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P25621

- FEN2_YEAST

UniProt

P25621 - FEN2_YEAST

Protein

Pantothenate transporter FEN2

Gene

FEN2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
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    Functioni

    Transports pantothenate into the cell. Also involved in the catabolite repression-mediated regulation of ergosterol biosynthesis and in fenpropimorph resistance.2 Publications

    GO - Molecular functioni

    1. pantothenate transmembrane transporter activity Source: SGD

    GO - Biological processi

    1. endocytosis Source: SGD
    2. pantothenate transmembrane transport Source: SGD

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29343-MONOMER.

    Protein family/group databases

    TCDBi2.A.1.14.18. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pantothenate transporter FEN2
    Alternative name(s):
    Fenpropimorph resistance protein 2
    Gene namesi
    Name:FEN2
    Ordered Locus Names:YCR028C
    ORF Names:YCR28C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome III

    Organism-specific databases

    CYGDiYCR028c.
    SGDiS000000623. FEN2.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: SGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 512512Pantothenate transporter FEN2PRO_0000121367Add
    BLAST

    Proteomic databases

    MaxQBiP25621.
    PaxDbiP25621.

    Expressioni

    Gene expression databases

    GenevestigatoriP25621.

    Interactioni

    Protein-protein interaction databases

    BioGridi31011. 39 interactions.
    DIPiDIP-7672N.
    IntActiP25621. 6 interactions.
    MINTiMINT-1357147.
    STRINGi4932.YCR028C.

    Structurei

    3D structure databases

    ProteinModelPortaliP25621.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2727CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini49 – 7931ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini101 – 1022CytoplasmicSequence Analysis
    Topological domaini124 – 1329ExtracellularSequence Analysis
    Topological domaini154 – 16411CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini186 – 19813ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini220 – 27152CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini293 – 31220ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini334 – 3429CytoplasmicSequence Analysis
    Topological domaini364 – 3729ExtracellularSequence Analysis
    Topological domaini394 – 4018CytoplasmicSequence Analysis
    Topological domaini423 – 43412ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini456 – 51257CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 4821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei80 – 10021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei103 – 12321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei133 – 15321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei165 – 18521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei199 – 21921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei272 – 29221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei313 – 33321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei343 – 36321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei373 – 39321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei402 – 42221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei435 – 45521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    GeneTreeiENSGT00620000088258.
    HOGENOMiHOG000179304.
    KOiK03448.
    OMAiFHGNQLN.
    OrthoDBiEOG7SV14V.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P25621-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMKESKSITQ HEVERESVSS KRAIKKRLLL FKIDLFVLSF VCLQYWINYV    50
    DRVGFTNAYI SGMKEDLKMV GNDLTVSNTV FMIGYIVGMV PNNLMLLCVP 100
    PRIWLSFCTF AWGLLTLGMY KVTSFKHICA IRFFQALFES CTFSGTHFVL 150
    GSWYKEDELP IRSAIFTGSG LVGSMFSGFM QTSIFTHLNG RNGLAGWRWL 200
    FIIDFCITLP IAIYGFIFFP GLPDQTSAVS KFSMTRYIFN EQELHYARRR 250
    LPARDESTRL DWSTIPRVLK RWHWWMFSLV WVLGGENLGF ASNSTFALWL 300
    QNQKYTLAQR NNYPSGIFAV GIVSTLCSAV YMSKIPRARH WHVSVFISLV 350
    MVIVAVLIRA DPLNPKVVFS AQYLGGVAYA GQAVFFSWAN IICHADLQER 400
    AIVLASMNMF SGAVNAWWSI LFFASDMVPK FERGCYALLA TAISSGIVSV 450
    VIRSLQIKEN LSKKQVPYID ANDMPGEDDD DDNQDNENDG DDESMEVELH 500
    NEEMAEISNP FR 512
    Length:512
    Mass (Da):58,256
    Last modified:May 1, 1992 - v1
    Checksum:i361942E74C62B3B4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59720 Genomic DNA. Translation: CAA42320.1.
    BK006937 Genomic DNA. Translation: DAA07507.1.
    PIRiS19439.
    RefSeqiNP_009957.1. NM_001178743.1.

    Genome annotation databases

    EnsemblFungiiYCR028C; YCR028C; YCR028C.
    GeneIDi850394.
    KEGGisce:YCR028C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59720 Genomic DNA. Translation: CAA42320.1 .
    BK006937 Genomic DNA. Translation: DAA07507.1 .
    PIRi S19439.
    RefSeqi NP_009957.1. NM_001178743.1.

    3D structure databases

    ProteinModelPortali P25621.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31011. 39 interactions.
    DIPi DIP-7672N.
    IntActi P25621. 6 interactions.
    MINTi MINT-1357147.
    STRINGi 4932.YCR028C.

    Protein family/group databases

    TCDBi 2.A.1.14.18. the major facilitator superfamily (mfs).

    Proteomic databases

    MaxQBi P25621.
    PaxDbi P25621.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YCR028C ; YCR028C ; YCR028C .
    GeneIDi 850394.
    KEGGi sce:YCR028C.

    Organism-specific databases

    CYGDi YCR028c.
    SGDi S000000623. FEN2.

    Phylogenomic databases

    eggNOGi COG0477.
    GeneTreei ENSGT00620000088258.
    HOGENOMi HOG000179304.
    KOi K03448.
    OMAi FHGNQLN.
    OrthoDBi EOG7SV14V.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29343-MONOMER.

    Miscellaneous databases

    NextBioi 965917.

    Gene expression databases

    Genevestigatori P25621.

    Family and domain databases

    InterProi IPR011701. MFS.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    Pfami PF07690. MFS_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of 9.2 kb left of CRY1 on yeast chromosome III from strain AB972: evidence for a Ty insertion and functional analysis of open reading frame YCR28."
      Carbone M.L.A., Panzeri L., Falconi M.M., Carcano C., Plevani P., Lucchini G.
      Yeast 8:805-812(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204511 / S288c / AB972.
    2. "The complete DNA sequence of yeast chromosome III."
      Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
      , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
      Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Yeast chromosome III: new gene functions."
      Koonin E.V., Bork P., Sander C.
      EMBO J. 13:493-503(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: SIMILARITY TO DAL5 FAMILY.
    5. "FEN2: a gene implicated in the catabolite repression-mediated regulation of ergosterol biosynthesis in yeast."
      Marcireau C., Joets J., Pousset D., Guilloton M., Karst F.
      Yeast 12:531-539(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "The fenpropimorph resistance gene FEN2 from Saccharomyces cerevisiae encodes a plasma membrane H+-pantothenate symporter."
      Stolz J., Sauer N.
      J. Biol. Chem. 274:18747-18752(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    8. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.

    Entry informationi

    Entry nameiFEN2_YEAST
    AccessioniPrimary (citable) accession number: P25621
    Secondary accession number(s): D6VR38
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 3060 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome III
      Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

    External Data

    Dasty 3