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P25499 (HRCA_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Heat-inducible transcription repressor HrcA
Gene names
Name:hrcA
Synonyms:yqeS, yqxE
Ordered Locus Names:BSU25490
OrganismBacillus subtilis
Taxonomic identifier1423 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons. Ref.4

Sequence similarities

Belongs to the HrcA family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 343343Heat-inducible transcription repressor HrcA HAMAP MF_00081
PRO_0000182449

Sequences

Sequence LengthMass (Da)Tools
P25499 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: 0F60521FC8E30E94

FASTA34339,028
        10         20         30         40         50         60 
MLTNRQLLIL QVIINDFIKS AQPVGSRTLS KKDEITFSSA TIRNEMADLE ELGFIEKTHS 

        70         80         90        100        110        120 
SSGRVPSEKG YRYYVDHLLS PVKLTKSDLD QIHSIFKEKI FELEKTVQKS AQILSDLTNY 

       130        140        150        160        170        180 
TSIVLGPKLS ENYLKQIQII PIQPDMAVAI LVTNTGHVEN KTINFPTKMD LSDIEKLVNI 

       190        200        210        220        230        240 
LNDRLSGVPM DELNERIFKE VVMYLRQHIK NYDNILDALR STFHSTNHVE KLFFGGKINM 

       250        260        270        280        290        300 
LNQPEFHDIT RVRSLLSLIE KEQDVLKLVQ SPHTGISIKI GKENDYEEME NCSLITASYS 

       310        320        330        340 
VDQKQIGSIA IIGPTRMNYS RVVSLLQHVT SDLSKALTSL YDE

« Hide

References

« Hide 'large scale' references
[1]"Cloning, sequencing, and molecular analysis of the dnaK locus from Bacillus subtilis."
Wetzstein M., Voelker U., Dedio J., Loebau S., Zuber U., Schiesswohl M., Herget C., Hecker M., Schumann W.
J. Bacteriol. 174:3300-3310(1992) [PubMed: 1339421] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168 / MB11.
[2]"Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the Bacillus subtilis genome containing the skin element and many sporulation genes."
Mizuno M., Masuda S., Takemaru K., Hosono S., Sato T., Takeuchi M., Kobayashi Y.
Microbiology 142:3103-3111(1996) [PubMed: 8969508] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168 / JH642.
[3]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed: 9384377] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[4]"hrcA, the first gene of the Bacillus subtilis dnaK operon encodes a negative regulator of class I heat shock genes."
Schulz A., Schumann W.
J. Bacteriol. 178:1088-1093(1996) [PubMed: 8576042] [Abstract]
Cited for: FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M84964 Genomic DNA. Translation: AAA22526.1.
D84432 Genomic DNA. Translation: BAA12462.1.
AL009126 Genomic DNA. Translation: CAB14491.1.
PIRA41874.
RefSeqNP_390427.1. NC_000964.3.

3D structure databases

ProteinModelPortalP25499.
SMRP25499. Positions 2-340.
ModBaseSearch...

Protein-protein interaction databases

IntActP25499. 6 interactions.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000002699; EBBACP00000002699; EBBACG00000002694.
GeneID937843.
GenomeReviewsGene locus BSU25490 in contig AL009126_GR.
KEGGbsu:BSU25490.
NMPDRfig|224308.1.peg.2552.
PATRIC18976936. VBIBacSub10457_2657.

Organism-specific databases

GenoListBSU25490. [Micado]

Phylogenomic databases

GeneTreeEBGT00050000002539.
HOGENOMHBG729878.
OMALEQPHTS.
PhylomeDBP25499.
ProtClustDBPRK00082.

Enzyme and pathway databases

BioCycBSUB:BSU25490-MONOMER.

Family and domain databases

HAMAPMF_00081. HrcA.
[Tree]
InterProIPR002571. WHTH_transcript_rep_HrcA.
IPR021153. WHTH_transcript_rep_HrcA_C.
IPR011991. WHTH_trsnscrt_rep_DNA-bd.
[Graphical view]
Gene3DG3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
KOK03705.
PfamPF01628. HrcA. 1 hit.
[Graphical view]
PIRSFPIRSF005485. HrcA. 1 hit.
TIGRFAMsTIGR00331. HrcA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHRCA_BACSU
AccessionPrimary (citable) accession number: P25499
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: January 25, 2012
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents