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Protein

Factor-induced gene 2 protein

Gene

FIG2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for efficient mating. Plays a role in maintenance of cell wall integrity during mating. Important for mating cell projection shape and conjugation bridge diameter. Plays a role in cell fusion and nuclear migration.4 Publications

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • cell morphogenesis involved in conjugation with cellular fusion Source: UniProtKB
  • cell wall organization Source: UniProtKB-KW
  • cytogamy Source: UniProtKB
  • filamentous growth of a population of unicellular organisms Source: SGD
  • invasive growth in response to glucose limitation Source: SGD
  • regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Cell shape, Cell wall biogenesis/degradation, Conjugation, Pheromone response

Enzyme and pathway databases

BioCyciYEAST:G3O-29383-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Factor-induced gene 2 protein
Alternative name(s):
Cell wall adhesin FIG2
Gene namesi
Name:FIG2
Ordered Locus Names:YCR089W
ORF Names:YCR1102, YCR89W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCR089W.
SGDiS000000685. FIG2.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • extracellular region Source: UniProtKB-KW
  • fungal-type cell wall Source: UniProtKB
  • mating projection Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000002126423 – 1588Factor-induced gene 2 proteinAdd BLAST1566
PropeptideiPRO_00003724521589 – 1609Removed in mature formSequence analysisAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...)Sequence analysis1
Glycosylationi231N-linked (GlcNAc...)Sequence analysis1
Glycosylationi298N-linked (GlcNAc...)Sequence analysis1
Glycosylationi347N-linked (GlcNAc...)Sequence analysis1
Glycosylationi386N-linked (GlcNAc...)Sequence analysis1
Glycosylationi426N-linked (GlcNAc...)Sequence analysis1
Glycosylationi495N-linked (GlcNAc...)Sequence analysis1
Glycosylationi535N-linked (GlcNAc...)Sequence analysis1
Glycosylationi661N-linked (GlcNAc...)Sequence analysis1
Glycosylationi674N-linked (GlcNAc...)Sequence analysis1
Glycosylationi713N-linked (GlcNAc...)Sequence analysis1
Glycosylationi889N-linked (GlcNAc...)Sequence analysis1
Glycosylationi907N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1079N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1400N-linked (GlcNAc...)Sequence analysis1
Lipidationi1588GPI-anchor amidated glycineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Expressioni

Inductioni

By mating pheromones. By cells of the opposite mating type.3 Publications

Interactioni

Protein-protein interaction databases

BioGridi31061. 32 interactors.
IntActiP25653. 1 interactor.
MINTiMINT-2781749.

Structurei

3D structure databases

ProteinModelPortaliP25653.
SMRiP25653.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi30 – 1366Ser-richAdd BLAST1337
Compositional biasi529 – 1554Thr-richAdd BLAST1026

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiP25653.
OMAiITEYVTW.
OrthoDBiEOG092C0ELQ.

Family and domain databases

InterProiIPR025928. Flocculin_t3_rpt.
[Graphical view]
PfamiPF13928. Flocculin_t3. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25653-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSFASLGLI YSVVNLLTRV EAQIVFYQNS STSLPVPTLV STSIADFHES
60 70 80 90 100
SSTGEVQYSS SYSYVQPSID SFTSSSFLTS FEAPTETSSS YAVSSSLITS
110 120 130 140 150
DTFSSYSDIF DEETSSLIST SAASSEKASS TLSSTAQPHR TSHSSSSFEL
160 170 180 190 200
PVTAPSSSSL PSSTSLTFTS VNPSQSWTSF NSEKSSALSS TIDFTSSEIS
210 220 230 240 250
GSTSPKSLES FDTTGTITSS YSPSPSSKNS NQTSLLSPLE PLSSSSGDLI
260 270 280 290 300
LSSTIQATTN DQTSKTIPTL VDATSSLPPT LRSSSMAPTS GSDSISHNFT
310 320 330 340 350
SPPSKTSGNY DVLTSNSIDP SLFTTTSEYS STQLSSLNRA SKSETVNFTA
360 370 380 390 400
SIASTPFGTD SATSLIDPIS SVGSTASSFV GISTANFSTQ GNSNYVPEST
410 420 430 440 450
ASGSSQYQDW SSSSLPLSQT TWVVINTTNT QGSVTSTTSP AYVSTATKTV
460 470 480 490 500
DGVITEYVTW CPLTQTKSQA IGVSSSISSV PQASSFSGSS ILSSNSSTLA
510 520 530 540 550
ASNNVPESTA SGSSQYQDWS SSSLPLSQTT WVVINTTNTQ GSVTSTTSPA
560 570 580 590 600
YVSTATKTVD GVITEYVTWC PLTQTKSQAI GISSSTISAT QTSKPSSILT
610 620 630 640 650
LGISTLQLSD ATFKGTETIN THLMTESTSI TEPTYFSGTS DSFYLCTSEV
660 670 680 690 700
NLASSLSSYP NFSSSEGSTA TITNSTVTFG STSKYPSTSV SNPTEASQHV
710 720 730 740 750
SSSVNSLTDF TSNSTETIAV ISNIHKTSSN KDYSLTTTQL KTSGMQTLVL
760 770 780 790 800
STVTTTVNGA ATEYTTWCPA SSIAYTTSIS YKTLVLTTEV CSHSECTPTV
810 820 830 840 850
ITSVTATSST IPLLSTSSST VLSSTVSEGA KNPAASEVTI NTQVSATSEA
860 870 880 890 900
TSTSTQVSAT SATATASESS TTSQVSTASE TISTLGTQNF TTTGSLLFPA
910 920 930 940 950
LSTEMINTTV VSRKTLIIST EVCSHSKCVP TVITEVVTSK GTPSNGHSSQ
960 970 980 990 1000
TLQTEAVEVT LSSHQTVTMS TEVCSNSICT PTVITSVQMR STPFPYLTSS
1010 1020 1030 1040 1050
TSSSSLASTK KSSLEASSEM STFSVSTQSL PLAFTSSEKR STTSVSQWSN
1060 1070 1080 1090 1100
TVLTNTIMSS SSNVISTNEK PSSTTSPYNF SSGYSLPSSS TPSQYSLSTA
1110 1120 1130 1140 1150
TTTINGIKTV YTTWCPLAEK STVAASSQSS RSVDRFVSSS KPSSSLSQTS
1160 1170 1180 1190 1200
IQYTLSTATT TISGLKTVYT TWCPLTSKST LGATTQTSST AKVRITSASS
1210 1220 1230 1240 1250
ATSTSISLST STESESSSGY LSKGVCSGTE CTQDVPTQSS SPASTLAYSP
1260 1270 1280 1290 1300
SVSTSSSSSF STTTASTLTS THTSVPLLPS SSSISASSPS STSLLSTSLP
1310 1320 1330 1340 1350
SPAFTSSTLP TATAVSSSTF IASSLPLSSK SSLSLSPVSS SILMSQFSSS
1360 1370 1380 1390 1400
SSSSSSLASL PSLSISPTVD TVSVLQPTTS IATLTCTDSQ CQQEVSTICN
1410 1420 1430 1440 1450
GSNCDDVTST ATTPPSTVTD TMTCTGSECQ KTTSSSCDGY SCKVSETYKS
1460 1470 1480 1490 1500
SATISACSGE GCQASATSEL NSQYVTMTSV ITPSAITTTS VEVHSTESTI
1510 1520 1530 1540 1550
SITTVKPVTY TSSDTNGELI TITSSSQTVI PSVTTIITRT KVAITSAPKP
1560 1570 1580 1590 1600
TTTTYVEQRL SSSGIATSFV AAASSTWITT PIVSTYAGSA SKFLCSKFFM

IMVMVINFI
Length:1,609
Mass (Da):166,036
Last modified:March 1, 2004 - v2
Checksum:iB9B6E08F98996B54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42254.2.
BK006937 Genomic DNA. Translation: DAA07558.1.
PIRiS25345.
RefSeqiNP_010013.2. NM_001178795.1.

Genome annotation databases

EnsemblFungiiCAA42254; CAA42254; CAA42254.
YCR089W; YCR089W; YCR089W.
GeneIDi850451.
KEGGisce:YCR089W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42254.2.
BK006937 Genomic DNA. Translation: DAA07558.1.
PIRiS25345.
RefSeqiNP_010013.2. NM_001178795.1.

3D structure databases

ProteinModelPortaliP25653.
SMRiP25653.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31061. 32 interactors.
IntActiP25653. 1 interactor.
MINTiMINT-2781749.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAA42254; CAA42254; CAA42254.
YCR089W; YCR089W; YCR089W.
GeneIDi850451.
KEGGisce:YCR089W.

Organism-specific databases

EuPathDBiFungiDB:YCR089W.
SGDiS000000685. FIG2.

Phylogenomic databases

InParanoidiP25653.
OMAiITEYVTW.
OrthoDBiEOG092C0ELQ.

Enzyme and pathway databases

BioCyciYEAST:G3O-29383-MONOMER.

Miscellaneous databases

PROiP25653.

Family and domain databases

InterProiIPR025928. Flocculin_t3_rpt.
[Graphical view]
PfamiPF13928. Flocculin_t3. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFIG2_YEAST
AccessioniPrimary (citable) accession number: P25653
Secondary accession number(s): D6VR89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: March 1, 2004
Last modified: November 2, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.