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P25569

- GID7_YEAST

UniProt

P25569 - GID7_YEAST

Protein

Glucose-induced degradation protein 7

Gene

GID7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Has a role in the negative regulation of gluconeogenesis. Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase).1 Publication

    GO - Biological processi

    1. negative regulation of gluconeogenesis Source: SGD
    2. proteasome-mediated ubiquitin-dependent protein catabolic process Source: SGD

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29298-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-induced degradation protein 7
    Gene namesi
    Name:GID7
    Synonyms:MOH2
    Ordered Locus Names:YCL039W
    ORF Names:YCL311, YCL39W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome III

    Organism-specific databases

    CYGDiYCL039w.
    SGDiS000000544. GID7.

    Subcellular locationi

    Nucleus 1 Publication. Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. GID complex Source: SGD
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 745745Glucose-induced degradation protein 7PRO_0000051006Add
    BLAST

    Proteomic databases

    MaxQBiP25569.
    PaxDbiP25569.
    PeptideAtlasiP25569.

    Expressioni

    Gene expression databases

    GenevestigatoriP25569.

    Interactioni

    Protein-protein interaction databases

    BioGridi30944. 27 interactions.
    DIPiDIP-4496N.
    IntActiP25569. 2 interactions.
    MINTiMINT-572840.
    STRINGi4932.YCL039W.

    Structurei

    3D structure databases

    ProteinModelPortaliP25569.
    SMRiP25569. Positions 622-741.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati167 – 20943WD 1Add
    BLAST
    Repeati322 – 36544WD 2Add
    BLAST
    Repeati369 – 40840WD 3Add
    BLAST
    Repeati540 – 57940WD 4Add
    BLAST
    Repeati613 – 65240WD 5Add
    BLAST
    Repeati657 – 69640WD 6Add
    BLAST
    Repeati710 – 74536WD 7Add
    BLAST

    Sequence similaritiesi

    Contains 7 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiNOG281318.
    GeneTreeiENSGT00730000111021.
    HOGENOMiHOG000057092.
    OMAiKNMTCIS.
    OrthoDBiEOG7FR7S6.

    Family and domain databases

    Gene3Di2.130.10.10. 3 hits.
    InterProiIPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 2 hits.
    [Graphical view]
    SMARTiSM00320. WD40. 5 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 4 hits.
    PROSITEiPS50082. WD_REPEATS_2. 2 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P25569-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHTNKIAYV LNNDTEETAS PSSVGCFDKK QLTKLLIHTL KELGYDSAAN    50
    QLLLESGGYQ NESNHIQTFF KLIKTGQFHL INWQIVCSLP LAHSSPLRSE 100
    WLQRLLIPTP TPATTSLFDH MLLQLQYLQQ LMSSVNSSTC SDAEIATLRN 150
    YVEIMILVNR QIFLEFFHPV TNSASHKGPH TALPVLYLRK ILKNFIEIWD 200
    SLLVSNDQFL NEENIFNPET TLRELSTYLT NPKLTAQLNL ERDHLIDAIS 250
    KYIDPNELVP KGRLLHLLKQ AIKYQQSQDI FNIIDPDDDA SFSSPPHRIN 300
    LLQDNFSHDL TVTFQEWKTI QDTTDEIWFL TFSPNGKYLA SATSESSRGY 350
    FITVYDVEQD FKIYKTCVSL SQSVLYLMFS PDSRYLVACP FSEDVTIYDM 400
    NATSLPDASA TDSFLLYPST RLSPMDSFKL DTTTYPDDTE SSASSSSRPA 450
    NANSNQSRVW CCDAFHTAER AGWMVVGSPD REAIVHSLTT KESLFSLKGR 500
    TCIALGHDEN ISGRKSIDPA KVLYKPTSSN GNWQYVEDDE TFPRVHDVKI 550
    SYDDKYVLLM THQGVIDVYD FSGFPSKEEL SKQTVDPKNF LIPRIARLDV 600
    GKNMTCISLP LNTTHQGFHR QQISESQHLV LVSLQDNELQ MWDYKENILI 650
    QKYFGQKQQH FIIRSCFAYG NKLVMSGSED GKIYIWDRIR GNLVSVLSGH 700
    STVMSNSTKP MGKNCNVVAS NPADKEMFAS GGDDGKIKIW KISRN 745
    Length:745
    Mass (Da):84,517
    Last modified:September 5, 2006 - v2
    Checksum:i558D538AD27E3B71
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59720 Genomic DNA. Translation: CAA42377.1.
    BK006937 Genomic DNA. Translation: DAA07445.1.
    PIRiS74281.
    RefSeqiNP_009891.1. NM_001178684.1.

    Genome annotation databases

    EnsemblFungiiYCL039W; YCL039W; YCL039W.
    GeneIDi850318.
    KEGGisce:YCL039W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59720 Genomic DNA. Translation: CAA42377.1 .
    BK006937 Genomic DNA. Translation: DAA07445.1 .
    PIRi S74281.
    RefSeqi NP_009891.1. NM_001178684.1.

    3D structure databases

    ProteinModelPortali P25569.
    SMRi P25569. Positions 622-741.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 30944. 27 interactions.
    DIPi DIP-4496N.
    IntActi P25569. 2 interactions.
    MINTi MINT-572840.
    STRINGi 4932.YCL039W.

    Proteomic databases

    MaxQBi P25569.
    PaxDbi P25569.
    PeptideAtlasi P25569.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YCL039W ; YCL039W ; YCL039W .
    GeneIDi 850318.
    KEGGi sce:YCL039W.

    Organism-specific databases

    CYGDi YCL039w.
    SGDi S000000544. GID7.

    Phylogenomic databases

    eggNOGi NOG281318.
    GeneTreei ENSGT00730000111021.
    HOGENOMi HOG000057092.
    OMAi KNMTCIS.
    OrthoDBi EOG7FR7S6.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29298-MONOMER.

    Miscellaneous databases

    NextBioi 965724.
    PROi P25569.

    Gene expression databases

    Genevestigatori P25569.

    Family and domain databases

    Gene3Di 2.130.10.10. 3 hits.
    InterProi IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 2 hits.
    [Graphical view ]
    SMARTi SM00320. WD40. 5 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 4 hits.
    PROSITEi PS50082. WD_REPEATS_2. 2 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete sequence of a 9,543 bp segment on the left arm of chromosome III reveals five open reading frames including glucokinase and the protein disulfide isomerase."
      Scherens B., Messenguy F., Gigot D., Dubois E.
      Yeast 8:577-586(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The complete DNA sequence of yeast chromosome III."
      Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
      , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
      Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Catabolite degradation of fructose-1,6-bisphosphatase in the yeast Saccharomyces cerevisiae: a genome-wide screen identifies eight novel GID genes and indicates the existence of two degradation pathways."
      Regelmann J., Schuele T., Josupeit F.S., Horak J., Rose M., Entian K.-D., Thumm M., Wolf D.H.
      Mol. Biol. Cell 14:1652-1663(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiGID7_YEAST
    AccessioniPrimary (citable) accession number: P25569
    Secondary accession number(s): D6VQX6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1200 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome III
      Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

    External Data

    Dasty 3