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P25583 (KAR4_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Karyogamy protein KAR4
Gene names
Name:KAR4
Ordered Locus Names:YCL055W
ORF Names:YCL432, YCL55W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May assist STE12 in the pheromone-dependent expression of KAR3 and CIK1. Also required for meiosis.

Subcellular location

Nucleus.

Miscellaneous

Present with 1690 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the MT-A70-like family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 335335Karyogamy protein KAR4
PRO_0000207635

Sequences

Sequence LengthMass (Da)Tools
P25583 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: B54A4E2E6563EC81

FASTA33538,672
        10         20         30         40         50         60 
MAFQDPTYDQ NKSRHINNSH LQGPNQETIE MKSKHVSFKP SRDFHTNDYS NNYIHGKSLP 

        70         80         90        100        110        120 
QQHVTNIENR VDGYPKLQKL FQAKAKQINQ FATTPFGCKI GIDSIVPTLN HWIQNENLTF 

       130        140        150        160        170        180 
DVVMIGCLTE NQFIYPILTQ LPLDRLISKP GFLFIWANSQ KINELTKLLN NEIWAKKFRR 

       190        200        210        220        230        240 
SEELVFVPID KKSPFYPGLD QDDETLMEKM QWHCWMCITG TVRRSTDGHL IHCNVDTDLS 

       250        260        270        280        290        300 
IETKDTTNGA VPSHLYRIAE NFSTATRRLH IIPARTGYET PVKVRPGWVI VSPDVMLDNF 

       310        320        330 
SPKRYKEEIA NLGSNIPLKN EIELLRPRSP VQKAQ 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of D10B, a BamHI fragment on the small-ring chromosome III of Saccharomyces cerevisiae."
Defoor E., Debrabandere R., Keyers B., Voet M., Volckaert G.
Yeast 8:681-687(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The complete DNA sequence of yeast chromosome III."
Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M. expand/collapse author list , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Kar4p, a karyogamy-specific component of the yeast pheromone response pathway."
Kurihara L.J., Stewart B.G., Gammie A.E., Rose M.D.
Mol. Cell. Biol. 16:3990-4002(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X59720 Genomic DNA. Translation: CAA42390.1.
BK006937 Genomic DNA. Translation: DAA07431.1.
PIRS19385.
RefSeqNP_009876.1. NM_001178699.1.

3D structure databases

ProteinModelPortalP25583.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid30931. 30 interactions.
DIPDIP-1401N.
IntActP25583. 5 interactions.
MINTMINT-399602.
STRING4932.YCL055W.

Proteomic databases

PaxDbP25583.
PeptideAtlasP25583.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYCL055W; YCL055W; YCL055W.
GeneID850303.
KEGGsce:YCL055W.

Organism-specific databases

CYGDYCL055w.
SGDS000000560. KAR4.

Phylogenomic databases

eggNOGNOG297307.
GeneTreeENSGT00550000075003.
HOGENOMHOG000247875.
OMAQQWHCWM.
OrthoDBEOG7NSBBS.

Enzyme and pathway databases

BioCycYEAST:G3O-29307-MONOMER.

Gene expression databases

GenevestigatorP25583.

Family and domain databases

InterProIPR007757. MT-A70-like.
[Graphical view]
PfamPF05063. MT-A70. 1 hit.
[Graphical view]
PROSITEPS51143. MT_A70. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio965685.
PROP25583.

Entry information

Entry nameKAR4_YEAST
AccessionPrimary (citable) accession number: P25583
Secondary accession number(s): D6VQW2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome III

Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families