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P25653

- FIG2_YEAST

UniProt

P25653 - FIG2_YEAST

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Protein

Factor-induced gene 2 protein

Gene

FIG2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Required for efficient mating. Plays a role in maintenance of cell wall integrity during mating. Important for mating cell projection shape and conjugation bridge diameter. Plays a role in cell fusion and nuclear migration.4 Publications

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. cell morphogenesis involved in conjugation with cellular fusion Source: UniProtKB
  3. cell wall organization Source: UniProtKB-KW
  4. cytogamy Source: UniProtKB
  5. filamentous growth of a population of unicellular organisms Source: SGD
  6. invasive growth in response to glucose limitation Source: SGD
  7. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Cell shape, Cell wall biogenesis/degradation, Conjugation, Pheromone response

Enzyme and pathway databases

BioCyciYEAST:G3O-29383-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Factor-induced gene 2 protein
Alternative name(s):
Cell wall adhesin FIG2
Gene namesi
Name:FIG2
Ordered Locus Names:YCR089W
ORF Names:YCR1102, YCR89W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome III

Organism-specific databases

CYGDiYCR089w.
SGDiS000000685. FIG2.

Subcellular locationi

Secretedcell wall 3 Publications. Membrane Curated; Lipid-anchorGPI-anchor Curated
Note: Periphery of the mating cells. Localized to the mating projection.

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. extracellular region Source: UniProtKB-KW
  3. fungal-type cell wall Source: UniProtKB
  4. mating projection Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 15881566Factor-induced gene 2 proteinPRO_0000021264Add
BLAST
Propeptidei1589 – 160921Removed in mature formSequence AnalysisPRO_0000372452Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi347 – 3471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi386 – 3861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi426 – 4261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi495 – 4951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi535 – 5351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi661 – 6611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi674 – 6741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi713 – 7131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi889 – 8891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi907 – 9071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1079 – 10791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1400 – 14001N-linked (GlcNAc...)Sequence Analysis
Lipidationi1588 – 15881GPI-anchor amidated glycineSequence Analysis

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Expressioni

Inductioni

By mating pheromones. By cells of the opposite mating type.3 Publications

Gene expression databases

GenevestigatoriP25653.

Interactioni

Protein-protein interaction databases

BioGridi31061. 30 interactions.
IntActiP25653. 1 interaction.
MINTiMINT-2781749.
STRINGi4932.YCR089W.

Structurei

3D structure databases

ProteinModelPortaliP25653.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi30 – 13661337Ser-richAdd
BLAST
Compositional biasi529 – 15541026Thr-richAdd
BLAST

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG12793.
InParanoidiP25653.
OMAiFFIEINP.
OrthoDBiEOG7C8GRH.

Family and domain databases

InterProiIPR025928. Flocculin_t3_rpt.
[Graphical view]
PfamiPF13928. Flocculin_t3. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25653-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSFASLGLI YSVVNLLTRV EAQIVFYQNS STSLPVPTLV STSIADFHES
60 70 80 90 100
SSTGEVQYSS SYSYVQPSID SFTSSSFLTS FEAPTETSSS YAVSSSLITS
110 120 130 140 150
DTFSSYSDIF DEETSSLIST SAASSEKASS TLSSTAQPHR TSHSSSSFEL
160 170 180 190 200
PVTAPSSSSL PSSTSLTFTS VNPSQSWTSF NSEKSSALSS TIDFTSSEIS
210 220 230 240 250
GSTSPKSLES FDTTGTITSS YSPSPSSKNS NQTSLLSPLE PLSSSSGDLI
260 270 280 290 300
LSSTIQATTN DQTSKTIPTL VDATSSLPPT LRSSSMAPTS GSDSISHNFT
310 320 330 340 350
SPPSKTSGNY DVLTSNSIDP SLFTTTSEYS STQLSSLNRA SKSETVNFTA
360 370 380 390 400
SIASTPFGTD SATSLIDPIS SVGSTASSFV GISTANFSTQ GNSNYVPEST
410 420 430 440 450
ASGSSQYQDW SSSSLPLSQT TWVVINTTNT QGSVTSTTSP AYVSTATKTV
460 470 480 490 500
DGVITEYVTW CPLTQTKSQA IGVSSSISSV PQASSFSGSS ILSSNSSTLA
510 520 530 540 550
ASNNVPESTA SGSSQYQDWS SSSLPLSQTT WVVINTTNTQ GSVTSTTSPA
560 570 580 590 600
YVSTATKTVD GVITEYVTWC PLTQTKSQAI GISSSTISAT QTSKPSSILT
610 620 630 640 650
LGISTLQLSD ATFKGTETIN THLMTESTSI TEPTYFSGTS DSFYLCTSEV
660 670 680 690 700
NLASSLSSYP NFSSSEGSTA TITNSTVTFG STSKYPSTSV SNPTEASQHV
710 720 730 740 750
SSSVNSLTDF TSNSTETIAV ISNIHKTSSN KDYSLTTTQL KTSGMQTLVL
760 770 780 790 800
STVTTTVNGA ATEYTTWCPA SSIAYTTSIS YKTLVLTTEV CSHSECTPTV
810 820 830 840 850
ITSVTATSST IPLLSTSSST VLSSTVSEGA KNPAASEVTI NTQVSATSEA
860 870 880 890 900
TSTSTQVSAT SATATASESS TTSQVSTASE TISTLGTQNF TTTGSLLFPA
910 920 930 940 950
LSTEMINTTV VSRKTLIIST EVCSHSKCVP TVITEVVTSK GTPSNGHSSQ
960 970 980 990 1000
TLQTEAVEVT LSSHQTVTMS TEVCSNSICT PTVITSVQMR STPFPYLTSS
1010 1020 1030 1040 1050
TSSSSLASTK KSSLEASSEM STFSVSTQSL PLAFTSSEKR STTSVSQWSN
1060 1070 1080 1090 1100
TVLTNTIMSS SSNVISTNEK PSSTTSPYNF SSGYSLPSSS TPSQYSLSTA
1110 1120 1130 1140 1150
TTTINGIKTV YTTWCPLAEK STVAASSQSS RSVDRFVSSS KPSSSLSQTS
1160 1170 1180 1190 1200
IQYTLSTATT TISGLKTVYT TWCPLTSKST LGATTQTSST AKVRITSASS
1210 1220 1230 1240 1250
ATSTSISLST STESESSSGY LSKGVCSGTE CTQDVPTQSS SPASTLAYSP
1260 1270 1280 1290 1300
SVSTSSSSSF STTTASTLTS THTSVPLLPS SSSISASSPS STSLLSTSLP
1310 1320 1330 1340 1350
SPAFTSSTLP TATAVSSSTF IASSLPLSSK SSLSLSPVSS SILMSQFSSS
1360 1370 1380 1390 1400
SSSSSSLASL PSLSISPTVD TVSVLQPTTS IATLTCTDSQ CQQEVSTICN
1410 1420 1430 1440 1450
GSNCDDVTST ATTPPSTVTD TMTCTGSECQ KTTSSSCDGY SCKVSETYKS
1460 1470 1480 1490 1500
SATISACSGE GCQASATSEL NSQYVTMTSV ITPSAITTTS VEVHSTESTI
1510 1520 1530 1540 1550
SITTVKPVTY TSSDTNGELI TITSSSQTVI PSVTTIITRT KVAITSAPKP
1560 1570 1580 1590 1600
TTTTYVEQRL SSSGIATSFV AAASSTWITT PIVSTYAGSA SKFLCSKFFM

IMVMVINFI
Length:1,609
Mass (Da):166,036
Last modified:March 1, 2004 - v2
Checksum:iB9B6E08F98996B54
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59720 Genomic DNA. Translation: CAA42254.2.
BK006937 Genomic DNA. Translation: DAA07558.1.
PIRiS25345.
RefSeqiNP_010013.2. NM_001178795.1.

Genome annotation databases

EnsemblFungiiYCR089W; YCR089W; YCR089W.
GeneIDi850451.
KEGGisce:YCR089W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59720 Genomic DNA. Translation: CAA42254.2 .
BK006937 Genomic DNA. Translation: DAA07558.1 .
PIRi S25345.
RefSeqi NP_010013.2. NM_001178795.1.

3D structure databases

ProteinModelPortali P25653.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31061. 30 interactions.
IntActi P25653. 1 interaction.
MINTi MINT-2781749.
STRINGi 4932.YCR089W.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YCR089W ; YCR089W ; YCR089W .
GeneIDi 850451.
KEGGi sce:YCR089W.

Organism-specific databases

CYGDi YCR089w.
SGDi S000000685. FIG2.

Phylogenomic databases

eggNOGi NOG12793.
InParanoidi P25653.
OMAi FFIEINP.
OrthoDBi EOG7C8GRH.

Enzyme and pathway databases

BioCyci YEAST:G3O-29383-MONOMER.

Miscellaneous databases

NextBioi 966069.

Gene expression databases

Genevestigatori P25653.

Family and domain databases

InterProi IPR025928. Flocculin_t3_rpt.
[Graphical view ]
Pfami PF13928. Flocculin_t3. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete sequence of a 6146 bp fragment of Saccharomyces cerevisiae chromosome III contains two new open reading frames."
    Wilson C., Grisanti P., Frontali L.
    Yeast 8:569-575(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete DNA sequence of yeast chromosome III."
    Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
    , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
    Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Valles G., Volckaerts G.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 745 AND 1036.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "Comparison of cell wall proteins of Saccharomyces cerevisiae as anchors for cell surface expression of heterologous proteins."
    Van der Vaart J.M., te Biesebeke R., Chapman J.W., Toschka H.Y., Klis F.M., Verrips C.T.
    Appl. Environ. Microbiol. 63:615-620(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  6. "Pheromone-regulated genes required for yeast mating differentiation."
    Erdman S., Lin L., Malczynski M., Snyder M.
    J. Cell Biol. 140:461-483(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION.
  7. "A Saccharomyces gene family involved in invasive growth, cell-cell adhesion, and mating."
    Guo B., Styles C.A., Feng Q., Fink G.R.
    Proc. Natl. Acad. Sci. U.S.A. 97:12158-12163(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION.
  8. "Maintenance of mating cell integrity requires the adhesin Fig2p."
    Zhang M., Bennett D., Erdman S.E.
    Eukaryot. Cell 1:811-822(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "Role of Fig2p in agglutination in Saccharomyces cerevisiae."
    Jue C.K., Lipke P.N.
    Eukaryot. Cell 1:843-845(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  10. "Global analysis of the glycoproteome in Saccharomyces cerevisiae reveals new roles for protein glycosylation in eukaryotes."
    Kung L.A., Tao S.-C., Qian J., Smith M.G., Snyder M., Zhu H.
    Mol. Syst. Biol. 5:308-308(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFIG2_YEAST
AccessioniPrimary (citable) accession number: P25653
Secondary accession number(s): D6VR89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: March 1, 2004
Last modified: October 29, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

External Data

Dasty 3