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Protein

[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

Gene

PTC6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein phosphatase that shows typical type 2C protein phosphatase (PP2C) activity (PubMed:17002782). Catalyzes the dephosphorylation and concomitant reactivation of the E1 alpha subunit (PDA1) of the pyruvate dehydrogenase complex (PubMed:18180296). Required for efficient mitophagy in stationary phase cells (PubMed:17166847).3 Publications

Miscellaneous

Present with 432 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

[Pyruvate dehydrogenase (acetyl-transferring)] phosphate + H2O = [pyruvate dehydrogenase (acetyl-transferring)] + phosphate.1 Publication
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.1 Publication

Cofactori

Mg2+1 Publication, Mn2+1 Publication

GO - Molecular functioni

  • [pyruvate dehydrogenase (lipoamide)] phosphatase activity Source: SGD
  • protein serine/threonine phosphatase activity Source: SGD

GO - Biological processi

  • autophagy of mitochondrion Source: SGD
  • macroautophagy Source: SGD
  • peptidyl-serine dephosphorylation Source: SGD
  • positive regulation of pyruvate dehydrogenase activity Source: SGD
  • protein dephosphorylation Source: SGD

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processAutophagy
LigandMagnesium, Manganese

Enzyme and pathway databases

BioCyciYEAST:G3O-29400-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrialCurated (EC:3.1.3.161 Publication, EC:3.1.3.431 Publication)
Short name:
PDP 2Curated
Alternative name(s):
Autophagy-related protein phosphatase 11 Publication
Phosphatase two C protein 61 Publication
Protein phosphatase 2C homolog 6Curated
Short name:
PP2C-6Curated
Protein phosphatase of PDH protein 2
Pyruvate dehydrogenase complex phosphatase 21 Publication
Short name:
PDC phosphatase 2Curated
Gene namesi
Name:PTC61 Publication
Synonyms:AUP11 Publication, PPP21 Publication
Ordered Locus Names:YCR079WImported
ORF Names:YCR79CImported, YCR79WImported
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCR079W
SGDiS000002133 PTC6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Disruption phenotypei

Confers rapamycin-sensitivity.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 34MitochondrionSequence analysisAdd BLAST34
ChainiPRO_000005778835 – 442[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrialAdd BLAST408

Proteomic databases

PaxDbiP25646
PRIDEiP25646

PTM databases

iPTMnetiP25646

Interactioni

Subunit structurei

Interacts with PRO2.1 Publication

Protein-protein interaction databases

BioGridi31053, 217 interactors
DIPiDIP-2963N
IntActiP25646, 30 interactors
MINTiP25646
STRINGi4932.YCR079W

Structurei

3D structure databases

ProteinModelPortaliP25646
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 411PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST377

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000000910
InParanoidiP25646
KOiK19708
OrthoDBiEOG092C1LOS

Family and domain databases

CDDicd00143 PP2Cc, 1 hit
InterProiView protein in InterPro
IPR015655 PP2C
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
PANTHERiPTHR13832 PTHR13832, 1 hit
PfamiView protein in Pfam
PF00481 PP2C, 1 hit
SMARTiView protein in SMART
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 2 hits
PROSITEiView protein in PROSITE
PS51746 PPM_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25646-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLGNAYAYC KPSQNVGLKL DLLRGLPGYV GHATSRINRL ENQDNYSIKM
60 70 80 90 100
MRSWPNAYGS ALNCSVFDGH GEKGAQLSQL LADKLCSSLD FPEPSWDKQD
110 120 130 140 150
LKKLVQEYAR RFPEGNYWKH KLSTFEKFYN KFIKNCNSKQ ELLLMKEGDS
160 170 180 190 200
AILGQNGGRM IFDKMGNIID KIALLTELDR LRLFYGFARF DLDQCCGLGT
210 220 230 240 250
AAGSTASSIF LYPYDDPNAP IDEGKDDDSW IISHSGLLKL IVTQVGDSKI
260 270 280 290 300
ILCDQDGIAH ALTTTHHINS SRERHRLSID PSRLDPDAFG ETRFLNNFAN
310 320 330 340 350
TRSFGDVAGK PYGISSEPDI FSFLVGNTLH LPRSERSKLP FNGDECFLAL
360 370 380 390 400
VTDGITNKLA DQEVVDLITS TVNSWGLKKA TPQFVAEETI KFIQAIATKH
410 420 430 440
SDNATCVVVR LSNWGNWPNV DRTGPQRETK LMNAQSNETK LN
Length:442
Mass (Da):49,421
Last modified:October 10, 2003 - v2
Checksum:i0F3303047F957515
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA Translation: CAC42991.1
BK006937 Genomic DNA Translation: DAA07550.1
PIRiS19493
RefSeqiNP_010003.2, NM_001180034.1

Genome annotation databases

EnsemblFungiiCAC42991; CAC42991; CAC42991
YCR079W; YCR079W; YCR079W
GeneIDi850441
KEGGisce:YCR079W

Similar proteinsi

Entry informationi

Entry nameiPDP2_YEAST
AccessioniPrimary (citable) accession number: P25646
Secondary accession number(s): D6VR81, Q8NIL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: October 10, 2003
Last modified: May 23, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

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