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P25568

- ATG22_YEAST

UniProt

P25568 - ATG22_YEAST

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Protein

Autophagy-related protein 22

Gene
ATG22, AUT4, YCL038C, YCL38C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Vacuolar effluxer which mediate the efflux of leucine and other amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.3 Publications

GO - Biological processi

  1. amino acid transmembrane export from vacuole Source: SGD
  2. autophagy Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Autophagy, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29297-MONOMER.

Protein family/group databases

TCDBi2.A.1.24.1. the major facilitator superfamily (mfs).
9.A.15.1.1. the autophagy-related phagophore-formation transporter (apt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 22
Gene namesi
Name:ATG22
Synonyms:AUT4
Ordered Locus Names:YCL038C
ORF Names:YCL38C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome III

Organism-specific databases

CYGDiYCL038c.
SGDiS000000543. ATG22.

Subcellular locationi

Vacuole membrane; Multi-pass membrane protein
Note: Vacuole and punctate structures.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9898Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei99 – 11921Helical; Reviewed predictionAdd
BLAST
Topological domaini120 – 13011Vacuolar Reviewed predictionAdd
BLAST
Transmembranei131 – 15121Helical; Reviewed predictionAdd
BLAST
Topological domaini152 – 1532Cytoplasmic Reviewed prediction
Transmembranei154 – 17421Helical; Reviewed predictionAdd
BLAST
Topological domaini175 – 21036Vacuolar Reviewed predictionAdd
BLAST
Transmembranei211 – 23121Helical; Reviewed predictionAdd
BLAST
Topological domaini232 – 24110Cytoplasmic Reviewed prediction
Transmembranei242 – 26221Helical; Reviewed predictionAdd
BLAST
Topological domaini263 – 31856Vacuolar Reviewed predictionAdd
BLAST
Transmembranei319 – 33921Helical; Reviewed predictionAdd
BLAST
Topological domaini340 – 35213Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei353 – 37321Helical; Reviewed predictionAdd
BLAST
Topological domaini374 – 38815Vacuolar Reviewed predictionAdd
BLAST
Transmembranei389 – 40921Helical; Reviewed predictionAdd
BLAST
Topological domaini410 – 4178Cytoplasmic Reviewed prediction
Transmembranei418 – 43821Helical; Reviewed predictionAdd
BLAST
Topological domaini439 – 48547Vacuolar Reviewed predictionAdd
BLAST
Transmembranei486 – 50621Helical; Reviewed predictionAdd
BLAST
Topological domaini507 – 52822Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of fungal-type vacuolar membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 528528Autophagy-related protein 22PRO_0000207629Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei278 – 2781Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP25568.
PaxDbiP25568.
PeptideAtlasiP25568.

Expressioni

Gene expression databases

GenevestigatoriP25568.

Interactioni

Protein-protein interaction databases

BioGridi30945. 18 interactions.
DIPiDIP-4976N.
IntActiP25568. 3 interactions.
MINTiMINT-478200.
STRINGi4932.YCL038C.

Structurei

3D structure databases

ProteinModelPortaliP25568.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATG22 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2270.
HOGENOMiHOG000034115.
KOiK06902.
OMAiIRPAFWF.
OrthoDBiEOG71GB3P.

Family and domain databases

InterProiIPR024671. Atg22-like.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamiPF11700. ATG22. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.

Sequencei

Sequence statusi: Complete.

P25568-1 [UniParc]FASTAAdd to Basket

« Hide

MSYGTINDMN ESVTNYRIKK AQNNIKGWYA YSFSSEPFVV SAVSTYIPLL    50
LQQFASINGV KVHDHSIPCL SETGSDSDKC VLGLFNNRIF VDTSSFALYV 100
FSLSVLFQTI IVISVSGIVD LWGSVKFKGR ILVWFGIVGA LSTVAISKLN 150
DTQIYSLAGL YIVANGCFGV INVVGNSLLP IFVKDSLKCQ SQGAYEPDKV 200
DSLTTVISGR GASLGYSSAL IVQIVSMFLV ASKKGSKQDV QVAVLFVGIW 250
WFVWQLPMIW LIDDVTIPIR VDDSTLASAR SPYPGEQDAL GQLNWKNYLS 300
YGWVSLFESF KHARLLKDVM IFLIAWFIIS DSITTINSTA VLFSKAELHM 350
STLNLIMISV LTVVNAMLGA FMIPQFLATK FRWTSSQTLM YIIIWASFIP 400
FYGILGFFFN AFGLKHKFEM FLLAIWYGLS LGGLSAVSRS VFSLIVPPGK 450
ESTFFSMFSI TDKGSSILGP FLVGLLTDKT HNIRYSFYFF FLLLMLSLPV 500
LNCLDVKRGR REAEELSQVL PESERRLD 528
Length:528
Mass (Da):58,844
Last modified:May 1, 1992 - v1
Checksum:iFC26CAFD581A66DB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59720 Genomic DNA. Translation: CAA42378.1.
BK006937 Genomic DNA. Translation: DAA07446.1.
PIRiS19366.
RefSeqiNP_009892.1. NM_001178683.1.

Genome annotation databases

EnsemblFungiiYCL038C; YCL038C; YCL038C.
GeneIDi850319.
KEGGisce:YCL038C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59720 Genomic DNA. Translation: CAA42378.1 .
BK006937 Genomic DNA. Translation: DAA07446.1 .
PIRi S19366.
RefSeqi NP_009892.1. NM_001178683.1.

3D structure databases

ProteinModelPortali P25568.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 30945. 18 interactions.
DIPi DIP-4976N.
IntActi P25568. 3 interactions.
MINTi MINT-478200.
STRINGi 4932.YCL038C.

Protein family/group databases

TCDBi 2.A.1.24.1. the major facilitator superfamily (mfs).
9.A.15.1.1. the autophagy-related phagophore-formation transporter (apt) family.

Proteomic databases

MaxQBi P25568.
PaxDbi P25568.
PeptideAtlasi P25568.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YCL038C ; YCL038C ; YCL038C .
GeneIDi 850319.
KEGGi sce:YCL038C.

Organism-specific databases

CYGDi YCL038c.
SGDi S000000543. ATG22.

Phylogenomic databases

eggNOGi COG2270.
HOGENOMi HOG000034115.
KOi K06902.
OMAi IRPAFWF.
OrthoDBi EOG71GB3P.

Enzyme and pathway databases

BioCyci YEAST:G3O-29297-MONOMER.

Miscellaneous databases

NextBioi 965727.

Gene expression databases

Genevestigatori P25568.

Family and domain databases

InterProi IPR024671. Atg22-like.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
Pfami PF11700. ATG22. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete DNA sequence of yeast chromosome III."
    Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
    , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
    Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Genetic and phenotypic overlap between autophagy and the cytoplasm to vacuole protein targeting pathway."
    Harding T.M., Hefner-Gravink A., Thumm M., Klionsky D.J.
    J. Biol. Chem. 271:17621-17624(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "The breakdown of autophagic vesicles inside the vacuole depends on Aut4p."
    Suriapranata I., Epple U.D., Bernreuther D., Bredschneider M., Sovarasteanu K., Thumm M.
    J. Cell Sci. 113:4025-4033(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. Cited for: NOMENCLATURE.
  6. "Atg22 recycles amino acids to link the degradative and recycling functions of autophagy."
    Yang Z., Huang J., Geng J., Nair U., Klionsky D.J.
    Mol. Biol. Cell 17:5094-5104(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  7. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-278, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiATG22_YEAST
AccessioniPrimary (citable) accession number: P25568
Secondary accession number(s): D6VQX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: June 11, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

External Data

Dasty 3

Similar proteinsi