SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P25619

- HSP30_YEAST

UniProt

P25619 - HSP30_YEAST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

30 kDa heat shock protein

Gene
HSP30, YCR021C, YCR21C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Probably cooperates with other heat shock proteins in the translocation of polypeptides through membranes. It may counteract the altering effect of heat shock on the plasma membrane.

GO - Molecular functioni

  1. ion channel activity Source: InterPro

GO - Biological processi

  1. cellular response to DNA damage stimulus Source: SGD
  2. cellular response to ethanol Source: SGD
  3. cellular response to heat Source: SGD
  4. cellular response to hydrogen peroxide Source: SGD
  5. cellular response to osmotic stress Source: SGD
  6. negative regulation of ATPase activity Source: SGD
Complete GO annotation...

Keywords - Biological processi

Stress response

Enzyme and pathway databases

BioCyciYEAST:G3O-29337-MONOMER.

Protein family/group databases

TCDBi3.E.1.4.1. the ion-translocating microbial rhodopsin (mr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
30 kDa heat shock protein
Gene namesi
Name:HSP30
Ordered Locus Names:YCR021C
ORF Names:YCR21C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome III

Organism-specific databases

CYGDiYCR021c.
SGDiS000000615. HSP30.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434Extracellular Reviewed predictionAdd
BLAST
Transmembranei35 – 5521Helical; Reviewed predictionAdd
BLAST
Topological domaini56 – 6510Cytoplasmic Reviewed prediction
Transmembranei66 – 8621Helical; Reviewed predictionAdd
BLAST
Topological domaini87 – 12135Extracellular Reviewed predictionAdd
BLAST
Transmembranei122 – 14221Helical; Reviewed predictionAdd
BLAST
Topological domaini143 – 15715Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei158 – 17821Helical; Reviewed predictionAdd
BLAST
Topological domaini179 – 1813Extracellular Reviewed prediction
Transmembranei182 – 20221Helical; Reviewed predictionAdd
BLAST
Topological domaini203 – 21513Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei216 – 23621Helical; Reviewed predictionAdd
BLAST
Topological domaini237 – 24812Extracellular Reviewed predictionAdd
BLAST
Transmembranei249 – 26921Helical; Reviewed predictionAdd
BLAST
Topological domaini270 – 33263Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 33233230 kDa heat shock proteinPRO_0000196284Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei308 – 3081Phosphoserine1 Publication
Modified residuei331 – 3311Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP25619.
PeptideAtlasiP25619.

Expressioni

Developmental stagei

Expressed during the entry into stationary phase resulting from glucose limitation.

Gene expression databases

GenevestigatoriP25619.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself1EBI-8563,EBI-8563
AGP1P253761EBI-8563,EBI-2357
CYS4P325821EBI-8563,EBI-4167
FLC1Q089671EBI-8563,EBI-36673
FMP27Q061791EBI-8563,EBI-32551
FMP45Q076511EBI-8563,EBI-2051056
GLN1P322881EBI-8563,EBI-7665
GPA2P108231EBI-8563,EBI-7382
HNM1P198071EBI-8563,EBI-8409
HXT1P324651EBI-8563,EBI-8759
HXT3P324661EBI-8563,EBI-8770
HXT5P386951EBI-8563,EBI-8778
HXT7P390041EBI-8563,EBI-8790
IST2P382501EBI-8563,EBI-21520
ITR1P306051EBI-8563,EBI-2050956
MBF1O144671EBI-8563,EBI-2043025
MID2P360271EBI-8563,EBI-10901
NHA1Q992711EBI-8563,EBI-11808
OSH7P387551EBI-8563,EBI-12641
PDR12Q027851EBI-8563,EBI-13065
PMP3P872841EBI-8563,EBI-13555
PPZ1P265701EBI-8563,EBI-13807
RNR2P099381EBI-8563,EBI-15240
RTN1Q049471EBI-8563,EBI-38020
SFK1P357351EBI-8563,EBI-26678
SNA3P143591EBI-8563,EBI-26122
SNQ2P325681EBI-8563,EBI-17590
STE20Q034971EBI-8563,EBI-18285
TCB3Q036401EBI-8563,EBI-27872
TPO2P532831EBI-8563,EBI-2044753
TPO4Q122561EBI-8563,EBI-37213
UBP1P250371EBI-8563,EBI-19819
YBL029C-AQ3E7561EBI-8563,EBI-2044812
YGR130CP532781EBI-8563,EBI-23314
YHR146WP388451EBI-8563,EBI-24770

Protein-protein interaction databases

BioGridi31004. 90 interactions.
DIPiDIP-4586N.
IntActiP25619. 31 interactions.
MINTiMINT-511943.
STRINGi4932.YCR021C.

Structurei

3D structure databases

ProteinModelPortaliP25619.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi290 – 33243Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5524.
GeneTreeiENSGT00390000004481.
HOGENOMiHOG000248243.
OMAiAQEHIST.
OrthoDBiEOG754J0K.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25619-1 [UniParc]FASTAAdd to Basket

« Hide

MNDTLSSFLN RNEALGLNPP HGLDMHITKR GSDWLWAVFA VFGFILLCYV    50
VMFFIAENKG SRLTRYALAP AFLITFFEFF AFFTYASDLG WTGVQAEFNH 100
VKVSKSITGE VPGIRQIFYS KYIAWFLSWP CLLFLIELAA STTGENDDIS 150
ALDMVHSLLI QIVGTLFWVV SLLVGSLIKS TYKWGYYTIG AVAMLVTQGV 200
ICQRQFFNLK TRGFNALMLC TCMVIVWLYF ICWGLSDGGN RIQPDGEAIF 250
YGVLDLCVFA IYPCYLLIAV SRDGKLPRLS LTGGFSHHHA TDDVEDAAPE 300
TKEAVPESPR ASGETAIHEP EPEAEQAVED TA 332
Length:332
Mass (Da):37,045
Last modified:May 1, 1992 - v1
Checksum:i260474A481D29AC5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M93123 Unassigned DNA. Translation: AAA02903.1.
X59720 Genomic DNA. Translation: CAA42313.1.
BK006937 Genomic DNA. Translation: DAA07500.1.
PIRiS31848.
RefSeqiNP_009950.1. NM_001178735.1.

Genome annotation databases

EnsemblFungiiYCR021C; YCR021C; YCR021C.
GeneIDi850385.
KEGGisce:YCR021C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M93123 Unassigned DNA. Translation: AAA02903.1 .
X59720 Genomic DNA. Translation: CAA42313.1 .
BK006937 Genomic DNA. Translation: DAA07500.1 .
PIRi S31848.
RefSeqi NP_009950.1. NM_001178735.1.

3D structure databases

ProteinModelPortali P25619.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31004. 90 interactions.
DIPi DIP-4586N.
IntActi P25619. 31 interactions.
MINTi MINT-511943.
STRINGi 4932.YCR021C.

Protein family/group databases

TCDBi 3.E.1.4.1. the ion-translocating microbial rhodopsin (mr) family.

Proteomic databases

PaxDbi P25619.
PeptideAtlasi P25619.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YCR021C ; YCR021C ; YCR021C .
GeneIDi 850385.
KEGGi sce:YCR021C.

Organism-specific databases

CYGDi YCR021c.
SGDi S000000615. HSP30.

Phylogenomic databases

eggNOGi COG5524.
GeneTreei ENSGT00390000004481.
HOGENOMi HOG000248243.
OMAi AQEHIST.
OrthoDBi EOG754J0K.

Enzyme and pathway databases

BioCyci YEAST:G3O-29337-MONOMER.

Miscellaneous databases

NextBioi 965897.

Gene expression databases

Genevestigatori P25619.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and sequence of HSP30, a yeast heat-shock gene coding for a hydrophobic membrane protein."
    Regnacq M., Boucherie H.
    Curr. Genet. 23:435-442(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC 44827 / SKQ2N.
  2. "The complete DNA sequence of yeast chromosome III."
    Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
    , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
    Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-331, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-308, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHSP30_YEAST
AccessioniPrimary (citable) accession number: P25619
Secondary accession number(s): D6VR31, Q04556
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: September 3, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 7800 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

External Data

Dasty 3

Similar proteinsi