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Protein

54S ribosomal protein IMG2, mitochondrial

Gene

IMG2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.2 Publications

Miscellaneous

Present with 1700 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • mitochondrial translation Source: SGD

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-29371-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
54S ribosomal protein IMG2, mitochondrial
Alternative name(s):
Integrity of mitochondrial genome protein 2
Mitochondrial large ribosomal subunit protein mL491 Publication
Gene namesi
Name:IMG2
Ordered Locus Names:YCR071C
ORF Names:YCR71C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCR071C
SGDiS000000667 IMG2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 38MitochondrionSequence analysisAdd BLAST38
ChainiPRO_000003053739 – 14654S ribosomal protein IMG2, mitochondrialAdd BLAST108

Proteomic databases

MaxQBiP25642
PaxDbiP25642
PRIDEiP25642

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.2 Publications

Protein-protein interaction databases

BioGridi31046, 379 interactors
DIPiDIP-6696N
IntActiP25642, 6 interactors
MINTiP25642
STRINGi4932.YCR071C

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J6Belectron microscopy3.2071-146[»]
5MRCelectron microscopy3.25741-146[»]
5MREelectron microscopy3.75741-146[»]
5MRFelectron microscopy4.97741-146[»]
ProteinModelPortaliP25642
SMRiP25642
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000000907
InParanoidiP25642
KOiK17430
OMAiFNCNEEA
OrthoDBiEOG092C5PAI

Family and domain databases

InterProiView protein in InterPro
IPR007740 Ribosomal_L49/IMG2
PANTHERiPTHR13477 PTHR13477, 1 hit
PfamiView protein in Pfam
PF05046 Img2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25642-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISSCVTRCF GRGKCLPGPA TASIYQTIRC ISTNSNKAAE APIFPKLEDV
60 70 80 90 100
KMHELIGNNN FGKKTYYVER SRTGNLPVYS AYKNGGNKII TEIRKIEGDV
110 120 130 140
IQLRNDLQEQ LPFIPKKSWS VVMQSKKIII KGNAVEAVKR VLTKKF
Length:146
Mass (Da):16,380
Last modified:May 16, 2003 - v2
Checksum:i0A703005418F783F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120 – 121SV → LW in AAT92839 (PubMed:17322287).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA Translation: CAC42988.1
AY692820 Genomic DNA Translation: AAT92839.1
BK006937 Genomic DNA Translation: DAA07542.1
PIRiS19486
RefSeqiNP_009996.2, NM_001178781.1

Genome annotation databases

EnsemblFungiiCAC42988; CAC42988; CAC42988
YCR071C; YCR071C; YCR071C
GeneIDi850434
KEGGisce:YCR071C

Similar proteinsi

Entry informationi

Entry nameiIMG2_YEAST
AccessioniPrimary (citable) accession number: P25642
Secondary accession number(s): D6VR73, Q6B2B0, Q96VG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 16, 2003
Last modified: May 23, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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