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P25651

- CSM1_YEAST

UniProt

P25651 - CSM1_YEAST

Protein

Monopolin complex subunit CSM1

Gene

CSM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
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    Functioni

    Component of the monopolin complex which promotes monoorientation during meiosis I, required for chromosome segregation during meiosis. Plays also a mitotic role in DNA replication.5 Publications

    GO - Molecular functioni

    1. identical protein binding Source: IntAct
    2. protein binding Source: IntAct

    GO - Biological processi

    1. homologous chromosome segregation Source: SGD
    2. meiotic chromosome segregation Source: SGD
    3. protein localization to nucleolar rDNA repeats Source: SGD
    4. rDNA condensation Source: SGD

    Keywords - Biological processi

    Meiosis

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29381-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Monopolin complex subunit CSM1
    Alternative name(s):
    Chromosome segregation in meiosis protein 1
    Gene namesi
    Name:CSM1
    Synonyms:SPO86
    Ordered Locus Names:YCR086W
    ORF Names:YCR86W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome III

    Organism-specific databases

    CYGDiYCR086w.
    SGDiS000000682. CSM1.

    Subcellular locationi

    Nucleusnucleolus. Chromosomecentromere
    Note: Transiently released from the nucleolus and localizes to the centromere regions during late pachytene.

    GO - Cellular componenti

    1. monopolin complex Source: SGD
    2. nuclear envelope Source: SGD
    3. nucleolus Source: SGD

    Keywords - Cellular componenti

    Centromere, Chromosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 190190Monopolin complex subunit CSM1PRO_0000202577Add
    BLAST

    Proteomic databases

    MaxQBiP25651.
    PaxDbiP25651.
    PeptideAtlasiP25651.

    Expressioni

    Gene expression databases

    GenevestigatoriP25651.

    Interactioni

    Subunit structurei

    Component of the monopolin complex composed of at least CSM1, LRS4 and MAM1. The complex associates with the kinetochore. Interacts with CDC46, CDC47, GIC1, GIC2, MCM3 and NUR1.4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself3EBI-22001,EBI-22001
    DSE3Q087293EBI-22001,EBI-32325
    DSN1P405683EBI-22001,EBI-25398
    LRS4Q0408716EBI-22001,EBI-32189
    MAM1P400658EBI-22001,EBI-22643
    MCM3P242792EBI-22001,EBI-10541
    MCM5P294962EBI-22001,EBI-10549
    MCM7P381323EBI-22001,EBI-4300
    TOF2Q022084EBI-22001,EBI-27048

    Protein-protein interaction databases

    BioGridi31058. 280 interactions.
    DIPiDIP-1283N.
    IntActiP25651. 54 interactions.
    MINTiMINT-391333.
    STRINGi4932.YCR086W.

    Structurei

    Secondary structure

    1
    190
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi71 – 8212
    Beta strandi83 – 919
    Beta strandi96 – 1027
    Beta strandi116 – 1227
    Beta strandi131 – 1377
    Beta strandi139 – 1413
    Helixi143 – 1508
    Helixi155 – 1584
    Beta strandi161 – 1644
    Helixi165 – 1673
    Helixi168 – 17912

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3N4RX-ray2.60A/B/C/D69-181[»]
    3N4SX-ray2.35A/B/C/D69-181[»]
    3N4XX-ray3.41A/B/C/D1-190[»]
    3N7NX-ray3.90A/B/C/D1-190[»]
    4EMCX-ray3.05A/B1-190[»]
    ProteinModelPortaliP25651.
    SMRiP25651. Positions 13-181.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP25651.

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili31 – 7040Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG43170.
    HOGENOMiHOG000000914.
    OMAiNGIMDYK.
    OrthoDBiEOG7S4XJP.

    Family and domain databases

    InterProiIPR020981. Monopolin_cplx_su-Csm1/Pcs1.
    [Graphical view]
    PfamiPF12539. Csm1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P25651-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPLTVYKNS VKQQIDSADL LVANLVNENF VLSEKLDTKA TEIKQLQKQI    50
    DSLNAQVKEL KTQTSQQAEN SEVIKDLYEY LCNVRVHKSY EDDSGLWFDI 100
    SQGTHSGGSS DDYSIMDYKL GFVKGQAQVT EVIYAPVLKQ RSTEELYSLQ 150
    SKLPEYLFET LSFPLSSLNQ FYNKIAKSLN KKREKKDETE 190
    Length:190
    Mass (Da):21,751
    Last modified:May 1, 1992 - v1
    Checksum:i9650E0DA89B31CC5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59720 Genomic DNA. Translation: CAA42261.1.
    AY558153 Genomic DNA. Translation: AAS56479.1.
    BK006937 Genomic DNA. Translation: DAA07555.1.
    PIRiS19501.
    RefSeqiNP_010009.1. NM_001178792.1.

    Genome annotation databases

    EnsemblFungiiYCR086W; YCR086W; YCR086W.
    GeneIDi850447.
    KEGGisce:YCR086W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59720 Genomic DNA. Translation: CAA42261.1 .
    AY558153 Genomic DNA. Translation: AAS56479.1 .
    BK006937 Genomic DNA. Translation: DAA07555.1 .
    PIRi S19501.
    RefSeqi NP_010009.1. NM_001178792.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3N4R X-ray 2.60 A/B/C/D 69-181 [» ]
    3N4S X-ray 2.35 A/B/C/D 69-181 [» ]
    3N4X X-ray 3.41 A/B/C/D 1-190 [» ]
    3N7N X-ray 3.90 A/B/C/D 1-190 [» ]
    4EMC X-ray 3.05 A/B 1-190 [» ]
    ProteinModelPortali P25651.
    SMRi P25651. Positions 13-181.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31058. 280 interactions.
    DIPi DIP-1283N.
    IntActi P25651. 54 interactions.
    MINTi MINT-391333.
    STRINGi 4932.YCR086W.

    Proteomic databases

    MaxQBi P25651.
    PaxDbi P25651.
    PeptideAtlasi P25651.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YCR086W ; YCR086W ; YCR086W .
    GeneIDi 850447.
    KEGGi sce:YCR086W.

    Organism-specific databases

    CYGDi YCR086w.
    SGDi S000000682. CSM1.

    Phylogenomic databases

    eggNOGi NOG43170.
    HOGENOMi HOG000000914.
    OMAi NGIMDYK.
    OrthoDBi EOG7S4XJP.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29381-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P25651.
    NextBioi 966060.

    Gene expression databases

    Genevestigatori P25651.

    Family and domain databases

    InterProi IPR020981. Monopolin_cplx_su-Csm1/Pcs1.
    [Graphical view ]
    Pfami PF12539. Csm1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete DNA sequence of yeast chromosome III."
      Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
      , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
      Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: FUNCTION.
    5. Cited for: INTERACTION WITH GIC1 AND GIC2, SUBCELLULAR LOCATION.
    6. "Kinetochore recruitment of two nucleolar proteins is required for homolog segregation in meiosis I."
      Rabitsch K.P., Petronczki M., Javerzat J.-P., Genier S., Chwalla B., Schleiffer A., Tanaka T.U., Nasmyth K.
      Dev. Cell 4:535-548(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION IN THE MONOPOLIN COMPLEX.
    7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    9. "Saccharomyces cerevisiae CSM1 gene encoding a protein influencing chromosome segregation in meiosis I interacts with elements of the DNA replication complex."
      Wysocka M., Rytka J., Kurlandzka A.
      Exp. Cell Res. 294:592-602(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CDC46; CDC47 AND MCM3.
    10. "A DNA integrity network in the yeast Saccharomyces cerevisiae."
      Pan X., Ye P., Yuan D.S., Wang X., Bader J.S., Boeke J.D.
      Cell 124:1069-1081(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    11. "Role for perinuclear chromosome tethering in maintenance of genome stability."
      Mekhail K., Seebacher J., Gygi S.P., Moazed D.
      Nature 456:667-670(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH NUR1.

    Entry informationi

    Entry nameiCSM1_YEAST
    AccessioniPrimary (citable) accession number: P25651
    Secondary accession number(s): D6VR86
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1920 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome III
      Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

    External Data

    Dasty 3