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Protein

Protein RER1

Gene

RER1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment. Required for correct localization of SEC12, SEC71 and SEC63 in the endoplasmic reticulum.1 Publication

Miscellaneous

Present with 2840 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: SGD
  • protein retention in ER lumen Source: SGD
  • retrograde vesicle-mediated transport, Golgi to ER Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-29275-MONOMER

Protein family/group databases

TCDBi9.B.82.1.1 the endoplasmic reticulum retrieval protein1 (putative heavy metal transporter) (rer1) family

Names & Taxonomyi

Protein namesi
Recommended name:
Protein RER1
Alternative name(s):
Retention of ER proteins 1
Gene namesi
Name:RER1
Ordered Locus Names:YCL001W
ORF Names:YCL1W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCL001W
SGDiS000000507 RER1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 61CytoplasmicSequence analysisAdd BLAST61
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 138LumenalSequence analysisAdd BLAST56
Transmembranei139 – 161HelicalSequence analysisAdd BLAST23
Topological domaini162 – 188CytoplasmicSequence analysisAdd BLAST27

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002075931 – 188Protein RER1Add BLAST188

Proteomic databases

MaxQBiP25560
PaxDbiP25560
PRIDEiP25560

PTM databases

iPTMnetiP25560

Interactioni

Protein-protein interaction databases

BioGridi30977, 211 interactors
STRINGi4932.YCL001W

Structurei

3D structure databases

ProteinModelPortaliP25560
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RER1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00510000047137
HOGENOMiHOG000163668
InParanoidiP25560
OMAiLPEWQFW
OrthoDBiEOG092C5G2T

Family and domain databases

InterProiView protein in InterPro
IPR004932 Rer1
PANTHERiPTHR10743 PTHR10743, 1 hit
PfamiView protein in Pfam
PF03248 Rer1, 1 hit
PIRSFiPIRSF016013 AtER_Rer1p, 1 hit

Sequencei

Sequence statusi: Complete.

P25560-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYDSSDTMN GGSSNPLITK MNTMKLLYQH YLDKVTPHAK ERWAVLGGLL
60 70 80 90 100
CLFMVRITMA EGWYVICYGL GLFLLNQFLA FLTPKFDMSL QQDEENNELE
110 120 130 140 150
AGEKSEEFRP FIRRLPEFKF WYNSIRATVI SLLLSLFSIF DIPVFWPILL
160 170 180
MYFILLFFLT MRRQIQHMIK YRYIPLDIGK KKYSHSSN
Length:188
Mass (Da):22,270
Last modified:February 1, 1995 - v2
Checksum:iACD0DAFA757C3622
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti109 – 125RPFIR…WYNSI → LSIHQKTYQSSNSGITAF (PubMed:1574125).CuratedAdd BLAST17
Sequence conflicti136L → V (PubMed:1574125).Curated1
Sequence conflicti141D → S (PubMed:1574125).Curated1
Sequence conflicti145 – 188FWPIL…SHSSN → IFAHSLFDCYFHYYCFF (PubMed:1574125).CuratedAdd BLAST44

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28552 Genomic DNA Translation: BAA05906.1
X59720 Genomic DNA Translation: CAA42336.1
BK006937 Genomic DNA Translation: DAA07478.1
PIRiS50158
RefSeqiNP_009925.1, NM_001178651.1

Genome annotation databases

EnsemblFungiiCAA42336; CAA42336; CAA42336
YCL001W; YCL001W; YCL001W
GeneIDi850354
KEGGisce:YCL001W

Similar proteinsi

Entry informationi

Entry nameiRER1_YEAST
AccessioniPrimary (citable) accession number: P25560
Secondary accession number(s): D6VR09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: February 1, 1995
Last modified: February 28, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health