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P25560 (RER1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein RER1
Alternative name(s):
Retention of ER proteins 1
Gene names
Name:RER1
Ordered Locus Names:YCL001W
ORF Names:YCL1W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length188 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment. Required for correct localization of SEC12, SEC71 and SEC63 in the endoplasmic reticulum. Ref.5

Subcellular location

Golgi apparatus membrane; Multi-pass membrane protein.

Miscellaneous

Present with 2840 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the RER1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 188188Protein RER1
PRO_0000207593

Regions

Topological domain1 – 6161Cytoplasmic Potential
Transmembrane62 – 8221Helical; Potential
Topological domain83 – 13856Lumenal Potential
Transmembrane139 – 16123Helical; Potential
Topological domain162 – 18827Cytoplasmic Potential

Experimental info

Sequence conflict109 – 12517RPFIR…WYNSI → LSIHQKTYQSSNSGITAF Ref.2
Sequence conflict1361L → V Ref.2
Sequence conflict1411D → S Ref.2
Sequence conflict145 – 18844FWPIL…SHSSN → IFAHSLFDCYFHYYCFF Ref.2

Sequences

Sequence LengthMass (Da)Tools
P25560 [UniParc].

Last modified February 1, 1995. Version 2.
Checksum: ACD0DAFA757C3622

FASTA18822,270
        10         20         30         40         50         60 
MDYDSSDTMN GGSSNPLITK MNTMKLLYQH YLDKVTPHAK ERWAVLGGLL CLFMVRITMA 

        70         80         90        100        110        120 
EGWYVICYGL GLFLLNQFLA FLTPKFDMSL QQDEENNELE AGEKSEEFRP FIRRLPEFKF 

       130        140        150        160        170        180 
WYNSIRATVI SLLLSLFSIF DIPVFWPILL MYFILLFFLT MRRQIQHMIK YRYIPLDIGK 


KKYSHSSN 

« Hide

References

« Hide 'large scale' references
[1]"Membrane protein retrieval from the Golgi apparatus to the endoplasmic reticulum (ER): characterization of the RER1 gene product as a component involved in ER localization of Sec12p."
Sato K., Nishikawa S., Nakano A.
Mol. Biol. Cell 6:1459-1477(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The complete DNA sequence of yeast chromosome III."
Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M. expand/collapse author list , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Identification of a gene required for membrane protein retention in the early secretory pathway."
Nishikawa S., Nakano A.
Proc. Natl. Acad. Sci. U.S.A. 90:8179-8183(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[5]"Rer1p as common machinery for the endoplasmic reticulum localization of membrane proteins."
Sato K., Sato M., Nakano A.
Proc. Natl. Acad. Sci. U.S.A. 94:9693-9698(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D28552 Genomic DNA. Translation: BAA05906.1.
X59720 Genomic DNA. Translation: CAA42336.1.
BK006937 Genomic DNA. Translation: DAA07478.1.
PIRS50158.
RefSeqNP_009925.1. NM_001178651.1.

3D structure databases

ProteinModelPortalP25560.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid30977. 126 interactions.
MINTMINT-4478009.
STRING4932.YCL001W.

Protein family/group databases

TCDB9.B.82.1.1. endoplasmic reticulum retrieval protein1 (putative heavy metal transporter) (rer1) family.

Proteomic databases

PaxDbP25560.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYCL001W; YCL001W; YCL001W.
GeneID850354.
KEGGsce:YCL001W.

Organism-specific databases

CYGDYCL001w.
SGDS000000507. RER1.

Phylogenomic databases

eggNOGCOG5249.
GeneTreeENSGT00510000047137.
HOGENOMHOG000163668.
OMATRRSDEY.
OrthoDBEOG7QC87H.

Enzyme and pathway databases

BioCycYEAST:G3O-29275-MONOMER.

Gene expression databases

GenevestigatorP25560.

Family and domain databases

InterProIPR004932. Rer1.
[Graphical view]
PANTHERPTHR10743. PTHR10743. 1 hit.
PfamPF03248. Rer1. 1 hit.
[Graphical view]
PIRSFPIRSF016013. AtER_Rer1p. 1 hit.
ProtoNetSearch...

Other

NextBio965821.
PROP25560.

Entry information

Entry nameRER1_YEAST
AccessionPrimary (citable) accession number: P25560
Secondary accession number(s): D6VR09
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: February 1, 1995
Last modified: March 19, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome III

Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families