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Protein

Glucose-induced degradation protein 7

Gene

GID7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has a role in the negative regulation of gluconeogenesis. Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase).1 Publication

Miscellaneous

Present with 1200 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • negative regulation of gluconeogenesis Source: SGD
  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: SGD

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

BioCyciYEAST:G3O-29298-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-induced degradation protein 7
Gene namesi
Name:GID7
Synonyms:MOH2
Ordered Locus Names:YCL039W
ORF Names:YCL311, YCL39W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCL039W
SGDiS000000544 GID7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000510061 – 745Glucose-induced degradation protein 7Add BLAST745

Proteomic databases

MaxQBiP25569
PaxDbiP25569
PRIDEiP25569
TopDownProteomicsiP25569

PTM databases

iPTMnetiP25569

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
VID30P530766EBI-21727,EBI-24173

Protein-protein interaction databases

BioGridi30944, 109 interactors
DIPiDIP-4496N
IntActiP25569, 22 interactors
MINTiP25569
STRINGi4932.YCL039W

Structurei

3D structure databases

ProteinModelPortaliP25569
SMRiP25569
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati167 – 209WD 1Add BLAST43
Repeati322 – 365WD 2Add BLAST44
Repeati369 – 408WD 3Add BLAST40
Repeati540 – 579WD 4Add BLAST40
Repeati613 – 652WD 5Add BLAST40
Repeati657 – 696WD 6Add BLAST40
Repeati710 – 745WD 7Add BLAST36

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00730000111021
HOGENOMiHOG000057092
InParanoidiP25569
KOiK22382
OMAiAVIYCCW
OrthoDBiEOG092C1APW

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 4 hits
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

P25569-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHTNKIAYV LNNDTEETAS PSSVGCFDKK QLTKLLIHTL KELGYDSAAN
60 70 80 90 100
QLLLESGGYQ NESNHIQTFF KLIKTGQFHL INWQIVCSLP LAHSSPLRSE
110 120 130 140 150
WLQRLLIPTP TPATTSLFDH MLLQLQYLQQ LMSSVNSSTC SDAEIATLRN
160 170 180 190 200
YVEIMILVNR QIFLEFFHPV TNSASHKGPH TALPVLYLRK ILKNFIEIWD
210 220 230 240 250
SLLVSNDQFL NEENIFNPET TLRELSTYLT NPKLTAQLNL ERDHLIDAIS
260 270 280 290 300
KYIDPNELVP KGRLLHLLKQ AIKYQQSQDI FNIIDPDDDA SFSSPPHRIN
310 320 330 340 350
LLQDNFSHDL TVTFQEWKTI QDTTDEIWFL TFSPNGKYLA SATSESSRGY
360 370 380 390 400
FITVYDVEQD FKIYKTCVSL SQSVLYLMFS PDSRYLVACP FSEDVTIYDM
410 420 430 440 450
NATSLPDASA TDSFLLYPST RLSPMDSFKL DTTTYPDDTE SSASSSSRPA
460 470 480 490 500
NANSNQSRVW CCDAFHTAER AGWMVVGSPD REAIVHSLTT KESLFSLKGR
510 520 530 540 550
TCIALGHDEN ISGRKSIDPA KVLYKPTSSN GNWQYVEDDE TFPRVHDVKI
560 570 580 590 600
SYDDKYVLLM THQGVIDVYD FSGFPSKEEL SKQTVDPKNF LIPRIARLDV
610 620 630 640 650
GKNMTCISLP LNTTHQGFHR QQISESQHLV LVSLQDNELQ MWDYKENILI
660 670 680 690 700
QKYFGQKQQH FIIRSCFAYG NKLVMSGSED GKIYIWDRIR GNLVSVLSGH
710 720 730 740
STVMSNSTKP MGKNCNVVAS NPADKEMFAS GGDDGKIKIW KISRN
Length:745
Mass (Da):84,517
Last modified:September 5, 2006 - v2
Checksum:i558D538AD27E3B71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA Translation: CAA42377.1
BK006937 Genomic DNA Translation: DAA07445.1
PIRiS74281
RefSeqiNP_009891.1, NM_001178684.1

Genome annotation databases

EnsemblFungiiCAA42377; CAA42377; CAA42377
YCL039W; YCL039W; YCL039W
GeneIDi850318
KEGGisce:YCL039W

Similar proteinsi

Entry informationi

Entry nameiGID7_YEAST
AccessioniPrimary (citable) accession number: P25569
Secondary accession number(s): D6VQX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: September 5, 2006
Last modified: May 23, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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