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P25489

- AT1A1_CATCO

UniProt

P25489 - AT1A1_CATCO

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Protein
Sodium/potassium-transporting ATPase subunit alpha-1
Gene
atp1a1
Organism
Catostomus commersonii (White sucker) (Cyprinus commersonnii)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Catalytic activityi

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei379 – 37914-aspartylphosphate intermediate By similarity
Binding sitei490 – 4901ATP By similarity
Metal bindingi721 – 7211Magnesium By similarity
Metal bindingi725 – 7251Magnesium By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sodium:potassium-exchanging ATPase activity Source: UniProtKB-EC

GO - Biological processi

  1. ATP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha-1 (EC:3.6.3.9)
Short name:
Na(+)/K(+) ATPase alpha-1 subunit
Alternative name(s):
Sodium pump subunit alpha-1
Gene namesi
Name:atp1a1
OrganismiCatostomus commersonii (White sucker) (Cyprinus commersonnii)
Taxonomic identifieri7971 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCatostomidaeCatostomus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini6 – 9085Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei91 – 11121Helical; Reviewed prediction
Add
BLAST
Topological domaini112 – 13423Extracellular Reviewed prediction
Add
BLAST
Transmembranei135 – 15521Helical; Reviewed prediction
Add
BLAST
Topological domaini156 – 291136Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei292 – 31120Helical; Reviewed prediction
Add
BLAST
Topological domaini312 – 32312Extracellular Reviewed prediction
Add
BLAST
Transmembranei324 – 34118Helical; Reviewed prediction
Add
BLAST
Topological domaini342 – 776435Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei777 – 79620Helical; Reviewed prediction
Add
BLAST
Topological domaini797 – 80610Extracellular Reviewed prediction
Transmembranei807 – 82721Helical; Reviewed prediction
Add
BLAST
Topological domaini828 – 84720Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei848 – 87023Helical; Reviewed prediction
Add
BLAST
Topological domaini871 – 92252Extracellular Reviewed prediction
Add
BLAST
Transmembranei923 – 94220Helical; Reviewed prediction
Add
BLAST
Topological domaini943 – 95513Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei956 – 97419Helical; Reviewed prediction
Add
BLAST
Topological domaini975 – 98915Extracellular Reviewed prediction
Add
BLAST
Transmembranei990 – 101021Helical; Reviewed prediction
Add
BLAST
Topological domaini1011 – 102717Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 55 By similarity
PRO_0000002497
Chaini6 – 10271022Sodium/potassium-transporting ATPase subunit alpha-1
PRO_0000002498Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei16 – 161Phosphoserine; by PKC By similarity
Modified residuei947 – 9471Phosphoserine; by PKA By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP25489.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.

Structurei

3D structure databases

ProteinModelPortaliP25489.
SMRiP25489. Positions 30-1027.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni85 – 873Interaction with phosphoinositide-3 kinase By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004298.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25489-1 [UniParc]FASTAAdd to Basket

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MGVGDGRDQY ELAAMSEQSG KKKSKNKKEK KEKDMDELKK EVDLDDHKLS     50
LEELHHKYGT DLSKGLSNSR AEEILARDGP NALTPPPTTP EWVKFCKQMF 100
GGFSMLLWTG AVLCFLAYGI LAAMEDEPAN DNLYLGVVLS AVVIITGCFS 150
YYQDAKSSKI MDSFKNLVPQ QALVVRDGEK KQINAEEVVI GDLVEVKGGD 200
RIPADLRIIS SHGCKVDNSS LTGESEPQTR SPDFSNDNPL ETKNIAFFST 250
NCVEGTARGI VISTGDRTVM GRIATLASGL EVGRTPISIE IEHFIHIITG 300
VAVFLGVSFL LLSLVLGYSW LEAVIFLIGI IVANVPEGLL ATVTVCLTLT 350
AKRMAKKNCL VKNLEAVETL GSTSTICSDK TGTLTQNRMT VAHMWFDNQI 400
HEADTTENQS GTSFDRSSDT WASLARIAGL CNRAVFLAEQ IDVPILKRDV 450
AGDASESALL KCIELCCGSV KEMREKFTKV AEIPFNSTNK YQLSVHKIPS 500
GGKESQHLLV MKGAPERILD RCATIMIQGK EQLLDDEIKE SFQNAYLELG 550
GLGERVLGFC HFYLPDEQFP EGFQFDADDV NFPTENLCFV GLMSMIDPPR 600
AAVPDAVGKC RSAGIKVIMV TGDHPITAKA IAKGVGIISE GNETVEDIAA 650
RLNIPVNEVN PRDAKACVVH GGDLKDLSCE QLDDILKYHT EIVFARTSPQ 700
QKLIIVEGCQ RTGAIVAVTG DGVNDSPALK KADIGVAMGI AGSDVSKQAA 750
DMILLDDNFA SIVTGVEEGR LIFDNLKKSI AYTLTSNIPE ITPFLFFIIA 800
NIPLPLGTVT ILCIDLGTDM LPAISLAYEA AESDIMKRQP RNPKTDKLVN 850
ERLISIAYGQ IGMIQALAGF FTYFVILAEN GFLPPRLLGI RMNWDDKYIN 900
DLEDSYGQQW TYEQRKIVEF TCHTAFFTSI VIVQWADLII CKTRRNSVFQ 950
QGMKNKILIF GLFEETALAA FLSYCPGMDV ALRMYPLKPN WWFCAFPYSL 1000
LIFIYDEIRK LILRRNPGGW MERETYY 1027
Length:1,027
Mass (Da):113,314
Last modified:May 1, 1992 - v1
Checksum:iBA821A12F85DF8EB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58629 mRNA. Translation: CAA41483.1.
PIRiS14740. PWCCNM.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58629 mRNA. Translation: CAA41483.1 .
PIRi S14740. PWCCNM.

3D structure databases

ProteinModelPortali P25489.
SMRi P25489. Positions 30-1027.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P25489.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG004298.

Family and domain databases

Gene3Di 1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SMARTi SM00831. Cation_ATPase_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
SSF81660. SSF81660. 1 hit.
TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sodium and potassium ATPase of the teleost fish Catostomus commersoni. Sequence, protein structure and evolutionary conservation of the alpha-subunit."
    Schoenrock C., Morley S.D., Okawara Y., Lederis K., Richter D.
    Biol. Chem. Hoppe-Seyler 372:279-286(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hypothalamus.

Entry informationi

Entry nameiAT1A1_CATCO
AccessioniPrimary (citable) accession number: P25489
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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