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P25489

- AT1A1_CATCO

UniProt

P25489 - AT1A1_CATCO

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Protein

Sodium/potassium-transporting ATPase subunit alpha-1

Gene

atp1a1

Organism
Catostomus commersonii (White sucker) (Cyprinus commersonnii)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Catalytic activityi

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei379 – 37914-aspartylphosphate intermediateBy similarity
Binding sitei490 – 4901ATPBy similarity
Metal bindingi721 – 7211MagnesiumBy similarity
Metal bindingi725 – 7251MagnesiumBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sodium:potassium-exchanging ATPase activity Source: UniProtKB-EC

GO - Biological processi

  1. ATP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha-1 (EC:3.6.3.9)
Short name:
Na(+)/K(+) ATPase alpha-1 subunit
Alternative name(s):
Sodium pump subunit alpha-1
Gene namesi
Name:atp1a1
OrganismiCatostomus commersonii (White sucker) (Cyprinus commersonnii)
Taxonomic identifieri7971 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCatostomidaeCatostomus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini6 – 9085CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei91 – 11121HelicalSequence AnalysisAdd
BLAST
Topological domaini112 – 13423ExtracellularSequence AnalysisAdd
BLAST
Transmembranei135 – 15521HelicalSequence AnalysisAdd
BLAST
Topological domaini156 – 291136CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei292 – 31120HelicalSequence AnalysisAdd
BLAST
Topological domaini312 – 32312ExtracellularSequence AnalysisAdd
BLAST
Transmembranei324 – 34118HelicalSequence AnalysisAdd
BLAST
Topological domaini342 – 776435CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei777 – 79620HelicalSequence AnalysisAdd
BLAST
Topological domaini797 – 80610ExtracellularSequence Analysis
Transmembranei807 – 82721HelicalSequence AnalysisAdd
BLAST
Topological domaini828 – 84720CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei848 – 87023HelicalSequence AnalysisAdd
BLAST
Topological domaini871 – 92252ExtracellularSequence AnalysisAdd
BLAST
Transmembranei923 – 94220HelicalSequence AnalysisAdd
BLAST
Topological domaini943 – 95513CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei956 – 97419HelicalSequence AnalysisAdd
BLAST
Topological domaini975 – 98915ExtracellularSequence AnalysisAdd
BLAST
Transmembranei990 – 101021HelicalSequence AnalysisAdd
BLAST
Topological domaini1011 – 102717CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 55By similarityPRO_0000002497
Chaini6 – 10271022Sodium/potassium-transporting ATPase subunit alpha-1PRO_0000002498Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei16 – 161Phosphoserine; by PKCBy similarity
Modified residuei947 – 9471Phosphoserine; by PKABy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP25489.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.

Structurei

3D structure databases

ProteinModelPortaliP25489.
SMRiP25489. Positions 30-1027.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni85 – 873Interaction with phosphoinositide-3 kinaseBy similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004298.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25489-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGVGDGRDQY ELAAMSEQSG KKKSKNKKEK KEKDMDELKK EVDLDDHKLS
60 70 80 90 100
LEELHHKYGT DLSKGLSNSR AEEILARDGP NALTPPPTTP EWVKFCKQMF
110 120 130 140 150
GGFSMLLWTG AVLCFLAYGI LAAMEDEPAN DNLYLGVVLS AVVIITGCFS
160 170 180 190 200
YYQDAKSSKI MDSFKNLVPQ QALVVRDGEK KQINAEEVVI GDLVEVKGGD
210 220 230 240 250
RIPADLRIIS SHGCKVDNSS LTGESEPQTR SPDFSNDNPL ETKNIAFFST
260 270 280 290 300
NCVEGTARGI VISTGDRTVM GRIATLASGL EVGRTPISIE IEHFIHIITG
310 320 330 340 350
VAVFLGVSFL LLSLVLGYSW LEAVIFLIGI IVANVPEGLL ATVTVCLTLT
360 370 380 390 400
AKRMAKKNCL VKNLEAVETL GSTSTICSDK TGTLTQNRMT VAHMWFDNQI
410 420 430 440 450
HEADTTENQS GTSFDRSSDT WASLARIAGL CNRAVFLAEQ IDVPILKRDV
460 470 480 490 500
AGDASESALL KCIELCCGSV KEMREKFTKV AEIPFNSTNK YQLSVHKIPS
510 520 530 540 550
GGKESQHLLV MKGAPERILD RCATIMIQGK EQLLDDEIKE SFQNAYLELG
560 570 580 590 600
GLGERVLGFC HFYLPDEQFP EGFQFDADDV NFPTENLCFV GLMSMIDPPR
610 620 630 640 650
AAVPDAVGKC RSAGIKVIMV TGDHPITAKA IAKGVGIISE GNETVEDIAA
660 670 680 690 700
RLNIPVNEVN PRDAKACVVH GGDLKDLSCE QLDDILKYHT EIVFARTSPQ
710 720 730 740 750
QKLIIVEGCQ RTGAIVAVTG DGVNDSPALK KADIGVAMGI AGSDVSKQAA
760 770 780 790 800
DMILLDDNFA SIVTGVEEGR LIFDNLKKSI AYTLTSNIPE ITPFLFFIIA
810 820 830 840 850
NIPLPLGTVT ILCIDLGTDM LPAISLAYEA AESDIMKRQP RNPKTDKLVN
860 870 880 890 900
ERLISIAYGQ IGMIQALAGF FTYFVILAEN GFLPPRLLGI RMNWDDKYIN
910 920 930 940 950
DLEDSYGQQW TYEQRKIVEF TCHTAFFTSI VIVQWADLII CKTRRNSVFQ
960 970 980 990 1000
QGMKNKILIF GLFEETALAA FLSYCPGMDV ALRMYPLKPN WWFCAFPYSL
1010 1020
LIFIYDEIRK LILRRNPGGW MERETYY
Length:1,027
Mass (Da):113,314
Last modified:May 1, 1992 - v1
Checksum:iBA821A12F85DF8EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58629 mRNA. Translation: CAA41483.1.
PIRiS14740. PWCCNM.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58629 mRNA. Translation: CAA41483.1 .
PIRi S14740. PWCCNM.

3D structure databases

ProteinModelPortali P25489.
SMRi P25489. Positions 30-1027.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P25489.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG004298.

Family and domain databases

Gene3Di 1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SMARTi SM00831. Cation_ATPase_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
SSF81660. SSF81660. 1 hit.
TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sodium and potassium ATPase of the teleost fish Catostomus commersoni. Sequence, protein structure and evolutionary conservation of the alpha-subunit."
    Schoenrock C., Morley S.D., Okawara Y., Lederis K., Richter D.
    Biol. Chem. Hoppe-Seyler 372:279-286(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hypothalamus.

Entry informationi

Entry nameiAT1A1_CATCO
AccessioniPrimary (citable) accession number: P25489
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: October 1, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3