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P25560

- RER1_YEAST

UniProt

P25560 - RER1_YEAST

Protein

Protein RER1

Gene

RER1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment. Required for correct localization of SEC12, SEC71 and SEC63 in the endoplasmic reticulum.1 Publication

    GO - Biological processi

    1. ER to Golgi vesicle-mediated transport Source: SGD
    2. protein retention in ER lumen Source: SGD
    3. retrograde vesicle-mediated transport, Golgi to ER Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29275-MONOMER.

    Protein family/group databases

    TCDBi9.B.82.1.1. endoplasmic reticulum retrieval protein1 (putative heavy metal transporter) (rer1) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein RER1
    Alternative name(s):
    Retention of ER proteins 1
    Gene namesi
    Name:RER1
    Ordered Locus Names:YCL001W
    ORF Names:YCL1W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome III

    Organism-specific databases

    CYGDiYCL001w.
    SGDiS000000507. RER1.

    Subcellular locationi

    GO - Cellular componenti

    1. COPI-coated vesicle Source: SGD
    2. ER to Golgi transport vesicle Source: SGD
    3. fungal-type vacuole Source: SGD
    4. Golgi membrane Source: UniProtKB-SubCell
    5. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 188188Protein RER1PRO_0000207593Add
    BLAST

    Proteomic databases

    MaxQBiP25560.
    PaxDbiP25560.

    Expressioni

    Gene expression databases

    GenevestigatoriP25560.

    Interactioni

    Protein-protein interaction databases

    BioGridi30977. 126 interactions.
    MINTiMINT-4478009.
    STRINGi4932.YCL001W.

    Structurei

    3D structure databases

    ProteinModelPortaliP25560.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6161CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini83 – 13856LumenalSequence AnalysisAdd
    BLAST
    Topological domaini162 – 18827CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei62 – 8221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei139 – 16123HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RER1 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5249.
    GeneTreeiENSGT00510000047137.
    HOGENOMiHOG000163668.
    OMAiPHAKERW.
    OrthoDBiEOG7QC87H.

    Family and domain databases

    InterProiIPR004932. Rer1.
    [Graphical view]
    PANTHERiPTHR10743. PTHR10743. 1 hit.
    PfamiPF03248. Rer1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF016013. AtER_Rer1p. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P25560-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDYDSSDTMN GGSSNPLITK MNTMKLLYQH YLDKVTPHAK ERWAVLGGLL    50
    CLFMVRITMA EGWYVICYGL GLFLLNQFLA FLTPKFDMSL QQDEENNELE 100
    AGEKSEEFRP FIRRLPEFKF WYNSIRATVI SLLLSLFSIF DIPVFWPILL 150
    MYFILLFFLT MRRQIQHMIK YRYIPLDIGK KKYSHSSN 188
    Length:188
    Mass (Da):22,270
    Last modified:February 1, 1995 - v2
    Checksum:iACD0DAFA757C3622
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti109 – 12517RPFIR…WYNSI → LSIHQKTYQSSNSGITAF(PubMed:1574125)CuratedAdd
    BLAST
    Sequence conflicti136 – 1361L → V(PubMed:1574125)Curated
    Sequence conflicti141 – 1411D → S(PubMed:1574125)Curated
    Sequence conflicti145 – 18844FWPIL…SHSSN → IFAHSLFDCYFHYYCFF(PubMed:1574125)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D28552 Genomic DNA. Translation: BAA05906.1.
    X59720 Genomic DNA. Translation: CAA42336.1.
    BK006937 Genomic DNA. Translation: DAA07478.1.
    PIRiS50158.
    RefSeqiNP_009925.1. NM_001178651.1.

    Genome annotation databases

    EnsemblFungiiYCL001W; YCL001W; YCL001W.
    GeneIDi850354.
    KEGGisce:YCL001W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D28552 Genomic DNA. Translation: BAA05906.1 .
    X59720 Genomic DNA. Translation: CAA42336.1 .
    BK006937 Genomic DNA. Translation: DAA07478.1 .
    PIRi S50158.
    RefSeqi NP_009925.1. NM_001178651.1.

    3D structure databases

    ProteinModelPortali P25560.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 30977. 126 interactions.
    MINTi MINT-4478009.
    STRINGi 4932.YCL001W.

    Protein family/group databases

    TCDBi 9.B.82.1.1. endoplasmic reticulum retrieval protein1 (putative heavy metal transporter) (rer1) family.

    Proteomic databases

    MaxQBi P25560.
    PaxDbi P25560.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YCL001W ; YCL001W ; YCL001W .
    GeneIDi 850354.
    KEGGi sce:YCL001W.

    Organism-specific databases

    CYGDi YCL001w.
    SGDi S000000507. RER1.

    Phylogenomic databases

    eggNOGi COG5249.
    GeneTreei ENSGT00510000047137.
    HOGENOMi HOG000163668.
    OMAi PHAKERW.
    OrthoDBi EOG7QC87H.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29275-MONOMER.

    Miscellaneous databases

    NextBioi 965821.
    PROi P25560.

    Gene expression databases

    Genevestigatori P25560.

    Family and domain databases

    InterProi IPR004932. Rer1.
    [Graphical view ]
    PANTHERi PTHR10743. PTHR10743. 1 hit.
    Pfami PF03248. Rer1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF016013. AtER_Rer1p. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Membrane protein retrieval from the Golgi apparatus to the endoplasmic reticulum (ER): characterization of the RER1 gene product as a component involved in ER localization of Sec12p."
      Sato K., Nishikawa S., Nakano A.
      Mol. Biol. Cell 6:1459-1477(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The complete DNA sequence of yeast chromosome III."
      Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
      , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
      Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Identification of a gene required for membrane protein retention in the early secretory pathway."
      Nishikawa S., Nakano A.
      Proc. Natl. Acad. Sci. U.S.A. 90:8179-8183(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    5. "Rer1p as common machinery for the endoplasmic reticulum localization of membrane proteins."
      Sato K., Sato M., Nakano A.
      Proc. Natl. Acad. Sci. U.S.A. 94:9693-9698(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.

    Entry informationi

    Entry nameiRER1_YEAST
    AccessioniPrimary (citable) accession number: P25560
    Secondary accession number(s): D6VR09
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 2840 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome III
      Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

    External Data

    Dasty 3