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P25638

- TAH1_YEAST

UniProt

P25638 - TAH1_YEAST

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Protein

TPR repeat-containing protein associated with Hsp90

Gene
TAH1, YCR060W, YCR60W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. chaperone binding Source: SGD
  2. protein binding Source: IntAct

GO - Biological processi

  1. box C/D snoRNP assembly Source: SGD
  2. protein folding Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-29365-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
TPR repeat-containing protein associated with Hsp90
Gene namesi
Name:TAH1
Ordered Locus Names:YCR060W
ORF Names:YCR60W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome III

Organism-specific databases

CYGDiYCR060w.
SGDiS000000656. TAH1.

Subcellular locationi

Cytoplasm. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
  3. R2TP complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 111110TPR repeat-containing protein associated with Hsp90PRO_0000106352Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP25638.
PeptideAtlasiP25638.

Expressioni

Gene expression databases

GenevestigatoriP25638.

Interactioni

Subunit structurei

Component of the R2TP complex composed at least of RVB1, RVB2, TAH1 and PIH1. Interacts also with HSP90.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
HSP82P028293EBI-21956,EBI-8659
PIH1P387688EBI-21956,EBI-24499

Protein-protein interaction databases

BioGridi31037. 37 interactions.
DIPiDIP-5000N.
IntActiP25638. 6 interactions.
MINTiMINT-488866.
STRINGi4932.YCR060W.

Structurei

Secondary structure

1
111
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 1715
Helixi20 – 3314
Helixi38 – 5013
Helixi54 – 6411
Helixi65 – 673
Helixi71 – 733
Helixi74 – 9118
Beta strandi92 – 954
Beta strandi98 – 1003
Beta strandi105 – 1095

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2L6JNMR-A1-111[»]
2LSUNMR-A2-111[»]
2LSVNMR-A2-111[»]
4CGUX-ray2.11A1-111[»]
ProteinModelPortaliP25638.
SMRiP25638. Positions 1-111.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati4 – 3734TPR 1Add
BLAST
Repeati39 – 7133TPR 2Add
BLAST

Sequence similaritiesi

Contains 2 TPR repeats.

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiCOG0457.
HOGENOMiHOG000000905.
OrthoDBiEOG71GB6F.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
[Graphical view]
PROSITEiPS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25638-1 [UniParc]FASTAAdd to Basket

« Hide

MSQFEKQKEQ GNSLFKQGLY REAVHCYDQL ITAQPQNPVG YSNKAMALIK    50
LGEYTQAIQM CQQGLRYTST AEHVAIRSKL QYRLELAQGA VGSVQIPVVE 100
VDELPEGYDR S 111
Length:111
Mass (Da):12,511
Last modified:May 1, 1992 - v1
Checksum:i3738DE6F227F803A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59720 Genomic DNA. Translation: CAA42288.1.
AY558151 Genomic DNA. Translation: AAS56477.1.
BK006937 Genomic DNA. Translation: DAA07534.1.
PIRiS19475.
RefSeqiNP_009986.1. NM_001178771.1.

Genome annotation databases

EnsemblFungiiYCR060W; YCR060W; YCR060W.
GeneIDi850424.
KEGGisce:YCR060W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59720 Genomic DNA. Translation: CAA42288.1 .
AY558151 Genomic DNA. Translation: AAS56477.1 .
BK006937 Genomic DNA. Translation: DAA07534.1 .
PIRi S19475.
RefSeqi NP_009986.1. NM_001178771.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2L6J NMR - A 1-111 [» ]
2LSU NMR - A 2-111 [» ]
2LSV NMR - A 2-111 [» ]
4CGU X-ray 2.11 A 1-111 [» ]
ProteinModelPortali P25638.
SMRi P25638. Positions 1-111.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31037. 37 interactions.
DIPi DIP-5000N.
IntActi P25638. 6 interactions.
MINTi MINT-488866.
STRINGi 4932.YCR060W.

Proteomic databases

PaxDbi P25638.
PeptideAtlasi P25638.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YCR060W ; YCR060W ; YCR060W .
GeneIDi 850424.
KEGGi sce:YCR060W.

Organism-specific databases

CYGDi YCR060w.
SGDi S000000656. TAH1.

Phylogenomic databases

eggNOGi COG0457.
HOGENOMi HOG000000905.
OrthoDBi EOG71GB6F.

Enzyme and pathway databases

BioCyci YEAST:G3O-29365-MONOMER.

Miscellaneous databases

NextBioi 965998.

Gene expression databases

Genevestigatori P25638.

Family and domain databases

Gene3Di 1.25.40.10. 1 hit.
InterProi IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
[Graphical view ]
PROSITEi PS50293. TPR_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete DNA sequence of yeast chromosome III."
    Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
    , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
    Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone."
    Zhao R., Davey M.G., Hsu Y.-C., Kaplanek P., Tong A., Parsons A.B., Krogan N.J., Cagney G., Mai D., Greenblatt J.F., Boone C., Emili A., Houry W.A.
    Cell 120:715-727(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HSP90, IDENTIFICATION IN THE R2PT COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTAH1_YEAST
AccessioniPrimary (citable) accession number: P25638
Secondary accession number(s): D6VR65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: September 3, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1660 molecules/cell in log phase SD medium.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

External Data

Dasty 3

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