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Protein

GABA permease

Gene

gabP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transporter for GABA.

Pathwayi: 4-aminobutanoate degradation

This protein is involved in the pathway 4-aminobutanoate degradation, which is part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the pathway 4-aminobutanoate degradation and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:GABP-MONOMER.
ECOL316407:JW2638-MONOMER.
MetaCyc:GABP-MONOMER.
UniPathwayiUPA00733.

Protein family/group databases

TCDBi2.A.3.1.4. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
GABA permease
Alternative name(s):
4-amino butyrate transport carrier
Gamma-aminobutyrate permease
Gene namesi
Name:gabP
Ordered Locus Names:b2663, JW2638
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11330. gabP.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Topological domaini63 – 96CytoplasmicSequence analysisAdd BLAST34
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Topological domaini118PeriplasmicSequence analysis1
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 153CytoplasmicSequence analysisAdd BLAST14
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Topological domaini175 – 199PeriplasmicSequence analysisAdd BLAST25
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Topological domaini221 – 246CytoplasmicSequence analysisAdd BLAST26
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Topological domaini268 – 286PeriplasmicSequence analysisAdd BLAST19
Transmembranei287 – 307HelicalSequence analysisAdd BLAST21
Topological domaini308 – 334CytoplasmicSequence analysisAdd BLAST27
Transmembranei335 – 355HelicalSequence analysisAdd BLAST21
Topological domaini356 – 359PeriplasmicSequence analysis4
Transmembranei360 – 380HelicalSequence analysisAdd BLAST21
Topological domaini381 – 402CytoplasmicSequence analysisAdd BLAST22
Transmembranei403 – 423HelicalSequence analysisAdd BLAST21
Topological domaini424 – 428PeriplasmicSequence analysis5
Transmembranei429 – 449HelicalSequence analysisAdd BLAST21
Topological domaini450 – 466CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000542021 – 466GABA permeaseAdd BLAST466

Proteomic databases

PaxDbiP25527.
PRIDEiP25527.

Expressioni

Inductioni

Induced by RpoS, but not in response to multiple stress conditions.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4261470. 17 interactors.
DIPiDIP-9724N.
IntActiP25527. 2 interactors.
MINTiMINT-1248489.
STRINGi511145.b2663.

Structurei

3D structure databases

ProteinModelPortaliP25527.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C85. Bacteria.
COG1113. LUCA.
HOGENOMiHOG000261846.
InParanoidiP25527.
KOiK11735.
OMAiFENARHI.
PhylomeDBiP25527.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004840. Amoino_acid_permease_CS.
IPR011265. GABA_permease.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR01773. GABAperm. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25527-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQSSQPHEL GGGLKSRHVT MLSIAGVIGA SLFVGSSVAI AEAGPAVLLA
60 70 80 90 100
YLFAGLLVVM IMRMLAEMAV ATPDTGSFST YADKAIGRWA GYTIGWLYWW
110 120 130 140 150
FWVLVIPLEA NIAAMILHSW VPGIPIWLFS LVITLALTGS NLLSVKNYGE
160 170 180 190 200
FEFWLALCKV IAILAFIFLG AVAISGFYPY AEVSGISRLW DSGGFMPNGF
210 220 230 240 250
GAVLSAMLIT MFSFMGAEIV TIAAAESDTP EKHIVRATNS VIWRISIFYL
260 270 280 290 300
CSIFVVVALI PWNMPGLKAV GSYRSVLELL NIPHAKLIMD CVILLSVTSC
310 320 330 340 350
LNSALYTASR MLYSLSRRGD APAVMGKINR SKTPYVAVLL STGAAFLTVV
360 370 380 390 400
VNYYAPAKVF KFLIDSSGAI ALLVYLVIAV SQLRMRKILR AEGSEIRLRM
410 420 430 440 450
WLYPWLTWLV IGFITFVLVV MLFRPAQQLE VISTGLLAIG IICTVPIMAR
460
WKKLVLWQKT PVHNTR
Length:466
Mass (Da):51,080
Last modified:May 1, 1992 - v1
Checksum:i87998A83C80BA4EC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72T → R in CAA46229 (Ref. 2) Curated1
Sequence conflicti385 – 386MR → IG in CAA46229 (Ref. 2) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88334 Genomic DNA. Translation: AAC36833.1.
X65104 Genomic DNA. Translation: CAA46229.1.
U00096 Genomic DNA. Translation: AAC75710.1.
AP009048 Genomic DNA. Translation: BAA16526.1.
PIRiH65045.
RefSeqiNP_417149.1. NC_000913.3.
WP_001295173.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75710; AAC75710; b2663.
BAA16526; BAA16526; BAA16526.
GeneIDi948049.
KEGGiecj:JW2638.
eco:b2663.
PATRICi32120716. VBIEscCol129921_2755.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88334 Genomic DNA. Translation: AAC36833.1.
X65104 Genomic DNA. Translation: CAA46229.1.
U00096 Genomic DNA. Translation: AAC75710.1.
AP009048 Genomic DNA. Translation: BAA16526.1.
PIRiH65045.
RefSeqiNP_417149.1. NC_000913.3.
WP_001295173.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP25527.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261470. 17 interactors.
DIPiDIP-9724N.
IntActiP25527. 2 interactors.
MINTiMINT-1248489.
STRINGi511145.b2663.

Protein family/group databases

TCDBi2.A.3.1.4. the amino acid-polyamine-organocation (apc) family.

Proteomic databases

PaxDbiP25527.
PRIDEiP25527.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75710; AAC75710; b2663.
BAA16526; BAA16526; BAA16526.
GeneIDi948049.
KEGGiecj:JW2638.
eco:b2663.
PATRICi32120716. VBIEscCol129921_2755.

Organism-specific databases

EchoBASEiEB1306.
EcoGeneiEG11330. gabP.

Phylogenomic databases

eggNOGiENOG4105C85. Bacteria.
COG1113. LUCA.
HOGENOMiHOG000261846.
InParanoidiP25527.
KOiK11735.
OMAiFENARHI.
PhylomeDBiP25527.

Enzyme and pathway databases

UniPathwayiUPA00733.
BioCyciEcoCyc:GABP-MONOMER.
ECOL316407:JW2638-MONOMER.
MetaCyc:GABP-MONOMER.

Miscellaneous databases

PROiP25527.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004840. Amoino_acid_permease_CS.
IPR011265. GABA_permease.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR01773. GABAperm. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGABP_ECOLI
AccessioniPrimary (citable) accession number: P25527
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 2, 2016
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.