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Protein

Accumulation of dyads protein 2

Gene

ADY2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transporter protein required for ammonia export and acetate uptake and resistance. Necessary for up-regulation and down-regulation of meiotic plaque (MP) component levels in a dependency on external acetate. Has a role in ascus formation.5 Publications

GO - Molecular functioni

  • acetate transmembrane transporter activity Source: SGD
  • ammonium transmembrane transporter activity Source: SGD

GO - Biological processi

  • acetate transport Source: SGD
  • ammonium transport Source: SGD
  • meiotic cell cycle Source: UniProtKB-KW
  • nitrogen utilization Source: SGD
  • plasma membrane acetate transport Source: GO_Central
  • transmembrane transport Source: SGD

Keywordsi

Biological processAmmonia transport, Ion transport, Meiosis, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29327-MONOMER

Protein family/group databases

TCDBi2.A.96.1.4 the acetate uptake transporter (acetr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Accumulation of dyads protein 2
Alternative name(s):
Ammonia transport outward protein 1
Gene namesi
Name:ADY2
Synonyms:ATO1
Ordered Locus Names:YCR010C
ORF Names:YCR10C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCR010C
SGDiS000000603 ADY2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 89CytoplasmicSequence analysisAdd BLAST89
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Topological domaini111 – 120ExtracellularSequence analysis10
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Topological domaini142 – 151CytoplasmicSequence analysis10
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Topological domaini173 – 185ExtracellularSequence analysisAdd BLAST13
Transmembranei186 – 206HelicalSequence analysisAdd BLAST21
Topological domaini207 – 208CytoplasmicSequence analysis2
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Topological domaini230 – 240ExtracellularSequence analysisAdd BLAST11
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Topological domaini262 – 283CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001357061 – 283Accumulation of dyads protein 2Add BLAST283

Proteomic databases

PaxDbiP25613
PRIDEiP25613

PTM databases

CarbonylDBiP25613
iPTMnetiP25613

Expressioni

Inductioni

During meiosis and by external ammonia.2 Publications

Interactioni

Protein-protein interaction databases

BioGridi30989, 71 interactors
DIPiDIP-7894N
IntActiP25613, 4 interactors
MINTiP25613
STRINGi4932.YCR010C

Structurei

3D structure databases

ProteinModelPortaliP25613
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000006887
HOGENOMiHOG000224167
InParanoidiP25613
KOiK07034
OMAiWKKGNTF
OrthoDBiEOG092C3O7T

Family and domain databases

InterProiView protein in InterPro
IPR000791 Grp1/Fun34/SatP
PfamiView protein in Pfam
PF01184 Grp1_Fun34_YaaH, 1 hit
PROSITEiView protein in PROSITE
PS01114 GPR1_FUN34_YAAH, 1 hit

Sequencei

Sequence statusi: Complete.

P25613-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDKEQTSGN TDLENAPAGY YSSHDNDVNG VAEDERPSHD SLGKIYTGGD
60 70 80 90 100
NNEYIYIGRQ KFLKSDLYQA FGGTLNPGLA PAPVHKFANP APLGLSAFAL
110 120 130 140 150
TTFVLSMFNA RAQGITVPNV VVGCAMFYGG LVQLIAGIWE IALENTFGGT
160 170 180 190 200
ALCSYGGFWL SFAAIYIPWF GILEAYEDNE SDLNNALGFY LLGWAIFTFG
210 220 230 240 250
LTVCTMKSTV MFFLLFFLLA LTFLLLSIGH FANRLGVTRA GGVLGVVVAF
260 270 280
IAWYNAYAGV ATKQNSYVLA RPFPLPSTER VIF
Length:283
Mass (Da):30,726
Last modified:May 1, 1992 - v1
Checksum:i36DE421B09D8BB40
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA Translation: CAA42327.1
BK006937 Genomic DNA Translation: DAA07488.1
PIRiS19420
RefSeqiNP_009936.1, NM_001178723.1

Genome annotation databases

EnsemblFungiiCAA42327; CAA42327; CAA42327
YCR010C; YCR010C; YCR010C
GeneIDi850368
KEGGisce:YCR010C

Similar proteinsi

Entry informationi

Entry nameiADY2_YEAST
AccessioniPrimary (citable) accession number: P25613
Secondary accession number(s): D6VR19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

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