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Protein

Monopolin complex subunit CSM1

Gene

CSM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the monopolin complex which promotes monoorientation during meiosis I, required for chromosome segregation during meiosis. Plays also a mitotic role in DNA replication.5 Publications

Miscellaneous

Present with 1920 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • microtubule site clamp Source: GO_Central

GO - Biological processi

  • attachment of mitotic spindle microtubules to kinetochore Source: GO_Central
  • attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation Source: SGD
  • homologous chromosome segregation Source: SGD
  • meiotic chromosome segregation Source: SGD
  • meiotic sister chromatid segregation Source: GO_Central
  • protein localization to nucleolar rDNA repeats Source: SGD
  • rDNA condensation Source: SGD

Keywordsi

Biological processMeiosis

Enzyme and pathway databases

BioCyciYEAST:G3O-29381-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Monopolin complex subunit CSM1
Alternative name(s):
Chromosome segregation in meiosis protein 1
Gene namesi
Name:CSM1
Synonyms:SPO86
Ordered Locus Names:YCR086W
ORF Names:YCR86W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCR086W.
SGDiS000000682. CSM1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002025771 – 190Monopolin complex subunit CSM1Add BLAST190

Proteomic databases

MaxQBiP25651.
PRIDEiP25651.

Interactioni

Subunit structurei

Component of the monopolin complex composed of at least CSM1, LRS4 and MAM1. The complex associates with the kinetochore. Interacts with CDC46, CDC47, GIC1, GIC2, MCM3 and NUR1.4 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • microtubule site clamp Source: GO_Central

Protein-protein interaction databases

BioGridi31058. 449 interactors.
DIPiDIP-1283N.
IntActiP25651. 61 interactors.
MINTiMINT-391333.
STRINGi4932.YCR086W.

Structurei

Secondary structure

1190
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 15Combined sources5
Helixi71 – 82Combined sources12
Beta strandi83 – 91Combined sources9
Beta strandi96 – 102Combined sources7
Beta strandi116 – 122Combined sources7
Turni126 – 128Combined sources3
Beta strandi131 – 137Combined sources7
Helixi143 – 150Combined sources8
Helixi155 – 158Combined sources4
Beta strandi161 – 164Combined sources4
Helixi165 – 167Combined sources3
Helixi168 – 179Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3N4RX-ray2.60A/B/C/D69-181[»]
3N4SX-ray2.35A/B/C/D69-181[»]
3N4XX-ray3.41A/B/C/D1-190[»]
3N7NX-ray3.90A/B/C/D1-190[»]
5KTBX-ray3.05A/B1-190[»]
5V1AX-ray2.14A69-190[»]
5V3NX-ray1.30A69-181[»]
ProteinModelPortaliP25651.
SMRiP25651.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP25651.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili31 – 70Sequence analysisAdd BLAST40

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000000914.
InParanoidiP25651.
OMAiMDYKLGF.
OrthoDBiEOG092C5FOA.

Family and domain databases

InterProiView protein in InterPro
IPR020981. Monopolin_cplx_su-Csm1/Pcs1.
PfamiView protein in Pfam
PF12539. Csm1. 1 hit.

Sequencei

Sequence statusi: Complete.

P25651-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPLTVYKNS VKQQIDSADL LVANLVNENF VLSEKLDTKA TEIKQLQKQI
60 70 80 90 100
DSLNAQVKEL KTQTSQQAEN SEVIKDLYEY LCNVRVHKSY EDDSGLWFDI
110 120 130 140 150
SQGTHSGGSS DDYSIMDYKL GFVKGQAQVT EVIYAPVLKQ RSTEELYSLQ
160 170 180 190
SKLPEYLFET LSFPLSSLNQ FYNKIAKSLN KKREKKDETE
Length:190
Mass (Da):21,751
Last modified:May 1, 1992 - v1
Checksum:i9650E0DA89B31CC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42261.1.
AY558153 Genomic DNA. Translation: AAS56479.1.
BK006937 Genomic DNA. Translation: DAA07555.1.
PIRiS19501.
RefSeqiNP_010009.1. NM_001178792.1.

Genome annotation databases

EnsemblFungiiCAA42261; CAA42261; CAA42261.
YCR086W; YCR086W; YCR086W.
GeneIDi850447.
KEGGisce:YCR086W.

Similar proteinsi

Entry informationi

Entry nameiCSM1_YEAST
AccessioniPrimary (citable) accession number: P25651
Secondary accession number(s): D6VR86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: September 27, 2017
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names