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P25653

- FIG2_YEAST

UniProt

P25653 - FIG2_YEAST

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Protein
Factor-induced gene 2 protein
Gene
FIG2, YCR089W, YCR1102, YCR89W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Required for efficient mating. Plays a role in maintenance of cell wall integrity during mating. Important for mating cell projection shape and conjugation bridge diameter. Plays a role in cell fusion and nuclear migration.4 Publications

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. cell morphogenesis involved in conjugation with cellular fusion Source: UniProtKB
  3. cytogamy Source: UniProtKB
  4. filamentous growth of a population of unicellular organisms Source: SGD
  5. invasive growth in response to glucose limitation Source: SGD
  6. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Cell shape, Cell wall biogenesis/degradation, Conjugation, Pheromone response

Enzyme and pathway databases

BioCyciYEAST:G3O-29383-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Factor-induced gene 2 protein
Alternative name(s):
Cell wall adhesin FIG2
Gene namesi
Name:FIG2
Ordered Locus Names:YCR089W
ORF Names:YCR1102, YCR89W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome III

Organism-specific databases

CYGDiYCR089w.
SGDiS000000685. FIG2.

Subcellular locationi

Secretedcell wall. Membrane; Lipid-anchorGPI-anchor Reviewed prediction
Note: Periphery of the mating cells. Localized to the mating projection.3 Publications

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. extracellular region Source: UniProtKB-KW
  3. fungal-type cell wall Source: UniProtKB
  4. mating projection Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed prediction
Add
BLAST
Chaini23 – 15881566Factor-induced gene 2 protein
PRO_0000021264Add
BLAST
Propeptidei1589 – 160921Removed in mature form Reviewed prediction
PRO_0000372452Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi231 – 2311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi298 – 2981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi347 – 3471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi386 – 3861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi426 – 4261N-linked (GlcNAc...) Reviewed prediction
Glycosylationi495 – 4951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi535 – 5351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi661 – 6611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi674 – 6741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi713 – 7131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi889 – 8891N-linked (GlcNAc...) Reviewed prediction
Glycosylationi907 – 9071N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1079 – 10791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1400 – 14001N-linked (GlcNAc...) Reviewed prediction
Lipidationi1588 – 15881GPI-anchor amidated glycine Reviewed prediction

Post-translational modificationi

N-glycosylated.

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Expressioni

Inductioni

By mating pheromones. By cells of the opposite mating type.3 Publications

Gene expression databases

GenevestigatoriP25653.

Interactioni

Protein-protein interaction databases

BioGridi31061. 30 interactions.
IntActiP25653. 1 interaction.
MINTiMINT-2781749.
STRINGi4932.YCR089W.

Structurei

3D structure databases

ProteinModelPortaliP25653.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi30 – 13661337Ser-rich
Add
BLAST
Compositional biasi529 – 15541026Thr-rich
Add
BLAST

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG12793.
OMAiFFIEINP.
OrthoDBiEOG7C8GRH.

Family and domain databases

InterProiIPR025928. Flocculin_t3_rpt.
[Graphical view]
PfamiPF13928. Flocculin_t3. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25653-1 [UniParc]FASTAAdd to Basket

« Hide

MNSFASLGLI YSVVNLLTRV EAQIVFYQNS STSLPVPTLV STSIADFHES     50
SSTGEVQYSS SYSYVQPSID SFTSSSFLTS FEAPTETSSS YAVSSSLITS 100
DTFSSYSDIF DEETSSLIST SAASSEKASS TLSSTAQPHR TSHSSSSFEL 150
PVTAPSSSSL PSSTSLTFTS VNPSQSWTSF NSEKSSALSS TIDFTSSEIS 200
GSTSPKSLES FDTTGTITSS YSPSPSSKNS NQTSLLSPLE PLSSSSGDLI 250
LSSTIQATTN DQTSKTIPTL VDATSSLPPT LRSSSMAPTS GSDSISHNFT 300
SPPSKTSGNY DVLTSNSIDP SLFTTTSEYS STQLSSLNRA SKSETVNFTA 350
SIASTPFGTD SATSLIDPIS SVGSTASSFV GISTANFSTQ GNSNYVPEST 400
ASGSSQYQDW SSSSLPLSQT TWVVINTTNT QGSVTSTTSP AYVSTATKTV 450
DGVITEYVTW CPLTQTKSQA IGVSSSISSV PQASSFSGSS ILSSNSSTLA 500
ASNNVPESTA SGSSQYQDWS SSSLPLSQTT WVVINTTNTQ GSVTSTTSPA 550
YVSTATKTVD GVITEYVTWC PLTQTKSQAI GISSSTISAT QTSKPSSILT 600
LGISTLQLSD ATFKGTETIN THLMTESTSI TEPTYFSGTS DSFYLCTSEV 650
NLASSLSSYP NFSSSEGSTA TITNSTVTFG STSKYPSTSV SNPTEASQHV 700
SSSVNSLTDF TSNSTETIAV ISNIHKTSSN KDYSLTTTQL KTSGMQTLVL 750
STVTTTVNGA ATEYTTWCPA SSIAYTTSIS YKTLVLTTEV CSHSECTPTV 800
ITSVTATSST IPLLSTSSST VLSSTVSEGA KNPAASEVTI NTQVSATSEA 850
TSTSTQVSAT SATATASESS TTSQVSTASE TISTLGTQNF TTTGSLLFPA 900
LSTEMINTTV VSRKTLIIST EVCSHSKCVP TVITEVVTSK GTPSNGHSSQ 950
TLQTEAVEVT LSSHQTVTMS TEVCSNSICT PTVITSVQMR STPFPYLTSS 1000
TSSSSLASTK KSSLEASSEM STFSVSTQSL PLAFTSSEKR STTSVSQWSN 1050
TVLTNTIMSS SSNVISTNEK PSSTTSPYNF SSGYSLPSSS TPSQYSLSTA 1100
TTTINGIKTV YTTWCPLAEK STVAASSQSS RSVDRFVSSS KPSSSLSQTS 1150
IQYTLSTATT TISGLKTVYT TWCPLTSKST LGATTQTSST AKVRITSASS 1200
ATSTSISLST STESESSSGY LSKGVCSGTE CTQDVPTQSS SPASTLAYSP 1250
SVSTSSSSSF STTTASTLTS THTSVPLLPS SSSISASSPS STSLLSTSLP 1300
SPAFTSSTLP TATAVSSSTF IASSLPLSSK SSLSLSPVSS SILMSQFSSS 1350
SSSSSSLASL PSLSISPTVD TVSVLQPTTS IATLTCTDSQ CQQEVSTICN 1400
GSNCDDVTST ATTPPSTVTD TMTCTGSECQ KTTSSSCDGY SCKVSETYKS 1450
SATISACSGE GCQASATSEL NSQYVTMTSV ITPSAITTTS VEVHSTESTI 1500
SITTVKPVTY TSSDTNGELI TITSSSQTVI PSVTTIITRT KVAITSAPKP 1550
TTTTYVEQRL SSSGIATSFV AAASSTWITT PIVSTYAGSA SKFLCSKFFM 1600
IMVMVINFI 1609
Length:1,609
Mass (Da):166,036
Last modified:March 1, 2004 - v2
Checksum:iB9B6E08F98996B54
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59720 Genomic DNA. Translation: CAA42254.2.
BK006937 Genomic DNA. Translation: DAA07558.1.
PIRiS25345.
RefSeqiNP_010013.2. NM_001178795.1.

Genome annotation databases

EnsemblFungiiYCR089W; YCR089W; YCR089W.
GeneIDi850451.
KEGGisce:YCR089W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59720 Genomic DNA. Translation: CAA42254.2 .
BK006937 Genomic DNA. Translation: DAA07558.1 .
PIRi S25345.
RefSeqi NP_010013.2. NM_001178795.1.

3D structure databases

ProteinModelPortali P25653.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31061. 30 interactions.
IntActi P25653. 1 interaction.
MINTi MINT-2781749.
STRINGi 4932.YCR089W.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YCR089W ; YCR089W ; YCR089W .
GeneIDi 850451.
KEGGi sce:YCR089W.

Organism-specific databases

CYGDi YCR089w.
SGDi S000000685. FIG2.

Phylogenomic databases

eggNOGi NOG12793.
OMAi FFIEINP.
OrthoDBi EOG7C8GRH.

Enzyme and pathway databases

BioCyci YEAST:G3O-29383-MONOMER.

Miscellaneous databases

NextBioi 966069.

Gene expression databases

Genevestigatori P25653.

Family and domain databases

InterProi IPR025928. Flocculin_t3_rpt.
[Graphical view ]
Pfami PF13928. Flocculin_t3. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete sequence of a 6146 bp fragment of Saccharomyces cerevisiae chromosome III contains two new open reading frames."
    Wilson C., Grisanti P., Frontali L.
    Yeast 8:569-575(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete DNA sequence of yeast chromosome III."
    Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
    , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
    Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Valles G., Volckaerts G.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 745 AND 1036.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "Comparison of cell wall proteins of Saccharomyces cerevisiae as anchors for cell surface expression of heterologous proteins."
    Van der Vaart J.M., te Biesebeke R., Chapman J.W., Toschka H.Y., Klis F.M., Verrips C.T.
    Appl. Environ. Microbiol. 63:615-620(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  6. "Pheromone-regulated genes required for yeast mating differentiation."
    Erdman S., Lin L., Malczynski M., Snyder M.
    J. Cell Biol. 140:461-483(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION.
  7. "A Saccharomyces gene family involved in invasive growth, cell-cell adhesion, and mating."
    Guo B., Styles C.A., Feng Q., Fink G.R.
    Proc. Natl. Acad. Sci. U.S.A. 97:12158-12163(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION.
  8. "Maintenance of mating cell integrity requires the adhesin Fig2p."
    Zhang M., Bennett D., Erdman S.E.
    Eukaryot. Cell 1:811-822(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "Role of Fig2p in agglutination in Saccharomyces cerevisiae."
    Jue C.K., Lipke P.N.
    Eukaryot. Cell 1:843-845(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  10. "Global analysis of the glycoproteome in Saccharomyces cerevisiae reveals new roles for protein glycosylation in eukaryotes."
    Kung L.A., Tao S.-C., Qian J., Smith M.G., Snyder M., Zhu H.
    Mol. Syst. Biol. 5:308-308(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFIG2_YEAST
AccessioniPrimary (citable) accession number: P25653
Secondary accession number(s): D6VR89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: March 1, 2004
Last modified: May 14, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

External Data

Dasty 3

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