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P25611 (RDS1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Regulator of drug sensitivity 1
Gene names
Name:RDS1
Ordered Locus Names:YCR106W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length832 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Zinc cluster transcription factor involved in resistance to cycloheximide. Ref.4 Ref.5

Subcellular location

Nucleus Probable.

Sequence similarities

Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 832832Regulator of drug sensitivity 1
PRO_0000114994

Regions

DNA binding15 – 4228Zn(2)-C6 fungal-type Ref.6

Sequences

Sequence LengthMass (Da)Tools
P25611 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: 7DF91D86AF08E4E3

FASTA83295,690
        10         20         30         40         50         60 
MDSITVKKPR LRLVCLQCKK IKRKCDKLRP ACSRCQQNSL QCEYEERTDL SANVAANDSD 

        70         80         90        100        110        120 
GFNSSHKLNF EQQPVLERTG LRYSLQVPEG VVNATLSIWN AEDMLVIVGL VTFLDYPFAA 

       130        140        150        160        170        180 
HSLAQHDQYI RALCASLYGM ALVDFSNYAN GIPCEDTSRS ILGPLSFIEK AIFRRIEHSK 

       190        200        210        220        230        240 
QFRVQSAALG LLYNAFSMEE ENFSTLLPSL IAEVEDVLMQ KKDCEILLRC FYQNIYPFYP 

       250        260        270        280        290        300 
FMDISLFESD LTSLLLQDDN NRWKISTEVK NVRKKIETLS LLTIVMAMAL MHSKLDANLL 

       310        320        330        340        350        360 
SMVKENASES ARKLSLLCHK LLCLLDVFRY PNENTFTCLL YFYVSEHLDP ESPDCVLSPT 

       370        380        390        400        410        420 
NLLTLHHLLN LSMTLGLQYE PSKYKRFKDP EVIRQRRILW LGVQSLLFQI SLAEGDAGKS 

       430        440        450        460        470        480 
NSEYMEAYLT DFEEYIEASS EYEKSSASES NVQMNDIVWN KYKFHVILSK LMSDCTSVIQ 

       490        500        510        520        530        540 
HPQLFHILGN IKRSEDFMAE NFPTSSIYQP LHEKEPNAIK VGKSTVLDVM DIQKTEIFLT 

       550        560        570        580        590        600 
NIVGSMCFLN IFDVLSLHFE KKCVMHWEEY EKNYHFLTLK SFNAYLKLAG LISDYLENKF 

       610        620        630        640        650        660 
QGNILESRGY IIDKQICFML VRIWMFQCRI LLRFSYKQES QKKLASSSIS TNDNEKEDEM 

       670        680        690        700        710        720 
IVILERLIKH IRNQMAHLVD LAKGKLQDSY FGAYQTVPMF RYVVYLIDVG GLVSVTNGFW 

       730        740        750        760        770        780 
DKISSDGEIP PKVQQAVRLK WGLDCNNSRR IKQKLISSQS LQSFNQVLLC QMEDAVLSSS 

       790        800        810        820        830 
FAIKANTAMS QNTAEEFFNI SEEEALNQLL ENNNFDAFWD LLGENLSDMP SL 

« Hide

References

« Hide 'large scale' references
[1]"The complete DNA sequence of yeast chromosome III."
Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M. expand/collapse author list , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"What's in a genome?"
Bork P., Ouzounis C., Sander C., Scharf M., Schneider R., Sonnhammer E.
Nature 358:287-287(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: PRESENCE OF A ZN(2)-CYS(6) FUNGAL-TYPE BINUCLEAR CLUSTER.
[4]"New regulators of drug sensitivity in the family of yeast zinc cluster proteins."
Akache B., Turcotte B.
J. Biol. Chem. 277:21254-21260(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"Transcriptional regulatory code of a eukaryotic genome."
Harbison C.T., Gordon D.B., Lee T.I., Rinaldi N.J., Macisaac K.D., Danford T.W., Hannett N.M., Tagne J.B., Reynolds D.B., Yoo J., Jennings E.G., Zeitlinger J., Pokholok D.K., Kellis M., Rolfe P.A., Takusagawa K.T., Lander E.S., Gifford D.K., Fraenkel E., Young R.A.
Nature 431:99-104(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"High-resolution DNA-binding specificity analysis of yeast transcription factors."
Zhu C., Byers K.J., McCord R.P., Shi Z., Berger M.F., Newburger D.E., Saulrieta K., Smith Z., Shah M.V., Radhakrishnan M., Philippakis A.A., Hu Y., De Masi F., Pacek M., Rolfs A., Murthy T.V.S., Labaer J., Bulyk M.L.
Genome Res. 19:556-566(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: DNA-BINDING.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X59720 Genomic DNA. Translation: CAA42238.1.
BK006937 Genomic DNA. Translation: DAA07575.1.
PIRS19418.
RefSeqNP_010031.1. NM_001178813.1.

3D structure databases

ProteinModelPortalP25611.
SMRP25611. Positions 11-48.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31078. 24 interactions.
DIPDIP-2014N.
IntActP25611. 22 interactions.
MINTMINT-409534.
STRING4932.YCR106W.

Proteomic databases

MaxQBP25611.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYCR106W; YCR106W; YCR106W.
GeneID850470.
KEGGsce:YCR106W.

Organism-specific databases

CYGDYCR106w.
SGDS000000703. RDS1.

Phylogenomic databases

eggNOGNOG78874.
GeneTreeENSGT00390000000033.
OMACEYEERT.
OrthoDBEOG73FQXR.

Enzyme and pathway databases

BioCycYEAST:G3O-29398-MONOMER.

Gene expression databases

GenevestigatorP25611.

Family and domain databases

Gene3D4.10.240.10. 1 hit.
InterProIPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamPF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMSSF57701. SSF57701. 1 hit.
PROSITEPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio966119.

Entry information

Entry nameRDS1_YEAST
AccessionPrimary (citable) accession number: P25611
Secondary accession number(s): D6VRA6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: May 14, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome III

Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families