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Protein

Protein PER1

Gene

PER1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for efficient transport of GPI-anchor proteins.1 Publication

GO - Biological processi

  1. cellular manganese ion homeostasis Source: SGD
  2. GPI anchor biosynthetic process Source: SGD
Complete GO annotation...

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

BioCyciYEAST:G3O-29355-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein PER1
Alternative name(s):
Protein processing in the ER protein 1
Gene namesi
Name:PER1
Synonyms:COS16
Ordered Locus Names:YCR044C
ORF Names:YCR44C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome III

Organism-specific databases

CYGDiYCR044c.
EuPathDBiFungiDB:YCR044C.
SGDiS000000640. PER1.

Subcellular locationi

  1. Endoplasmic reticulum membrane 2 Publications; Multi-pass membrane protein 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 11391LumenalSequence AnalysisAdd
BLAST
Transmembranei114 – 13421HelicalSequence AnalysisAdd
BLAST
Topological domaini135 – 15521CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei156 – 17621HelicalSequence AnalysisAdd
BLAST
Topological domaini177 – 18913LumenalSequence AnalysisAdd
BLAST
Transmembranei190 – 21021HelicalSequence AnalysisAdd
BLAST
Topological domaini211 – 2122CytoplasmicSequence Analysis
Transmembranei213 – 23321HelicalSequence AnalysisAdd
BLAST
Topological domaini234 – 24815LumenalSequence AnalysisAdd
BLAST
Transmembranei249 – 26921HelicalSequence AnalysisAdd
BLAST
Topological domaini270 – 29324CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei294 – 31421HelicalSequence AnalysisAdd
BLAST
Topological domaini315 – 32410LumenalSequence Analysis
Transmembranei325 – 34521HelicalSequence AnalysisAdd
BLAST
Topological domaini346 – 35712CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: SGD
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. fungal-type vacuole membrane Source: SGD
  4. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 357336Protein PER1PRO_0000202569Add
BLAST

Proteomic databases

PaxDbiP25625.
PeptideAtlasiP25625.

Expressioni

Gene expression databases

GenevestigatoriP25625.

Interactioni

Protein-protein interaction databases

BioGridi31026. 187 interactions.
DIPiDIP-5598N.
IntActiP25625. 1 interaction.
MINTiMINT-575198.
STRINGi4932.YCR044C.

Structurei

3D structure databases

ProteinModelPortaliP25625.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PGAP3/PER1 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5237.
GeneTreeiENSGT00390000001304.
HOGENOMiHOG000210016.
InParanoidiP25625.
OMAiCEEQNCS.
OrthoDBiEOG7JDR89.

Family and domain databases

InterProiIPR007217. Per1.
[Graphical view]
PANTHERiPTHR13148. PTHR13148. 1 hit.
PfamiPF04080. Per1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25625-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLAVVVTLL VHCFLVTCSP GDNLDEFIDC TYACEYNRRC PNSQINYIDP
60 70 80 90 100
ETNMFHDIEF FDTPPLYSKL LFWDCISDCD YQCQHIITRW RIDEEEEIYQ
110 120 130 140 150
FHGKWPFLRV LGTQEFFSTI FSIGNFIPHY KGFVKFSRII REEGDRRRKN
160 170 180 190 200
SRSILIWNYL YVTVAGMLAW TASSVFHCRD LIITEKLDYF FAGLTVLTGF
210 220 230 240 250
HAIFARMTSM FLYPKIAQAF TASVAAIFAL HILRLYVDWS YTYNMRFNIF
260 270 280 290 300
FGVLQYILLI MLSCQNYHAL QKQKLMGEFK KTAYSSFKRQ IFKLCVIPIL
310 320 330 340 350
LVIVTTMAMS LELFDFFSYE WQIDAHALWH LCTIWPSWVL YDFFLEDYAY

WGNRQLY
Length:357
Mass (Da):42,541
Last modified:May 1, 1992 - v1
Checksum:i6841B84BBFAF9187
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42292.1.
BK006937 Genomic DNA. Translation: DAA07522.1.
PIRiS19457.
RefSeqiNP_009973.1. NM_001178758.1.

Genome annotation databases

EnsemblFungiiYCR044C; YCR044C; YCR044C.
GeneIDi850411.
KEGGisce:YCR044C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42292.1.
BK006937 Genomic DNA. Translation: DAA07522.1.
PIRiS19457.
RefSeqiNP_009973.1. NM_001178758.1.

3D structure databases

ProteinModelPortaliP25625.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31026. 187 interactions.
DIPiDIP-5598N.
IntActiP25625. 1 interaction.
MINTiMINT-575198.
STRINGi4932.YCR044C.

Proteomic databases

PaxDbiP25625.
PeptideAtlasiP25625.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYCR044C; YCR044C; YCR044C.
GeneIDi850411.
KEGGisce:YCR044C.

Organism-specific databases

CYGDiYCR044c.
EuPathDBiFungiDB:YCR044C.
SGDiS000000640. PER1.

Phylogenomic databases

eggNOGiCOG5237.
GeneTreeiENSGT00390000001304.
HOGENOMiHOG000210016.
InParanoidiP25625.
OMAiCEEQNCS.
OrthoDBiEOG7JDR89.

Enzyme and pathway databases

BioCyciYEAST:G3O-29355-MONOMER.

Miscellaneous databases

NextBioi965962.
PROiP25625.

Gene expression databases

GenevestigatoriP25625.

Family and domain databases

InterProiIPR007217. Per1.
[Graphical view]
PANTHERiPTHR13148. PTHR13148. 1 hit.
PfamiPF04080. Per1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The complete DNA sequence of yeast chromosome III."
    Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
    , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
    Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "PER1 is required for GPI-phospholipase A2 activity and involved in lipid remodeling of GPI-anchored proteins."
    Fujita M., Umemura M., Yoko-o T., Jigami Y.
    Mol. Biol. Cell 17:5253-5264(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiPER1_YEAST
AccessioniPrimary (citable) accession number: P25625
Secondary accession number(s): D6VR53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: April 29, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3050 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.