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P25653 (FIG2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Factor-induced gene 2 protein
Alternative name(s):
Cell wall adhesin FIG2
Gene names
Name:FIG2
Ordered Locus Names:YCR089W
ORF Names:YCR1102, YCR89W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length1609 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for efficient mating. Plays a role in maintenance of cell wall integrity during mating. Important for mating cell projection shape and conjugation bridge diameter. Plays a role in cell fusion and nuclear migration. Ref.6 Ref.7 Ref.8 Ref.9

Subcellular location

Secretedcell wall. Membrane; Lipid-anchorGPI-anchor Potential. Note: Periphery of the mating cells. Localized to the mating projection. Ref.5 Ref.6 Ref.7

Induction

By mating pheromones. By cells of the opposite mating type. Ref.6 Ref.7 Ref.9

Post-translational modification

N-glycosylated.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 15881566Factor-induced gene 2 protein
PRO_0000021264
Propeptide1589 – 160921Removed in mature form Potential
PRO_0000372452

Regions

Compositional bias30 – 13661337Ser-rich
Compositional bias529 – 15541026Thr-rich

Amino acid modifications

Lipidation15881GPI-anchor amidated glycine Potential
Glycosylation291N-linked (GlcNAc...) Potential
Glycosylation2311N-linked (GlcNAc...) Potential
Glycosylation2981N-linked (GlcNAc...) Potential
Glycosylation3471N-linked (GlcNAc...) Potential
Glycosylation3861N-linked (GlcNAc...) Potential
Glycosylation4261N-linked (GlcNAc...) Potential
Glycosylation4951N-linked (GlcNAc...) Potential
Glycosylation5351N-linked (GlcNAc...) Potential
Glycosylation6611N-linked (GlcNAc...) Potential
Glycosylation6741N-linked (GlcNAc...) Potential
Glycosylation7131N-linked (GlcNAc...) Potential
Glycosylation8891N-linked (GlcNAc...) Potential
Glycosylation9071N-linked (GlcNAc...) Potential
Glycosylation10791N-linked (GlcNAc...) Potential
Glycosylation14001N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P25653 [UniParc].

Last modified March 1, 2004. Version 2.
Checksum: B9B6E08F98996B54

FASTA1,609166,036
        10         20         30         40         50         60 
MNSFASLGLI YSVVNLLTRV EAQIVFYQNS STSLPVPTLV STSIADFHES SSTGEVQYSS 

        70         80         90        100        110        120 
SYSYVQPSID SFTSSSFLTS FEAPTETSSS YAVSSSLITS DTFSSYSDIF DEETSSLIST 

       130        140        150        160        170        180 
SAASSEKASS TLSSTAQPHR TSHSSSSFEL PVTAPSSSSL PSSTSLTFTS VNPSQSWTSF 

       190        200        210        220        230        240 
NSEKSSALSS TIDFTSSEIS GSTSPKSLES FDTTGTITSS YSPSPSSKNS NQTSLLSPLE 

       250        260        270        280        290        300 
PLSSSSGDLI LSSTIQATTN DQTSKTIPTL VDATSSLPPT LRSSSMAPTS GSDSISHNFT 

       310        320        330        340        350        360 
SPPSKTSGNY DVLTSNSIDP SLFTTTSEYS STQLSSLNRA SKSETVNFTA SIASTPFGTD 

       370        380        390        400        410        420 
SATSLIDPIS SVGSTASSFV GISTANFSTQ GNSNYVPEST ASGSSQYQDW SSSSLPLSQT 

       430        440        450        460        470        480 
TWVVINTTNT QGSVTSTTSP AYVSTATKTV DGVITEYVTW CPLTQTKSQA IGVSSSISSV 

       490        500        510        520        530        540 
PQASSFSGSS ILSSNSSTLA ASNNVPESTA SGSSQYQDWS SSSLPLSQTT WVVINTTNTQ 

       550        560        570        580        590        600 
GSVTSTTSPA YVSTATKTVD GVITEYVTWC PLTQTKSQAI GISSSTISAT QTSKPSSILT 

       610        620        630        640        650        660 
LGISTLQLSD ATFKGTETIN THLMTESTSI TEPTYFSGTS DSFYLCTSEV NLASSLSSYP 

       670        680        690        700        710        720 
NFSSSEGSTA TITNSTVTFG STSKYPSTSV SNPTEASQHV SSSVNSLTDF TSNSTETIAV 

       730        740        750        760        770        780 
ISNIHKTSSN KDYSLTTTQL KTSGMQTLVL STVTTTVNGA ATEYTTWCPA SSIAYTTSIS 

       790        800        810        820        830        840 
YKTLVLTTEV CSHSECTPTV ITSVTATSST IPLLSTSSST VLSSTVSEGA KNPAASEVTI 

       850        860        870        880        890        900 
NTQVSATSEA TSTSTQVSAT SATATASESS TTSQVSTASE TISTLGTQNF TTTGSLLFPA 

       910        920        930        940        950        960 
LSTEMINTTV VSRKTLIIST EVCSHSKCVP TVITEVVTSK GTPSNGHSSQ TLQTEAVEVT 

       970        980        990       1000       1010       1020 
LSSHQTVTMS TEVCSNSICT PTVITSVQMR STPFPYLTSS TSSSSLASTK KSSLEASSEM 

      1030       1040       1050       1060       1070       1080 
STFSVSTQSL PLAFTSSEKR STTSVSQWSN TVLTNTIMSS SSNVISTNEK PSSTTSPYNF 

      1090       1100       1110       1120       1130       1140 
SSGYSLPSSS TPSQYSLSTA TTTINGIKTV YTTWCPLAEK STVAASSQSS RSVDRFVSSS 

      1150       1160       1170       1180       1190       1200 
KPSSSLSQTS IQYTLSTATT TISGLKTVYT TWCPLTSKST LGATTQTSST AKVRITSASS 

      1210       1220       1230       1240       1250       1260 
ATSTSISLST STESESSSGY LSKGVCSGTE CTQDVPTQSS SPASTLAYSP SVSTSSSSSF 

      1270       1280       1290       1300       1310       1320 
STTTASTLTS THTSVPLLPS SSSISASSPS STSLLSTSLP SPAFTSSTLP TATAVSSSTF 

      1330       1340       1350       1360       1370       1380 
IASSLPLSSK SSLSLSPVSS SILMSQFSSS SSSSSSLASL PSLSISPTVD TVSVLQPTTS 

      1390       1400       1410       1420       1430       1440 
IATLTCTDSQ CQQEVSTICN GSNCDDVTST ATTPPSTVTD TMTCTGSECQ KTTSSSCDGY 

      1450       1460       1470       1480       1490       1500 
SCKVSETYKS SATISACSGE GCQASATSEL NSQYVTMTSV ITPSAITTTS VEVHSTESTI 

      1510       1520       1530       1540       1550       1560 
SITTVKPVTY TSSDTNGELI TITSSSQTVI PSVTTIITRT KVAITSAPKP TTTTYVEQRL 

      1570       1580       1590       1600 
SSSGIATSFV AAASSTWITT PIVSTYAGSA SKFLCSKFFM IMVMVINFI 

« Hide

References

« Hide 'large scale' references
[1]"The complete sequence of a 6146 bp fragment of Saccharomyces cerevisiae chromosome III contains two new open reading frames."
Wilson C., Grisanti P., Frontali L.
Yeast 8:569-575(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The complete DNA sequence of yeast chromosome III."
Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M. expand/collapse author list , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Valles G., Volckaerts G.
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 745 AND 1036.
[4]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"Comparison of cell wall proteins of Saccharomyces cerevisiae as anchors for cell surface expression of heterologous proteins."
Van der Vaart J.M., te Biesebeke R., Chapman J.W., Toschka H.Y., Klis F.M., Verrips C.T.
Appl. Environ. Microbiol. 63:615-620(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[6]"Pheromone-regulated genes required for yeast mating differentiation."
Erdman S., Lin L., Malczynski M., Snyder M.
J. Cell Biol. 140:461-483(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION.
[7]"A Saccharomyces gene family involved in invasive growth, cell-cell adhesion, and mating."
Guo B., Styles C.A., Feng Q., Fink G.R.
Proc. Natl. Acad. Sci. U.S.A. 97:12158-12163(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION.
[8]"Maintenance of mating cell integrity requires the adhesin Fig2p."
Zhang M., Bennett D., Erdman S.E.
Eukaryot. Cell 1:811-822(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[9]"Role of Fig2p in agglutination in Saccharomyces cerevisiae."
Jue C.K., Lipke P.N.
Eukaryot. Cell 1:843-845(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION.
[10]"Global analysis of the glycoproteome in Saccharomyces cerevisiae reveals new roles for protein glycosylation in eukaryotes."
Kung L.A., Tao S.-C., Qian J., Smith M.G., Snyder M., Zhu H.
Mol. Syst. Biol. 5:308-308(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X59720 Genomic DNA. Translation: CAA42254.2.
BK006937 Genomic DNA. Translation: DAA07558.1.
PIRS25345.
RefSeqNP_010013.2. NM_001178795.1.

3D structure databases

ProteinModelPortalP25653.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31061. 30 interactions.
IntActP25653. 1 interaction.
MINTMINT-2781749.
STRING4932.YCR089W.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYCR089W; YCR089W; YCR089W.
GeneID850451.
KEGGsce:YCR089W.

Organism-specific databases

CYGDYCR089w.
SGDS000000685. FIG2.

Phylogenomic databases

eggNOGNOG12793.
OMAFFIEINP.
OrthoDBEOG7C8GRH.

Enzyme and pathway databases

BioCycYEAST:G3O-29383-MONOMER.

Gene expression databases

GenevestigatorP25653.

Family and domain databases

InterProIPR025928. Flocculin_t3_rpt.
[Graphical view]
PfamPF13928. Flocculin_t3. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio966069.

Entry information

Entry nameFIG2_YEAST
AccessionPrimary (citable) accession number: P25653
Secondary accession number(s): D6VR89
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: March 1, 2004
Last modified: May 14, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome III

Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD