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Protein

Single-strand telomeric DNA-binding protein GBP2

Gene

GBP2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds single-stranded telomeric sequences of the type (TG[1-3])n in vitro. Also binds to RNA. Influences the localization of RAP1 in the nuclei. Involved in modulating telomere length.

Miscellaneous

Present with 2540 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • mRNA binding Source: SGD
  • single-stranded telomeric DNA binding Source: SGD

GO - Biological processi

  • nuclear mRNA surveillance Source: SGD
  • poly(A)+ mRNA export from nucleus Source: SGD
  • telomere maintenance Source: SGD

Keywordsi

Molecular functionDNA-binding, RNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29280-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Single-strand telomeric DNA-binding protein GBP2
Short name:
G-strand-binding protein 2
Alternative name(s):
RAP1 localization factor 6
Gene namesi
Name:GBP2
Synonyms:RLF6
Ordered Locus Names:YCL011C
ORF Names:YCL11C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCL011C
SGDiS000000517 GBP2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000815961 – 427Single-strand telomeric DNA-binding protein GBP2Add BLAST427

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei130PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP25555
PaxDbiP25555
PRIDEiP25555

PTM databases

iPTMnetiP25555

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi30970, 177 interactors
DIPiDIP-2735N
IntActiP25555, 61 interactors
MINTiP25555
STRINGi4932.YCL011C

Structurei

Secondary structure

1427
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi332 – 336Combined sources5
Turni337 – 340Combined sources4
Beta strandi349 – 354Combined sources6
Helixi362 – 364Combined sources3
Helixi365 – 368Combined sources4
Turni370 – 372Combined sources3
Beta strandi375 – 380Combined sources6
Beta strandi390 – 398Combined sources9
Helixi399 – 408Combined sources10
Beta strandi420 – 423Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MZQNMR-A329-427[»]
ProteinModelPortaliP25555
SMRiP25555
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini122 – 198RRM 1PROSITE-ProRule annotationAdd BLAST77
Domaini219 – 296RRM 2PROSITE-ProRule annotationAdd BLAST78
Domaini349 – 426RRM 3PROSITE-ProRule annotationAdd BLAST78

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00410000025635
HOGENOMiHOG000111155
InParanoidiP25555
OMAiVIFVYNI
OrthoDBiEOG092C5H62

Family and domain databases

Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 3 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits

Sequencei

Sequence statusi: Complete.

P25555-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERELGMYGN DRSRSRSPVR RRLSDDRDRY DDYNDSSSNN GNGSRRQRRD
60 70 80 90 100
RGSRFNDRYD QSYGGSRYHD DRNWPPRRGG RGRGGSRSFR GGRGGGRGRT
110 120 130 140 150
LGPIVERDLE RQFDATKRNF ENSIFVRNLT FDCTPEDLKE LFGTVGEVVE
160 170 180 190 200
ADIITSKGHH RGMGTVEFTK NESVQDAISK FDGALFMDRK LMVRQDNPPP
210 220 230 240 250
EAAKEFSKKA TREEIDNGFE VFIINLPYSM NWQSLKDMFK ECGHVLRADV
260 270 280 290 300
ELDFNGFSRG FGSVIYPTED EMIRAIDTFN GMEVEGRVLE VREGRFNKRK
310 320 330 340 350
NNDRYNQRRE DLEDTRGTEP GLAQDAAVHI DETAAKFTEG VNPGGDRNCF
360 370 380 390 400
IYCSNLPFST ARSDLFDLFG PIGKINNAEL KPQENGQPTG VAVVEYENLV
410 420
DADFCIQKLN NYNYGGCSLQ ISYARRD
Length:427
Mass (Da):48,729
Last modified:May 1, 1992 - v1
Checksum:i5341D7A0E07F208C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA Translation: CAA42348.1
AY692807 Genomic DNA Translation: AAT92826.1
BK006937 Genomic DNA Translation: DAA07470.1
PIRiS19338
RefSeqiNP_009916.1, NM_001178660.1

Genome annotation databases

EnsemblFungiiCAA42348; CAA42348; CAA42348
YCL011C; YCL011C; YCL011C
GeneIDi850346
KEGGisce:YCL011C

Similar proteinsi

Entry informationi

Entry nameiGBP2_YEAST
AccessioniPrimary (citable) accession number: P25555
Secondary accession number(s): D6VR01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: April 25, 2018
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health