ID   TAH1_YEAST              Reviewed;         111 AA.
AC   P25638; D6VR65;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   27-MAR-2024, entry version 176.
DE   RecName: Full=TPR repeat-containing protein associated with Hsp90;
GN   Name=TAH1; OrderedLocusNames=YCR060W; ORFNames=YCR60W;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=1574125; DOI=10.1038/357038a0;
RA   Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M.,
RA   Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G.,
RA   Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A.,
RA   Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M., Carcano C.,
RA   Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M.,
RA   Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C.,
RA   Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F.,
RA   Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C.,
RA   Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E.,
RA   Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P.,
RA   Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J.,
RA   Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P.,
RA   Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M.,
RA   Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P.,
RA   Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G.,
RA   Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E.,
RA   Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F.,
RA   Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L.,
RA   Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J.,
RA   Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M.,
RA   Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A.,
RA   Richterich P., Roberts A.B., Rodriguez F., Sanz E.,
RA   Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J.,
RA   Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I.,
RA   Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M.,
RA   Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M.,
RA   Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D.,
RA   Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K.,
RA   Sgouros J.G.;
RT   "The complete DNA sequence of yeast chromosome III.";
RL   Nature 357:38-46(1992).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
RN   [4]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [5]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [6]
RP   INTERACTION WITH HSP90, IDENTIFICATION IN THE R2PT COMPLEX, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=15766533; DOI=10.1016/j.cell.2004.12.024;
RA   Zhao R., Davey M.G., Hsu Y.-C., Kaplanek P., Tong A., Parsons A.B.,
RA   Krogan N.J., Cagney G., Mai D., Greenblatt J.F., Boone C., Emili A.,
RA   Houry W.A.;
RT   "Navigating the chaperone network: an integrative map of physical and
RT   genetic interactions mediated by the hsp90 chaperone.";
RL   Cell 120:715-727(2005).
RN   [7]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR
RP   METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP   [LARGE SCALE ANALYSIS].
RX   PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA   Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA   Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA   Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT   "N-terminal acetylome analyses and functional insights of the N-terminal
RT   acetyltransferase NatB.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC   -!- SUBUNIT: Component of the R2TP complex composed at least of RVB1, RVB2,
CC       TAH1 and PIH1. Interacts also with HSP90.
CC       {ECO:0000269|PubMed:15766533}.
CC   -!- INTERACTION:
CC       P25638; P02829: HSP82; NbExp=10; IntAct=EBI-21956, EBI-8659;
CC       P25638; P38768: PIH1; NbExp=17; IntAct=EBI-21956, EBI-24499;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus
CC       {ECO:0000269|PubMed:14562095}.
CC   -!- MISCELLANEOUS: Present with 1660 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
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DR   EMBL; X59720; CAA42288.1; -; Genomic_DNA.
DR   EMBL; AY558151; AAS56477.1; -; Genomic_DNA.
DR   EMBL; BK006937; DAA07534.1; -; Genomic_DNA.
DR   PIR; S19475; S19475.
DR   RefSeq; NP_009986.1; NM_001178771.1.
DR   PDB; 2L6J; NMR; -; A=1-111.
DR   PDB; 2LSU; NMR; -; A=2-111.
DR   PDB; 2LSV; NMR; -; A=2-111.
DR   PDB; 2MNJ; NMR; -; A=93-111.
DR   PDB; 4CGQ; X-ray; 2.00 A; A=1-111.
DR   PDB; 4CGU; X-ray; 2.11 A; A=1-111.
DR   PDBsum; 2L6J; -.
DR   PDBsum; 2LSU; -.
DR   PDBsum; 2LSV; -.
DR   PDBsum; 2MNJ; -.
DR   PDBsum; 4CGQ; -.
DR   PDBsum; 4CGU; -.
DR   AlphaFoldDB; P25638; -.
DR   BMRB; P25638; -.
DR   SMR; P25638; -.
DR   BioGRID; 31037; 144.
DR   ComplexPortal; CPX-1814; R2TP co-chaperone complex.
DR   DIP; DIP-5000N; -.
DR   IntAct; P25638; 7.
DR   MINT; P25638; -.
DR   STRING; 4932.YCR060W; -.
DR   iPTMnet; P25638; -.
DR   PaxDb; 4932-YCR060W; -.
DR   PeptideAtlas; P25638; -.
DR   EnsemblFungi; YCR060W_mRNA; YCR060W; YCR060W.
DR   GeneID; 850424; -.
DR   KEGG; sce:YCR060W; -.
DR   AGR; SGD:S000000656; -.
DR   SGD; S000000656; TAH1.
DR   VEuPathDB; FungiDB:YCR060W; -.
DR   eggNOG; KOG1124; Eukaryota.
DR   HOGENOM; CLU_132745_0_0_1; -.
DR   InParanoid; P25638; -.
DR   OMA; PIGYSNK; -.
DR   OrthoDB; 178259at2759; -.
DR   BioCyc; YEAST:G3O-29365-MONOMER; -.
DR   BioGRID-ORCS; 850424; 6 hits in 10 CRISPR screens.
DR   ChiTaRS; TAH1; yeast.
DR   PRO; PR:P25638; -.
DR   Proteomes; UP000002311; Chromosome III.
DR   RNAct; P25638; Protein.
DR   GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR   GO; GO:0005634; C:nucleus; HDA:SGD.
DR   GO; GO:0097255; C:R2TP complex; IDA:SGD.
DR   GO; GO:0051087; F:protein-folding chaperone binding; IDA:SGD.
DR   GO; GO:0000492; P:box C/D snoRNP assembly; IMP:SGD.
DR   GO; GO:0006457; P:protein folding; IMP:SGD.
DR   GO; GO:0050821; P:protein stabilization; NAS:ComplexPortal.
DR   DisProt; DP01243; -.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   IDEAL; IID50204; -.
DR   InterPro; IPR047150; SGT.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR45831; LD24721P; 1.
DR   PANTHER; PTHR45831:SF2; LD24721P; 1.
DR   Pfam; PF13432; TPR_16; 1.
DR   SMART; SM00028; TPR; 2.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Acetylation; Cytoplasm; Nucleus; Reference proteome; Repeat;
KW   TPR repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0007744|PubMed:22814378"
FT   CHAIN           2..111
FT                   /note="TPR repeat-containing protein associated with Hsp90"
FT                   /id="PRO_0000106352"
FT   REPEAT          4..37
FT                   /note="TPR 1"
FT   REPEAT          39..71
FT                   /note="TPR 2"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0007744|PubMed:22814378"
FT   HELIX           3..16
FT                   /evidence="ECO:0007829|PDB:4CGQ"
FT   HELIX           20..33
FT                   /evidence="ECO:0007829|PDB:4CGQ"
FT   HELIX           38..50
FT                   /evidence="ECO:0007829|PDB:4CGQ"
FT   HELIX           54..65
FT                   /evidence="ECO:0007829|PDB:4CGQ"
FT   HELIX           71..73
FT                   /evidence="ECO:0007829|PDB:4CGU"
FT   HELIX           76..90
FT                   /evidence="ECO:0007829|PDB:4CGQ"
FT   STRAND          92..95
FT                   /evidence="ECO:0007829|PDB:4CGU"
FT   STRAND          98..100
FT                   /evidence="ECO:0007829|PDB:4CGU"
FT   STRAND          105..109
FT                   /evidence="ECO:0007829|PDB:2L6J"
SQ   SEQUENCE   111 AA;  12511 MW;  3738DE6F227F803A CRC64;
     MSQFEKQKEQ GNSLFKQGLY REAVHCYDQL ITAQPQNPVG YSNKAMALIK LGEYTQAIQM
     CQQGLRYTST AEHVAIRSKL QYRLELAQGA VGSVQIPVVE VDELPEGYDR S
//