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P25555

- GBP2_YEAST

UniProt

P25555 - GBP2_YEAST

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Protein

Single-strand telomeric DNA-binding protein GBP2

Gene

GBP2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Binds single-stranded telomeric sequences of the type (TG[1-3])n in vitro. Also binds to RNA. Influences the localization of RAP1 in the nuclei. Involved in modulating telomere length.

GO - Molecular functioni

  1. nucleotide binding Source: InterPro
  2. RNA binding Source: SGD
  3. telomeric DNA binding Source: SGD

GO - Biological processi

  1. nuclear mRNA surveillance Source: SGD
  2. poly(A)+ mRNA export from nucleus Source: SGD
  3. telomere maintenance Source: SGD
Complete GO annotation...

Keywords - Ligandi

DNA-binding, RNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29280-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Single-strand telomeric DNA-binding protein GBP2
Short name:
G-strand-binding protein 2
Alternative name(s):
RAP1 localization factor 6
Gene namesi
Name:GBP2
Synonyms:RLF6
Ordered Locus Names:YCL011C
ORF Names:YCL11C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome III

Organism-specific databases

CYGDiYCL011c.
SGDiS000000517. GBP2.

Subcellular locationi

GO - Cellular componenti

  1. chromosome, telomeric region Source: UniProtKB-KW
  2. cytoplasmic stress granule Source: SGD
  3. cytosol Source: SGD
  4. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 427427Single-strand telomeric DNA-binding protein GBP2PRO_0000081596Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei130 – 1301Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP25555.
PaxDbiP25555.
PeptideAtlasiP25555.

Expressioni

Gene expression databases

GenevestigatoriP25555.

Interactioni

Protein-protein interaction databases

BioGridi30970. 122 interactions.
DIPiDIP-2735N.
IntActiP25555. 46 interactions.
MINTiMINT-481140.
STRINGi4932.YCL011C.

Structurei

3D structure databases

ProteinModelPortaliP25555.
SMRiP25555. Positions 122-296, 347-426.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini122 – 19877RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini219 – 29678RRM 2PROSITE-ProRule annotationAdd
BLAST
Domaini349 – 42678RRM 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0724.
GeneTreeiENSGT00410000025635.
HOGENOMiHOG000111155.
InParanoidiP25555.
OMAiISMEAIN.
OrthoDBiEOG76TB3G.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25555-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERELGMYGN DRSRSRSPVR RRLSDDRDRY DDYNDSSSNN GNGSRRQRRD
60 70 80 90 100
RGSRFNDRYD QSYGGSRYHD DRNWPPRRGG RGRGGSRSFR GGRGGGRGRT
110 120 130 140 150
LGPIVERDLE RQFDATKRNF ENSIFVRNLT FDCTPEDLKE LFGTVGEVVE
160 170 180 190 200
ADIITSKGHH RGMGTVEFTK NESVQDAISK FDGALFMDRK LMVRQDNPPP
210 220 230 240 250
EAAKEFSKKA TREEIDNGFE VFIINLPYSM NWQSLKDMFK ECGHVLRADV
260 270 280 290 300
ELDFNGFSRG FGSVIYPTED EMIRAIDTFN GMEVEGRVLE VREGRFNKRK
310 320 330 340 350
NNDRYNQRRE DLEDTRGTEP GLAQDAAVHI DETAAKFTEG VNPGGDRNCF
360 370 380 390 400
IYCSNLPFST ARSDLFDLFG PIGKINNAEL KPQENGQPTG VAVVEYENLV
410 420
DADFCIQKLN NYNYGGCSLQ ISYARRD
Length:427
Mass (Da):48,729
Last modified:May 1, 1992 - v1
Checksum:i5341D7A0E07F208C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59720 Genomic DNA. Translation: CAA42348.1.
AY692807 Genomic DNA. Translation: AAT92826.1.
BK006937 Genomic DNA. Translation: DAA07470.1.
PIRiS19338.
RefSeqiNP_009916.1. NM_001178660.1.

Genome annotation databases

EnsemblFungiiYCL011C; YCL011C; YCL011C.
GeneIDi850346.
KEGGisce:YCL011C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59720 Genomic DNA. Translation: CAA42348.1 .
AY692807 Genomic DNA. Translation: AAT92826.1 .
BK006937 Genomic DNA. Translation: DAA07470.1 .
PIRi S19338.
RefSeqi NP_009916.1. NM_001178660.1.

3D structure databases

ProteinModelPortali P25555.
SMRi P25555. Positions 122-296, 347-426.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 30970. 122 interactions.
DIPi DIP-2735N.
IntActi P25555. 46 interactions.
MINTi MINT-481140.
STRINGi 4932.YCL011C.

Proteomic databases

MaxQBi P25555.
PaxDbi P25555.
PeptideAtlasi P25555.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YCL011C ; YCL011C ; YCL011C .
GeneIDi 850346.
KEGGi sce:YCL011C.

Organism-specific databases

CYGDi YCL011c.
SGDi S000000517. GBP2.

Phylogenomic databases

eggNOGi COG0724.
GeneTreei ENSGT00410000025635.
HOGENOMi HOG000111155.
InParanoidi P25555.
OMAi ISMEAIN.
OrthoDBi EOG76TB3G.

Enzyme and pathway databases

BioCyci YEAST:G3O-29280-MONOMER.

Miscellaneous databases

NextBioi 965800.

Gene expression databases

Genevestigatori P25555.

Family and domain databases

Gene3Di 3.30.70.330. 3 hits.
InterProi IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view ]
Pfami PF00076. RRM_1. 3 hits.
[Graphical view ]
SMARTi SM00360. RRM. 3 hits.
[Graphical view ]
PROSITEi PS50102. RRM. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete DNA sequence of yeast chromosome III."
    Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
    , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
    Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Isolation and characterization of two Saccharomyces cerevisiae genes that encode proteins that bind to (TG1-3)n single strand telomeric DNA in vitro."
    Lin J.-J., Zakian V.A.
    Nucleic Acids Res. 22:4906-4913(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  5. "A class of single-stranded telomeric DNA-binding proteins required for Rap1p localization in yeast nuclei."
    Konkel L.C., Enomoto S., Chamberlain E., McCune-Zierath P., Iyadurai S.J.P., Berman J.
    Proc. Natl. Acad. Sci. U.S.A. 92:5558-5562(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  6. "Exposure of single-stranded telomeric DNA causes G2/M cell cycle arrest in Saccharomyces cerevisiae."
    Pang T.-L., Wang C.-Y., Hsu C.-L., Chen M.-Y., Lin J.-J.
    J. Biol. Chem. 278:9318-9321(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-130, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGBP2_YEAST
AccessioniPrimary (citable) accession number: P25555
Secondary accession number(s): D6VR01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: October 29, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2540 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

External Data

Dasty 3