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Protein

Promoter of filamentation protein 1

Gene

POF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the filamentation pathway. Suppresses the filamentation defect of a KSS1 deletion.1 Publication

GO - Molecular functioni

  1. ATPase activity Source: SGD
  2. nicotinamide-nucleotide adenylyltransferase activity Source: SGD

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. ER-associated ubiquitin-dependent protein catabolic process Source: SGD
  3. invasive growth in response to glucose limitation Source: SGD
  4. NAD biosynthesis via nicotinamide riboside salvage pathway Source: SGD
  5. pseudohyphal growth Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-29302-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Promoter of filamentation protein 1
Gene namesi
Name:POF1
Ordered Locus Names:YCL047C
ORF Names:YCL47C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome III

Organism-specific databases

CYGDiYCL047c.
SGDiS000000552. POF1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: SGD
  2. nucleus Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Promoter of filamentation protein 1PRO_0000202549Add
BLAST

Proteomic databases

MaxQBiP25576.
PaxDbiP25576.
PeptideAtlasiP25576.

Expressioni

Gene expression databases

GenevestigatoriP25576.

Interactioni

Subunit structurei

Interacts with KSS1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PRP40P332031EBI-21752,EBI-701
SSM4P403181EBI-21752,EBI-18208

Protein-protein interaction databases

BioGridi30938. 6 interactions.
IntActiP25576. 3 interactions.
MINTiMINT-2492497.
STRINGi4932.YCL047C.

Structurei

3D structure databases

ProteinModelPortaliP25576.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the POF1 family.Curated

Phylogenomic databases

eggNOGiNOG77130.
InParanoidiP25576.
OMAiTNHAKFV.
OrthoDBiEOG7BGHZG.

Family and domain databases

Gene3Di3.40.50.620. 2 hits.
InterProiIPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25576-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKTFEQFRK SNLLFQVLKG PQHLECQKLF VLDSSFNPPH LAHFQLLSQT
60 70 80 90 100
IKNFKLKDTR SHVLLLLAVN NADKLPKPAS FPTRLEMMCL FADYLQEKLP
110 120 130 140 150
QSVVSVGLTV FSKFIDKDKI LHEQFVKGCS ADIGYLVGFD TIARIFDEKY
160 170 180 190 200
YHPLKISDVM ESFMSGSQLY CLARGDCHLS AESQLRYASD ILEGKFEPVI
210 220 230 240 250
PREWGARIHV MQNDYPALRN VSSSEIRNKL KNGQVESLKD ELPLCIYDYL

INNKTIFD
Length:258
Mass (Da):29,673
Last modified:May 1, 1992 - v1
Checksum:i1A55281FC19854C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42369.1.
BK006937 Genomic DNA. Translation: DAA07439.1.
PIRiS19376.
RefSeqiNP_009883.1. NM_001178692.1.

Genome annotation databases

EnsemblFungiiYCL047C; YCL047C; YCL047C.
GeneIDi850310.
KEGGisce:YCL047C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42369.1.
BK006937 Genomic DNA. Translation: DAA07439.1.
PIRiS19376.
RefSeqiNP_009883.1. NM_001178692.1.

3D structure databases

ProteinModelPortaliP25576.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi30938. 6 interactions.
IntActiP25576. 3 interactions.
MINTiMINT-2492497.
STRINGi4932.YCL047C.

Proteomic databases

MaxQBiP25576.
PaxDbiP25576.
PeptideAtlasiP25576.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYCL047C; YCL047C; YCL047C.
GeneIDi850310.
KEGGisce:YCL047C.

Organism-specific databases

CYGDiYCL047c.
SGDiS000000552. POF1.

Phylogenomic databases

eggNOGiNOG77130.
InParanoidiP25576.
OMAiTNHAKFV.
OrthoDBiEOG7BGHZG.

Enzyme and pathway databases

BioCyciYEAST:G3O-29302-MONOMER.

Miscellaneous databases

NextBioi965706.

Gene expression databases

GenevestigatoriP25576.

Family and domain databases

Gene3Di3.40.50.620. 2 hits.
InterProiIPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The complete DNA sequence of yeast chromosome III."
    Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
    , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
    Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  4. "Diverse protein kinase interactions identified by protein microarrays reveal novel connections between cellular processes."
    Fasolo J., Sboner A., Sun M.G., Yu H., Chen R., Sharon D., Kim P.M., Gerstein M., Snyder M.
    Genes Dev. 25:767-778(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH KSS1.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPOF1_YEAST
AccessioniPrimary (citable) accession number: P25576
Secondary accession number(s): D6VQX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: January 7, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 830 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.