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Protein

30 kDa heat shock protein

Gene

HSP30

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably cooperates with other heat shock proteins in the translocation of polypeptides through membranes. It may counteract the altering effect of heat shock on the plasma membrane.

Miscellaneous

Present with 7800 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: SGD
  • cellular response to ethanol Source: SGD
  • cellular response to heat Source: SGD
  • cellular response to hydrogen peroxide Source: SGD
  • cellular response to osmotic stress Source: SGD
  • negative regulation of ATPase activity Source: SGD

Keywordsi

Biological processStress response

Enzyme and pathway databases

BioCyciYEAST:G3O-29337-MONOMER

Protein family/group databases

TCDBi3.E.1.4.1 the ion-translocating microbial rhodopsin (mr) family

Names & Taxonomyi

Protein namesi
Recommended name:
30 kDa heat shock protein
Gene namesi
Name:HSP30
Ordered Locus Names:YCR021C
ORF Names:YCR21C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCR021C
SGDiS000000615 HSP30

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34ExtracellularSequence analysisAdd BLAST34
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Topological domaini56 – 65CytoplasmicSequence analysis10
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Topological domaini87 – 121ExtracellularSequence analysisAdd BLAST35
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Topological domaini143 – 157CytoplasmicSequence analysisAdd BLAST15
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 181ExtracellularSequence analysis3
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Topological domaini203 – 215CytoplasmicSequence analysisAdd BLAST13
Transmembranei216 – 236HelicalSequence analysisAdd BLAST21
Topological domaini237 – 248ExtracellularSequence analysisAdd BLAST12
Transmembranei249 – 269HelicalSequence analysisAdd BLAST21
Topological domaini270 – 332CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001962841 – 33230 kDa heat shock proteinAdd BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei308PhosphoserineCombined sources1
Modified residuei331PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP25619
PRIDEiP25619

PTM databases

iPTMnetiP25619

Expressioni

Developmental stagei

Expressed during the entry into stationary phase resulting from glucose limitation.

Interactioni

Protein-protein interaction databases

BioGridi31004, 121 interactors
DIPiDIP-4586N
IntActiP25619, 33 interactors
MINTiP25619
STRINGi4932.YCR021C

Structurei

3D structure databases

ProteinModelPortaliP25619
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi290 – 332Glu-rich (acidic)Add BLAST43

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000004481
HOGENOMiHOG000248243
InParanoidiP25619
OMAiRVFHYLF
OrthoDBiEOG092C44CH

Family and domain databases

InterProiView protein in InterPro
IPR001425 Arc/bac/fun_rhodopsins
PANTHERiPTHR28286 PTHR28286, 1 hit
PfamiView protein in Pfam
PF01036 Bac_rhodopsin, 1 hit
SMARTiView protein in SMART
SM01021 Bac_rhodopsin, 1 hit

Sequencei

Sequence statusi: Complete.

P25619-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDTLSSFLN RNEALGLNPP HGLDMHITKR GSDWLWAVFA VFGFILLCYV
60 70 80 90 100
VMFFIAENKG SRLTRYALAP AFLITFFEFF AFFTYASDLG WTGVQAEFNH
110 120 130 140 150
VKVSKSITGE VPGIRQIFYS KYIAWFLSWP CLLFLIELAA STTGENDDIS
160 170 180 190 200
ALDMVHSLLI QIVGTLFWVV SLLVGSLIKS TYKWGYYTIG AVAMLVTQGV
210 220 230 240 250
ICQRQFFNLK TRGFNALMLC TCMVIVWLYF ICWGLSDGGN RIQPDGEAIF
260 270 280 290 300
YGVLDLCVFA IYPCYLLIAV SRDGKLPRLS LTGGFSHHHA TDDVEDAAPE
310 320 330
TKEAVPESPR ASGETAIHEP EPEAEQAVED TA
Length:332
Mass (Da):37,045
Last modified:May 1, 1992 - v1
Checksum:i260474A481D29AC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93123 Unassigned DNA Translation: AAA02903.1
X59720 Genomic DNA Translation: CAA42313.1
BK006937 Genomic DNA Translation: DAA07500.1
PIRiS31848
RefSeqiNP_009950.1, NM_001178735.1

Genome annotation databases

EnsemblFungiiCAA42313; CAA42313; CAA42313
YCR021C; YCR021C; YCR021C
GeneIDi850385
KEGGisce:YCR021C

Similar proteinsi

Entry informationi

Entry nameiHSP30_YEAST
AccessioniPrimary (citable) accession number: P25619
Secondary accession number(s): D6VR31, Q04556
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: May 23, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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