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P25625 (PER1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein PER1
Alternative name(s):
Protein processing in the ER protein 1
Gene names
Name:PER1
Synonyms:COS16
Ordered Locus Names:YCR044C
ORF Names:YCR44C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length357 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for efficient transport of GPI-anchor proteins. Ref.5

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein Ref.3 Ref.5.

Miscellaneous

Present with 3050 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the PGAP3/PER1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 357336Protein PER1
PRO_0000202569

Regions

Topological domain23 – 11391Lumenal Potential
Transmembrane114 – 13421Helical; Potential
Topological domain135 – 15521Cytoplasmic Potential
Transmembrane156 – 17621Helical; Potential
Topological domain177 – 18913Lumenal Potential
Transmembrane190 – 21021Helical; Potential
Topological domain211 – 2122Cytoplasmic Potential
Transmembrane213 – 23321Helical; Potential
Topological domain234 – 24815Lumenal Potential
Transmembrane249 – 26921Helical; Potential
Topological domain270 – 29324Cytoplasmic Potential
Transmembrane294 – 31421Helical; Potential
Topological domain315 – 32410Lumenal Potential
Transmembrane325 – 34521Helical; Potential
Topological domain346 – 35712Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
P25625 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: 6841B84BBFAF9187

FASTA35742,541
        10         20         30         40         50         60 
MRLAVVVTLL VHCFLVTCSP GDNLDEFIDC TYACEYNRRC PNSQINYIDP ETNMFHDIEF 

        70         80         90        100        110        120 
FDTPPLYSKL LFWDCISDCD YQCQHIITRW RIDEEEEIYQ FHGKWPFLRV LGTQEFFSTI 

       130        140        150        160        170        180 
FSIGNFIPHY KGFVKFSRII REEGDRRRKN SRSILIWNYL YVTVAGMLAW TASSVFHCRD 

       190        200        210        220        230        240 
LIITEKLDYF FAGLTVLTGF HAIFARMTSM FLYPKIAQAF TASVAAIFAL HILRLYVDWS 

       250        260        270        280        290        300 
YTYNMRFNIF FGVLQYILLI MLSCQNYHAL QKQKLMGEFK KTAYSSFKRQ IFKLCVIPIL 

       310        320        330        340        350 
LVIVTTMAMS LELFDFFSYE WQIDAHALWH LCTIWPSWVL YDFFLEDYAY WGNRQLY

« Hide

References

« Hide 'large scale' references
[1]"The complete DNA sequence of yeast chromosome III."
Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M. expand/collapse author list , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"PER1 is required for GPI-phospholipase A2 activity and involved in lipid remodeling of GPI-anchored proteins."
Fujita M., Umemura M., Yoko-o T., Jigami Y.
Mol. Biol. Cell 17:5253-5264(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[6]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X59720 Genomic DNA. Translation: CAA42292.1.
BK006937 Genomic DNA. Translation: DAA07522.1.
PIRS19457.
RefSeqNP_009973.1. NM_001178758.1.

3D structure databases

ProteinModelPortalP25625.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-5598N.
MINTMINT-575198.
STRING4932.YCR044C.

Proteomic databases

PaxDbP25625.
PeptideAtlasP25625.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYCR044C; YCR044C; YCR044C.
GeneID850411.
KEGGsce:YCR044C.

Organism-specific databases

CYGDYCR044c.
SGDS000000640. PER1.

Phylogenomic databases

eggNOGCOG5237.
GeneTreeENSGT00390000001304.
HOGENOMHOG000210016.
OMAWVSLNAW.
OrthoDBEOG486CNH.

Gene expression databases

GenevestigatorP25625.
GermOnlineYCR044C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR007217. Per1.
[Graphical view]
PANTHERPTHR13148. PTHR13148. 1 hit.
PfamPF04080. Per1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio965962.

Entry information

Entry namePER1_YEAST
AccessionPrimary (citable) accession number: P25625
Secondary accession number(s): D6VR53
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: April 3, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome III

Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents