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Protein

Autophagy-related protein 22

Gene

ATG22

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Vacuolar effluxer which mediate the efflux of leucine and other amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.3 Publications

GO - Molecular functioni

GO - Biological processi

  • amino acid transmembrane export from vacuole Source: SGD
  • autophagy Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Autophagy, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29297-MONOMER.

Protein family/group databases

TCDBi2.A.1.24.1. the major facilitator superfamily (mfs).
9.A.15.1.1. the autophagy-related phagophore-formation transporter (apt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 22
Gene namesi
Name:ATG22
Synonyms:AUT4
Ordered Locus Names:YCL038C
ORF Names:YCL38C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCL038C.
SGDiS000000543. ATG22.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 98CytoplasmicSequence analysisAdd BLAST98
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Topological domaini120 – 130VacuolarSequence analysisAdd BLAST11
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Topological domaini152 – 153CytoplasmicSequence analysis2
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Topological domaini175 – 210VacuolarSequence analysisAdd BLAST36
Transmembranei211 – 231HelicalSequence analysisAdd BLAST21
Topological domaini232 – 241CytoplasmicSequence analysis10
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Topological domaini263 – 318VacuolarSequence analysisAdd BLAST56
Transmembranei319 – 339HelicalSequence analysisAdd BLAST21
Topological domaini340 – 352CytoplasmicSequence analysisAdd BLAST13
Transmembranei353 – 373HelicalSequence analysisAdd BLAST21
Topological domaini374 – 388VacuolarSequence analysisAdd BLAST15
Transmembranei389 – 409HelicalSequence analysisAdd BLAST21
Topological domaini410 – 417CytoplasmicSequence analysis8
Transmembranei418 – 438HelicalSequence analysisAdd BLAST21
Topological domaini439 – 485VacuolarSequence analysisAdd BLAST47
Transmembranei486 – 506HelicalSequence analysisAdd BLAST21
Topological domaini507 – 528CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

  • integral component of fungal-type vacuolar membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002076291 – 528Autophagy-related protein 22Add BLAST528

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei278PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP25568.
PRIDEiP25568.

PTM databases

iPTMnetiP25568.

Interactioni

Protein-protein interaction databases

BioGridi30945. 17 interactors.
DIPiDIP-4976N.
IntActiP25568. 3 interactors.
MINTiMINT-478200.

Structurei

3D structure databases

ProteinModelPortaliP25568.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATG22 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000034115.
InParanoidiP25568.
KOiK06902.
OMAiIRPAFWF.
OrthoDBiEOG092C2E0G.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR024671. Atg22-like.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF11700. ATG22. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.

Sequencei

Sequence statusi: Complete.

P25568-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYGTINDMN ESVTNYRIKK AQNNIKGWYA YSFSSEPFVV SAVSTYIPLL
60 70 80 90 100
LQQFASINGV KVHDHSIPCL SETGSDSDKC VLGLFNNRIF VDTSSFALYV
110 120 130 140 150
FSLSVLFQTI IVISVSGIVD LWGSVKFKGR ILVWFGIVGA LSTVAISKLN
160 170 180 190 200
DTQIYSLAGL YIVANGCFGV INVVGNSLLP IFVKDSLKCQ SQGAYEPDKV
210 220 230 240 250
DSLTTVISGR GASLGYSSAL IVQIVSMFLV ASKKGSKQDV QVAVLFVGIW
260 270 280 290 300
WFVWQLPMIW LIDDVTIPIR VDDSTLASAR SPYPGEQDAL GQLNWKNYLS
310 320 330 340 350
YGWVSLFESF KHARLLKDVM IFLIAWFIIS DSITTINSTA VLFSKAELHM
360 370 380 390 400
STLNLIMISV LTVVNAMLGA FMIPQFLATK FRWTSSQTLM YIIIWASFIP
410 420 430 440 450
FYGILGFFFN AFGLKHKFEM FLLAIWYGLS LGGLSAVSRS VFSLIVPPGK
460 470 480 490 500
ESTFFSMFSI TDKGSSILGP FLVGLLTDKT HNIRYSFYFF FLLLMLSLPV
510 520
LNCLDVKRGR REAEELSQVL PESERRLD
Length:528
Mass (Da):58,844
Last modified:May 1, 1992 - v1
Checksum:iFC26CAFD581A66DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42378.1.
BK006937 Genomic DNA. Translation: DAA07446.1.
PIRiS19366.
RefSeqiNP_009892.1. NM_001178683.1.

Genome annotation databases

EnsemblFungiiCAA42378; CAA42378; CAA42378.
YCL038C; YCL038C; YCL038C.
GeneIDi850319.
KEGGisce:YCL038C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42378.1.
BK006937 Genomic DNA. Translation: DAA07446.1.
PIRiS19366.
RefSeqiNP_009892.1. NM_001178683.1.

3D structure databases

ProteinModelPortaliP25568.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi30945. 17 interactors.
DIPiDIP-4976N.
IntActiP25568. 3 interactors.
MINTiMINT-478200.

Protein family/group databases

TCDBi2.A.1.24.1. the major facilitator superfamily (mfs).
9.A.15.1.1. the autophagy-related phagophore-formation transporter (apt) family.

PTM databases

iPTMnetiP25568.

Proteomic databases

MaxQBiP25568.
PRIDEiP25568.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAA42378; CAA42378; CAA42378.
YCL038C; YCL038C; YCL038C.
GeneIDi850319.
KEGGisce:YCL038C.

Organism-specific databases

EuPathDBiFungiDB:YCL038C.
SGDiS000000543. ATG22.

Phylogenomic databases

HOGENOMiHOG000034115.
InParanoidiP25568.
KOiK06902.
OMAiIRPAFWF.
OrthoDBiEOG092C2E0G.

Enzyme and pathway databases

BioCyciYEAST:G3O-29297-MONOMER.

Miscellaneous databases

PROiP25568.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR024671. Atg22-like.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF11700. ATG22. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiATG22_YEAST
AccessioniPrimary (citable) accession number: P25568
Secondary accession number(s): D6VQX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.