActiP25656. 4 interactions.
MINTiMINT-492575.

Protein family/group databases

TCDBi8.A.27.1.2. the cdc50 p-type atpase lipid flippase subunit (cdc50) family.

Proteomic databases

MaxQBiP25656.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAA42249; CAA42249; CAA42249.
YCR094W; YCR094W; YCR094W.
GeneIDi850456.
KEGGisce:YCR094W.

Organism-specific databases

EuPathDBiFungiDB:YCR094W.
SGDiS000000690. CDC50.

Phylogenomic databases

GeneTreeiENSGT00390000004660.
HOGENOMiHOG000209056.
InParanoidiP25656.
OMAiGWRKPAN.
OrthoDBiEOG092C2TU8.

Enzyme and pathway databases

BioCyciYEAST:G3O-29388-MONOMER.

Miscellaneous databases

PROiP25656.

Family and domain databases

InterProiIPR005045. CDC50/LEM3_fam.
[Graphical view]
PANTHERiPTHR10926. PTHR10926. 1 hit.
PfamiPF03381. CDC50. 1 hit.
[Graphical view]
PIRSFiPIRSF015840. DUF284_TM_euk. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCDC50_YEAST
AccessioniPrimary (citable) accession number: P25656
Secondary accession number(s): D6VR94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: September 7, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 589 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.