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Protein

TPR repeat-containing protein associated with Hsp90

Gene

TAH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • chaperone binding Source: SGD

GO - Biological processi

  • box C/D snoRNP assembly Source: SGD
  • protein folding Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-29365-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
TPR repeat-containing protein associated with Hsp90
Gene namesi
Name:TAH1
Ordered Locus Names:YCR060W
ORF Names:YCR60W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCR060W.
SGDiS000000656. TAH1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB-SubCell
  • R2TP complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 111110TPR repeat-containing protein associated with Hsp90PRO_0000106352Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Component of the R2TP complex composed at least of RVB1, RVB2, TAH1 and PIH1. Interacts also with HSP90.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
HSP82P028293EBI-21956,EBI-8659
PIH1P3876811EBI-21956,EBI-24499

GO - Molecular functioni

  • chaperone binding Source: SGD

Protein-protein interaction databases

BioGridi31037. 40 interactions.
DIPiDIP-5000N.
IntActiP25638. 7 interactions.
MINTiMINT-488866.

Structurei

Secondary structure

1
111
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 1614Combined sources
Helixi20 – 3314Combined sources
Helixi38 – 5013Combined sources
Helixi54 – 6512Combined sources
Helixi71 – 733Combined sources
Helixi76 – 9015Combined sources
Beta strandi92 – 954Combined sources
Beta strandi98 – 1003Combined sources
Beta strandi105 – 1095Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2L6JNMR-A1-111[»]
2LSUNMR-A2-111[»]
2LSVNMR-A2-111[»]
2MNJNMR-A93-111[»]
4CGQX-ray2.00A1-111[»]
4CGUX-ray2.11A1-111[»]
ProteinModelPortaliP25638.
SMRiP25638. Positions 1-111.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati4 – 3734TPR 1Add
BLAST
Repeati39 – 7133TPR 2Add
BLAST

Sequence similaritiesi

Contains 2 TPR repeats.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

HOGENOMiHOG000000905.
InParanoidiP25638.
OMAiCAMALIK.
OrthoDBiEOG092C5WTZ.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
SMARTiSM00028. TPR. 2 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25638-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQFEKQKEQ GNSLFKQGLY REAVHCYDQL ITAQPQNPVG YSNKAMALIK
60 70 80 90 100
LGEYTQAIQM CQQGLRYTST AEHVAIRSKL QYRLELAQGA VGSVQIPVVE
110
VDELPEGYDR S
Length:111
Mass (Da):12,511
Last modified:May 1, 1992 - v1
Checksum:i3738DE6F227F803A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42288.1.
AY558151 Genomic DNA. Translation: AAS56477.1.
BK006937 Genomic DNA. Translation: DAA07534.1.
PIRiS19475.
RefSeqiNP_009986.1. NM_001178771.1.

Genome annotation databases

EnsemblFungiiCAA42288; CAA42288; CAA42288.
YCR060W; YCR060W; YCR060W.
GeneIDi850424.
KEGGisce:YCR060W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42288.1.
AY558151 Genomic DNA. Translation: AAS56477.1.
BK006937 Genomic DNA. Translation: DAA07534.1.
PIRiS19475.
RefSeqiNP_009986.1. NM_001178771.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2L6JNMR-A1-111[»]
2LSUNMR-A2-111[»]
2LSVNMR-A2-111[»]
2MNJNMR-A93-111[»]
4CGQX-ray2.00A1-111[»]
4CGUX-ray2.11A1-111[»]
ProteinModelPortaliP25638.
SMRiP25638. Positions 1-111.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31037. 40 interactions.
DIPiDIP-5000N.
IntActiP25638. 7 interactions.
MINTiMINT-488866.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAA42288; CAA42288; CAA42288.
YCR060W; YCR060W; YCR060W.
GeneIDi850424.
KEGGisce:YCR060W.

Organism-specific databases

EuPathDBiFungiDB:YCR060W.
SGDiS000000656. TAH1.

Phylogenomic databases

HOGENOMiHOG000000905.
InParanoidiP25638.
OMAiCAMALIK.
OrthoDBiEOG092C5WTZ.

Enzyme and pathway databases

BioCyciYEAST:G3O-29365-MONOMER.

Miscellaneous databases

PROiP25638.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
SMARTiSM00028. TPR. 2 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAH1_YEAST
AccessioniPrimary (citable) accession number: P25638
Secondary accession number(s): D6VR65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: September 7, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1660 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.