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Protein

TPR repeat-containing protein associated with Hsp90

Gene

TAH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • chaperone binding Source: SGD

GO - Biological processi

  • box C/D snoRNP assembly Source: SGD
  • protein folding Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-29365-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
TPR repeat-containing protein associated with Hsp90
Gene namesi
Name:TAH1
Ordered Locus Names:YCR060W
ORF Names:YCR60W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCR060W.
SGDiS000000656. TAH1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB-SubCell
  • R2TP complex Source: SGD

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001063522 – 111TPR repeat-containing protein associated with Hsp90Add BLAST110

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP25638.

Interactioni

Subunit structurei

Component of the R2TP complex composed at least of RVB1, RVB2, TAH1 and PIH1. Interacts also with HSP90.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • chaperone binding Source: SGD

Protein-protein interaction databases

BioGridi31037. 106 interactors.
DIPiDIP-5000N.
IntActiP25638. 7 interactors.
MINTiMINT-488866.

Structurei

Secondary structure

1111
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 16Combined sources14
Helixi20 – 33Combined sources14
Helixi38 – 50Combined sources13
Helixi54 – 65Combined sources12
Helixi71 – 73Combined sources3
Helixi76 – 90Combined sources15
Beta strandi92 – 95Combined sources4
Beta strandi98 – 100Combined sources3
Beta strandi105 – 109Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L6JNMR-A1-111[»]
2LSUNMR-A2-111[»]
2LSVNMR-A2-111[»]
2MNJNMR-A93-111[»]
4CGQX-ray2.00A1-111[»]
4CGUX-ray2.11A1-111[»]
ProteinModelPortaliP25638.
SMRiP25638.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati4 – 37TPR 1Add BLAST34
Repeati39 – 71TPR 2Add BLAST33

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

HOGENOMiHOG000000905.
InParanoidiP25638.
OMAiCAMALIK.
OrthoDBiEOG09265QEC.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiView protein in InterPro
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
SMARTiView protein in SMART
SM00028. TPR. 2 hits.
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiView protein in PROSITE
PS50293. TPR_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25638-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQFEKQKEQ GNSLFKQGLY REAVHCYDQL ITAQPQNPVG YSNKAMALIK
60 70 80 90 100
LGEYTQAIQM CQQGLRYTST AEHVAIRSKL QYRLELAQGA VGSVQIPVVE
110
VDELPEGYDR S
Length:111
Mass (Da):12,511
Last modified:May 1, 1992 - v1
Checksum:i3738DE6F227F803A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42288.1.
AY558151 Genomic DNA. Translation: AAS56477.1.
BK006937 Genomic DNA. Translation: DAA07534.1.
PIRiS19475.
RefSeqiNP_009986.1. NM_001178771.1.

Genome annotation databases

EnsemblFungiiCAA42288; CAA42288; CAA42288.
YCR060W; YCR060W; YCR060W.
GeneIDi850424.
KEGGisce:YCR060W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42288.1.
AY558151 Genomic DNA. Translation: AAS56477.1.
BK006937 Genomic DNA. Translation: DAA07534.1.
PIRiS19475.
RefSeqiNP_009986.1. NM_001178771.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L6JNMR-A1-111[»]
2LSUNMR-A2-111[»]
2LSVNMR-A2-111[»]
2MNJNMR-A93-111[»]
4CGQX-ray2.00A1-111[»]
4CGUX-ray2.11A1-111[»]
ProteinModelPortaliP25638.
SMRiP25638.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31037. 106 interactors.
DIPiDIP-5000N.
IntActiP25638. 7 interactors.
MINTiMINT-488866.

Proteomic databases

PRIDEiP25638.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAA42288; CAA42288; CAA42288.
YCR060W; YCR060W; YCR060W.
GeneIDi850424.
KEGGisce:YCR060W.

Organism-specific databases

EuPathDBiFungiDB:YCR060W.
SGDiS000000656. TAH1.

Phylogenomic databases

HOGENOMiHOG000000905.
InParanoidiP25638.
OMAiCAMALIK.
OrthoDBiEOG09265QEC.

Enzyme and pathway databases

BioCyciYEAST:G3O-29365-MONOMER.

Miscellaneous databases

PROiP25638.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiView protein in InterPro
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
SMARTiView protein in SMART
SM00028. TPR. 2 hits.
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiView protein in PROSITE
PS50293. TPR_REGION. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTAH1_YEAST
AccessioniPrimary (citable) accession number: P25638
Secondary accession number(s): D6VR65
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: February 15, 2017
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1660 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.