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Protein

Anaerobic sulfatase-maturating enzyme homolog AslB

Gene

aslB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Despite its homology to the anaerobic sulfatase-maturating enzymes, it is not involved in Cys-type sulfatase maturation in vivo.Curated

Cofactori

Protein has several cofactor binding sites:
  • [4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.By similarity
  • iron-sulfur clusterCuratedNote: May bind at least one other iron-sulfur cluster.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi21Iron-sulfur 1 (4Fe-4S-S-AdoMet)Sequence analysis1
Metal bindingi25Iron-sulfur 1 (4Fe-4S-S-AdoMet)Sequence analysis1
Metal bindingi28Iron-sulfur 1 (4Fe-4S-S-AdoMet)Sequence analysis1
Metal bindingi276Iron-sulfurSequence analysis1
Metal bindingi282Iron-sulfurSequence analysis1
Metal bindingi297Iron-sulfurSequence analysis1
Metal bindingi339Iron-sulfurSequence analysis1
Metal bindingi342Iron-sulfurSequence analysis1
Metal bindingi348Iron-sulfurSequence analysis1
Metal bindingi352Iron-sulfurSequence analysis1

GO - Molecular functioni

GO - Biological processi

  • protein maturation Source: EcoCyc

Keywordsi

Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciEcoCyc:EG10090-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Anaerobic sulfatase-maturating enzyme homolog AslB
Short name:
AnSME homolog
Gene namesi
Name:aslB
Synonyms:atsB
Ordered Locus Names:b3800, JW5594
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi

Organism-specific databases

EcoGeneiEG10090 aslB

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001344591 – 411Anaerobic sulfatase-maturating enzyme homolog AslBAdd BLAST411

Proteomic databases

PaxDbiP25550
PRIDEiP25550

Interactioni

Protein-protein interaction databases

BioGridi4259322, 5 interactors
STRINGi316385.ECDH10B_3990

Structurei

3D structure databases

ProteinModelPortaliP25550
SMRiP25550
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C4X Bacteria
COG0641 LUCA
HOGENOMiHOG000000300
InParanoidiP25550
KOiK06871
OMAiVEYNILT
PhylomeDBiP25550

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR023885 4Fe4S-binding_SPASM_dom
IPR013785 Aldolase_TIM
IPR034491 Anaerob_Ser_sulfatase-maturase
IPR034481 Main_SPASM_domain-containing
IPR007197 rSAM
IPR034395 SPASM/twitch_domain-containing
IPR023867 Sulphatase_maturase_rSAM
PfamiView protein in Pfam
PF04055 Radical_SAM, 1 hit
PF13186 SPASM, 1 hit
SFLDiSFLDF00285 anaerobic_Ser-type_sulfatase-m, 1 hit
SFLDG01067 SPASM/twitch_domain_containing, 1 hit
SFLDG01072 dehydrogenase_like, 1 hit
SFLDG01386 main_SPASM_domain-containing, 1 hit
SFLDS00029 Radical_SAM, 1 hit
TIGRFAMsiTIGR04085 rSAM_more_4Fe4S, 1 hit
TIGR03942 sulfatase_rSAM, 1 hit

Sequencei

Sequence statusi: Complete.

P25550-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQQVPTRAF HVMAKPSGSD CNLNCDYCFY LEKQSLYREK PVTHMDDDTL
60 70 80 90 100
EAYVRHYIAA SEPQNEVAFT WQGGEPTLLG LAFYRRAVAL QAKYGAGRKI
110 120 130 140 150
SNSFQTNGVL LDDEWCAFLA EHHFLVGLSL DGPPEIHNQY RVTKGGRPTH
160 170 180 190 200
KLVMRALTLL QKHHVDYNVL VCVNRTSAQQ PLQVYDFLCD AGVEFIQFIP
210 220 230 240 250
VVERLADETT ARDGLKLHAP GDIQGELTEW SVRPEEFGEF LVAIFDHWIK
260 270 280 290 300
RDVGKIFVMN IEWAFANFVG APGAVCHHQP TCGRSVIVEH NGDVYACDHY
310 320 330 340 350
VYPQYRLGNM HQQTIAEMID SPQQQAFGED KFKQLPAQCR SCNVLKACWG
360 370 380 390 400
GCPKHRFMLD ASGKPGLNYL CAGYQRYFRH LPPYLKAMAD LLAHGRPASD
410
IMHAHLLVVS K
Length:411
Mass (Da):46,513
Last modified:October 11, 2004 - v4
Checksum:iE819FE44BE9501AA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti116 – 117CA → WP in AAA67596 (PubMed:1379743).Curated2
Sequence conflicti391L → C in AAA67596 (PubMed:1379743).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90498 Genomic DNA Translation: AAC32035.1
M87049 Genomic DNA Translation: AAA67596.1
U00096 Genomic DNA Translation: AAT48217.1
AP009048 Genomic DNA Translation: BAE77501.1
PIRiA65184
RefSeqiWP_000941517.1, NZ_LN832404.1
YP_026259.1, NC_000913.3

Genome annotation databases

EnsemblBacteriaiAAT48217; AAT48217; b3800
BAE77501; BAE77501; BAE77501
GeneIDi949013
KEGGiecj:JW5594
eco:b3800
PATRICifig|511145.12.peg.3914

Entry informationi

Entry nameiASLB_ECOLI
AccessioniPrimary (citable) accession number: P25550
Secondary accession number(s): Q2M8A5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: October 11, 2004
Last modified: March 28, 2018
This is version 123 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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