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P25638

- TAH1_YEAST

UniProt

P25638 - TAH1_YEAST

Protein

TPR repeat-containing protein associated with Hsp90

Gene

TAH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. chaperone binding Source: SGD
    2. protein binding Source: IntAct

    GO - Biological processi

    1. box C/D snoRNP assembly Source: SGD
    2. protein folding Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29365-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    TPR repeat-containing protein associated with Hsp90
    Gene namesi
    Name:TAH1
    Ordered Locus Names:YCR060W
    ORF Names:YCR60W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome III

    Organism-specific databases

    CYGDiYCR060w.
    SGDiS000000656. TAH1.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell
    3. R2TP complex Source: SGD

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 111110TPR repeat-containing protein associated with Hsp90PRO_0000106352Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiP25638.
    PeptideAtlasiP25638.

    Expressioni

    Gene expression databases

    GenevestigatoriP25638.

    Interactioni

    Subunit structurei

    Component of the R2TP complex composed at least of RVB1, RVB2, TAH1 and PIH1. Interacts also with HSP90.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HSP82P028293EBI-21956,EBI-8659
    PIH1P387688EBI-21956,EBI-24499

    Protein-protein interaction databases

    BioGridi31037. 38 interactions.
    DIPiDIP-5000N.
    IntActiP25638. 6 interactions.
    MINTiMINT-488866.
    STRINGi4932.YCR060W.

    Structurei

    Secondary structure

    1
    111
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi3 – 1715
    Helixi20 – 3314
    Helixi38 – 5013
    Helixi54 – 6411
    Helixi65 – 673
    Helixi71 – 733
    Helixi74 – 9118
    Beta strandi92 – 954
    Beta strandi98 – 1003
    Beta strandi105 – 1095

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2L6JNMR-A1-111[»]
    2LSUNMR-A2-111[»]
    2LSVNMR-A2-111[»]
    4CGUX-ray2.11A1-111[»]
    ProteinModelPortaliP25638.
    SMRiP25638. Positions 1-111.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati4 – 3734TPR 1Add
    BLAST
    Repeati39 – 7133TPR 2Add
    BLAST

    Sequence similaritiesi

    Contains 2 TPR repeats.Curated

    Keywords - Domaini

    Repeat, TPR repeat

    Phylogenomic databases

    eggNOGiCOG0457.
    HOGENOMiHOG000000905.
    OrthoDBiEOG71GB6F.

    Family and domain databases

    Gene3Di1.25.40.10. 1 hit.
    InterProiIPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    [Graphical view]
    PROSITEiPS50293. TPR_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P25638-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQFEKQKEQ GNSLFKQGLY REAVHCYDQL ITAQPQNPVG YSNKAMALIK    50
    LGEYTQAIQM CQQGLRYTST AEHVAIRSKL QYRLELAQGA VGSVQIPVVE 100
    VDELPEGYDR S 111
    Length:111
    Mass (Da):12,511
    Last modified:May 1, 1992 - v1
    Checksum:i3738DE6F227F803A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59720 Genomic DNA. Translation: CAA42288.1.
    AY558151 Genomic DNA. Translation: AAS56477.1.
    BK006937 Genomic DNA. Translation: DAA07534.1.
    PIRiS19475.
    RefSeqiNP_009986.1. NM_001178771.1.

    Genome annotation databases

    EnsemblFungiiYCR060W; YCR060W; YCR060W.
    GeneIDi850424.
    KEGGisce:YCR060W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59720 Genomic DNA. Translation: CAA42288.1 .
    AY558151 Genomic DNA. Translation: AAS56477.1 .
    BK006937 Genomic DNA. Translation: DAA07534.1 .
    PIRi S19475.
    RefSeqi NP_009986.1. NM_001178771.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2L6J NMR - A 1-111 [» ]
    2LSU NMR - A 2-111 [» ]
    2LSV NMR - A 2-111 [» ]
    4CGU X-ray 2.11 A 1-111 [» ]
    ProteinModelPortali P25638.
    SMRi P25638. Positions 1-111.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31037. 38 interactions.
    DIPi DIP-5000N.
    IntActi P25638. 6 interactions.
    MINTi MINT-488866.
    STRINGi 4932.YCR060W.

    Proteomic databases

    PaxDbi P25638.
    PeptideAtlasi P25638.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YCR060W ; YCR060W ; YCR060W .
    GeneIDi 850424.
    KEGGi sce:YCR060W.

    Organism-specific databases

    CYGDi YCR060w.
    SGDi S000000656. TAH1.

    Phylogenomic databases

    eggNOGi COG0457.
    HOGENOMi HOG000000905.
    OrthoDBi EOG71GB6F.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29365-MONOMER.

    Miscellaneous databases

    NextBioi 965998.

    Gene expression databases

    Genevestigatori P25638.

    Family and domain databases

    Gene3Di 1.25.40.10. 1 hit.
    InterProi IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    [Graphical view ]
    PROSITEi PS50293. TPR_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete DNA sequence of yeast chromosome III."
      Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
      , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
      Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone."
      Zhao R., Davey M.G., Hsu Y.-C., Kaplanek P., Tong A., Parsons A.B., Krogan N.J., Cagney G., Mai D., Greenblatt J.F., Boone C., Emili A., Houry W.A.
      Cell 120:715-727(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HSP90, IDENTIFICATION IN THE R2PT COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTAH1_YEAST
    AccessioniPrimary (citable) accession number: P25638
    Secondary accession number(s): D6VR65
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1660 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome III
      Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

    External Data

    Dasty 3