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P25611

- RDS1_YEAST

UniProt

P25611 - RDS1_YEAST

Protein

Regulator of drug sensitivity 1

Gene

RDS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
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    Functioni

    Zinc cluster transcription factor involved in resistance to cycloheximide.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi15 – 4228Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. response to xenobiotic stimulus Source: SGD

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29398-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of drug sensitivity 1
    Gene namesi
    Name:RDS1
    Ordered Locus Names:YCR106W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome III

    Organism-specific databases

    CYGDiYCR106w.
    SGDiS000000703. RDS1.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 832832Regulator of drug sensitivity 1PRO_0000114994Add
    BLAST

    Proteomic databases

    MaxQBiP25611.

    Expressioni

    Gene expression databases

    GenevestigatoriP25611.

    Interactioni

    Protein-protein interaction databases

    BioGridi31078. 24 interactions.
    DIPiDIP-2014N.
    IntActiP25611. 22 interactions.
    MINTiMINT-409534.
    STRINGi4932.YCR106W.

    Structurei

    3D structure databases

    ProteinModelPortaliP25611.
    SMRiP25611. Positions 11-48.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG78874.
    GeneTreeiENSGT00390000000033.
    OMAiCEYEERT.
    OrthoDBiEOG73FQXR.

    Family and domain databases

    Gene3Di4.10.240.10. 1 hit.
    InterProiIPR001138. Zn2-C6_fun-type_DNA-bd.
    [Graphical view]
    PfamiPF00172. Zn_clus. 1 hit.
    [Graphical view]
    SMARTiSM00066. GAL4. 1 hit.
    [Graphical view]
    SUPFAMiSSF57701. SSF57701. 1 hit.
    PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
    PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P25611-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSITVKKPR LRLVCLQCKK IKRKCDKLRP ACSRCQQNSL QCEYEERTDL    50
    SANVAANDSD GFNSSHKLNF EQQPVLERTG LRYSLQVPEG VVNATLSIWN 100
    AEDMLVIVGL VTFLDYPFAA HSLAQHDQYI RALCASLYGM ALVDFSNYAN 150
    GIPCEDTSRS ILGPLSFIEK AIFRRIEHSK QFRVQSAALG LLYNAFSMEE 200
    ENFSTLLPSL IAEVEDVLMQ KKDCEILLRC FYQNIYPFYP FMDISLFESD 250
    LTSLLLQDDN NRWKISTEVK NVRKKIETLS LLTIVMAMAL MHSKLDANLL 300
    SMVKENASES ARKLSLLCHK LLCLLDVFRY PNENTFTCLL YFYVSEHLDP 350
    ESPDCVLSPT NLLTLHHLLN LSMTLGLQYE PSKYKRFKDP EVIRQRRILW 400
    LGVQSLLFQI SLAEGDAGKS NSEYMEAYLT DFEEYIEASS EYEKSSASES 450
    NVQMNDIVWN KYKFHVILSK LMSDCTSVIQ HPQLFHILGN IKRSEDFMAE 500
    NFPTSSIYQP LHEKEPNAIK VGKSTVLDVM DIQKTEIFLT NIVGSMCFLN 550
    IFDVLSLHFE KKCVMHWEEY EKNYHFLTLK SFNAYLKLAG LISDYLENKF 600
    QGNILESRGY IIDKQICFML VRIWMFQCRI LLRFSYKQES QKKLASSSIS 650
    TNDNEKEDEM IVILERLIKH IRNQMAHLVD LAKGKLQDSY FGAYQTVPMF 700
    RYVVYLIDVG GLVSVTNGFW DKISSDGEIP PKVQQAVRLK WGLDCNNSRR 750
    IKQKLISSQS LQSFNQVLLC QMEDAVLSSS FAIKANTAMS QNTAEEFFNI 800
    SEEEALNQLL ENNNFDAFWD LLGENLSDMP SL 832
    Length:832
    Mass (Da):95,690
    Last modified:May 1, 1992 - v1
    Checksum:i7DF91D86AF08E4E3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59720 Genomic DNA. Translation: CAA42238.1.
    BK006937 Genomic DNA. Translation: DAA07575.1.
    PIRiS19418.
    RefSeqiNP_010031.1. NM_001178813.1.

    Genome annotation databases

    EnsemblFungiiYCR106W; YCR106W; YCR106W.
    GeneIDi850470.
    KEGGisce:YCR106W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59720 Genomic DNA. Translation: CAA42238.1 .
    BK006937 Genomic DNA. Translation: DAA07575.1 .
    PIRi S19418.
    RefSeqi NP_010031.1. NM_001178813.1.

    3D structure databases

    ProteinModelPortali P25611.
    SMRi P25611. Positions 11-48.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31078. 24 interactions.
    DIPi DIP-2014N.
    IntActi P25611. 22 interactions.
    MINTi MINT-409534.
    STRINGi 4932.YCR106W.

    Proteomic databases

    MaxQBi P25611.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YCR106W ; YCR106W ; YCR106W .
    GeneIDi 850470.
    KEGGi sce:YCR106W.

    Organism-specific databases

    CYGDi YCR106w.
    SGDi S000000703. RDS1.

    Phylogenomic databases

    eggNOGi NOG78874.
    GeneTreei ENSGT00390000000033.
    OMAi CEYEERT.
    OrthoDBi EOG73FQXR.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29398-MONOMER.

    Miscellaneous databases

    NextBioi 966119.

    Gene expression databases

    Genevestigatori P25611.

    Family and domain databases

    Gene3Di 4.10.240.10. 1 hit.
    InterProi IPR001138. Zn2-C6_fun-type_DNA-bd.
    [Graphical view ]
    Pfami PF00172. Zn_clus. 1 hit.
    [Graphical view ]
    SMARTi SM00066. GAL4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57701. SSF57701. 1 hit.
    PROSITEi PS00463. ZN2_CY6_FUNGAL_1. 1 hit.
    PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete DNA sequence of yeast chromosome III."
      Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
      , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
      Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: PRESENCE OF A ZN(2)-CYS(6) FUNGAL-TYPE BINUCLEAR CLUSTER.
    4. "New regulators of drug sensitivity in the family of yeast zinc cluster proteins."
      Akache B., Turcotte B.
      J. Biol. Chem. 277:21254-21260(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. Cited for: FUNCTION.
    6. Cited for: DNA-BINDING.

    Entry informationi

    Entry nameiRDS1_YEAST
    AccessioniPrimary (citable) accession number: P25611
    Secondary accession number(s): D6VRA6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome III
      Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

    External Data

    Dasty 3