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P25560

- RER1_YEAST

UniProt

P25560 - RER1_YEAST

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Protein

Protein RER1

Gene

RER1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment. Required for correct localization of SEC12, SEC71 and SEC63 in the endoplasmic reticulum.1 Publication

GO - Biological processi

  1. ER to Golgi vesicle-mediated transport Source: SGD
  2. protein retention in ER lumen Source: SGD
  3. retrograde vesicle-mediated transport, Golgi to ER Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-29275-MONOMER.

Protein family/group databases

TCDBi9.B.82.1.1. endoplasmic reticulum retrieval protein1 (putative heavy metal transporter) (rer1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein RER1
Alternative name(s):
Retention of ER proteins 1
Gene namesi
Name:RER1
Ordered Locus Names:YCL001W
ORF Names:YCL1W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome III

Organism-specific databases

CYGDiYCL001w.
SGDiS000000507. RER1.

Subcellular locationi

GO - Cellular componenti

  1. COPI-coated vesicle Source: SGD
  2. ER to Golgi transport vesicle Source: SGD
  3. fungal-type vacuole Source: SGD
  4. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188Protein RER1PRO_0000207593Add
BLAST

Proteomic databases

MaxQBiP25560.
PaxDbiP25560.

Expressioni

Gene expression databases

GenevestigatoriP25560.

Interactioni

Protein-protein interaction databases

BioGridi30977. 126 interactions.
MINTiMINT-4478009.
STRINGi4932.YCL001W.

Structurei

3D structure databases

ProteinModelPortaliP25560.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6161CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini83 – 13856LumenalSequence AnalysisAdd
BLAST
Topological domaini162 – 18827CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei62 – 8221HelicalSequence AnalysisAdd
BLAST
Transmembranei139 – 16123HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the RER1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5249.
GeneTreeiENSGT00510000047137.
HOGENOMiHOG000163668.
InParanoidiP25560.
OMAiPHAKERW.
OrthoDBiEOG7QC87H.

Family and domain databases

InterProiIPR004932. Rer1.
[Graphical view]
PANTHERiPTHR10743. PTHR10743. 1 hit.
PfamiPF03248. Rer1. 1 hit.
[Graphical view]
PIRSFiPIRSF016013. AtER_Rer1p. 1 hit.

Sequencei

Sequence statusi: Complete.

P25560-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDYDSSDTMN GGSSNPLITK MNTMKLLYQH YLDKVTPHAK ERWAVLGGLL
60 70 80 90 100
CLFMVRITMA EGWYVICYGL GLFLLNQFLA FLTPKFDMSL QQDEENNELE
110 120 130 140 150
AGEKSEEFRP FIRRLPEFKF WYNSIRATVI SLLLSLFSIF DIPVFWPILL
160 170 180
MYFILLFFLT MRRQIQHMIK YRYIPLDIGK KKYSHSSN
Length:188
Mass (Da):22,270
Last modified:February 1, 1995 - v2
Checksum:iACD0DAFA757C3622
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti109 – 12517RPFIR…WYNSI → LSIHQKTYQSSNSGITAF(PubMed:1574125)CuratedAdd
BLAST
Sequence conflicti136 – 1361L → V(PubMed:1574125)Curated
Sequence conflicti141 – 1411D → S(PubMed:1574125)Curated
Sequence conflicti145 – 18844FWPIL…SHSSN → IFAHSLFDCYFHYYCFF(PubMed:1574125)CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D28552 Genomic DNA. Translation: BAA05906.1.
X59720 Genomic DNA. Translation: CAA42336.1.
BK006937 Genomic DNA. Translation: DAA07478.1.
PIRiS50158.
RefSeqiNP_009925.1. NM_001178651.1.

Genome annotation databases

EnsemblFungiiYCL001W; YCL001W; YCL001W.
GeneIDi850354.
KEGGisce:YCL001W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D28552 Genomic DNA. Translation: BAA05906.1 .
X59720 Genomic DNA. Translation: CAA42336.1 .
BK006937 Genomic DNA. Translation: DAA07478.1 .
PIRi S50158.
RefSeqi NP_009925.1. NM_001178651.1.

3D structure databases

ProteinModelPortali P25560.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 30977. 126 interactions.
MINTi MINT-4478009.
STRINGi 4932.YCL001W.

Protein family/group databases

TCDBi 9.B.82.1.1. endoplasmic reticulum retrieval protein1 (putative heavy metal transporter) (rer1) family.

Proteomic databases

MaxQBi P25560.
PaxDbi P25560.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YCL001W ; YCL001W ; YCL001W .
GeneIDi 850354.
KEGGi sce:YCL001W.

Organism-specific databases

CYGDi YCL001w.
SGDi S000000507. RER1.

Phylogenomic databases

eggNOGi COG5249.
GeneTreei ENSGT00510000047137.
HOGENOMi HOG000163668.
InParanoidi P25560.
OMAi PHAKERW.
OrthoDBi EOG7QC87H.

Enzyme and pathway databases

BioCyci YEAST:G3O-29275-MONOMER.

Miscellaneous databases

NextBioi 965821.
PROi P25560.

Gene expression databases

Genevestigatori P25560.

Family and domain databases

InterProi IPR004932. Rer1.
[Graphical view ]
PANTHERi PTHR10743. PTHR10743. 1 hit.
Pfami PF03248. Rer1. 1 hit.
[Graphical view ]
PIRSFi PIRSF016013. AtER_Rer1p. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Membrane protein retrieval from the Golgi apparatus to the endoplasmic reticulum (ER): characterization of the RER1 gene product as a component involved in ER localization of Sec12p."
    Sato K., Nishikawa S., Nakano A.
    Mol. Biol. Cell 6:1459-1477(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete DNA sequence of yeast chromosome III."
    Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
    , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
    Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Identification of a gene required for membrane protein retention in the early secretory pathway."
    Nishikawa S., Nakano A.
    Proc. Natl. Acad. Sci. U.S.A. 90:8179-8183(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  5. "Rer1p as common machinery for the endoplasmic reticulum localization of membrane proteins."
    Sato K., Sato M., Nakano A.
    Proc. Natl. Acad. Sci. U.S.A. 94:9693-9698(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiRER1_YEAST
AccessioniPrimary (citable) accession number: P25560
Secondary accession number(s): D6VR09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2840 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

External Data

Dasty 3