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P25587

- LDB16_YEAST

UniProt

P25587 - LDB16_YEAST

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Protein
Protein LDB16
Gene
LDB16, YCL005W, YCL5W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in protein-linked oligosaccharide phosphorylation since the deletion reduces the negative charge of the cell surface.1 Publication

Enzyme and pathway databases

BioCyciYEAST:G3O-29277-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LDB16
Alternative name(s):
Low dye-binding protein 16
Gene namesi
Name:LDB16
Ordered Locus Names:YCL005W
ORF Names:YCL5W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome III

Organism-specific databases

CYGDiYCL005w.
SGDiS000000511. LDB16.

Subcellular locationi

Membrane; Multi-pass membrane protein. Lipid droplet 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121Helical; Reviewed prediction
Add
BLAST
Transmembranei22 – 4221Helical; Reviewed prediction
Add
BLAST
Topological domaini43 – 7533Extracellular Reviewed prediction
Add
BLAST
Transmembranei76 – 9621Helical; Reviewed prediction
Add
BLAST
Topological domaini97 – 256160Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. lipid particle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Lipid droplet, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 256256Protein LDB16
PRO_0000202538Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei180 – 1801Phosphothreonine1 Publication
Modified residuei184 – 1841Phosphothreonine1 Publication
Modified residuei241 – 2411Phosphoserine3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP25587.

Expressioni

Gene expression databases

GenevestigatoriP25587.

Interactioni

Protein-protein interaction databases

BioGridi30974. 7 interactions.
DIPiDIP-5141N.
IntActiP25587. 2 interactions.
MINTiMINT-531438.
STRINGi4932.YCL005W.

Structurei

3D structure databases

ProteinModelPortaliP25587.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG83696.
OrthoDBiEOG7VX98H.

Sequencei

Sequence statusi: Complete.

P25587-1 [UniParc]FASTAAdd to Basket

« Hide

MFVVDWSVQL CMGVISPLFR ALVQLPLSIF VWNGFQLVAL PINIPLRLFL    50
GTSLSRLVAQ TSTLDFYVVL TLFQYFAVLC AFGSIIGLIF GFILGVFHSI 100
CGVPSVYISL EWKRWFAPIR TVLERASTSI VNIMRGQTIA PIPMPKPNPT 150
HISKPNMKKF HDEPGADDMT ITHDVNCYIT PCQTPTNEKI QHYNNDSFNT 200
TTTDDEPTDI WDRSDTYQNS FVTNETLMSL SNRAKLRRNA SDADIVNIKI 250
LRRNSR 256
Length:256
Mass (Da):29,024
Last modified:May 16, 2003 - v2
Checksum:i49C8084FFCAF50E3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59720 Genomic DNA. Translation: CAC42965.1.
BK006937 Genomic DNA. Translation: DAA07475.1.
PIRiS19390.
RefSeqiNP_009922.2. NM_001178654.1.

Genome annotation databases

EnsemblFungiiYCL005W; YCL005W; YCL005W.
GeneIDi850351.
KEGGisce:YCL005W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59720 Genomic DNA. Translation: CAC42965.1 .
BK006937 Genomic DNA. Translation: DAA07475.1 .
PIRi S19390.
RefSeqi NP_009922.2. NM_001178654.1.

3D structure databases

ProteinModelPortali P25587.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 30974. 7 interactions.
DIPi DIP-5141N.
IntActi P25587. 2 interactions.
MINTi MINT-531438.
STRINGi 4932.YCL005W.

Proteomic databases

PaxDbi P25587.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YCL005W ; YCL005W ; YCL005W .
GeneIDi 850351.
KEGGi sce:YCL005W.

Organism-specific databases

CYGDi YCL005w.
SGDi S000000511. LDB16.

Phylogenomic databases

eggNOGi NOG83696.
OrthoDBi EOG7VX98H.

Enzyme and pathway databases

BioCyci YEAST:G3O-29277-MONOMER.

Miscellaneous databases

NextBioi 965812.

Gene expression databases

Genevestigatori P25587.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete DNA sequence of yeast chromosome III."
    Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
    , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
    Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Valles G., Volckaerts G.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "A genome-wide screen for Saccharomyces cerevisiae nonessential genes involved in mannosyl phosphate transfer to mannoprotein-linked oligosaccharides."
    Corbacho I., Olivero I., Hernandez L.M.
    Fungal Genet. Biol. 42:773-790(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  8. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-241, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-241, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-180; THR-184 AND SER-241, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiLDB16_YEAST
AccessioniPrimary (citable) accession number: P25587
Secondary accession number(s): D6VR06, Q8NIM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 16, 2003
Last modified: May 14, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 149 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

External Data

Dasty 3

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