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Protein

Pantothenate transporter FEN2

Gene

FEN2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transports pantothenate into the cell. Also involved in the catabolite repression-mediated regulation of ergosterol biosynthesis and in fenpropimorph resistance.2 Publications

GO - Molecular functioni

  • pantothenate transmembrane transporter activity Source: SGD

GO - Biological processi

  • endocytosis Source: SGD
  • pantothenate import into cell Source: GO_Central
  • pantothenate transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29343-MONOMER.

Protein family/group databases

TCDBi2.A.1.14.18. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate transporter FEN2
Alternative name(s):
Fenpropimorph resistance protein 2
Gene namesi
Name:FEN2
Ordered Locus Names:YCR028C
ORF Names:YCR28C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCR028C.
SGDiS000000623. FEN2.

Subcellular locationi

  • Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27CytoplasmicSequence analysisAdd BLAST27
Transmembranei28 – 48HelicalSequence analysisAdd BLAST21
Topological domaini49 – 79ExtracellularSequence analysisAdd BLAST31
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Topological domaini101 – 102CytoplasmicSequence analysis2
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Topological domaini124 – 132ExtracellularSequence analysis9
Transmembranei133 – 153HelicalSequence analysisAdd BLAST21
Topological domaini154 – 164CytoplasmicSequence analysisAdd BLAST11
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Topological domaini186 – 198ExtracellularSequence analysisAdd BLAST13
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Topological domaini220 – 271CytoplasmicSequence analysisAdd BLAST52
Transmembranei272 – 292HelicalSequence analysisAdd BLAST21
Topological domaini293 – 312ExtracellularSequence analysisAdd BLAST20
Transmembranei313 – 333HelicalSequence analysisAdd BLAST21
Topological domaini334 – 342CytoplasmicSequence analysis9
Transmembranei343 – 363HelicalSequence analysisAdd BLAST21
Topological domaini364 – 372ExtracellularSequence analysis9
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Topological domaini394 – 401CytoplasmicSequence analysis8
Transmembranei402 – 422HelicalSequence analysisAdd BLAST21
Topological domaini423 – 434ExtracellularSequence analysisAdd BLAST12
Transmembranei435 – 455HelicalSequence analysisAdd BLAST21
Topological domaini456 – 512CytoplasmicSequence analysisAdd BLAST57

GO - Cellular componenti

  • integral component of membrane Source: GO_Central
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001213671 – 512Pantothenate transporter FEN2Add BLAST512

Proteomic databases

MaxQBiP25621.
PRIDEiP25621.

Interactioni

Protein-protein interaction databases

BioGridi31011. 38 interactors.
DIPiDIP-7672N.
IntActiP25621. 6 interactors.
MINTiMINT-1357147.

Structurei

3D structure databases

ProteinModelPortaliP25621.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00620000088258.
HOGENOMiHOG000179304.
InParanoidiP25621.
KOiK03448.
OMAiRWHWWLF.
OrthoDBiEOG092C2VR3.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.

Sequencei

Sequence statusi: Complete.

P25621-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKESKSITQ HEVERESVSS KRAIKKRLLL FKIDLFVLSF VCLQYWINYV
60 70 80 90 100
DRVGFTNAYI SGMKEDLKMV GNDLTVSNTV FMIGYIVGMV PNNLMLLCVP
110 120 130 140 150
PRIWLSFCTF AWGLLTLGMY KVTSFKHICA IRFFQALFES CTFSGTHFVL
160 170 180 190 200
GSWYKEDELP IRSAIFTGSG LVGSMFSGFM QTSIFTHLNG RNGLAGWRWL
210 220 230 240 250
FIIDFCITLP IAIYGFIFFP GLPDQTSAVS KFSMTRYIFN EQELHYARRR
260 270 280 290 300
LPARDESTRL DWSTIPRVLK RWHWWMFSLV WVLGGENLGF ASNSTFALWL
310 320 330 340 350
QNQKYTLAQR NNYPSGIFAV GIVSTLCSAV YMSKIPRARH WHVSVFISLV
360 370 380 390 400
MVIVAVLIRA DPLNPKVVFS AQYLGGVAYA GQAVFFSWAN IICHADLQER
410 420 430 440 450
AIVLASMNMF SGAVNAWWSI LFFASDMVPK FERGCYALLA TAISSGIVSV
460 470 480 490 500
VIRSLQIKEN LSKKQVPYID ANDMPGEDDD DDNQDNENDG DDESMEVELH
510
NEEMAEISNP FR
Length:512
Mass (Da):58,256
Last modified:May 1, 1992 - v1
Checksum:i361942E74C62B3B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42320.1.
BK006937 Genomic DNA. Translation: DAA07507.1.
PIRiS19439.
RefSeqiNP_009957.1. NM_001178743.1.

Genome annotation databases

EnsemblFungiiCAA42320; CAA42320; CAA42320.
YCR028C; YCR028C; YCR028C.
GeneIDi850394.
KEGGisce:YCR028C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42320.1.
BK006937 Genomic DNA. Translation: DAA07507.1.
PIRiS19439.
RefSeqiNP_009957.1. NM_001178743.1.

3D structure databases

ProteinModelPortaliP25621.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31011. 38 interactors.
DIPiDIP-7672N.
IntActiP25621. 6 interactors.
MINTiMINT-1357147.

Protein family/group databases

TCDBi2.A.1.14.18. the major facilitator superfamily (mfs).

Proteomic databases

MaxQBiP25621.
PRIDEiP25621.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAA42320; CAA42320; CAA42320.
YCR028C; YCR028C; YCR028C.
GeneIDi850394.
KEGGisce:YCR028C.

Organism-specific databases

EuPathDBiFungiDB:YCR028C.
SGDiS000000623. FEN2.

Phylogenomic databases

GeneTreeiENSGT00620000088258.
HOGENOMiHOG000179304.
InParanoidiP25621.
KOiK03448.
OMAiRWHWWLF.
OrthoDBiEOG092C2VR3.

Enzyme and pathway databases

BioCyciYEAST:G3O-29343-MONOMER.

Miscellaneous databases

PROiP25621.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFEN2_YEAST
AccessioniPrimary (citable) accession number: P25621
Secondary accession number(s): D6VR38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3060 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.