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P25621

- FEN2_YEAST

UniProt

P25621 - FEN2_YEAST

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Protein

Pantothenate transporter FEN2

Gene

FEN2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Transports pantothenate into the cell. Also involved in the catabolite repression-mediated regulation of ergosterol biosynthesis and in fenpropimorph resistance.2 Publications

GO - Molecular functioni

  1. pantothenate transmembrane transporter activity Source: SGD

GO - Biological processi

  1. endocytosis Source: SGD
  2. pantothenate transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29343-MONOMER.

Protein family/group databases

TCDBi2.A.1.14.18. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate transporter FEN2
Alternative name(s):
Fenpropimorph resistance protein 2
Gene namesi
Name:FEN2
Ordered Locus Names:YCR028C
ORF Names:YCR28C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome III

Organism-specific databases

CYGDiYCR028c.
SGDiS000000623. FEN2.

Subcellular locationi

Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei28 – 4821HelicalSequence AnalysisAdd
BLAST
Topological domaini49 – 7931ExtracellularSequence AnalysisAdd
BLAST
Transmembranei80 – 10021HelicalSequence AnalysisAdd
BLAST
Topological domaini101 – 1022CytoplasmicSequence Analysis
Transmembranei103 – 12321HelicalSequence AnalysisAdd
BLAST
Topological domaini124 – 1329ExtracellularSequence Analysis
Transmembranei133 – 15321HelicalSequence AnalysisAdd
BLAST
Topological domaini154 – 16411CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei165 – 18521HelicalSequence AnalysisAdd
BLAST
Topological domaini186 – 19813ExtracellularSequence AnalysisAdd
BLAST
Transmembranei199 – 21921HelicalSequence AnalysisAdd
BLAST
Topological domaini220 – 27152CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei272 – 29221HelicalSequence AnalysisAdd
BLAST
Topological domaini293 – 31220ExtracellularSequence AnalysisAdd
BLAST
Transmembranei313 – 33321HelicalSequence AnalysisAdd
BLAST
Topological domaini334 – 3429CytoplasmicSequence Analysis
Transmembranei343 – 36321HelicalSequence AnalysisAdd
BLAST
Topological domaini364 – 3729ExtracellularSequence Analysis
Transmembranei373 – 39321HelicalSequence AnalysisAdd
BLAST
Topological domaini394 – 4018CytoplasmicSequence Analysis
Transmembranei402 – 42221HelicalSequence AnalysisAdd
BLAST
Topological domaini423 – 43412ExtracellularSequence AnalysisAdd
BLAST
Transmembranei435 – 45521HelicalSequence AnalysisAdd
BLAST
Topological domaini456 – 51257CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Pantothenate transporter FEN2PRO_0000121367Add
BLAST

Proteomic databases

MaxQBiP25621.
PaxDbiP25621.

Expressioni

Gene expression databases

GenevestigatoriP25621.

Interactioni

Protein-protein interaction databases

BioGridi31011. 39 interactions.
DIPiDIP-7672N.
IntActiP25621. 6 interactions.
MINTiMINT-1357147.
STRINGi4932.YCR028C.

Structurei

3D structure databases

ProteinModelPortaliP25621.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00620000088258.
HOGENOMiHOG000179304.
InParanoidiP25621.
KOiK03448.
OMAiFHGNQLN.
OrthoDBiEOG7SV14V.

Family and domain databases

InterProiIPR011701. MFS.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.

Sequencei

Sequence statusi: Complete.

P25621-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMKESKSITQ HEVERESVSS KRAIKKRLLL FKIDLFVLSF VCLQYWINYV
60 70 80 90 100
DRVGFTNAYI SGMKEDLKMV GNDLTVSNTV FMIGYIVGMV PNNLMLLCVP
110 120 130 140 150
PRIWLSFCTF AWGLLTLGMY KVTSFKHICA IRFFQALFES CTFSGTHFVL
160 170 180 190 200
GSWYKEDELP IRSAIFTGSG LVGSMFSGFM QTSIFTHLNG RNGLAGWRWL
210 220 230 240 250
FIIDFCITLP IAIYGFIFFP GLPDQTSAVS KFSMTRYIFN EQELHYARRR
260 270 280 290 300
LPARDESTRL DWSTIPRVLK RWHWWMFSLV WVLGGENLGF ASNSTFALWL
310 320 330 340 350
QNQKYTLAQR NNYPSGIFAV GIVSTLCSAV YMSKIPRARH WHVSVFISLV
360 370 380 390 400
MVIVAVLIRA DPLNPKVVFS AQYLGGVAYA GQAVFFSWAN IICHADLQER
410 420 430 440 450
AIVLASMNMF SGAVNAWWSI LFFASDMVPK FERGCYALLA TAISSGIVSV
460 470 480 490 500
VIRSLQIKEN LSKKQVPYID ANDMPGEDDD DDNQDNENDG DDESMEVELH
510
NEEMAEISNP FR
Length:512
Mass (Da):58,256
Last modified:May 1, 1992 - v1
Checksum:i361942E74C62B3B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42320.1.
BK006937 Genomic DNA. Translation: DAA07507.1.
PIRiS19439.
RefSeqiNP_009957.1. NM_001178743.1.

Genome annotation databases

EnsemblFungiiYCR028C; YCR028C; YCR028C.
GeneIDi850394.
KEGGisce:YCR028C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42320.1 .
BK006937 Genomic DNA. Translation: DAA07507.1 .
PIRi S19439.
RefSeqi NP_009957.1. NM_001178743.1.

3D structure databases

ProteinModelPortali P25621.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31011. 39 interactions.
DIPi DIP-7672N.
IntActi P25621. 6 interactions.
MINTi MINT-1357147.
STRINGi 4932.YCR028C.

Protein family/group databases

TCDBi 2.A.1.14.18. the major facilitator superfamily (mfs).

Proteomic databases

MaxQBi P25621.
PaxDbi P25621.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YCR028C ; YCR028C ; YCR028C .
GeneIDi 850394.
KEGGi sce:YCR028C.

Organism-specific databases

CYGDi YCR028c.
SGDi S000000623. FEN2.

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00620000088258.
HOGENOMi HOG000179304.
InParanoidi P25621.
KOi K03448.
OMAi FHGNQLN.
OrthoDBi EOG7SV14V.

Enzyme and pathway databases

BioCyci YEAST:G3O-29343-MONOMER.

Miscellaneous databases

NextBioi 965917.

Gene expression databases

Genevestigatori P25621.

Family and domain databases

InterProi IPR011701. MFS.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of 9.2 kb left of CRY1 on yeast chromosome III from strain AB972: evidence for a Ty insertion and functional analysis of open reading frame YCR28."
    Carbone M.L.A., Panzeri L., Falconi M.M., Carcano C., Plevani P., Lucchini G.
    Yeast 8:805-812(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204511 / S288c / AB972.
  2. "The complete DNA sequence of yeast chromosome III."
    Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
    , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
    Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Yeast chromosome III: new gene functions."
    Koonin E.V., Bork P., Sander C.
    EMBO J. 13:493-503(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: SIMILARITY TO DAL5 FAMILY.
  5. "FEN2: a gene implicated in the catabolite repression-mediated regulation of ergosterol biosynthesis in yeast."
    Marcireau C., Joets J., Pousset D., Guilloton M., Karst F.
    Yeast 12:531-539(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "The fenpropimorph resistance gene FEN2 from Saccharomyces cerevisiae encodes a plasma membrane H+-pantothenate symporter."
    Stolz J., Sauer N.
    J. Biol. Chem. 274:18747-18752(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiFEN2_YEAST
AccessioniPrimary (citable) accession number: P25621
Secondary accession number(s): D6VR38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3060 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

External Data

Dasty 3