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Protein

Accumulation of dyads protein 2

Gene

ADY2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transporter protein required for ammonia export and acetate uptake and resistance. Necessary for up-regulation and down-regulation of meiotic plaque (MP) component levels in a dependency on external acetate. Has a role in ascus formation.5 Publications

GO - Molecular functioni

  • acetate transmembrane transporter activity Source: SGD
  • ammonium transmembrane transporter activity Source: SGD

GO - Biological processi

  • acetate transport Source: SGD
  • ammonium transport Source: SGD
  • meiotic cell cycle Source: UniProtKB-KW
  • nitrogen utilization Source: SGD
  • plasma membrane acetate transport Source: GO_Central
  • transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ammonia transport, Ion transport, Meiosis, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29327-MONOMER.

Protein family/group databases

TCDBi2.A.96.1.4. 2.a.96. the acetate uptake transporter (acetr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Accumulation of dyads protein 2
Alternative name(s):
Ammonia transport outward protein 1
Gene namesi
Name:ADY2
Synonyms:ATO1
Ordered Locus Names:YCR010C
ORF Names:YCR10C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCR010C.
SGDiS000000603. ADY2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8989CytoplasmicSequence analysisAdd
BLAST
Transmembranei90 – 11021HelicalSequence analysisAdd
BLAST
Topological domaini111 – 12010ExtracellularSequence analysis
Transmembranei121 – 14121HelicalSequence analysisAdd
BLAST
Topological domaini142 – 15110CytoplasmicSequence analysis
Transmembranei152 – 17221HelicalSequence analysisAdd
BLAST
Topological domaini173 – 18513ExtracellularSequence analysisAdd
BLAST
Transmembranei186 – 20621HelicalSequence analysisAdd
BLAST
Topological domaini207 – 2082CytoplasmicSequence analysis
Transmembranei209 – 22921HelicalSequence analysisAdd
BLAST
Topological domaini230 – 24011ExtracellularSequence analysisAdd
BLAST
Transmembranei241 – 26121HelicalSequence analysisAdd
BLAST
Topological domaini262 – 28322CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
  • vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283Accumulation of dyads protein 2PRO_0000135706Add
BLAST

PTM databases

iPTMnetiP25613.

Expressioni

Inductioni

During meiosis and by external ammonia.2 Publications

Interactioni

Protein-protein interaction databases

BioGridi30989. 10 interactions.
DIPiDIP-7894N.
IntActiP25613. 4 interactions.
MINTiMINT-1355103.

Structurei

3D structure databases

ProteinModelPortaliP25613.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000006887.
HOGENOMiHOG000224167.
InParanoidiP25613.
KOiK07034.
OMAiIDSEIHT.
OrthoDBiEOG092C3O7T.

Family and domain databases

InterProiIPR000791. Grp1/Fun34/SatP.
[Graphical view]
PfamiPF01184. Grp1_Fun34_YaaH. 1 hit.
[Graphical view]
PROSITEiPS01114. GPR1_FUN34_YAAH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25613-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDKEQTSGN TDLENAPAGY YSSHDNDVNG VAEDERPSHD SLGKIYTGGD
60 70 80 90 100
NNEYIYIGRQ KFLKSDLYQA FGGTLNPGLA PAPVHKFANP APLGLSAFAL
110 120 130 140 150
TTFVLSMFNA RAQGITVPNV VVGCAMFYGG LVQLIAGIWE IALENTFGGT
160 170 180 190 200
ALCSYGGFWL SFAAIYIPWF GILEAYEDNE SDLNNALGFY LLGWAIFTFG
210 220 230 240 250
LTVCTMKSTV MFFLLFFLLA LTFLLLSIGH FANRLGVTRA GGVLGVVVAF
260 270 280
IAWYNAYAGV ATKQNSYVLA RPFPLPSTER VIF
Length:283
Mass (Da):30,726
Last modified:May 1, 1992 - v1
Checksum:i36DE421B09D8BB40
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42327.1.
BK006937 Genomic DNA. Translation: DAA07488.1.
PIRiS19420.
RefSeqiNP_009936.1. NM_001178723.1.

Genome annotation databases

EnsemblFungiiCAA42327; CAA42327; CAA42327.
YCR010C; YCR010C; YCR010C.
GeneIDi850368.
KEGGisce:YCR010C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42327.1.
BK006937 Genomic DNA. Translation: DAA07488.1.
PIRiS19420.
RefSeqiNP_009936.1. NM_001178723.1.

3D structure databases

ProteinModelPortaliP25613.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi30989. 10 interactions.
DIPiDIP-7894N.
IntActiP25613. 4 interactions.
MINTiMINT-1355103.

Protein family/group databases

TCDBi2.A.96.1.4. 2.a.96. the acetate uptake transporter (acetr) family.

PTM databases

iPTMnetiP25613.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAA42327; CAA42327; CAA42327.
YCR010C; YCR010C; YCR010C.
GeneIDi850368.
KEGGisce:YCR010C.

Organism-specific databases

EuPathDBiFungiDB:YCR010C.
SGDiS000000603. ADY2.

Phylogenomic databases

GeneTreeiENSGT00390000006887.
HOGENOMiHOG000224167.
InParanoidiP25613.
KOiK07034.
OMAiIDSEIHT.
OrthoDBiEOG092C3O7T.

Enzyme and pathway databases

BioCyciYEAST:G3O-29327-MONOMER.

Miscellaneous databases

PROiP25613.

Family and domain databases

InterProiIPR000791. Grp1/Fun34/SatP.
[Graphical view]
PfamiPF01184. Grp1_Fun34_YaaH. 1 hit.
[Graphical view]
PROSITEiPS01114. GPR1_FUN34_YAAH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADY2_YEAST
AccessioniPrimary (citable) accession number: P25613
Secondary accession number(s): D6VR19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: September 7, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.