Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P25489

- AT1A1_CATCO

UniProt

P25489 - AT1A1_CATCO

Protein

Sodium/potassium-transporting ATPase subunit alpha-1

Gene

atp1a1

Organism
Catostomus commersonii (White sucker) (Cyprinus commersonnii)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

    Catalytic activityi

    ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei379 – 37914-aspartylphosphate intermediateBy similarity
    Binding sitei490 – 4901ATPBy similarity
    Metal bindingi721 – 7211MagnesiumBy similarity
    Metal bindingi725 – 7251MagnesiumBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sodium:potassium-exchanging ATPase activity Source: UniProtKB-EC

    GO - Biological processi

    1. ATP biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/potassium-transporting ATPase subunit alpha-1 (EC:3.6.3.9)
    Short name:
    Na(+)/K(+) ATPase alpha-1 subunit
    Alternative name(s):
    Sodium pump subunit alpha-1
    Gene namesi
    Name:atp1a1
    OrganismiCatostomus commersonii (White sucker) (Cyprinus commersonnii)
    Taxonomic identifieri7971 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCatostomidaeCatostomus

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei1 – 55By similarityPRO_0000002497
    Chaini6 – 10271022Sodium/potassium-transporting ATPase subunit alpha-1PRO_0000002498Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei16 – 161Phosphoserine; by PKCBy similarity
    Modified residuei947 – 9471Phosphoserine; by PKABy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP25489.

    Interactioni

    Subunit structurei

    Composed of three subunits: alpha (catalytic), beta and gamma.

    Structurei

    3D structure databases

    ProteinModelPortaliP25489.
    SMRiP25489. Positions 30-1027.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini6 – 9085CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini112 – 13423ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini156 – 291136CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini312 – 32312ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini342 – 776435CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini797 – 80610ExtracellularSequence Analysis
    Topological domaini828 – 84720CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini871 – 92252ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini943 – 95513CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini975 – 98915ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1011 – 102717CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei91 – 11121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei135 – 15521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei292 – 31120HelicalSequence AnalysisAdd
    BLAST
    Transmembranei324 – 34118HelicalSequence AnalysisAdd
    BLAST
    Transmembranei777 – 79620HelicalSequence AnalysisAdd
    BLAST
    Transmembranei807 – 82721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei848 – 87023HelicalSequence AnalysisAdd
    BLAST
    Transmembranei923 – 94220HelicalSequence AnalysisAdd
    BLAST
    Transmembranei956 – 97419HelicalSequence AnalysisAdd
    BLAST
    Transmembranei990 – 101021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni85 – 873Interaction with phosphoinositide-3 kinaseBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG004298.

    Family and domain databases

    Gene3Di1.20.1110.10. 2 hits.
    2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR005775. ATPase_P-typ_Na/K_IIC.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view]
    PfamiPF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view]
    PRINTSiPR00119. CATATPASE.
    SMARTiSM00831. Cation_ATPase_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 1 hit.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P25489-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGVGDGRDQY ELAAMSEQSG KKKSKNKKEK KEKDMDELKK EVDLDDHKLS     50
    LEELHHKYGT DLSKGLSNSR AEEILARDGP NALTPPPTTP EWVKFCKQMF 100
    GGFSMLLWTG AVLCFLAYGI LAAMEDEPAN DNLYLGVVLS AVVIITGCFS 150
    YYQDAKSSKI MDSFKNLVPQ QALVVRDGEK KQINAEEVVI GDLVEVKGGD 200
    RIPADLRIIS SHGCKVDNSS LTGESEPQTR SPDFSNDNPL ETKNIAFFST 250
    NCVEGTARGI VISTGDRTVM GRIATLASGL EVGRTPISIE IEHFIHIITG 300
    VAVFLGVSFL LLSLVLGYSW LEAVIFLIGI IVANVPEGLL ATVTVCLTLT 350
    AKRMAKKNCL VKNLEAVETL GSTSTICSDK TGTLTQNRMT VAHMWFDNQI 400
    HEADTTENQS GTSFDRSSDT WASLARIAGL CNRAVFLAEQ IDVPILKRDV 450
    AGDASESALL KCIELCCGSV KEMREKFTKV AEIPFNSTNK YQLSVHKIPS 500
    GGKESQHLLV MKGAPERILD RCATIMIQGK EQLLDDEIKE SFQNAYLELG 550
    GLGERVLGFC HFYLPDEQFP EGFQFDADDV NFPTENLCFV GLMSMIDPPR 600
    AAVPDAVGKC RSAGIKVIMV TGDHPITAKA IAKGVGIISE GNETVEDIAA 650
    RLNIPVNEVN PRDAKACVVH GGDLKDLSCE QLDDILKYHT EIVFARTSPQ 700
    QKLIIVEGCQ RTGAIVAVTG DGVNDSPALK KADIGVAMGI AGSDVSKQAA 750
    DMILLDDNFA SIVTGVEEGR LIFDNLKKSI AYTLTSNIPE ITPFLFFIIA 800
    NIPLPLGTVT ILCIDLGTDM LPAISLAYEA AESDIMKRQP RNPKTDKLVN 850
    ERLISIAYGQ IGMIQALAGF FTYFVILAEN GFLPPRLLGI RMNWDDKYIN 900
    DLEDSYGQQW TYEQRKIVEF TCHTAFFTSI VIVQWADLII CKTRRNSVFQ 950
    QGMKNKILIF GLFEETALAA FLSYCPGMDV ALRMYPLKPN WWFCAFPYSL 1000
    LIFIYDEIRK LILRRNPGGW MERETYY 1027
    Length:1,027
    Mass (Da):113,314
    Last modified:May 1, 1992 - v1
    Checksum:iBA821A12F85DF8EB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58629 mRNA. Translation: CAA41483.1.
    PIRiS14740. PWCCNM.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58629 mRNA. Translation: CAA41483.1 .
    PIRi S14740. PWCCNM.

    3D structure databases

    ProteinModelPortali P25489.
    SMRi P25489. Positions 30-1027.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P25489.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG004298.

    Family and domain databases

    Gene3Di 1.20.1110.10. 2 hits.
    2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR005775. ATPase_P-typ_Na/K_IIC.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view ]
    Pfami PF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view ]
    PRINTSi PR00119. CATATPASE.
    SMARTi SM00831. Cation_ATPase_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 1 hit.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sodium and potassium ATPase of the teleost fish Catostomus commersoni. Sequence, protein structure and evolutionary conservation of the alpha-subunit."
      Schoenrock C., Morley S.D., Okawara Y., Lederis K., Richter D.
      Biol. Chem. Hoppe-Seyler 372:279-286(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Hypothalamus.

    Entry informationi

    Entry nameiAT1A1_CATCO
    AccessioniPrimary (citable) accession number: P25489
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3