ID   CTO1_YEAST              Reviewed;         317 AA.
AC   P25616; D6VR23; Q8NIM3;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   24-OCT-2003, sequence version 2.
DT   08-NOV-2023, entry version 134.
DE   RecName: Full=Cold tolerance protein 1 {ECO:0000303|PubMed:25725023};
GN   Name=CTO1 {ECO:0000303|PubMed:25725023}; OrderedLocusNames=YCR015C;
GN   ORFNames=YCR15C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=1574125; DOI=10.1038/357038a0;
RA   Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M.,
RA   Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G.,
RA   Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A.,
RA   Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M., Carcano C.,
RA   Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M.,
RA   Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C.,
RA   Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F.,
RA   Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C.,
RA   Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E.,
RA   Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P.,
RA   Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J.,
RA   Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P.,
RA   Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M.,
RA   Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P.,
RA   Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G.,
RA   Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E.,
RA   Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F.,
RA   Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L.,
RA   Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J.,
RA   Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M.,
RA   Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A.,
RA   Richterich P., Roberts A.B., Rodriguez F., Sanz E.,
RA   Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J.,
RA   Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I.,
RA   Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M.,
RA   Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M.,
RA   Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D.,
RA   Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K.,
RA   Sgouros J.G.;
RT   "The complete DNA sequence of yeast chromosome III.";
RL   Nature 357:38-46(1992).
RN   [2]
RP   SEQUENCE REVISION TO 124.
RA   Valles G., Volckaerts G.;
RL   Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [4]
RP   FUNCTION.
RX   PubMed=25725023; DOI=10.1093/femsyr/fov008;
RA   Vicent I., Navarro A., Mulet J.M., Sharma S., Serrano R.;
RT   "Uptake of inorganic phosphate is a limiting factor for Saccharomyces
RT   cerevisiae during growth at low temperatures.";
RL   FEMS Yeast Res. 15:0-0(2015).
CC   -!- FUNCTION: Protein required for cold tolerance (PubMed:25725023). Plays
CC       a role in the regulation of phosphate uptake (PubMed:25725023).
CC       {ECO:0000269|PubMed:25725023}.
CC   -!- SIMILARITY: Belongs to the CTO1 family. {ECO:0000305}.
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DR   EMBL; X59720; CAC42970.1; -; Genomic_DNA.
DR   EMBL; BK006937; DAA07492.1; -; Genomic_DNA.
DR   PIR; S19425; S19425.
DR   RefSeq; NP_009941.2; NM_001178728.1.
DR   AlphaFoldDB; P25616; -.
DR   BioGRID; 30993; 78.
DR   DIP; DIP-6719N; -.
DR   IntAct; P25616; 1.
DR   STRING; 4932.YCR015C; -.
DR   MaxQB; P25616; -.
DR   PaxDb; 4932-YCR015C; -.
DR   PeptideAtlas; P25616; -.
DR   EnsemblFungi; YCR015C_mRNA; YCR015C; YCR015C.
DR   GeneID; 850373; -.
DR   KEGG; sce:YCR015C; -.
DR   AGR; SGD:S000000608; -.
DR   SGD; S000000608; CTO1.
DR   VEuPathDB; FungiDB:YCR015C; -.
DR   eggNOG; ENOG502S7B4; Eukaryota.
DR   HOGENOM; CLU_056574_0_0_1; -.
DR   InParanoid; P25616; -.
DR   OMA; STTDMEC; -.
DR   OrthoDB; 2414072at2759; -.
DR   BioCyc; YEAST:G3O-29330-MONOMER; -.
DR   BioGRID-ORCS; 850373; 0 hits in 10 CRISPR screens.
DR   PRO; PR:P25616; -.
DR   Proteomes; UP000002311; Chromosome III.
DR   RNAct; P25616; Protein.
DR   GO; GO:0042131; F:thiamine phosphate phosphatase activity; IDA:SGD.
DR   GO; GO:0006817; P:phosphate ion transport; IMP:SGD.
DR   Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR023214; HAD_sf.
DR   PANTHER; PTHR28181:SF1; COLD TOLERANCE PROTEIN 1; 1.
DR   PANTHER; PTHR28181; UPF0655 PROTEIN YCR015C; 1.
DR   SUPFAM; SSF56784; HAD-like; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..317
FT                   /note="Cold tolerance protein 1"
FT                   /id="PRO_0000202562"
SQ   SEQUENCE   317 AA;  36278 MW;  D568031253A15A34 CRC64;
     MKTIIISDFD ETITRVDTIC TIAKLPYLLN PRLKPEWGHF TKTYMDGYHK YKYNGTRSLP
     LLSSGVPTII SQSNFNKLFA DELKYQNHNR VVELNSVNEI TKQQIFKSIS LDQMKTFARD
     QNHEDCLLRD GFKTFCSSVV KNFESDFYVL SINWSKEFIH EVIGDRRLKN SHIFCNDLKK
     VSDKCSQSYN GEFDCRLLTG SDKVKILGEI LDKIDSGCNK EGNSCSYWYI GDSETDLLSI
     LHPSTNGVLL INPQENPSKF IKITEKIIGI PKDKISSFEA DNGPAWLQFC EKEGGKGAYL
     VKSWDSLKDL IMQVTKM
//