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Protein

Karyogamy protein KAR4

Gene

KAR4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May assist STE12 in the pheromone-dependent expression of KAR3 and CIK1. Also required for meiosis.

Miscellaneous

Present with 1690 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • DNA binding transcription factor activity Source: SGD

GO - Biological processi

  • karyogamy involved in conjugation with cellular fusion Source: SGD
  • meiotic cell cycle Source: SGD
  • negative regulation of transcription from RNA polymerase II promoter by pheromones Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter by pheromones Source: SGD

Keywordsi

Biological processKaryogamy, Meiosis

Enzyme and pathway databases

BioCyciYEAST:G3O-29307-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Karyogamy protein KAR4
Gene namesi
Name:KAR4
Ordered Locus Names:YCL055W
ORF Names:YCL432, YCL55W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCL055W
SGDiS000000560 KAR4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002076351 – 335Karyogamy protein KAR4Add BLAST335

Proteomic databases

MaxQBiP25583
PaxDbiP25583
PRIDEiP25583

PTM databases

iPTMnetiP25583

Interactioni

Protein-protein interaction databases

BioGridi30931, 70 interactors
DIPiDIP-1401N
IntActiP25583, 8 interactors
MINTiP25583
STRINGi4932.YCL055W

Structurei

3D structure databases

ProteinModelPortaliP25583
SMRiP25583
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MT-A70-like family.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00550000075003
HOGENOMiHOG000247875
InParanoidiP25583
OMAiRTNINKP
OrthoDBiEOG092C2QAF

Family and domain databases

InterProiView protein in InterPro
IPR007757 MT-A70-like
PfamiView protein in Pfam
PF05063 MT-A70, 1 hit
PROSITEiView protein in PROSITE
PS51143 MT_A70, 1 hit

Sequencei

Sequence statusi: Complete.

P25583-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFQDPTYDQ NKSRHINNSH LQGPNQETIE MKSKHVSFKP SRDFHTNDYS
60 70 80 90 100
NNYIHGKSLP QQHVTNIENR VDGYPKLQKL FQAKAKQINQ FATTPFGCKI
110 120 130 140 150
GIDSIVPTLN HWIQNENLTF DVVMIGCLTE NQFIYPILTQ LPLDRLISKP
160 170 180 190 200
GFLFIWANSQ KINELTKLLN NEIWAKKFRR SEELVFVPID KKSPFYPGLD
210 220 230 240 250
QDDETLMEKM QWHCWMCITG TVRRSTDGHL IHCNVDTDLS IETKDTTNGA
260 270 280 290 300
VPSHLYRIAE NFSTATRRLH IIPARTGYET PVKVRPGWVI VSPDVMLDNF
310 320 330
SPKRYKEEIA NLGSNIPLKN EIELLRPRSP VQKAQ
Length:335
Mass (Da):38,672
Last modified:May 1, 1992 - v1
Checksum:iB54A4E2E6563EC81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA Translation: CAA42390.1
BK006937 Genomic DNA Translation: DAA07431.1
PIRiS19385
RefSeqiNP_009876.1, NM_001178699.1

Genome annotation databases

EnsemblFungiiCAA42390; CAA42390; CAA42390
YCL055W; YCL055W; YCL055W
GeneIDi850303
KEGGisce:YCL055W

Similar proteinsi

Entry informationi

Entry nameiKAR4_YEAST
AccessioniPrimary (citable) accession number: P25583
Secondary accession number(s): D6VQW2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: March 28, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health