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Protein

Sterol O-acyltransferase 1

Gene

ARE1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Acyl-CoA + cholesterol = CoA + cholesterol ester.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei547Sequence analysis1

GO - Molecular functioni

  • ergosterol O-acyltransferase activity Source: SGD
  • lanosterol O-acyltransferase activity Source: SGD

GO - Biological processi

  • ergosterol metabolic process Source: GO_Central
  • sterol metabolic process Source: SGD

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BioCyciMetaCyc:YCR048W-MONOMER
YEAST:YCR048W-MONOMER
ReactomeiR-SCE-1482883 Acyl chain remodeling of DAG and TAG
R-SCE-6798695 Neutrophil degranulation
R-SCE-75109 Triglyceride biosynthesis
R-SCE-8964038 LDL clearance

Chemistry databases

SwissLipidsiSLP:000000706
SLP:000000709

Names & Taxonomyi

Protein namesi
Recommended name:
Sterol O-acyltransferase 1 (EC:2.3.1.26)
Alternative name(s):
Sterol-ester synthase 1
Gene namesi
Name:ARE1
Synonyms:SAT2
Ordered Locus Names:YCR048W
ORF Names:YCR48W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCR048W
SGDiS000000644 ARE1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Transmembranei371 – 391HelicalSequence analysisAdd BLAST21
Transmembranei409 – 429HelicalSequence analysisAdd BLAST21
Transmembranei535 – 555HelicalSequence analysisAdd BLAST21
Transmembranei590 – 610HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002076481 – 610Sterol O-acyltransferase 1Add BLAST610

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphoserineCombined sources1
Modified residuei45PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP25628
PaxDbiP25628
PRIDEiP25628
TopDownProteomicsiP25628

PTM databases

iPTMnetiP25628

Interactioni

Protein-protein interaction databases

BioGridi31030, 163 interactors
DIPiDIP-4998N
IntActiP25628, 6 interactors
MINTiP25628
STRINGi4932.YCR048W

Structurei

3D structure databases

ProteinModelPortaliP25628
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000063122
HOGENOMiHOG000210250
InParanoidiP25628
KOiK00637
OMAiQINYPRT
OrthoDBiEOG092C2MBI

Family and domain databases

InterProiView protein in InterPro
IPR004299 MBOAT_fam
IPR014371 Oat_ACAT_DAG_ARE
PANTHERiPTHR10408 PTHR10408, 1 hit
PfamiView protein in Pfam
PF03062 MBOAT, 1 hit
PIRSFiPIRSF000439 Oat_ACAT_DAG_ARE, 1 hit

Sequencei

Sequence statusi: Complete.

P25628-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTETKDLLQD EEFLKIRRLN SAEANKRHSV TYDNVILPQE SMEVSPRSST
60 70 80 90 100
TSLVEPVEST EGVESTEAER VAGKQEQEEE YPVDAHMQKY LSHLKSKSRS
110 120 130 140 150
RFHRKDASKY VSFFGDVSFD PRPTLLDSAI NVPFQTTFKG PVLEKQLKNL
160 170 180 190 200
QLTKTKTKAT VKTTVKTTEK TDKADAPPGE KLESNFSGIY VFAWMFLGWI
210 220 230 240 250
AIRCCTDYYA SYGSAWNKLE IVQYMTTDLF TIAMLDLAMF LCTFFVVFVH
260 270 280 290 300
WLVKKRIINW KWTGFVAVSI FELAFIPVTF PIYVYYFDFN WVTRIFLFLH
310 320 330 340 350
SVVFVMKSHS FAFYNGYLWD IKQELEYSSK QLQKYKESLS PETREILQKS
360 370 380 390 400
CDFCLFELNY QTKDNDFPNN ISCSNFFMFC LFPVLVYQIN YPRTSRIRWR
410 420 430 440 450
YVLEKVCAII GTIFLMMVTA QFFMHPVAMR CIQFHNTPTF GGWIPATQEW
460 470 480 490 500
FHLLFDMIPG FTVLYMLTFY MIWDALLNCV AELTRFADRY FYGDWWNCVS
510 520 530 540 550
FEEFSRIWNV PVHKFLLRHV YHSSMGALHL SKSQATLFTF FLSAVFHEMA
560 570 580 590 600
MFAIFRRVRG YLFMFQLSQF VWTALSNTKF LRARPQLSNV VFSFGVCSGP
610
SIIMTLYLTL
Length:610
Mass (Da):71,613
Last modified:May 1, 1992 - v1
Checksum:iFF72EFB9238B2205
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA Translation: CAA42296.1
AY692921 Genomic DNA Translation: AAT92940.1
BK006937 Genomic DNA Translation: DAA07526.1
PIRiS19461
RefSeqiNP_009978.1, NM_001178762.1

Genome annotation databases

EnsemblFungiiCAA42296; CAA42296; CAA42296
YCR048W; YCR048W; YCR048W
GeneIDi850415
KEGGisce:YCR048W

Similar proteinsi

Entry informationi

Entry nameiARE1_YEAST
AccessioniPrimary (citable) accession number: P25628
Secondary accession number(s): D6VR57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: June 20, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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