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Protein

RNA-binding protein SRO9

Gene

SRO9

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May overlap in function with tropomyosin and may be involved in organization of actin filaments. Acts as a multicopy suppressor of RHO3 mutation. RNA-binding protein which may modulate mRNA translation. Involved in heme regulation of HAP1, as a component of the high-molecular-weight complex (HMC).2 Publications

GO - Molecular functioni

  • RNA binding Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29296-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein SRO9
Alternative name(s):
Suppressor of RHO3 protein 9
Gene namesi
Name:SRO9
Ordered Locus Names:YCL037C
ORF Names:YCL37C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCL037C.
SGDiS000000542. SRO9.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic stress granule Source: SGD
  • polysome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002076151 – 434RNA-binding protein SRO9Add BLAST434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei55PhosphoserineCombined sources1
Modified residuei148PhosphoserineCombined sources1
Cross-linki156Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Cross-linki301Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Cross-linki342Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Cross-linki352Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei422PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP25567.
PRIDEiP25567.

PTM databases

iPTMnetiP25567.

Interactioni

Subunit structurei

Interacts with HAP1. Component of the HMC including HAP1, SRO9 and YDJ1.1 Publication

Protein-protein interaction databases

BioGridi30946. 938 interactors.
DIPiDIP-6638N.
IntActiP25567. 36 interactors.
MINTiMINT-8285517.

Structurei

3D structure databases

ProteinModelPortaliP25567.
SMRiP25567.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini255 – 351HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST97

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi168 – 171Poly-Gln4
Compositional biasi174 – 184His-richAdd BLAST11
Compositional biasi222 – 226Poly-Asn5

Sequence similaritiesi

Contains 1 HTH La-type RNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00530000067375.
HOGENOMiHOG000057093.
InParanoidiP25567.
KOiK18757.
OMAiAHEVATK.
OrthoDBiEOG092C3H6T.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR006630. Lupus_La_RNA-bd.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05383. La. 1 hit.
[Graphical view]
SMARTiSM00715. LA. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50961. HTH_LA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25567-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAETAAANT ATAPVPEVQE QESSKSKQVN LTPAPLPTSS PWKLAPTEIP
60 70 80 90 100
VSTISIEDLD ATRKKKNRTP TPKSSTATKW VPIKASITVS GTKRSGSKNG
110 120 130 140 150
ASNGNSNKSK NNKTAASSTS SSNANRKKKH HQHNAKKQQQ MKKDGFESAV
160 170 180 190 200
GEEDSKDATS QENGQSTQQQ QPPHHRNHHH SHHHNSNGPQ RRKFHNSNNA
210 220 230 240 250
GMPQNQGFPP QFKPYQGRNA RNNNNNRSKY HNHFHHNQQH PQQPMVKLQQ
260 270 280 290 300
QFYPVQPVLM AINNIARQIE YYFSEENLTV DNYLRSKLSK DGFAPLSLIS
310 320 330 340 350
KFYRVVNMSF GGDTNLILAA LREIVANEAA TVNVAEGTLA AKEGDNVTGE
360 370 380 390 400
AKEPSPLDKY FVRSKSWSNW LPETFETEIN IEKELVGDAL DQFMISLPPV
410 420 430
PQQEEESSTE LASQEQETKE DSAPVAAGES ESSL
Length:434
Mass (Da):48,060
Last modified:March 7, 2006 - v2
Checksum:iB1B720D40C7B9914
GO

Sequence cautioni

The sequence CAA42379 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42379.1. Different initiation.
BK006937 Genomic DNA. Translation: DAA07447.1.
PIRiS19365.
RefSeqiNP_009893.2. NM_001178682.1.

Genome annotation databases

EnsemblFungiiCAA42379; CAA42379; CAA42379.
YCL037C; YCL037C; YCL037C.
GeneIDi850320.
KEGGisce:YCL037C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42379.1. Different initiation.
BK006937 Genomic DNA. Translation: DAA07447.1.
PIRiS19365.
RefSeqiNP_009893.2. NM_001178682.1.

3D structure databases

ProteinModelPortaliP25567.
SMRiP25567.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi30946. 938 interactors.
DIPiDIP-6638N.
IntActiP25567. 36 interactors.
MINTiMINT-8285517.

PTM databases

iPTMnetiP25567.

Proteomic databases

MaxQBiP25567.
PRIDEiP25567.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAA42379; CAA42379; CAA42379.
YCL037C; YCL037C; YCL037C.
GeneIDi850320.
KEGGisce:YCL037C.

Organism-specific databases

EuPathDBiFungiDB:YCL037C.
SGDiS000000542. SRO9.

Phylogenomic databases

GeneTreeiENSGT00530000067375.
HOGENOMiHOG000057093.
InParanoidiP25567.
KOiK18757.
OMAiAHEVATK.
OrthoDBiEOG092C3H6T.

Enzyme and pathway databases

BioCyciYEAST:G3O-29296-MONOMER.

Miscellaneous databases

PROiP25567.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR006630. Lupus_La_RNA-bd.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05383. La. 1 hit.
[Graphical view]
SMARTiSM00715. LA. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50961. HTH_LA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSRO9_YEAST
AccessioniPrimary (citable) accession number: P25567
Secondary accession number(s): D6VQX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: March 7, 2006
Last modified: November 2, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 8430 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.