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Protein

TPR repeat-containing protein associated with Hsp90

Gene

TAH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 1660 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • chaperone binding Source: SGD

GO - Biological processi

  • box C/D snoRNP assembly Source: SGD
  • protein folding Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-29365-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
TPR repeat-containing protein associated with Hsp90
Gene namesi
Name:TAH1
Ordered Locus Names:YCR060W
ORF Names:YCR60W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCR060W
SGDiS000000656 TAH1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001063522 – 111TPR repeat-containing protein associated with Hsp90Add BLAST110

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP25638
PRIDEiP25638

PTM databases

iPTMnetiP25638

Interactioni

Subunit structurei

Component of the R2TP complex composed at least of RVB1, RVB2, TAH1 and PIH1. Interacts also with HSP90.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • chaperone binding Source: SGD

Protein-protein interaction databases

BioGridi31037106 interactors.
DIPiDIP-5000N
IntActiP25638 24 interactors.
MINTiP25638
STRINGi4932.YCR060W

Structurei

Secondary structure

1111
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 16Combined sources14
Helixi20 – 33Combined sources14
Helixi38 – 50Combined sources13
Helixi54 – 65Combined sources12
Helixi71 – 73Combined sources3
Helixi76 – 90Combined sources15
Beta strandi92 – 95Combined sources4
Beta strandi98 – 100Combined sources3
Beta strandi105 – 109Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L6JNMR-A1-111[»]
2LSUNMR-A2-111[»]
2LSVNMR-A2-111[»]
2MNJNMR-A93-111[»]
4CGQX-ray2.00A1-111[»]
4CGUX-ray2.11A1-111[»]
ProteinModelPortaliP25638
SMRiP25638
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati4 – 37TPR 1Add BLAST34
Repeati39 – 71TPR 2Add BLAST33

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

HOGENOMiHOG000000905
InParanoidiP25638
OMAiCAMALIK
OrthoDBiEOG092C5WTZ

Family and domain databases

Gene3Di1.25.40.101 hit
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
SMARTiView protein in SMART
SM00028 TPR, 2 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25638-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQFEKQKEQ GNSLFKQGLY REAVHCYDQL ITAQPQNPVG YSNKAMALIK
60 70 80 90 100
LGEYTQAIQM CQQGLRYTST AEHVAIRSKL QYRLELAQGA VGSVQIPVVE
110
VDELPEGYDR S
Length:111
Mass (Da):12,511
Last modified:May 1, 1992 - v1
Checksum:i3738DE6F227F803A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA Translation: CAA42288.1
AY558151 Genomic DNA Translation: AAS56477.1
BK006937 Genomic DNA Translation: DAA07534.1
PIRiS19475
RefSeqiNP_009986.1, NM_001178771.1

Genome annotation databases

EnsemblFungiiCAA42288; CAA42288; CAA42288
YCR060W; YCR060W; YCR060W
GeneIDi850424
KEGGisce:YCR060W

Similar proteinsi

Entry informationi

Entry nameiTAH1_YEAST
AccessioniPrimary (citable) accession number: P25638
Secondary accession number(s): D6VR65
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: March 28, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome