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Protein

Sodium/potassium-transporting ATPase subunit alpha-1

Gene

atp1a1

Organism
Catostomus commersonii (White sucker) (Cyprinus commersonnii)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Catalytic activityi

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3794-aspartylphosphate intermediateBy similarity1
Binding sitei490ATPBy similarity1
Metal bindingi721MagnesiumBy similarity1
Metal bindingi725MagnesiumBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha-1 (EC:3.6.3.9)
Short name:
Na(+)/K(+) ATPase alpha-1 subunit
Alternative name(s):
Sodium pump subunit alpha-1
Gene namesi
Name:atp1a1
OrganismiCatostomus commersonii (White sucker) (Cyprinus commersonnii)
Taxonomic identifieri7971 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCatostomidaeCatostomus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini6 – 90CytoplasmicSequence analysisAdd BLAST85
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Topological domaini112 – 134ExtracellularSequence analysisAdd BLAST23
Transmembranei135 – 155HelicalSequence analysisAdd BLAST21
Topological domaini156 – 291CytoplasmicSequence analysisAdd BLAST136
Transmembranei292 – 311HelicalSequence analysisAdd BLAST20
Topological domaini312 – 323ExtracellularSequence analysisAdd BLAST12
Transmembranei324 – 341HelicalSequence analysisAdd BLAST18
Topological domaini342 – 776CytoplasmicSequence analysisAdd BLAST435
Transmembranei777 – 796HelicalSequence analysisAdd BLAST20
Topological domaini797 – 806ExtracellularSequence analysis10
Transmembranei807 – 827HelicalSequence analysisAdd BLAST21
Topological domaini828 – 847CytoplasmicSequence analysisAdd BLAST20
Transmembranei848 – 870HelicalSequence analysisAdd BLAST23
Topological domaini871 – 922ExtracellularSequence analysisAdd BLAST52
Transmembranei923 – 942HelicalSequence analysisAdd BLAST20
Topological domaini943 – 955CytoplasmicSequence analysisAdd BLAST13
Transmembranei956 – 974HelicalSequence analysisAdd BLAST19
Topological domaini975 – 989ExtracellularSequence analysisAdd BLAST15
Transmembranei990 – 1010HelicalSequence analysisAdd BLAST21
Topological domaini1011 – 1027CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000024971 – 5By similarity5
ChainiPRO_00000024986 – 1027Sodium/potassium-transporting ATPase subunit alpha-1Add BLAST1022

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16Phosphoserine; by PKCBy similarity1
Modified residuei947Phosphoserine; by PKABy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP25489.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.

Structurei

3D structure databases

ProteinModelPortaliP25489.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni85 – 87Interaction with phosphoinositide-3 kinaseBy similarity3

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004298.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25489-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVGDGRDQY ELAAMSEQSG KKKSKNKKEK KEKDMDELKK EVDLDDHKLS
60 70 80 90 100
LEELHHKYGT DLSKGLSNSR AEEILARDGP NALTPPPTTP EWVKFCKQMF
110 120 130 140 150
GGFSMLLWTG AVLCFLAYGI LAAMEDEPAN DNLYLGVVLS AVVIITGCFS
160 170 180 190 200
YYQDAKSSKI MDSFKNLVPQ QALVVRDGEK KQINAEEVVI GDLVEVKGGD
210 220 230 240 250
RIPADLRIIS SHGCKVDNSS LTGESEPQTR SPDFSNDNPL ETKNIAFFST
260 270 280 290 300
NCVEGTARGI VISTGDRTVM GRIATLASGL EVGRTPISIE IEHFIHIITG
310 320 330 340 350
VAVFLGVSFL LLSLVLGYSW LEAVIFLIGI IVANVPEGLL ATVTVCLTLT
360 370 380 390 400
AKRMAKKNCL VKNLEAVETL GSTSTICSDK TGTLTQNRMT VAHMWFDNQI
410 420 430 440 450
HEADTTENQS GTSFDRSSDT WASLARIAGL CNRAVFLAEQ IDVPILKRDV
460 470 480 490 500
AGDASESALL KCIELCCGSV KEMREKFTKV AEIPFNSTNK YQLSVHKIPS
510 520 530 540 550
GGKESQHLLV MKGAPERILD RCATIMIQGK EQLLDDEIKE SFQNAYLELG
560 570 580 590 600
GLGERVLGFC HFYLPDEQFP EGFQFDADDV NFPTENLCFV GLMSMIDPPR
610 620 630 640 650
AAVPDAVGKC RSAGIKVIMV TGDHPITAKA IAKGVGIISE GNETVEDIAA
660 670 680 690 700
RLNIPVNEVN PRDAKACVVH GGDLKDLSCE QLDDILKYHT EIVFARTSPQ
710 720 730 740 750
QKLIIVEGCQ RTGAIVAVTG DGVNDSPALK KADIGVAMGI AGSDVSKQAA
760 770 780 790 800
DMILLDDNFA SIVTGVEEGR LIFDNLKKSI AYTLTSNIPE ITPFLFFIIA
810 820 830 840 850
NIPLPLGTVT ILCIDLGTDM LPAISLAYEA AESDIMKRQP RNPKTDKLVN
860 870 880 890 900
ERLISIAYGQ IGMIQALAGF FTYFVILAEN GFLPPRLLGI RMNWDDKYIN
910 920 930 940 950
DLEDSYGQQW TYEQRKIVEF TCHTAFFTSI VIVQWADLII CKTRRNSVFQ
960 970 980 990 1000
QGMKNKILIF GLFEETALAA FLSYCPGMDV ALRMYPLKPN WWFCAFPYSL
1010 1020
LIFIYDEIRK LILRRNPGGW MERETYY
Length:1,027
Mass (Da):113,314
Last modified:May 1, 1992 - v1
Checksum:iBA821A12F85DF8EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58629 mRNA. Translation: CAA41483.1.
PIRiS14740. PWCCNM.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58629 mRNA. Translation: CAA41483.1.
PIRiS14740. PWCCNM.

3D structure databases

ProteinModelPortaliP25489.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP25489.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG004298.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAT1A1_CATCO
AccessioniPrimary (citable) accession number: P25489
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: October 5, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.