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Protein

Regulator of drug sensitivity 1

Gene

RDS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Zinc cluster transcription factor involved in resistance to cycloheximide.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi15 – 4228Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • response to xenobiotic stimulus Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-29398-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of drug sensitivity 1
Gene namesi
Name:RDS1
Ordered Locus Names:YCR106W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome III

Organism-specific databases

CYGDiYCR106w.
EuPathDBiFungiDB:YCR106W.
SGDiS000000703. RDS1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 832832Regulator of drug sensitivity 1PRO_0000114994Add
BLAST

Proteomic databases

MaxQBiP25611.

Interactioni

Protein-protein interaction databases

BioGridi31078. 24 interactions.
DIPiDIP-2014N.
IntActiP25611. 22 interactions.
MINTiMINT-409534.
STRINGi4932.YCR106W.

Structurei

3D structure databases

ProteinModelPortaliP25611.
SMRiP25611. Positions 11-48.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG78874.
GeneTreeiENSGT00390000000033.
InParanoidiP25611.
OMAiNIYPFYP.
OrthoDBiEOG73FQXR.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25611-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSITVKKPR LRLVCLQCKK IKRKCDKLRP ACSRCQQNSL QCEYEERTDL
60 70 80 90 100
SANVAANDSD GFNSSHKLNF EQQPVLERTG LRYSLQVPEG VVNATLSIWN
110 120 130 140 150
AEDMLVIVGL VTFLDYPFAA HSLAQHDQYI RALCASLYGM ALVDFSNYAN
160 170 180 190 200
GIPCEDTSRS ILGPLSFIEK AIFRRIEHSK QFRVQSAALG LLYNAFSMEE
210 220 230 240 250
ENFSTLLPSL IAEVEDVLMQ KKDCEILLRC FYQNIYPFYP FMDISLFESD
260 270 280 290 300
LTSLLLQDDN NRWKISTEVK NVRKKIETLS LLTIVMAMAL MHSKLDANLL
310 320 330 340 350
SMVKENASES ARKLSLLCHK LLCLLDVFRY PNENTFTCLL YFYVSEHLDP
360 370 380 390 400
ESPDCVLSPT NLLTLHHLLN LSMTLGLQYE PSKYKRFKDP EVIRQRRILW
410 420 430 440 450
LGVQSLLFQI SLAEGDAGKS NSEYMEAYLT DFEEYIEASS EYEKSSASES
460 470 480 490 500
NVQMNDIVWN KYKFHVILSK LMSDCTSVIQ HPQLFHILGN IKRSEDFMAE
510 520 530 540 550
NFPTSSIYQP LHEKEPNAIK VGKSTVLDVM DIQKTEIFLT NIVGSMCFLN
560 570 580 590 600
IFDVLSLHFE KKCVMHWEEY EKNYHFLTLK SFNAYLKLAG LISDYLENKF
610 620 630 640 650
QGNILESRGY IIDKQICFML VRIWMFQCRI LLRFSYKQES QKKLASSSIS
660 670 680 690 700
TNDNEKEDEM IVILERLIKH IRNQMAHLVD LAKGKLQDSY FGAYQTVPMF
710 720 730 740 750
RYVVYLIDVG GLVSVTNGFW DKISSDGEIP PKVQQAVRLK WGLDCNNSRR
760 770 780 790 800
IKQKLISSQS LQSFNQVLLC QMEDAVLSSS FAIKANTAMS QNTAEEFFNI
810 820 830
SEEEALNQLL ENNNFDAFWD LLGENLSDMP SL
Length:832
Mass (Da):95,690
Last modified:May 1, 1992 - v1
Checksum:i7DF91D86AF08E4E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42238.1.
BK006937 Genomic DNA. Translation: DAA07575.1.
PIRiS19418.
RefSeqiNP_010031.1. NM_001178813.1.

Genome annotation databases

EnsemblFungiiYCR106W; YCR106W; YCR106W.
GeneIDi850470.
KEGGisce:YCR106W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42238.1.
BK006937 Genomic DNA. Translation: DAA07575.1.
PIRiS19418.
RefSeqiNP_010031.1. NM_001178813.1.

3D structure databases

ProteinModelPortaliP25611.
SMRiP25611. Positions 11-48.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31078. 24 interactions.
DIPiDIP-2014N.
IntActiP25611. 22 interactions.
MINTiMINT-409534.
STRINGi4932.YCR106W.

Proteomic databases

MaxQBiP25611.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYCR106W; YCR106W; YCR106W.
GeneIDi850470.
KEGGisce:YCR106W.

Organism-specific databases

CYGDiYCR106w.
EuPathDBiFungiDB:YCR106W.
SGDiS000000703. RDS1.

Phylogenomic databases

eggNOGiNOG78874.
GeneTreeiENSGT00390000000033.
InParanoidiP25611.
OMAiNIYPFYP.
OrthoDBiEOG73FQXR.

Enzyme and pathway databases

BioCyciYEAST:G3O-29398-MONOMER.

Miscellaneous databases

NextBioi966119.
PROiP25611.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The complete DNA sequence of yeast chromosome III."
    Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
    , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
    Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: PRESENCE OF A ZN(2)-CYS(6) FUNGAL-TYPE BINUCLEAR CLUSTER.
  4. "New regulators of drug sensitivity in the family of yeast zinc cluster proteins."
    Akache B., Turcotte B.
    J. Biol. Chem. 277:21254-21260(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. Cited for: FUNCTION.
  6. Cited for: DNA-BINDING.

Entry informationi

Entry nameiRDS1_YEAST
AccessioniPrimary (citable) accession number: P25611
Secondary accession number(s): D6VRA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: June 24, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.