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P25569

- GID7_YEAST

UniProt

P25569 - GID7_YEAST

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Protein
Glucose-induced degradation protein 7
Gene
GID7, MOH2, YCL039W, YCL311, YCL39W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Has a role in the negative regulation of gluconeogenesis. Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase).1 Publication

GO - Biological processi

  1. negative regulation of gluconeogenesis Source: SGD
  2. proteasome-mediated ubiquitin-dependent protein catabolic process Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

BioCyciYEAST:G3O-29298-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-induced degradation protein 7
Gene namesi
Name:GID7
Synonyms:MOH2
Ordered Locus Names:YCL039W
ORF Names:YCL311, YCL39W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome III

Organism-specific databases

CYGDiYCL039w.
SGDiS000000544. GID7.

Subcellular locationi

Nucleus. Cytoplasm 1 Publication

GO - Cellular componenti

  1. GID complex Source: SGD
  2. cytoplasm Source: UniProtKB-SubCell
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 745745Glucose-induced degradation protein 7
PRO_0000051006Add
BLAST

Proteomic databases

MaxQBiP25569.
PaxDbiP25569.
PeptideAtlasiP25569.

Expressioni

Gene expression databases

GenevestigatoriP25569.

Interactioni

Protein-protein interaction databases

BioGridi30944. 27 interactions.
DIPiDIP-4496N.
IntActiP25569. 2 interactions.
MINTiMINT-572840.
STRINGi4932.YCL039W.

Structurei

3D structure databases

ProteinModelPortaliP25569.
SMRiP25569. Positions 622-741.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati167 – 20943WD 1
Add
BLAST
Repeati322 – 36544WD 2
Add
BLAST
Repeati369 – 40840WD 3
Add
BLAST
Repeati540 – 57940WD 4
Add
BLAST
Repeati613 – 65240WD 5
Add
BLAST
Repeati657 – 69640WD 6
Add
BLAST
Repeati710 – 74536WD 7
Add
BLAST

Sequence similaritiesi

Contains 7 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG281318.
GeneTreeiENSGT00730000111021.
HOGENOMiHOG000057092.
OMAiKNMTCIS.
OrthoDBiEOG7FR7S6.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 4 hits.
PROSITEiPS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25569-1 [UniParc]FASTAAdd to Basket

« Hide

MSHTNKIAYV LNNDTEETAS PSSVGCFDKK QLTKLLIHTL KELGYDSAAN    50
QLLLESGGYQ NESNHIQTFF KLIKTGQFHL INWQIVCSLP LAHSSPLRSE 100
WLQRLLIPTP TPATTSLFDH MLLQLQYLQQ LMSSVNSSTC SDAEIATLRN 150
YVEIMILVNR QIFLEFFHPV TNSASHKGPH TALPVLYLRK ILKNFIEIWD 200
SLLVSNDQFL NEENIFNPET TLRELSTYLT NPKLTAQLNL ERDHLIDAIS 250
KYIDPNELVP KGRLLHLLKQ AIKYQQSQDI FNIIDPDDDA SFSSPPHRIN 300
LLQDNFSHDL TVTFQEWKTI QDTTDEIWFL TFSPNGKYLA SATSESSRGY 350
FITVYDVEQD FKIYKTCVSL SQSVLYLMFS PDSRYLVACP FSEDVTIYDM 400
NATSLPDASA TDSFLLYPST RLSPMDSFKL DTTTYPDDTE SSASSSSRPA 450
NANSNQSRVW CCDAFHTAER AGWMVVGSPD REAIVHSLTT KESLFSLKGR 500
TCIALGHDEN ISGRKSIDPA KVLYKPTSSN GNWQYVEDDE TFPRVHDVKI 550
SYDDKYVLLM THQGVIDVYD FSGFPSKEEL SKQTVDPKNF LIPRIARLDV 600
GKNMTCISLP LNTTHQGFHR QQISESQHLV LVSLQDNELQ MWDYKENILI 650
QKYFGQKQQH FIIRSCFAYG NKLVMSGSED GKIYIWDRIR GNLVSVLSGH 700
STVMSNSTKP MGKNCNVVAS NPADKEMFAS GGDDGKIKIW KISRN 745
Length:745
Mass (Da):84,517
Last modified:September 5, 2006 - v2
Checksum:i558D538AD27E3B71
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59720 Genomic DNA. Translation: CAA42377.1.
BK006937 Genomic DNA. Translation: DAA07445.1.
PIRiS74281.
RefSeqiNP_009891.1. NM_001178684.1.

Genome annotation databases

EnsemblFungiiYCL039W; YCL039W; YCL039W.
GeneIDi850318.
KEGGisce:YCL039W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59720 Genomic DNA. Translation: CAA42377.1 .
BK006937 Genomic DNA. Translation: DAA07445.1 .
PIRi S74281.
RefSeqi NP_009891.1. NM_001178684.1.

3D structure databases

ProteinModelPortali P25569.
SMRi P25569. Positions 622-741.
ModBasei Search...

Protein-protein interaction databases

BioGridi 30944. 27 interactions.
DIPi DIP-4496N.
IntActi P25569. 2 interactions.
MINTi MINT-572840.
STRINGi 4932.YCL039W.

Proteomic databases

MaxQBi P25569.
PaxDbi P25569.
PeptideAtlasi P25569.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YCL039W ; YCL039W ; YCL039W .
GeneIDi 850318.
KEGGi sce:YCL039W.

Organism-specific databases

CYGDi YCL039w.
SGDi S000000544. GID7.

Phylogenomic databases

eggNOGi NOG281318.
GeneTreei ENSGT00730000111021.
HOGENOMi HOG000057092.
OMAi KNMTCIS.
OrthoDBi EOG7FR7S6.

Enzyme and pathway databases

BioCyci YEAST:G3O-29298-MONOMER.

Miscellaneous databases

NextBioi 965724.
PROi P25569.

Gene expression databases

Genevestigatori P25569.

Family and domain databases

Gene3Di 2.130.10.10. 3 hits.
InterProi IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 2 hits.
[Graphical view ]
SMARTi SM00320. WD40. 5 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 4 hits.
PROSITEi PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete sequence of a 9,543 bp segment on the left arm of chromosome III reveals five open reading frames including glucokinase and the protein disulfide isomerase."
    Scherens B., Messenguy F., Gigot D., Dubois E.
    Yeast 8:577-586(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete DNA sequence of yeast chromosome III."
    Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
    , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
    Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Catabolite degradation of fructose-1,6-bisphosphatase in the yeast Saccharomyces cerevisiae: a genome-wide screen identifies eight novel GID genes and indicates the existence of two degradation pathways."
    Regelmann J., Schuele T., Josupeit F.S., Horak J., Rose M., Entian K.-D., Thumm M., Wolf D.H.
    Mol. Biol. Cell 14:1652-1663(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGID7_YEAST
AccessioniPrimary (citable) accession number: P25569
Secondary accession number(s): D6VQX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: September 5, 2006
Last modified: May 14, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1200 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

External Data

Dasty 3

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