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P25651 (CSM1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Monopolin complex subunit CSM1
Alternative name(s):
Chromosome segregation in meiosis protein 1
Gene names
Name:CSM1
Synonyms:SPO86
Ordered Locus Names:YCR086W
ORF Names:YCR86W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length190 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the monopolin complex which promotes monoorientation during meiosis I, required for chromosome segregation during meiosis. Plays also a mitotic role in DNA replication. Ref.4 Ref.6 Ref.9 Ref.10 Ref.11

Subunit structure

Component of the monopolin complex composed of at least CSM1, LRS4 and MAM1. The complex associates with the kinetochore. Interacts with CDC46, CDC47, GIC1, GIC2, MCM3 and NUR1. Ref.5 Ref.6 Ref.9 Ref.11

Subcellular location

Nucleusnucleolus. Chromosomecentromere. Note: Transiently released from the nucleolus and localizes to the centromere regions during late pachytene. Ref.5 Ref.6 Ref.7 Ref.9

Miscellaneous

Present with 1920 molecules/cell in log phase SD medium.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 190190Monopolin complex subunit CSM1
PRO_0000202577

Regions

Coiled coil31 – 7040 Potential

Secondary structure

.................... 190
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P25651 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: 9650E0DA89B31CC5

FASTA19021,751
        10         20         30         40         50         60 
MDPLTVYKNS VKQQIDSADL LVANLVNENF VLSEKLDTKA TEIKQLQKQI DSLNAQVKEL 

        70         80         90        100        110        120 
KTQTSQQAEN SEVIKDLYEY LCNVRVHKSY EDDSGLWFDI SQGTHSGGSS DDYSIMDYKL 

       130        140        150        160        170        180 
GFVKGQAQVT EVIYAPVLKQ RSTEELYSLQ SKLPEYLFET LSFPLSSLNQ FYNKIAKSLN 

       190 
KKREKKDETE 

« Hide

References

« Hide 'large scale' references
[1]"The complete DNA sequence of yeast chromosome III."
Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M. expand/collapse author list , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"A screen for genes required for meiosis and spore formation based on whole-genome expression."
Rabitsch K.P., Toth A., Galova M., Schleiffer A., Schaffner G., Aigner E., Rupp C., Penkner A.M., Moreno-Borchart A.C., Primig M., Esposito R.E., Klein F., Knop M., Nasmyth K.
Curr. Biol. 11:1001-1009(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"A protein interaction map for cell polarity development."
Drees B.L., Sundin B.A., Brazeau E., Caviston J.P., Chen G.-C., Guo W., Kozminski K.G., Lau M.W., Moskow J.J., Tong A., Schenkman L.R., McKenzie A. III, Brennwald P.J., Longtine M., Bi E., Chan C., Novick P., Boone C. expand/collapse author list , Pringle J.R., Davis T.N., Fields S., Drubin D.G.
J. Cell Biol. 154:549-571(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH GIC1 AND GIC2, SUBCELLULAR LOCATION.
[6]"Kinetochore recruitment of two nucleolar proteins is required for homolog segregation in meiosis I."
Rabitsch K.P., Petronczki M., Javerzat J.-P., Genier S., Chwalla B., Schleiffer A., Tanaka T.U., Nasmyth K.
Dev. Cell 4:535-548(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION IN THE MONOPOLIN COMPLEX.
[7]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[8]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[9]"Saccharomyces cerevisiae CSM1 gene encoding a protein influencing chromosome segregation in meiosis I interacts with elements of the DNA replication complex."
Wysocka M., Rytka J., Kurlandzka A.
Exp. Cell Res. 294:592-602(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CDC46; CDC47 AND MCM3.
[10]"A DNA integrity network in the yeast Saccharomyces cerevisiae."
Pan X., Ye P., Yuan D.S., Wang X., Bader J.S., Boeke J.D.
Cell 124:1069-1081(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[11]"Role for perinuclear chromosome tethering in maintenance of genome stability."
Mekhail K., Seebacher J., Gygi S.P., Moazed D.
Nature 456:667-670(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH NUR1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X59720 Genomic DNA. Translation: CAA42261.1.
AY558153 Genomic DNA. Translation: AAS56479.1.
BK006937 Genomic DNA. Translation: DAA07555.1.
PIRS19501.
RefSeqNP_010009.1. NM_001178792.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3N4RX-ray2.60A/B/C/D69-181[»]
3N4SX-ray2.35A/B/C/D69-181[»]
3N4XX-ray3.41A/B/C/D1-190[»]
3N7NX-ray3.90A/B/C/D1-190[»]
4EMCX-ray3.05A/B1-190[»]
ProteinModelPortalP25651.
SMRP25651. Positions 13-181.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31058. 279 interactions.
DIPDIP-1283N.
IntActP25651. 54 interactions.
MINTMINT-391333.
STRING4932.YCR086W.

Proteomic databases

MaxQBP25651.
PaxDbP25651.
PeptideAtlasP25651.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYCR086W; YCR086W; YCR086W.
GeneID850447.
KEGGsce:YCR086W.

Organism-specific databases

CYGDYCR086w.
SGDS000000682. CSM1.

Phylogenomic databases

eggNOGNOG43170.
HOGENOMHOG000000914.
OMANGIMDYK.
OrthoDBEOG7S4XJP.

Enzyme and pathway databases

BioCycYEAST:G3O-29381-MONOMER.

Gene expression databases

GenevestigatorP25651.

Family and domain databases

InterProIPR020981. Monopolin_cplx_su-Csm1/Pcs1.
[Graphical view]
PfamPF12539. Csm1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP25651.
NextBio966060.

Entry information

Entry nameCSM1_YEAST
AccessionPrimary (citable) accession number: P25651
Secondary accession number(s): D6VR86
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: June 11, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome III

Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

PDB cross-references

Index of Protein Data Bank (PDB) cross-references