Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P25555 (GBP2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Single-strand telomeric DNA-binding protein GBP2

Short name=G-strand-binding protein 2
Alternative name(s):
RAP1 localization factor 6
Gene names
Name:GBP2
Synonyms:RLF6
Ordered Locus Names:YCL011C
ORF Names:YCL11C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length427 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds single-stranded telomeric sequences of the type (TG[1-3])n in vitro. Also binds to RNA. Influences the localization of RAP1 in the nuclei. Involved in modulating telomere length.

Subcellular location

Nucleus Potential. Chromosometelomere.

Miscellaneous

Present with 2540 molecules/cell in log phase SD medium.

Sequence similarities

Contains 3 RRM (RNA recognition motif) domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 427427Single-strand telomeric DNA-binding protein GBP2
PRO_0000081596

Regions

Domain122 – 19877RRM 1
Domain219 – 29678RRM 2
Domain349 – 42678RRM 3

Amino acid modifications

Modified residue1301Phosphothreonine Ref.8

Sequences

Sequence LengthMass (Da)Tools
P25555 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: 5341D7A0E07F208C

FASTA42748,729
        10         20         30         40         50         60 
MERELGMYGN DRSRSRSPVR RRLSDDRDRY DDYNDSSSNN GNGSRRQRRD RGSRFNDRYD 

        70         80         90        100        110        120 
QSYGGSRYHD DRNWPPRRGG RGRGGSRSFR GGRGGGRGRT LGPIVERDLE RQFDATKRNF 

       130        140        150        160        170        180 
ENSIFVRNLT FDCTPEDLKE LFGTVGEVVE ADIITSKGHH RGMGTVEFTK NESVQDAISK 

       190        200        210        220        230        240 
FDGALFMDRK LMVRQDNPPP EAAKEFSKKA TREEIDNGFE VFIINLPYSM NWQSLKDMFK 

       250        260        270        280        290        300 
ECGHVLRADV ELDFNGFSRG FGSVIYPTED EMIRAIDTFN GMEVEGRVLE VREGRFNKRK 

       310        320        330        340        350        360 
NNDRYNQRRE DLEDTRGTEP GLAQDAAVHI DETAAKFTEG VNPGGDRNCF IYCSNLPFST 

       370        380        390        400        410        420 
ARSDLFDLFG PIGKINNAEL KPQENGQPTG VAVVEYENLV DADFCIQKLN NYNYGGCSLQ 


ISYARRD 

« Hide

References

« Hide 'large scale' references
[1]"The complete DNA sequence of yeast chromosome III."
Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M. expand/collapse author list , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"Isolation and characterization of two Saccharomyces cerevisiae genes that encode proteins that bind to (TG1-3)n single strand telomeric DNA in vitro."
Lin J.-J., Zakian V.A.
Nucleic Acids Res. 22:4906-4913(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[5]"A class of single-stranded telomeric DNA-binding proteins required for Rap1p localization in yeast nuclei."
Konkel L.C., Enomoto S., Chamberlain E., McCune-Zierath P., Iyadurai S.J.P., Berman J.
Proc. Natl. Acad. Sci. U.S.A. 92:5558-5562(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[6]"Exposure of single-stranded telomeric DNA causes G2/M cell cycle arrest in Saccharomyces cerevisiae."
Pang T.-L., Wang C.-Y., Hsu C.-L., Chen M.-Y., Lin J.-J.
J. Biol. Chem. 278:9318-9321(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[7]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-130, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X59720 Genomic DNA. Translation: CAA42348.1.
AY692807 Genomic DNA. Translation: AAT92826.1.
BK006937 Genomic DNA. Translation: DAA07470.1.
PIRS19338.
RefSeqNP_009916.1. NM_001178660.1.

3D structure databases

ProteinModelPortalP25555.
SMRP25555. Positions 122-296, 346-426.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid30970. 121 interactions.
DIPDIP-2735N.
IntActP25555. 46 interactions.
MINTMINT-481140.
STRING4932.YCL011C.

Proteomic databases

PaxDbP25555.
PeptideAtlasP25555.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYCL011C; YCL011C; YCL011C.
GeneID850346.
KEGGsce:YCL011C.

Organism-specific databases

CYGDYCL011c.
SGDS000000517. GBP2.

Phylogenomic databases

eggNOGCOG0724.
GeneTreeENSGT00410000025635.
HOGENOMHOG000111155.
OMAISMEAIN.
OrthoDBEOG76TB3G.

Enzyme and pathway databases

BioCycYEAST:G3O-29280-MONOMER.

Gene expression databases

GenevestigatorP25555.

Family and domain databases

Gene3D3.30.70.330. 3 hits.
InterProIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTSM00360. RRM. 3 hits.
[Graphical view]
PROSITEPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio965800.

Entry information

Entry nameGBP2_YEAST
AccessionPrimary (citable) accession number: P25555
Secondary accession number(s): D6VR01
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: March 19, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome III

Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families