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P25653

- FIG2_YEAST

UniProt

P25653 - FIG2_YEAST

Protein

Factor-induced gene 2 protein

Gene

FIG2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (01 Mar 2004)
      Previous versions | rss
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    Functioni

    Required for efficient mating. Plays a role in maintenance of cell wall integrity during mating. Important for mating cell projection shape and conjugation bridge diameter. Plays a role in cell fusion and nuclear migration.4 Publications

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. cell morphogenesis involved in conjugation with cellular fusion Source: UniProtKB
    3. cytogamy Source: UniProtKB
    4. filamentous growth of a population of unicellular organisms Source: SGD
    5. invasive growth in response to glucose limitation Source: SGD
    6. regulation of cell shape Source: UniProtKB-KW

    Keywords - Biological processi

    Cell adhesion, Cell shape, Cell wall biogenesis/degradation, Conjugation, Pheromone response

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29383-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Factor-induced gene 2 protein
    Alternative name(s):
    Cell wall adhesin FIG2
    Gene namesi
    Name:FIG2
    Ordered Locus Names:YCR089W
    ORF Names:YCR1102, YCR89W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome III

    Organism-specific databases

    CYGDiYCR089w.
    SGDiS000000685. FIG2.

    Subcellular locationi

    Secretedcell wall 3 Publications. Membrane Curated; Lipid-anchorGPI-anchor Curated
    Note: Periphery of the mating cells. Localized to the mating projection.

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. extracellular region Source: UniProtKB-KW
    3. fungal-type cell wall Source: UniProtKB
    4. mating projection Source: SGD

    Keywords - Cellular componenti

    Cell wall, Membrane, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 15881566Factor-induced gene 2 proteinPRO_0000021264Add
    BLAST
    Propeptidei1589 – 160921Removed in mature formSequence AnalysisPRO_0000372452Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi347 – 3471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi386 – 3861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi426 – 4261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi495 – 4951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi535 – 5351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi661 – 6611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi674 – 6741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi713 – 7131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi889 – 8891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi907 – 9071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1079 – 10791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1400 – 14001N-linked (GlcNAc...)Sequence Analysis
    Lipidationi1588 – 15881GPI-anchor amidated glycineSequence Analysis

    Post-translational modificationi

    N-glycosylated.1 Publication

    Keywords - PTMi

    Glycoprotein, GPI-anchor, Lipoprotein

    Expressioni

    Inductioni

    By mating pheromones. By cells of the opposite mating type.3 Publications

    Gene expression databases

    GenevestigatoriP25653.

    Interactioni

    Protein-protein interaction databases

    BioGridi31061. 30 interactions.
    IntActiP25653. 1 interaction.
    MINTiMINT-2781749.
    STRINGi4932.YCR089W.

    Structurei

    3D structure databases

    ProteinModelPortaliP25653.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi30 – 13661337Ser-richAdd
    BLAST
    Compositional biasi529 – 15541026Thr-richAdd
    BLAST

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    OMAiFFIEINP.
    OrthoDBiEOG7C8GRH.

    Family and domain databases

    InterProiIPR025928. Flocculin_t3_rpt.
    [Graphical view]
    PfamiPF13928. Flocculin_t3. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P25653-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSFASLGLI YSVVNLLTRV EAQIVFYQNS STSLPVPTLV STSIADFHES     50
    SSTGEVQYSS SYSYVQPSID SFTSSSFLTS FEAPTETSSS YAVSSSLITS 100
    DTFSSYSDIF DEETSSLIST SAASSEKASS TLSSTAQPHR TSHSSSSFEL 150
    PVTAPSSSSL PSSTSLTFTS VNPSQSWTSF NSEKSSALSS TIDFTSSEIS 200
    GSTSPKSLES FDTTGTITSS YSPSPSSKNS NQTSLLSPLE PLSSSSGDLI 250
    LSSTIQATTN DQTSKTIPTL VDATSSLPPT LRSSSMAPTS GSDSISHNFT 300
    SPPSKTSGNY DVLTSNSIDP SLFTTTSEYS STQLSSLNRA SKSETVNFTA 350
    SIASTPFGTD SATSLIDPIS SVGSTASSFV GISTANFSTQ GNSNYVPEST 400
    ASGSSQYQDW SSSSLPLSQT TWVVINTTNT QGSVTSTTSP AYVSTATKTV 450
    DGVITEYVTW CPLTQTKSQA IGVSSSISSV PQASSFSGSS ILSSNSSTLA 500
    ASNNVPESTA SGSSQYQDWS SSSLPLSQTT WVVINTTNTQ GSVTSTTSPA 550
    YVSTATKTVD GVITEYVTWC PLTQTKSQAI GISSSTISAT QTSKPSSILT 600
    LGISTLQLSD ATFKGTETIN THLMTESTSI TEPTYFSGTS DSFYLCTSEV 650
    NLASSLSSYP NFSSSEGSTA TITNSTVTFG STSKYPSTSV SNPTEASQHV 700
    SSSVNSLTDF TSNSTETIAV ISNIHKTSSN KDYSLTTTQL KTSGMQTLVL 750
    STVTTTVNGA ATEYTTWCPA SSIAYTTSIS YKTLVLTTEV CSHSECTPTV 800
    ITSVTATSST IPLLSTSSST VLSSTVSEGA KNPAASEVTI NTQVSATSEA 850
    TSTSTQVSAT SATATASESS TTSQVSTASE TISTLGTQNF TTTGSLLFPA 900
    LSTEMINTTV VSRKTLIIST EVCSHSKCVP TVITEVVTSK GTPSNGHSSQ 950
    TLQTEAVEVT LSSHQTVTMS TEVCSNSICT PTVITSVQMR STPFPYLTSS 1000
    TSSSSLASTK KSSLEASSEM STFSVSTQSL PLAFTSSEKR STTSVSQWSN 1050
    TVLTNTIMSS SSNVISTNEK PSSTTSPYNF SSGYSLPSSS TPSQYSLSTA 1100
    TTTINGIKTV YTTWCPLAEK STVAASSQSS RSVDRFVSSS KPSSSLSQTS 1150
    IQYTLSTATT TISGLKTVYT TWCPLTSKST LGATTQTSST AKVRITSASS 1200
    ATSTSISLST STESESSSGY LSKGVCSGTE CTQDVPTQSS SPASTLAYSP 1250
    SVSTSSSSSF STTTASTLTS THTSVPLLPS SSSISASSPS STSLLSTSLP 1300
    SPAFTSSTLP TATAVSSSTF IASSLPLSSK SSLSLSPVSS SILMSQFSSS 1350
    SSSSSSLASL PSLSISPTVD TVSVLQPTTS IATLTCTDSQ CQQEVSTICN 1400
    GSNCDDVTST ATTPPSTVTD TMTCTGSECQ KTTSSSCDGY SCKVSETYKS 1450
    SATISACSGE GCQASATSEL NSQYVTMTSV ITPSAITTTS VEVHSTESTI 1500
    SITTVKPVTY TSSDTNGELI TITSSSQTVI PSVTTIITRT KVAITSAPKP 1550
    TTTTYVEQRL SSSGIATSFV AAASSTWITT PIVSTYAGSA SKFLCSKFFM 1600
    IMVMVINFI 1609
    Length:1,609
    Mass (Da):166,036
    Last modified:March 1, 2004 - v2
    Checksum:iB9B6E08F98996B54
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59720 Genomic DNA. Translation: CAA42254.2.
    BK006937 Genomic DNA. Translation: DAA07558.1.
    PIRiS25345.
    RefSeqiNP_010013.2. NM_001178795.1.

    Genome annotation databases

    EnsemblFungiiYCR089W; YCR089W; YCR089W.
    GeneIDi850451.
    KEGGisce:YCR089W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59720 Genomic DNA. Translation: CAA42254.2 .
    BK006937 Genomic DNA. Translation: DAA07558.1 .
    PIRi S25345.
    RefSeqi NP_010013.2. NM_001178795.1.

    3D structure databases

    ProteinModelPortali P25653.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31061. 30 interactions.
    IntActi P25653. 1 interaction.
    MINTi MINT-2781749.
    STRINGi 4932.YCR089W.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YCR089W ; YCR089W ; YCR089W .
    GeneIDi 850451.
    KEGGi sce:YCR089W.

    Organism-specific databases

    CYGDi YCR089w.
    SGDi S000000685. FIG2.

    Phylogenomic databases

    eggNOGi NOG12793.
    OMAi FFIEINP.
    OrthoDBi EOG7C8GRH.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29383-MONOMER.

    Miscellaneous databases

    NextBioi 966069.

    Gene expression databases

    Genevestigatori P25653.

    Family and domain databases

    InterProi IPR025928. Flocculin_t3_rpt.
    [Graphical view ]
    Pfami PF13928. Flocculin_t3. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete sequence of a 6146 bp fragment of Saccharomyces cerevisiae chromosome III contains two new open reading frames."
      Wilson C., Grisanti P., Frontali L.
      Yeast 8:569-575(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The complete DNA sequence of yeast chromosome III."
      Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
      , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
      Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Valles G., Volckaerts G.
      Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 745 AND 1036.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. "Comparison of cell wall proteins of Saccharomyces cerevisiae as anchors for cell surface expression of heterologous proteins."
      Van der Vaart J.M., te Biesebeke R., Chapman J.W., Toschka H.Y., Klis F.M., Verrips C.T.
      Appl. Environ. Microbiol. 63:615-620(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    6. "Pheromone-regulated genes required for yeast mating differentiation."
      Erdman S., Lin L., Malczynski M., Snyder M.
      J. Cell Biol. 140:461-483(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION.
    7. "A Saccharomyces gene family involved in invasive growth, cell-cell adhesion, and mating."
      Guo B., Styles C.A., Feng Q., Fink G.R.
      Proc. Natl. Acad. Sci. U.S.A. 97:12158-12163(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION.
    8. "Maintenance of mating cell integrity requires the adhesin Fig2p."
      Zhang M., Bennett D., Erdman S.E.
      Eukaryot. Cell 1:811-822(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "Role of Fig2p in agglutination in Saccharomyces cerevisiae."
      Jue C.K., Lipke P.N.
      Eukaryot. Cell 1:843-845(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    10. "Global analysis of the glycoproteome in Saccharomyces cerevisiae reveals new roles for protein glycosylation in eukaryotes."
      Kung L.A., Tao S.-C., Qian J., Smith M.G., Snyder M., Zhu H.
      Mol. Syst. Biol. 5:308-308(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiFIG2_YEAST
    AccessioniPrimary (citable) accession number: P25653
    Secondary accession number(s): D6VR89
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: March 1, 2004
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome III
      Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

    External Data

    Dasty 3