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P25611

- RDS1_YEAST

UniProt

P25611 - RDS1_YEAST

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Protein
Regulator of drug sensitivity 1
Gene
RDS1, YCR106W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Zinc cluster transcription factor involved in resistance to cycloheximide.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi15 – 4228Zn(2)-C6 fungal-type1 Publication
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
  3. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. response to xenobiotic stimulus Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-29398-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of drug sensitivity 1
Gene namesi
Name:RDS1
Ordered Locus Names:YCR106W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome III

Organism-specific databases

CYGDiYCR106w.
SGDiS000000703. RDS1.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 832832Regulator of drug sensitivity 1
PRO_0000114994Add
BLAST

Proteomic databases

MaxQBiP25611.

Expressioni

Gene expression databases

GenevestigatoriP25611.

Interactioni

Protein-protein interaction databases

BioGridi31078. 24 interactions.
DIPiDIP-2014N.
IntActiP25611. 22 interactions.
MINTiMINT-409534.
STRINGi4932.YCR106W.

Structurei

3D structure databases

ProteinModelPortaliP25611.
SMRiP25611. Positions 11-48.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG78874.
GeneTreeiENSGT00390000000033.
OMAiCEYEERT.
OrthoDBiEOG73FQXR.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25611-1 [UniParc]FASTAAdd to Basket

« Hide

MDSITVKKPR LRLVCLQCKK IKRKCDKLRP ACSRCQQNSL QCEYEERTDL    50
SANVAANDSD GFNSSHKLNF EQQPVLERTG LRYSLQVPEG VVNATLSIWN 100
AEDMLVIVGL VTFLDYPFAA HSLAQHDQYI RALCASLYGM ALVDFSNYAN 150
GIPCEDTSRS ILGPLSFIEK AIFRRIEHSK QFRVQSAALG LLYNAFSMEE 200
ENFSTLLPSL IAEVEDVLMQ KKDCEILLRC FYQNIYPFYP FMDISLFESD 250
LTSLLLQDDN NRWKISTEVK NVRKKIETLS LLTIVMAMAL MHSKLDANLL 300
SMVKENASES ARKLSLLCHK LLCLLDVFRY PNENTFTCLL YFYVSEHLDP 350
ESPDCVLSPT NLLTLHHLLN LSMTLGLQYE PSKYKRFKDP EVIRQRRILW 400
LGVQSLLFQI SLAEGDAGKS NSEYMEAYLT DFEEYIEASS EYEKSSASES 450
NVQMNDIVWN KYKFHVILSK LMSDCTSVIQ HPQLFHILGN IKRSEDFMAE 500
NFPTSSIYQP LHEKEPNAIK VGKSTVLDVM DIQKTEIFLT NIVGSMCFLN 550
IFDVLSLHFE KKCVMHWEEY EKNYHFLTLK SFNAYLKLAG LISDYLENKF 600
QGNILESRGY IIDKQICFML VRIWMFQCRI LLRFSYKQES QKKLASSSIS 650
TNDNEKEDEM IVILERLIKH IRNQMAHLVD LAKGKLQDSY FGAYQTVPMF 700
RYVVYLIDVG GLVSVTNGFW DKISSDGEIP PKVQQAVRLK WGLDCNNSRR 750
IKQKLISSQS LQSFNQVLLC QMEDAVLSSS FAIKANTAMS QNTAEEFFNI 800
SEEEALNQLL ENNNFDAFWD LLGENLSDMP SL 832
Length:832
Mass (Da):95,690
Last modified:May 1, 1992 - v1
Checksum:i7DF91D86AF08E4E3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59720 Genomic DNA. Translation: CAA42238.1.
BK006937 Genomic DNA. Translation: DAA07575.1.
PIRiS19418.
RefSeqiNP_010031.1. NM_001178813.1.

Genome annotation databases

EnsemblFungiiYCR106W; YCR106W; YCR106W.
GeneIDi850470.
KEGGisce:YCR106W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59720 Genomic DNA. Translation: CAA42238.1 .
BK006937 Genomic DNA. Translation: DAA07575.1 .
PIRi S19418.
RefSeqi NP_010031.1. NM_001178813.1.

3D structure databases

ProteinModelPortali P25611.
SMRi P25611. Positions 11-48.
ModBasei Search...

Protein-protein interaction databases

BioGridi 31078. 24 interactions.
DIPi DIP-2014N.
IntActi P25611. 22 interactions.
MINTi MINT-409534.
STRINGi 4932.YCR106W.

Proteomic databases

MaxQBi P25611.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YCR106W ; YCR106W ; YCR106W .
GeneIDi 850470.
KEGGi sce:YCR106W.

Organism-specific databases

CYGDi YCR106w.
SGDi S000000703. RDS1.

Phylogenomic databases

eggNOGi NOG78874.
GeneTreei ENSGT00390000000033.
OMAi CEYEERT.
OrthoDBi EOG73FQXR.

Enzyme and pathway databases

BioCyci YEAST:G3O-29398-MONOMER.

Miscellaneous databases

NextBioi 966119.

Gene expression databases

Genevestigatori P25611.

Family and domain databases

Gene3Di 4.10.240.10. 1 hit.
InterProi IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view ]
Pfami PF00172. Zn_clus. 1 hit.
[Graphical view ]
SMARTi SM00066. GAL4. 1 hit.
[Graphical view ]
SUPFAMi SSF57701. SSF57701. 1 hit.
PROSITEi PS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete DNA sequence of yeast chromosome III."
    Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
    , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
    Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: PRESENCE OF A ZN(2)-CYS(6) FUNGAL-TYPE BINUCLEAR CLUSTER.
  4. "New regulators of drug sensitivity in the family of yeast zinc cluster proteins."
    Akache B., Turcotte B.
    J. Biol. Chem. 277:21254-21260(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. Cited for: FUNCTION.
  6. Cited for: DNA-BINDING.

Entry informationi

Entry nameiRDS1_YEAST
AccessioniPrimary (citable) accession number: P25611
Secondary accession number(s): D6VRA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: May 14, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

External Data

Dasty 3

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