Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P25625

- PER1_YEAST

UniProt

P25625 - PER1_YEAST

Protein

Protein PER1

Gene

PER1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for efficient transport of GPI-anchor proteins.1 Publication

    GO - Biological processi

    1. cellular manganese ion homeostasis Source: SGD
    2. GPI anchor biosynthetic process Source: SGD

    Keywords - Biological processi

    GPI-anchor biosynthesis

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29355-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein PER1
    Alternative name(s):
    Protein processing in the ER protein 1
    Gene namesi
    Name:PER1
    Synonyms:COS16
    Ordered Locus Names:YCR044C
    ORF Names:YCR44C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome III

    Organism-specific databases

    CYGDiYCR044c.
    SGDiS000000640. PER1.

    Subcellular locationi

    Endoplasmic reticulum membrane 2 Publications; Multi-pass membrane protein 2 Publications

    GO - Cellular componenti

    1. endoplasmic reticulum Source: SGD
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. fungal-type vacuole membrane Source: SGD
    4. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 357336Protein PER1PRO_0000202569Add
    BLAST

    Proteomic databases

    PaxDbiP25625.
    PeptideAtlasiP25625.

    Expressioni

    Gene expression databases

    GenevestigatoriP25625.

    Interactioni

    Protein-protein interaction databases

    BioGridi31026. 187 interactions.
    DIPiDIP-5598N.
    IntActiP25625. 1 interaction.
    MINTiMINT-575198.
    STRINGi4932.YCR044C.

    Structurei

    3D structure databases

    ProteinModelPortaliP25625.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 11391LumenalSequence AnalysisAdd
    BLAST
    Topological domaini135 – 15521CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini177 – 18913LumenalSequence AnalysisAdd
    BLAST
    Topological domaini211 – 2122CytoplasmicSequence Analysis
    Topological domaini234 – 24815LumenalSequence AnalysisAdd
    BLAST
    Topological domaini270 – 29324CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini315 – 32410LumenalSequence Analysis
    Topological domaini346 – 35712CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei114 – 13421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei156 – 17621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei190 – 21021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei213 – 23321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei249 – 26921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei294 – 31421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei325 – 34521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PGAP3/PER1 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5237.
    GeneTreeiENSGT00390000001304.
    HOGENOMiHOG000210016.
    OMAiWRIDEEE.
    OrthoDBiEOG7JDR89.

    Family and domain databases

    InterProiIPR007217. Per1.
    [Graphical view]
    PANTHERiPTHR13148. PTHR13148. 1 hit.
    PfamiPF04080. Per1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P25625-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLAVVVTLL VHCFLVTCSP GDNLDEFIDC TYACEYNRRC PNSQINYIDP    50
    ETNMFHDIEF FDTPPLYSKL LFWDCISDCD YQCQHIITRW RIDEEEEIYQ 100
    FHGKWPFLRV LGTQEFFSTI FSIGNFIPHY KGFVKFSRII REEGDRRRKN 150
    SRSILIWNYL YVTVAGMLAW TASSVFHCRD LIITEKLDYF FAGLTVLTGF 200
    HAIFARMTSM FLYPKIAQAF TASVAAIFAL HILRLYVDWS YTYNMRFNIF 250
    FGVLQYILLI MLSCQNYHAL QKQKLMGEFK KTAYSSFKRQ IFKLCVIPIL 300
    LVIVTTMAMS LELFDFFSYE WQIDAHALWH LCTIWPSWVL YDFFLEDYAY 350
    WGNRQLY 357
    Length:357
    Mass (Da):42,541
    Last modified:May 1, 1992 - v1
    Checksum:i6841B84BBFAF9187
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59720 Genomic DNA. Translation: CAA42292.1.
    BK006937 Genomic DNA. Translation: DAA07522.1.
    PIRiS19457.
    RefSeqiNP_009973.1. NM_001178758.1.

    Genome annotation databases

    EnsemblFungiiYCR044C; YCR044C; YCR044C.
    GeneIDi850411.
    KEGGisce:YCR044C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59720 Genomic DNA. Translation: CAA42292.1 .
    BK006937 Genomic DNA. Translation: DAA07522.1 .
    PIRi S19457.
    RefSeqi NP_009973.1. NM_001178758.1.

    3D structure databases

    ProteinModelPortali P25625.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31026. 187 interactions.
    DIPi DIP-5598N.
    IntActi P25625. 1 interaction.
    MINTi MINT-575198.
    STRINGi 4932.YCR044C.

    Proteomic databases

    PaxDbi P25625.
    PeptideAtlasi P25625.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YCR044C ; YCR044C ; YCR044C .
    GeneIDi 850411.
    KEGGi sce:YCR044C.

    Organism-specific databases

    CYGDi YCR044c.
    SGDi S000000640. PER1.

    Phylogenomic databases

    eggNOGi COG5237.
    GeneTreei ENSGT00390000001304.
    HOGENOMi HOG000210016.
    OMAi WRIDEEE.
    OrthoDBi EOG7JDR89.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29355-MONOMER.

    Miscellaneous databases

    NextBioi 965962.
    PROi P25625.

    Gene expression databases

    Genevestigatori P25625.

    Family and domain databases

    InterProi IPR007217. Per1.
    [Graphical view ]
    PANTHERi PTHR13148. PTHR13148. 1 hit.
    Pfami PF04080. Per1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete DNA sequence of yeast chromosome III."
      Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
      , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
      Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. "PER1 is required for GPI-phospholipase A2 activity and involved in lipid remodeling of GPI-anchored proteins."
      Fujita M., Umemura M., Yoko-o T., Jigami Y.
      Mol. Biol. Cell 17:5253-5264(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.

    Entry informationi

    Entry nameiPER1_YEAST
    AccessioniPrimary (citable) accession number: P25625
    Secondary accession number(s): D6VR53
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 3050 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome III
      Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

    External Data

    Dasty 3