P25611 (RDS1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Regulator of drug sensitivity 1

Gene names

Name:	RDS1
Ordered Locus Names:	YCR106W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	832 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Zinc cluster transcription factor involved in resistance to cycloheximide. Ref.4 Ref.5
Subcellular location	Nucleus Probable.
Sequence similarities	Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: GOC response to xenobiotic stimulus Inferred from mutant phenotype Ref.4. Source: SGD transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: GOC
Cellular_component	nucleus Inferred by curator Ref.5. Source: SGD
Molecular_function	sequence-specific DNA binding Inferred from direct assay PubMed 19111667Ref.6. Source: SGD sequence-specific DNA binding RNA polymerase II transcription factor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 832	832	Regulator of drug sensitivity 1		PRO_0000114994
Regions
	DNA binding	15 – 42	28	Zn(2)-C6 fungal-type Ref.6

Sequences

	Sequence		Length	Mass (Da)
	P25611 [UniParc]. Last modified May 1, 1992. Version 1. Checksum: 7DF91D86AF08E4E3	FASTA	832	95,690
	10 20 30 40 50 60 MDSITVKKPR LRLVCLQCKK IKRKCDKLRP ACSRCQQNSL QCEYEERTDL SANVAANDSD 70 80 90 100 110 120 GFNSSHKLNF EQQPVLERTG LRYSLQVPEG VVNATLSIWN AEDMLVIVGL VTFLDYPFAA 130 140 150 160 170 180 HSLAQHDQYI RALCASLYGM ALVDFSNYAN GIPCEDTSRS ILGPLSFIEK AIFRRIEHSK 190 200 210 220 230 240 QFRVQSAALG LLYNAFSMEE ENFSTLLPSL IAEVEDVLMQ KKDCEILLRC FYQNIYPFYP 250 260 270 280 290 300 FMDISLFESD LTSLLLQDDN NRWKISTEVK NVRKKIETLS LLTIVMAMAL MHSKLDANLL 310 320 330 340 350 360 SMVKENASES ARKLSLLCHK LLCLLDVFRY PNENTFTCLL YFYVSEHLDP ESPDCVLSPT 370 380 390 400 410 420 NLLTLHHLLN LSMTLGLQYE PSKYKRFKDP EVIRQRRILW LGVQSLLFQI SLAEGDAGKS 430 440 450 460 470 480 NSEYMEAYLT DFEEYIEASS EYEKSSASES NVQMNDIVWN KYKFHVILSK LMSDCTSVIQ 490 500 510 520 530 540 HPQLFHILGN IKRSEDFMAE NFPTSSIYQP LHEKEPNAIK VGKSTVLDVM DIQKTEIFLT 550 560 570 580 590 600 NIVGSMCFLN IFDVLSLHFE KKCVMHWEEY EKNYHFLTLK SFNAYLKLAG LISDYLENKF 610 620 630 640 650 660 QGNILESRGY IIDKQICFML VRIWMFQCRI LLRFSYKQES QKKLASSSIS TNDNEKEDEM 670 680 690 700 710 720 IVILERLIKH IRNQMAHLVD LAKGKLQDSY FGAYQTVPMF RYVVYLIDVG GLVSVTNGFW 730 740 750 760 770 780 DKISSDGEIP PKVQQAVRLK WGLDCNNSRR IKQKLISSQS LQSFNQVLLC QMEDAVLSSS 790 800 810 820 830 FAIKANTAMS QNTAEEFFNI SEEEALNQLL ENNNFDAFWD LLGENLSDMP SL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete DNA sequence of yeast chromosome III." Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M. , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G. Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"What's in a genome?" Bork P., Ouzounis C., Sander C., Scharf M., Schneider R., Sonnhammer E. Nature 358:287-287(1992) [PubMed] [Europe PMC] [Abstract] Cited for: PRESENCE OF A ZN(2)-CYS(6) FUNGAL-TYPE BINUCLEAR CLUSTER.
[4]	"New regulators of drug sensitivity in the family of yeast zinc cluster proteins." Akache B., Turcotte B. J. Biol. Chem. 277:21254-21260(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[5]	"Transcriptional regulatory code of a eukaryotic genome." Harbison C.T., Gordon D.B., Lee T.I., Rinaldi N.J., Macisaac K.D., Danford T.W., Hannett N.M., Tagne J.B., Reynolds D.B., Yoo J., Jennings E.G., Zeitlinger J., Pokholok D.K., Kellis M., Rolfe P.A., Takusagawa K.T., Lander E.S., Gifford D.K., Fraenkel E., Young R.A. Nature 431:99-104(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[6]	"High-resolution DNA-binding specificity analysis of yeast transcription factors." Zhu C., Byers K.J., McCord R.P., Shi Z., Berger M.F., Newburger D.E., Saulrieta K., Smith Z., Shah M.V., Radhakrishnan M., Philippakis A.A., Hu Y., De Masi F., Pacek M., Rolfs A., Murthy T.V.S., Labaer J., Bulyk M.L. Genome Res. 19:556-566(2009) [PubMed] [Europe PMC] [Abstract] Cited for: DNA-BINDING.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X59720 Genomic DNA. Translation: CAA42238.1. BK006937 Genomic DNA. Translation: DAA07575.1.
PIR	S19418.
RefSeq	NP_010031.1. NM_001178813.1.
3D structure databases
ProteinModelPortal	P25611.
SMR	P25611. Positions 11-48.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-2014N.
IntAct	P25611. 21 interactions.
MINT	MINT-409534.
STRING	4932.YCR106W.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YCR106W; YCR106W; YCR106W.
GeneID	850470.
KEGG	sce:YCR106W.
Organism-specific databases
CYGD	YCR106w.
SGD	S000000703. RDS1.
Phylogenomic databases
eggNOG	NOG78874.
GeneTree	ENSGT00390000000033.
OMA	NIYPFYP.
OrthoDB	EOG43NBNW.
Gene expression databases
Genevestigator	P25611.
GermOnline	YCR106W. Saccharomyces cerevisiae.
Family and domain databases
Gene3D	4.10.240.10. 1 hit.
InterPro	IPR001138. Zn2-C6_fun-type_DNA-bd. [Graphical view]
Pfam	PF00172. Zn_clus. 1 hit. [Graphical view]
SMART	SM00066. GAL4. 1 hit. [Graphical view]
SUPFAM	SSF57701. Fungi_TrN. 1 hit.
PROSITE	PS00463. ZN2_CY6_FUNGAL_1. 1 hit. PS50048. ZN2_CY6_FUNGAL_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	966119.

Entry information

Entry name

RDS1_YEAST

Accession

Primary (citable) accession number: P25611
Secondary accession number(s): D6VRA6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
Last sequence update:	May 1, 1992
Last modified:	May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program