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P25587

- LDB16_YEAST

UniProt

P25587 - LDB16_YEAST

Protein

Protein LDB16

Gene

LDB16

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 2 (16 May 2003)
      Previous versions | rss
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    Functioni

    May be involved in protein-linked oligosaccharide phosphorylation since the deletion reduces the negative charge of the cell surface.1 Publication

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29277-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein LDB16
    Alternative name(s):
    Low dye-binding protein 16
    Gene namesi
    Name:LDB16
    Ordered Locus Names:YCL005W
    ORF Names:YCL5W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome III

    Organism-specific databases

    CYGDiYCL005w.
    SGDiS000000511. LDB16.

    Subcellular locationi

    Membrane 1 Publication; Multi-pass membrane protein 1 Publication. Lipid droplet 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. lipid particle Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Lipid droplet, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 256256Protein LDB16PRO_0000202538Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei180 – 1801Phosphothreonine1 Publication
    Modified residuei184 – 1841Phosphothreonine1 Publication
    Modified residuei241 – 2411Phosphoserine3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP25587.

    Expressioni

    Gene expression databases

    GenevestigatoriP25587.

    Interactioni

    Protein-protein interaction databases

    BioGridi30974. 7 interactions.
    DIPiDIP-5141N.
    IntActiP25587. 2 interactions.
    MINTiMINT-531438.
    STRINGi4932.YCL005W.

    Structurei

    3D structure databases

    ProteinModelPortaliP25587.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini43 – 7533ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini97 – 256160CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei22 – 4221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei76 – 9621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG83696.
    OrthoDBiEOG7VX98H.

    Sequencei

    Sequence statusi: Complete.

    P25587-1 [UniParc]FASTAAdd to Basket

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    MFVVDWSVQL CMGVISPLFR ALVQLPLSIF VWNGFQLVAL PINIPLRLFL    50
    GTSLSRLVAQ TSTLDFYVVL TLFQYFAVLC AFGSIIGLIF GFILGVFHSI 100
    CGVPSVYISL EWKRWFAPIR TVLERASTSI VNIMRGQTIA PIPMPKPNPT 150
    HISKPNMKKF HDEPGADDMT ITHDVNCYIT PCQTPTNEKI QHYNNDSFNT 200
    TTTDDEPTDI WDRSDTYQNS FVTNETLMSL SNRAKLRRNA SDADIVNIKI 250
    LRRNSR 256
    Length:256
    Mass (Da):29,024
    Last modified:May 16, 2003 - v2
    Checksum:i49C8084FFCAF50E3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59720 Genomic DNA. Translation: CAC42965.1.
    BK006937 Genomic DNA. Translation: DAA07475.1.
    PIRiS19390.
    RefSeqiNP_009922.2. NM_001178654.1.

    Genome annotation databases

    EnsemblFungiiYCL005W; YCL005W; YCL005W.
    GeneIDi850351.
    KEGGisce:YCL005W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59720 Genomic DNA. Translation: CAC42965.1 .
    BK006937 Genomic DNA. Translation: DAA07475.1 .
    PIRi S19390.
    RefSeqi NP_009922.2. NM_001178654.1.

    3D structure databases

    ProteinModelPortali P25587.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 30974. 7 interactions.
    DIPi DIP-5141N.
    IntActi P25587. 2 interactions.
    MINTi MINT-531438.
    STRINGi 4932.YCL005W.

    Proteomic databases

    PaxDbi P25587.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YCL005W ; YCL005W ; YCL005W .
    GeneIDi 850351.
    KEGGi sce:YCL005W.

    Organism-specific databases

    CYGDi YCL005w.
    SGDi S000000511. LDB16.

    Phylogenomic databases

    eggNOGi NOG83696.
    OrthoDBi EOG7VX98H.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29277-MONOMER.

    Miscellaneous databases

    NextBioi 965812.

    Gene expression databases

    Genevestigatori P25587.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The complete DNA sequence of yeast chromosome III."
      Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
      , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
      Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Valles G., Volckaerts G.
      Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "A genome-wide screen for Saccharomyces cerevisiae nonessential genes involved in mannosyl phosphate transfer to mannoprotein-linked oligosaccharides."
      Corbacho I., Olivero I., Hernandez L.M.
      Fungal Genet. Biol. 42:773-790(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    8. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
      Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
      Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-241, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-241, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-180; THR-184 AND SER-241, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiLDB16_YEAST
    AccessioniPrimary (citable) accession number: P25587
    Secondary accession number(s): D6VR06, Q8NIM5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 16, 2003
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 149 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome III
      Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

    External Data

    Dasty 3