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Protein

Regulator of drug sensitivity 1

Gene

RDS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Zinc cluster transcription factor involved in resistance to cycloheximide.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi15 – 42Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd BLAST28

GO - Molecular functioni

GO - Biological processi

  • positive regulation of transcription by RNA polymerase II Source: GO_Central
  • response to xenobiotic stimulus Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-29398-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of drug sensitivity 1
Gene namesi
Name:RDS1
Ordered Locus Names:YCR106W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCR106W
SGDiS000000703 RDS1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001149941 – 832Regulator of drug sensitivity 1Add BLAST832

Proteomic databases

MaxQBiP25611
PaxDbiP25611
PRIDEiP25611

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
UBE2IP632793EBI-22052,EBI-80168From Homo sapiens.

Protein-protein interaction databases

BioGridi31078, 42 interactors
DIPiDIP-2014N
IntActiP25611, 25 interactors
MINTiP25611
STRINGi4932.YCR106W

Structurei

3D structure databases

ProteinModelPortaliP25611
SMRiP25611
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000000033
InParanoidiP25611
OMAiNIYPFYP
OrthoDBiEOG092C3HPK

Family and domain databases

CDDicd00067 GAL4, 1 hit
Gene3Di4.10.240.10, 1 hit
InterProiView protein in InterPro
IPR001138 Zn2-C6_fun-type_DNA-bd
IPR036864 Zn2-C6_fun-type_DNA-bd_sf
PfamiView protein in Pfam
PF00172 Zn_clus, 1 hit
SMARTiView protein in SMART
SM00066 GAL4, 1 hit
SUPFAMiSSF57701 SSF57701, 1 hit
PROSITEiView protein in PROSITE
PS00463 ZN2_CY6_FUNGAL_1, 1 hit
PS50048 ZN2_CY6_FUNGAL_2, 1 hit

Sequencei

Sequence statusi: Complete.

P25611-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSITVKKPR LRLVCLQCKK IKRKCDKLRP ACSRCQQNSL QCEYEERTDL
60 70 80 90 100
SANVAANDSD GFNSSHKLNF EQQPVLERTG LRYSLQVPEG VVNATLSIWN
110 120 130 140 150
AEDMLVIVGL VTFLDYPFAA HSLAQHDQYI RALCASLYGM ALVDFSNYAN
160 170 180 190 200
GIPCEDTSRS ILGPLSFIEK AIFRRIEHSK QFRVQSAALG LLYNAFSMEE
210 220 230 240 250
ENFSTLLPSL IAEVEDVLMQ KKDCEILLRC FYQNIYPFYP FMDISLFESD
260 270 280 290 300
LTSLLLQDDN NRWKISTEVK NVRKKIETLS LLTIVMAMAL MHSKLDANLL
310 320 330 340 350
SMVKENASES ARKLSLLCHK LLCLLDVFRY PNENTFTCLL YFYVSEHLDP
360 370 380 390 400
ESPDCVLSPT NLLTLHHLLN LSMTLGLQYE PSKYKRFKDP EVIRQRRILW
410 420 430 440 450
LGVQSLLFQI SLAEGDAGKS NSEYMEAYLT DFEEYIEASS EYEKSSASES
460 470 480 490 500
NVQMNDIVWN KYKFHVILSK LMSDCTSVIQ HPQLFHILGN IKRSEDFMAE
510 520 530 540 550
NFPTSSIYQP LHEKEPNAIK VGKSTVLDVM DIQKTEIFLT NIVGSMCFLN
560 570 580 590 600
IFDVLSLHFE KKCVMHWEEY EKNYHFLTLK SFNAYLKLAG LISDYLENKF
610 620 630 640 650
QGNILESRGY IIDKQICFML VRIWMFQCRI LLRFSYKQES QKKLASSSIS
660 670 680 690 700
TNDNEKEDEM IVILERLIKH IRNQMAHLVD LAKGKLQDSY FGAYQTVPMF
710 720 730 740 750
RYVVYLIDVG GLVSVTNGFW DKISSDGEIP PKVQQAVRLK WGLDCNNSRR
760 770 780 790 800
IKQKLISSQS LQSFNQVLLC QMEDAVLSSS FAIKANTAMS QNTAEEFFNI
810 820 830
SEEEALNQLL ENNNFDAFWD LLGENLSDMP SL
Length:832
Mass (Da):95,690
Last modified:May 1, 1992 - v1
Checksum:i7DF91D86AF08E4E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA Translation: CAA42238.1
BK006937 Genomic DNA Translation: DAA07575.1
PIRiS19418
RefSeqiNP_010031.1, NM_001178813.1

Genome annotation databases

EnsemblFungiiCAA42238; CAA42238; CAA42238
YCR106W; YCR106W; YCR106W
GeneIDi850470
KEGGisce:YCR106W

Similar proteinsi

Entry informationi

Entry nameiRDS1_YEAST
AccessioniPrimary (citable) accession number: P25611
Secondary accession number(s): D6VRA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: March 28, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health